Caught between triterpene-and steroid-metabolism: 4a-Carboxylic pregnane-derivative from the marine alga-derived fungus Phaeosphaeria spartinae

Steroids

Volumn 78, Issue 9, 2013, Pages 880-883

  Elsebai, Mahmoud Fahmi ^a,b   Kehraus, Stefan ^a   König, Gabriele M ^a  

^a UNIVERSITY OF BONN   (Germany)

^b MANSOURA UNIVERSITY   (Egypt)

Author keywords

Natural products; Phaeosphaeria spartinae; Pregnenolone; Spartopregnenolone

Indexed keywords

4ALPHA CARBOXYLIC PREGNANE DERIVATIVE; ACETIC ACID DERIVATIVE; CARBOXYL GROUP; CARBOXYLIC ACID; LANOSTEROL; PREGNANE DERIVATIVE; SPARTOPREGNENOLONE; TRITERPENE; TRITERPENOID; UNCLASSIFIED DRUG;

ARTICLE; BASIDIOMYCETES; CONTROLLED STUDY; FUNGUS; GANODERMA CONCINNA; NONHUMAN; PHAEOSPHAERIA SPARTINAE;

ALGAE; CERAMIUM; FUNGI; PHAEOSPHAERIA SPARTINAE; RHODOPHYTA;

EID: 84885003549     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2013.05.003     Document Type: Article

References (12)

1. Fernandes P, Cruz A, Angelova B, Pinheiro HM, Cabral JMS. Microbial conversion of steroid compounds: recent developments. Enzyme Microb Technol 2003;32:688-705. (Pubitemid 36513765)
2. Dewick PM. Medicinal natural products: a biosynthetic approach. 3rd ed. Chichester, UK: John Wiley & Sons Ltd.; 2009. p. 277.
3. Kelly D, Kelly S. Rewiring yeast for drug synthesis. Nat Biotechnol 2003;21:133-4.
4. Rateb ME, Ebel R. Secondary metabolites of fungi from marine habitats. Nat Prod Rep 2011;28:290-344.
5. Elsebai MF, Kehraus S, Gütschow M, König GM. New polyketides from the marine-derived fungus Phaeosphaeria spartinae. Nat Prod Commun 2009;4:1463-8.
6. Elsebai MF, Kehraus S, Gütschow M, König GM. Spartinoxide, a new enantiomer of A82775C with inhibitory activity toward HLE from the marine-derived fungus Phaeosphaeria spartinae. Nat Prod Commun 2010;5:1071-6.
7. Wu J, Tokuyama S, Nagai K, Yasuda N, Matsumoto T, Hirai H, Kwagishi H. Strophasterols A to D with an unprecedented steroid skeleton: from the mushroom Stropharia rugosannulata. Angew Chem Int Ed 2012;51:10820-2.
8. González AG, León F, Rivera A, Padrón JI, González-Plata J, Zuluaga JC, et al. New lanostanoids from the fungus Ganoderma concinna. J Nat Prod 2002;65:417-21. (Pubitemid 34260824)
9. Höller U, König GM, Wright AD. Three new metabolites from marine-derived fungi of the genera Coniothyrium and Microsphaeropsis. J Nat Prod 1999;62:114-8. (Pubitemid 29071389)
10. Hatori H, Shibata T, Tsurumi Y, Nakanishi T, Katsuoka M, Ohtsu Y, Sakamoto K, Takase S, Ueda H, Hino M, Fujii T. FR171456, a novel cholesterol synthesis inhibitor produced by Sporormiella minima No. 15604. J Antibiot 2004;57:253-9.
11. Dewick PM. Medicinal natural products: a biosynthetic approach. 3rd ed. Chichester, UK: John Wiley & Sons Ltd.; 2009. p. 249.
12. Duport C, Spagnoli R, Degryse E, Pompon D. Self-sufficient biosynthesis of pregnenolone and progesterone in engineered yeast. Nat Biotechnol 1998;16:186-9. (Pubitemid 28078509)