Botulinum toxin A in the treatment of sialorrhea

Annals of Pharmacotherapy

Volumn 41, Issue 1, 2007, Pages 79-85

  Benson, Jennifer ^a   Daugherty, Kimberly K ^b,c  

^a Kroger Pharmacy   (United States)

^b FERRIS STATE UNIVERSITY   (United States)

^c NONE   (United States)

Author keywords

Botox; Botulinum; Botulinum toxin; Drooling; Saliva; Salivary gland; Sialorrhea

Indexed keywords

BOTULINUM TOXIN A; SCOPOLAMINE;

CLINICAL TRIAL; DISEASE SEVERITY; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; GENERAL CONDITION IMPROVEMENT; HUMAN; HYPERSALIVATION; LANGUAGE; MEDLINE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; QUALITY OF LIFE; RATING SCALE; REVIEW; SALIVARY GLAND; SYSTEMATIC REVIEW;

BOTULINUM TOXIN TYPE A; HUMANS; SALIVARY GLANDS; SIALORRHEA;

EID: 33846426077     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1H381     Document Type: Review

References (17)

1. Lipp A, Trottenberg T, Schink T, Kupsch A, Arnold G. A randomized trial of botulinum toxin A for treatment of drooling. Neurology 2003; 61:1279-81.
2. Friedman A, Potulska A. Botulinum toxin for treatment of parkinsonian sialorrhea. Neurol Neurochir Pol 2001;35(suppl 3):23-7.
3. Dogu O, Apaydin D, Sevim S, Talas DU, Aral M. Ultrasound-guided versus 'blind' intraparotid injections of botulinum toxin-A for the treatment of sialorrhea in patients with Parkinson's disease. Clin Neurol Neurosurg 2004;106:93-6.
4. Jongerius PH, van den Hoogen FJ, van Limbeek J, Gabreels FJ, van Hulst K, Rotteveel JJ. Effect of botulinum toxin in the treatment of drooling: a controlled clinical trial. Pediatrics 2004;114:620-7.
5. Suskind DL, Tilton A. Clinical study of botulinum-A toxin in the treatment of sialorrhea in children with cerebral palsy. Laryngoscope 2002; 112:73-81.
6. Stuchell RN, Mandel ID. Salivary gland dysfunction and swallowing disorders. Otolaryngol Clin North Am 1988;21:649-61.
7. Jongerius PH, Joosten F, Hoogen FJ, Gabreels FJ, Rotteveel JJ. The treatment of drooling by ultrasound-guided intraglandular injections of botulinum toxin type A into the salivary glands. Laryngoscope 2003; 113:107-11.
8. Savarese R, Diamond M, Elovic E, Millis SR. Intraparotid injection of botulinum toxin A as a treatment to control sialorrhea in children with cerebral palsy. Am J Phys Med Rehabil 2004;83:304-11.
9. Thant Z, Tan E. Emerging therapeutic applications of botulinum toxin. Med Sci Monit 2003;9:40-8.
10. Ellies M, Gottstein U, Rohrbach-Volland S, Arglebe C, Laskawi R. Reduction of salivary flow with botulinum toxin: extended report on 33 patients with drooling, salivary fistulas, and sialadenitis. Laryngoscope 2004;114:1856-60.
11. Bothwell JE, Clarke K, Dooley JM, et al. Botulinum toxin A as a treatment for excessive drooling in children. Pediatr Neurol 2002;27:18-22.
12. Hassin-Baer S, Scheuer E, Buchman AS, Jacobson I, Ben-Zeev B. Botulinum toxin injections for children with excessive drooling. J Child Neurol 2005;20:120-3.
13. Pal PK, Calne DB, Calne S, Tsui JK. Botulinum toxin A as treatment for drooling saliva in PD. Neurology 2000;54:244-7.
14. Giess R, Naumann M, Werner E, et al. Injections of botulinum toxin A into the salivary glands improve sialorrhea in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 2001;70:417-8.
15. Porta M, Gamba M, Bertacchi G, Vaj P. Treatment of sialorrhea with ultrasound guided botulinum toxin type A injection in patients with neurological disorders. J Neurol Neurosurg Psychiatry 2001;70:538-40.
16. Mancini F, Zangaglia R, Cristina S, et al. Double-blind, placebo-controlled study to evaluate the efficacy and safety of botulinum toxin type A in the treatment of drooling in parkinsonism. Mov Disord 2003;18: 685-8.
17. Lagalla G, Millevolte M, Capecci M, Provinciali L, Ceravolo MG. Botulinum toxin type A for drooling in Parkinson's disease: a double-blind, randomized, placebo-controlled study. Mov Disord 2006;21:704-7.