A randomized trial of botulinum toxin A for treatment of drooling

Neurology

Volumn 61, Issue 9, 2003, Pages 1279-1281

  Lipp, Axel ^a   Trottenberg, T ^b   Schink, T ^b   Kupsch, A ^b   Arnold, G ^b  

^a HUMBOLDT UNIVERSITY   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM TOXIN A; PLACEBO;

ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG SAFETY; FEMALE; FOLLOW UP; HUMAN; HYPERSALIVATION; INJECTION; MALE; PAROTID GLAND; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TREATMENT OUTCOME;

EID: 0242662829     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.61.9.1279     Document Type: Article

References (10)

1. Eadie MJ, Tyrer JH. Alimentary disorder in parkinsonism. Aust Ann Med 1965;14:13-15.
2. Rose FC. The management of motor neuron disease. Adv Exp Med Biol 1987;209:167-174.
3. Townsend GL, Morimoto AM, Kralemann H. Management of sialorrhea in mentally retarded patients by transtympanic neurectomy. Mayo Clin Proc 1973;48:776-779.
4. Klem C, Mair EA. Four-duct ligation: a simple and effective treatment for chronic aspiration from sialorrhea. Arch Otolaryngol Head Neck Surg 1999;125:796-800.
5. Ethunandan M, Macpherson DW. Persistent drooling: treatment by bilateral submandibular duct transposition and simultaneous sublingual gland excision. Ann R Coll Surg Engl 1998;80:279-282.
6. Moore AP. Botulinum toxin A (BoNT-A) for spasticity in adults. What is the evidence? Eur J Neurol 2002;9(suppl 1):42-47.
7. Wissel J, Kanovsky P, Ruzicka E, et al. Efficacy and safety of a standardised 500 unit dose of Dysport (clostridium botulinum toxin type A haemaglutinin complex) in a heterogeneous cervical dystonia population: results of a prospective, multicentre, randomised, double-blind, placebo-controlled, parallel group study. J Neurol 2001;248:1073-1078.
8. Giess R, Naumann M, Werner E, et al. Injections of botulinum toxin A into the salivary glands improve sialorrhoea in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 2000;69:121-123.
9. Pal PK, Calne DB, Calne S, Tsui JK. Botulinum toxin A as treatment for drooling saliva in PD. Neurology 2000;54:244-247.
10. Brunner E, Domhof S, Langer F. Nonparametric Analysis of Longitudinal Data in Factorial Experiments. New York: Wiley, 2002.