Botulinum Toxin A and B in sialorrhea: Long-term data and literature overview

Toxicon

Volumn 107, Issue , 2015, Pages 129-140

  Petracca, Martina ^a,c   Guidubaldi, Arianna ^a   Ricciardi, Lucia ^a,b   Ialongo, Tàmara ^a   Del Grande, Alessandra ^a   Mulas, Delia ^a   Di Stasio, Enrico ^a   Bentivoglio, Anna Rita ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

Author keywords

Adverse effects; Amyotrophic Lateral Sclerosis; Botulinum Toxin; Long term treatment; Parkinson's Disease; Sialorrhea

Indexed keywords

BOTULINUM TOXIN A; BOTULINUM TOXIN B; PLACEBO;

ADULT; AGE; AGED; AIRWAY OBSTRUCTION; AMYOTROPHIC LATERAL SCLEROSIS; ASPIRATION PNEUMONIA; BULBAR PARALYSIS; BURNING SENSATION; CHEST INFECTION; DIARRHEA; DROOLING FREQUENCY SCALE; DROOLING SEVERITY SCALE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; DRUG TOLERABILITY; DYSARTHRIA; DYSPHAGIA; FACIAL NERVE PARALYSIS; FEMALE; GAIT DISORDER; GASTROINTESTINAL SYMPTOM; HEMATOMA; HUMAN; HYPERSALIVATION; INJECTION SITE PAIN; JAW DISEASE; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; NAUSEA; NECK PAIN; ORAL BLEEDING; PARKINSON DISEASE; PRIORITY JOURNAL; RATING SCALE; RESPIRATORY TRACT INFECTION; REVIEW; SALIVA; SALIVA THICKNESS; SEIZURE; SIDE EFFECT; SPEECH DISORDER; SWELLING; TREATMENT DURATION; ULTRASOUND; VISCOUS SALIVA; VOMITING; XEROSTOMIA; DRUG EFFECTS; INJECTION; SALIVARY GLAND; SIALORRHEA; TREATMENT OUTCOME;

BOTULINUM TOXINS, TYPE A; HUMANS; INJECTIONS; SALIVARY GLANDS; SIALORRHEA; TREATMENT OUTCOME;

EID: 84947866330     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2015.08.014     Document Type: Article

References (79)

