Genetic variations in pattern recognition receptor loci are associated with anti-TNF response in patients with rheumatoid arthritis

PLoS ONE

Volumn 10, Issue 10, 2015, Pages

  Sode, Jacob ^a,b,c,k   Vogel, Ulla ^d   Bank, Steffen ^e,f   Andersen, Paal Skytt ^a,g   Hetland, Merete Lund ^h,i   Locht, Henning ^b   Heegaard, Niels H H ^a,c   Andersen, Vibeke ^c,e,j,k  

^a STATENS SERUM INSTITUT   (Denmark)

^b FREDERIKSBERG HOSPITAL   (Denmark)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^d NATIONAL RESEARCH CENTRE FOR THE WORKING ENVIRONMENT   (Denmark)

^e VIBORG HOSPITAL   (Denmark)

^f AARHUS UNIVERSITY   (Denmark)

^g UNIVERSITY OF COPENHAGEN   (Denmark)

^h University of Copenhagen   (Denmark)

ⁱ UNIVERSITY OF COPENHAGEN   (Denmark)

^j Hospital of Southern Jutland   (Denmark)

^k ODENSE UNIVERSITY HOSPITAL   (Denmark)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADALIMUMAB; AZATHIOPRINE; CERTOLIZUMAB PEGOL; CHLOROQUINE; DISEASE MODIFYING ANTIRHEUMATIC DRUG; ETANERCEPT; GOLIMUMAB; INFLIXIMAB; LEFLUNOMIDE; METHOTREXATE; PATTERN RECOGNITION RECEPTOR; RHEUMATOID FACTOR; SALAZOSULFAPYRIDINE; ANTIRHEUMATIC AGENT; APOPTOSIS REGULATORY PROTEIN; GAMMA INTERFERON; INFLAMMASOME; NLRP1 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TOLL LIKE RECEPTOR;

ADULT; ARTICLE; CARD8 GENE; CONTROLLED STUDY; DATA BASE; FEMALE; GENE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; IFNGR1 GENE; IFNGR2 GENE; IL12B GENE; IL12RB1 GENE; IL12RB2 GENE; IL17A GENE; IL18 GENE; JAK2 GENE; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; NLRP1 GENE; NLRP3 GENE; RETROSPECTIVE STUDY; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM; TBX21 GENE; TIRAP GENE; TLR1 GENE; TLR5 GENE; VISUAL ANALOG SCALE; AGED; ALLELE; ARTHRITIS, RHEUMATOID; GENE FREQUENCY; GENETIC ASSOCIATION STUDY; GENETICS; MIDDLE AGED; TREATMENT OUTCOME;

ADALIMUMAB; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AGED; ALLELES; ANTIRHEUMATIC AGENTS; APOPTOSIS REGULATORY PROTEINS; ARTHRITIS, RHEUMATOID; ETANERCEPT; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC LOCI; HUMANS; INFLAMMASOMES; INFLIXIMAB; INTERFERON-GAMMA; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RETROSPECTIVE STUDIES; TOLL-LIKE RECEPTORS; TREATMENT OUTCOME;

EID: 84947907336     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0139781     Document Type: Article

References (25)