1. A.H. Alrefai, S.K. Aburahma, and Y.S. Khader Treatment of sialorrhea in children with cerebral palsy: a double-blind placebo controlled trial Clin. Neurol. Neurosurg. 111 1 2009 79 82
2. E. Anagnostou, M. Rentzos, T. Alexakis, V. Zouvelou, T. Zambelis, and I. Evdokimidis Volume matters: the influence of different botulinum toxin-A dilutions for sialorrhea in amyotrophic lateral sclerosis Muscle Nerve 47 2 2013 276 278
3. K.J. Banerjee, C. Glasson, and S.J. O'Flaherty Parotid and submandibular botulinum toxin A injections for sialorrhoea in children with cerebral palsy Dev. Med. Child. Neurol. 48 11 2006 883 887
4. M. Basciani, F. Di Rienzo, A. Fontana, M. Copetti, F. Pellegrini, and D. Intiso Botulinum toxin type B for sialorrhea in children with cerebral palsy: a randomized trial comparing dose Dev. Med. Child. Neurol. 53 2011 559 564
5. B.J. Baum, J.A. Ship, and A.J. Wu Salivary gland function and aging: a model for studying the interaction of aging and systemic disease Crit. Rev. Oral Biol. Med. 4 1992 53 64
6. J. Benson, and K.K. Daugherty Botulinum toxin A in the treatment of sialorrhea Ann. Pharmacother. 41 1 2007 79 85
7. K.P. Bhatia, A. Munchau, and P. Brown Botulinum toxin is a useful treatment in excessive drooling in saliva J. Neurol. Neurosurg. Psychiatry 67 5 1999 697
8. J.E. Bothwell, K. Clarke, J.M. Dooley, and et al. Botulinum toxin A as a treatment for excessive drooling in children Pediatr. Neurol. 27 1 2002 18 22
9. K.O. Bushara Sialorrhea in amyotrophic lateral sclerosis: a hypothesis of a new treatment-botulinum toxin A injections of the parotid glands Med. Hypotheses 48 4 1997 337 339
10. P. Capaccio, S. Torretta, M. Osio, and et al. Botulinum toxin therapy: a tempting tool in the management of salivary secretory disorders Am. J. Otolaryngol. 29 5 2008 333 338
11. K.H. Chan, C. Liang, P. Wilson, D. Higgins, and G.C. Allen Long-term safety and efficacy data on botulinum toxin type A: an injection for sialorrhea JAMA Otolaryngol. Head. Neck Surg. 139 2 2013 134 138
12. R. Chinnapongse, K. Gullo, P. Nemeth, Y. Zhang, and L. Griggs Safety and efficacy of botulinum toxin type B for treatment of sialorrhea in Parkinson's disease: a prospective double-blind trial Mov. Disord. 27 2 2012 219 226 Feb
13. T. Çiftçi, D. AkIncI, N. Yurttutan, and O. Akhan US-guided botulinum toxin injection for excessive drooling in children Diagn Interv. Radiol. 19 1 2013 56 60
14. C. Colosimo, M. Chianese, M. Giovannelli, M.F. Contarino, and A.R. Bentivoglio Botulinum toxin type B in blepharospasm and hemifacial spasm J. Neurol. Neurosurg. Psychiatry 74 5 2003 687
15. M.F. Contarino, M. Pompili, P. Tittoto, and et al. Botulinum toxin B ultrasound-guided injections for sialorrhea in amyotrophic lateral sclerosis and Parkinson's disease Park. Relat. Disord. 13 5 2007 299 303 Epub 2006 Jun 27
16. B. Corradino, S. Di Lorenzo, and F. Moschella Botulinum toxin A for oral cavity cancer patients: in microsurgical patients BTX injections in major salivary glands temporarily reduce salivary production and the risk of local complications related to saliva stagnation Toxins (Basel) 4 11 2012 956 961
17. J. Costa, C. Espirito-Santo, A. Borges, and et al. Botulinum toxin type B for cervical dystonia Cochrane Database Syst. Rev. 2005 10.1002/14651858 2005 Jan 25; (1): CD004315
18. J. Costa, M.L. Rocha, J. Ferreira, T. Evangelista, M. Coelho, and M. de Carvalho Botulinum toxin type-B improves sialorrhea and quality of life in bulbar onset amyotrophic lateral sclerosis J. Neurol. 255 4 2008 545 550
19. O. Dogu, D. Apaydin, S. Sevim, D.U. Talas, and M. Aral Ultrasound-guided versus 'blind' intraparotid injections of botulinum toxin-A for the treatment of sialorrhoea in patients with Parkinson's disease Clin. Neurol. Neurosurg. 106 2 2004 93 96
20. M. Ellies, U. Gottstein, S. Rohrbach-Volland, C. Arglebe, and R. Laskawi Reduction of salivary flow with botulinum toxin: extended report on 33 patients with drooling, salivary fistulas, and sialadenitis Laryngoscope 114 10 2004 1856 1860
21. M. Ellies, R. Laskawi, S. Rohrbach-Volland, C. Arglebe, and W. Beuche Botulinum toxin to reduce saliva flow: selected indications for ultrasound-guided toxin application into salivary glands Laryngoscope 112 1 2002 82 86
22. M. Ellies, R. Laskawi, S. Rohrbach-Volland, and C. Arglebe Up-to-date report of botulinum toxin therapy in patients with drooling caused by different etiologies J. Oral Maxillofac. Surg. 61 2003 454 457
23. C.E. Erasmus, K. van Hulst, A.R. Scheffer, and et al. What could predict effectiveness of botulinum toxin to treat drooling: a search for evidence of discriminatory factors on the level of body functions or structures Eur. J. Paediatr. Neurol. 16 2 2012 126 131
24. C.E. Erasmus, K. Van Hulst, F.J. Van Den Hoogen, and et al. Thickened saliva after effective management of drooling with botulinum toxin A Dev. Med. Child. Neurol. 52 6 2010 114 118
25. A. Friedman, and A. Potulska Quantitative assessment of parkinsonian sialorrhea and results of treatment with botulinum toxin Park. Relat. Disord. 7 4 2001 329 332
26. E.M. Ghezzi, and J.A. Ship Aging and secretory reserve capacity of major salivary glands J. Dent. Res. 82 10 2003 844 848
27. R. Giess, M. Naumann, E. Werner, and et al. Injections of botulinum toxin A into the salivary glands improve sialorrhoea in amyotrophic lateral sclerosis J. Neurol. Neurosurg. Psychiatry 69 1 2000 121 123
28. F. Gilio, E. Iacovelli, V. Frasca, and et al. Botulinum toxin type A for the treatment of sialorrhoea in amyotrophic lateral sclerosis: a clinical and neurophysiological study Amyotroph. Later. Scler. 11 4 2010 359 363
29. G. Gok, N. Cox, J. Bajwa, D. Christodoulou, A. Moody, and D.C. Howlett Ultrasound-guided injection of botulinum toxin A into the submandibular gland in children and young adults with sialorrhoea Br. J. Oral Maxillofac. Surg. 51 3 2013 231 233
30. A. Guidubaldi, A. Fasano, T. Ialongo, and et al. Botulinum toxin A versus B in sialorrhea: a prospective, randomized, double-blind, crossover pilot study in patients with amyotrophic lateral sclerosis or Parkinson's disease Mov. Disord. 26 2 2011 313 319
31. S. Hassin-Baer, E. Scheuer, A.S. Buchman, I. Jacobson, and B. Ben-Zeev Botulinum toxin injections for children with excessive drooling J. Child. Neurol. 20 2 2005 120 123
32. N. Hay, and C. Penn Botox to reduce drooling in a paediatric population with neurological impairments: a phase I study Int. J. Lang. Commun. Disord. 46 5 2011 550 563
33. R.G. Heine, A.G. Catto-Smith, and D.S. Reddihough Effect of antireflux medication on salivary drooling in children with cerebral palsy Dev. Med. Child. Neurol. 38 11 1996 1030 1036
34. G.-Y. Hsiung, S.K. Das, R. Ranawaya, A.L. Lafontaine, and O. Sucherowsky Long-term efficacy of botulinum toxin A in the treatment of various disorders over a 10 year period Mov. Disord. 17 2002 1288 1293
35. C.E. Jackson, G. Gronseth, J. Rosenfeld, and et al. Muscle study group. Randomized double-blind study of botulinum toxin type B for sialorrhea in ALS patients Muscle Nerve 39 2 2009 137 143
36. I.S. Jeung, S. Lee, H.S. Kim, and C.K. Yeo Effect of botulinum toxin A injection into the salivary glands for sialorrhea in children with neurologic disorders Ann. Rehabil. Med. 36 3 2012 340 346
37. P.H. Jongerius, J.J. Rotteveel, F. van den Hoogen, F. Joosten, K. van Hulst, and F.J. Gabreëls Botulinum toxin A: a new option for treatment of drooling in children with cerebral palsy. Presentation of a case series Eur. J. Pediatr. 160 8 2001 509 512
38. P.H. Jongerius, F.J. van den Hoogen, J. van Limbeek, F.J. Gabreëls, K. van Hulst, and J.J. Rotteveel Effect of botulinum toxin in the treatment of drooling: a controlled clinical trial Pediatrics 114 3 2004 620 627
39. W.H. Jost Treatment of drooling in Parkinson's disease with botulinum toxin Mov. Disord. 14 6 1999 1057