1. Plant D, Prajapati R, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, et al. Replication of association of the PTPRC gene with response to anti-tumor necrosis factor therapy in a large UK cohort. Arthritis Rheum. 2012 Mar; 64: 665-670. doi: 10.1002/art.33381 PMID: 21952740
2. Acosta-Colman I, Palau NF, Tornero JF, Fernandez-Nebro AF, Blanco FF, Gonzalez-Alvaro IF, et al. GWAS replication study confirms the association of PDE3A-SLCO1C1 with anti-TNF therapy response in rheumatoid arthritis. Pharmacogenomics. 2013; 14: 727-734. doi: 10.2217/pgs.13.60 PMID: 23651021
3. van den Broek M, Visser K, Allaart CF, Huizinga TW. Personalized medicine: predicting responses to therapy in patients with RA. Current Opinion in Pharmacology. 2013 Jun; 13: 463-469. doi: 10.1016/j.coph.2013.03.006 PMID: 23578763
4. Sode J, Vogel U, Bank S, Andersen PS, Thomsen MK, Hetland ML, et al. Anti-TNF treatment response in rheumatoid arthritis patients is associated with genetic variation in the NLRP3-inflammasome. PLoS One. 2014; 9: e100361. doi: 10.1371/journal.pone.0100361 PMID: 24967817
5. Mathews RJ, Robinson JI, Battellino M, Wong C, Taylor JC, Eyre S, et al. Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment. Ann Rheum Dis. 2013 May 17; 0: 1-9. annrheumdis-2013-203276 [pii]; doi: 10.1136/annrheumdis-2013-203276
6. Strowig T, Henao-Mejia J, Elinav E, Flavell R. Inflammasomes in health and disease. Nature. 2012 Jan 19; 481: 278-286. doi: 10.1038/nature10759 PMID: 22258606
7. Potter C, Cordell HJ, Barton A, Daly AK, Hyrich KL, Mann DA, et al. Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NFκB signalling pathways. Ann Rheum Dis. 2010 Jul; 69: 1315-1320. ard.2009.117309 [pii]; doi: 10.1136/ard.2009.117309 PMID: 20448286
8. Yang CA, Scheibenbogen C, Bauer S, Kleinle C, Wex T, Bornschein J, et al. A frequent Toll-like receptor 1 gene polymorphism affects NK- and T-cell IFN-gamma production and is associated with Helicobacter pylori-induced gastric disease. Helicobacter. 2013 Feb; 18: 13-21. doi: 10.1111/hel.12001 PMID: 23067142
9. Dhiman N, Ovsyannikova IG, Vierkant RA, Ryan JE, Shane Pankratz V, Jacobson RM, et al. Associations between SNPs in toll-like receptors and related intracellular signaling molecules and immune responses to measles vaccine: Preliminary results. Vaccine. 2008 Mar 25; 26: 1731-1736. doi: 10.1016/j.vaccine.2008.01.017 PMID: 18325643
10. Klimosch SN, Forsti A, Eckert J, Knezevic J, Bevier M, von SW, et al. Functional TLR5 genetic variants affect human colorectal cancer survival. Cancer Res. 2013 Dec 15; 73: 7232-7242. 0008-5472.CAN-13-1746 [pii]; doi: 10.1158/0008-5472.CAN-13-1746 PMID: 24154872
11. Schroder K, Hertzog PJ, Ravasi TF, Hume DA. Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol. 2004; 75: 163-189. PMID: 14525967
12. McInnes IB, Schett G. The Pathogenesis of Rheumatoid Arthritis. N Engl J Med. 2011 Dec 7; 365: 2205-2219. doi: 10.1056/NEJMra1004965 PMID: 22150039
13. Hetland ML. DANBIO-powerful research database and electronic patient record. Rheumatology (Oxford). 2011 Jan; 50: 69-77. keq309 [pii]; doi: 10.1093/rheumatology/keq309
14. Bank S, Nexo BA, Andersen V, Vogel U, Andersen PS. High-Quality and -Quantity DNA Extraction from Frozen Archival Blood Clots for Genotyping of Single-Nucleotide Polymorphisms. Genet Test Mol Biomarkers. 2013 Apr 10; 17: 501-503. doi: 10.1089/gtmb.2012.0429 PMID: 23574531
15. Fransen J, van Riel PL. The Disease Activity Score and the EULAR response criteria. Clin Exp Rheumatol. 2005 Sep; 23: S93-S99. PMID: 16273792
16. Felson DT, Anderson JJ, Boers M, Bombardier C, Chernoff M, Fried B, et al. The American College of Rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials. The Committee on Outcome Measures in Rheumatoid Arthritis Clinical Trials. Arthritis Rheum. 1993 Jun; 36: 729-740. PMID: 8507213
17. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Series B. 1995; 57: 289-300.
18. Coenen MJ, Enevold C, Barrera P, Schijvenaars MM, Toonen EJ, Scheffer H, et al. Genetic variants in toll-like receptors are not associated with rheumatoid arthritis susceptibility or anti-tumour necrosis factor treatment outcome. PLoS One. 2010; 5: e14326. doi: 10.1371/journal.pone.0014326 PMID: 21179534
19. Uciechowski P, Imhoff H, Lange C, Meyer CG, Browne EN, Kirsten DK, et al. Susceptibility to tuberculosis is associated with TLR1 polymorphisms resulting in a lack of TLR1 cell surface expression. J Leukoc Biol. 2011 Aug; 90: 377-388. jlb.0409233 [pii]; doi: 10.1189/jlb.0409233 PMID: 21642391
20. Hitomi Y, Ebisawa M, Tomikawa M, Imai T, Komata T, Hirota T, et al. Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma. J Allergy Clin Immunol. 2009 Oct; 124: 779-785. doi: 10.1016/j.jaci.2009.07.044 PMID: 19767079
21. Sheridan J, Mack DR, Amre DK, Israel DM, Cherkasov A, Li H, et al. A Non-Synonymous Coding Variant (L616F) in the TLR5 Gene Is Potentially Associated with Crohn's Disease and Influences Responses to Bacterial Flagellin. PLoS ONE. 2013 Apr 11; 8: e61326. doi: 10.1371/journal.pone.0061326 PMID: 23593463
22. Assassi S, Reveille JD, Arnett FC, Weisman MH, Ward MM, Agarwal SK, et al. Whole-blood gene expression profiling in ankylosing spondylitis shows upregulation of toll-like receptor 4 and 5. J Rheumatol. 2011 Jan; 38: 87-98. jrheum.100469 [pii]; doi: 10.3899/jrheum.100469 PMID: 20952467
23. Umicevic MM, Janss L, Vermeulen SH, van de Laar MAFJ, van Riel PLCM, Guchelaar HJ, et al. Estimation of heritability of different outcomes for genetic studies of TNFi response in patients with rheumatoid arthritis. Annals of the Rheumatic Diseases. 2014 Aug 11.
24. Nicotra L, Loram LC, Watkins LR, Hutchinson MR. Toll-like receptors in chronic pain. Exp Neurol. 2012 Apr; 234: 316-329. S0014-4886(11)00358-X [pii]; doi: 10.1016/j.expneurol.2011.09.038 PMID: 22001158
25. Stokes JA, Cheung J, Eddinger K, Corr M, Yaksh TL. Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice. J Neuroinflammation. 2013; 10: 1-14. 1742-2094-10-148 [pii]; doi: 10.1186/1742-2094-10-148