40. K.G. Kahl, J. Hagenah, S. Zapf, P. Trillenberg, C. Klein, and R. Lencer Botulinum toxin as an effective treatment of clozapine-induced hypersalivation Psychopharmacol. Berl. 173 1-2 2004 229 230
41. W.U. Khan, P. Campisi, S. Nadarajah, and et al. Botulinum toxin a for treatment of sialorrhea in children. An effective, minimally invasive approach Arch. Otolaryngoi. Head Neck Surg. 137 4 2011 339 344
42. S.H. Ko, Y.B. Shin, J.H. Min, and et al. Botulinum toxin in the treatment of drooling in tetraplegic patients with brain injury Ann. Rehabil. Med. 37 6 2013 796 803
43. G. Lagalla, M. Millevolte, M. Capecci, L. Provinciali, and M.G. Ceravolo Botulinum toxin type A for drooling in Parkinson's disease: a double-blind, randomized, placebo-controlled study Mov. Disord. 21 5 2006 704 707
44. G. Lagalla, M. Millevolte, M. Capecci, L. Provinciali, and M.G. Ceravolo Long-lasting benefits of botulinum toxin type B in Parkinson's disease-related drooling J. Neurol. 256 4 2009 563 567
45. M. Lim, A. Mace, S.A. Nouraei, and G. Sandhu Botulinum toxin in the management of sialorrhoea: a systematic review Clin. Otolaryngol. 31 4 2006 267 272
46. Y.C. Lin, J.Y. Shieh, M.L. Cheng, and P.Y. Yang Botulinum toxin type A for control of drooling in Asian patients with cerebral palsy Neurology 70 4 2008 316 318
47. A. Lipp, T. Trottenberg, T. Schink, A. Kupsch, and G. Arnold A randomized trial of botulinum toxin A for treatment of drooling Neurology 61 9 2003 1279 1281
48. F. Mancini, R. Zangaglia, S. Cristina, and et al. Double-blind, placebo-controlled study to evaluate the efficacy and safety of botulinum toxin type A in the treatment of drooling in parkinsonism Mov. Disord. 18 6 2003 685 688
49. D. Manrique Application of botulinum toxin to reduce the saliva in patients with amyotrophic lateral sclerosis Braz J. Otorhinolaryngol. 71 5 2005 566 569
50. R.P. Mehta, S.N. Goldman, and L.A. Orloff Long-term therapy for spasmodic dysphonia: acoustic and aerodynamic outcomes Arch. Otolaryngol. Head Neck Surg. 127 2001 393 399
51. E. Møller, M. Karlsborg, A. Bardow, J. Lykkeaa, F.H. Nissen, and M. Bakke Treatment of severe drooling with botulinum toxin in amyotrophic lateral sclerosis and Parkinson's disease: efficacy and possible mechanisms Acta Odontol. Scand. 69 3 2011 151 157
52. H. Nordgarden, I. ∅sterhus, A. Møystad, and et al. Drooling: are botulinum toxin injections into the major salivary glands a good treatment option? J. Child. Neurol. 27 4 2012 458 464
53. W.G. Ondo, C. Hunter, and W. Moore A double-blind placebo-controlled trial of botulinum toxin B for sialorrhea in Parkinson's disease Neurology 62 1 2004 37 40
54. H. Pajukoski, J.H. Meurman, S. Snellman-Grohn, S. Keinanen, and R. Sulkava Salivary flow and composition in elderly patients referred to an acute care geriatric ward Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 84 1997 265 271
55. P.K. Pal, D.B. Calne, S. Calne, and J.K. Tsui Botulinum toxin A as treatment for drooling saliva in PD Neurology 54 1 2000 244 247
56. H.D. Park, H.J. Kim, S.J. Park, and Y.M. Choi Comparing the effect of botulinum Toxin type B injection at different dosages for patient with drooling due to brain lesion Ann. Rehabil. Med. 36 6 2012 841 848
57. M. Porta, M. Gamba, G. Bertacchi, and P. Vaj Treatment of sialorrhea with ultrasound guided botulinum toxin type A injection in patients with neurological disorders J. Neurol. Neurosurg. Psychiatry 70 4 2001 538 540
58. B.A. Racette, L. Good, S. Sagitto, and J.S. Perlmutter Botulinum toxin B reduces sialorrhea in parkinsonism Mov. Disord. 18 9 2003 1059 1061
59. S.M. Reid, B.R. Johnstone, C. Westbury, B. Rawicki, and D.S. Reddihough Randomized trial of botulinum toxin injections into the salivary glands to reduce drooling in children with neurological disorders Dev. Med. Child. Neurol. 50 2 2008 123 128
60. S.M. Reid, J.E. Walstab, D. Chong, C. Westbury, and D.S. Reddihough Secondary effects of botulinum toxin injections into salivary glands for the management of pediatric drooling J. Craniofac. Surg. 24 1 2013 28 33
61. R. Savarese, M. Diamond, E. Elovic, and S.R. Millis Intraparotid injection of botulinum toxin A as a treatment to control sialorrhea in children with cerebral palsy Am. J. Phys. Med. Rehabil. 83 4 2004 304 311 quiz 312-4, 336
62. A.R. Scheffer, C. Erasmus, K. van Hulst, J. van Limbeek, P.H. Jongerius, and F.J. van den Hoogen Efficacy and duration of botulinum toxin treatment for drooling in 131 children Arch. Otolaryngol. Head Neck Surg. 136 9 2010 873 877
63. A.S. Schroeder, T. Kling, K. Huss, and et al. Botulinum toxin type A and B for the reduction of hypersalivation in children with neurological disorders: a focus on effectiveness and therapy adherence Neuropediatrics 43 1 2012 27 36
64. J. Scott, E.A. Flower, and J. Burns A quantitative study of histological changes in the human parotid gland occurring with adult age J. Oral Pathol. 16 1987 505 510
65. J.A. Ship, N.E. Nolan, and S.A. Puckett Longitudinal analysis of parotid and submandibular salivary flow rates in healthy, different-aged adults J. Gerontol. A Biol. Sci. Med. Sci. 50 1995 M285 M289
66. A.J. Sidebottom, J.E. May, and A.K. Madahar Role of botulinum toxin A injection into the submandibular salivary glands as an assessment for the subsequent removal of the submandibular glands in the management of children with sialorrhoea Br. J. Oral Maxillofac. Surg. 51 2 2013 113 116
67. N. Sriskandan, A. Moody, and D.C. Howlett Ultrasound-guided submandibular gland injection of botulinum toxin for hypersalivation in cerebral palsy Br. J. Oral Maxillofac. Surg. 48 1 2010 58 60
68. S. Steinlechner, C. Klein, A. Moser, R. Lencer, and J. Hagenah Botulinum toxin B as an effective and safe treatment for neuroleptic-induced sialorrhea Psychopharmacol. Berl. 207 4 2010 593 597
69. C.S. Su, M.Y. Lan, J.S. Liu, and et al. Botulinum toxin type A treatment for Parkinsonian patients with moderate to severe sialorrhea Acta Neurol. Taiwan 15 3 2006 170 176
70. D.L. Suskind, and A. Tilton Clinical study of botulinum-A toxin in the treatment of sialorrhea in children with cerebral palsy Laryngoscope 112 1 2002 73 81
71. M. Svetel, M. Vasić, N. Dragasević, T. Pekmezović, I. Petrović, and V. Kostić Botulinum toxin in the treatment of sialorrhea Vojnosanit. Pregl. 66 1 2009 9 12
72. E.K. Tan, Y.L. Lo, A. Seah, and A.P. Auchus Recurrent jaw dislocation after botulinum toxin treatment for sialorrhoea in amyotrophic lateral sclerosis J. Neurol. Sci. 190 1-2 2001 95 97
73. J. Tiigimäe-Saar, E. Leibur, A. Kolk, I. Talvik, and T. Tamme Use of botulinum neurotoxin A in uncontrolled salivation in children with cerebral palsy: a pilot study Int. J. Oral Maxillofac. Surg. 41 12 2012 1540 1545
74. B. Tousi, J.S. Perumal, K. Ahuja, A. Ahmed, and T. Subramanian Effects of botulinum toxin-B (BTX-B) injections for hemifacial spasm Park. Relat. Disord. 10 7 2004 455 456
75. M. Turk-Gonzales, and I.R. Odderson Quantitative reduction of saliva production with botulinum toxin type B injection into the salivary glands Neurorehabil Neural Repair 19 1 2005 58 61
76. A. Verma, and J. Steele Botulinum toxin improves sialorrhea and quality of living in bulbar amyotrophic lateral sclerosis Muscle Nerve 34 2 2006 235 237
77. B. Wilken, B. Aslami, and H. Backes Successful treatment of drooling in children with neurological disorders with botulinum toxin A or B Neuropediatrics 39 4 2008 200 204
78. M.G. Winterholler, F.J. Erbguth, S. Wolf, and S. Kat Botulinum toxin for the treatment of sialorrhoea in ALS: serious side effects of a transductal approach J. Neurol. Neurosurg. Psychiatry 70 3 2001 417 418
79. K.P. Wu, J.Y. Ke, C.Y. Chen, C.L. Chen, M.Y. Chou, and Y.C. Pei Botulinum toxin type A on oral health in treating sialorrhea in children with cerebral palsy: a randomized, double-blind, placebo-controlled study J. Child. Neurol. 26 7 2011 838 843