Synthesis and antibacterial activity of novel quaternary ammonium pyridoxine derivatives

Medicinal Chemistry

Volumn 11, Issue 7, 2015, Pages 656-665

  Shtyrlin, Nikita V ^a   Sapozhnikov, Sergey V ^a   Koshkin, Sergey A ^a   Iksanova, Alfiya G ^a   Sabirov, Arthur H ^a   Kayumov, Airat R ^a   Nureeva, Aliya A ^a   Zeldi, Marina I ^a   Shtyrlin, Yurii G ^a  

^a KAZAN FEDERAL UNIVERSITY   (Russian Federation)

Author keywords

Antibacterial activity; Cytotoxicity; Genotoxicity; Pyridoxine; Quaternary ammonium salts

Indexed keywords

2 [(DIMETHYL(OCTADECYL)AMMONIO)METHYL] 5 HYDROXY 3,4 BIS(HYDROXYMETHYL) 6 METHYLPYRIDIN 1 IUM DIBROMIDE; 2 [(DIMETHYL(OCTYL)AMMONIO)METHYL] 5 HYDROXY 3,4 BIS(HYDROXYMETHYL) 6 METHYLPYRIDIN 1 IUM DIBROMIDE; 2,3 BIS[(DIMETHYL(OCTYL)AMMONIO)METHYL] 5 HYDROXY 4 (HYDROXYMETHYL) 6 METHYLPYRIDIN 1 IUM TRICHLORIDE; 3 HYDROXY 4 (HYDROXYMETHYL) 2 METHYL 6,6 DIOCTYL 6,7 DIHYDRO 5H PYRROLO[3,4 B]PYRIDINE 1,6 DIIUM DICHLORIDE; 3 HYDROXY 4 (HYDROXYMETHYL) 2,6,6 TRIMETHYL 6,7 DIHYDRO 5H PYRROLO[3,4 B]PYRIDINE 1,6 DIIUM DICHLORIDE; 3 HYDROXY 4,5 BIS(HYDROXYMETHYL) 2 METHYL 6 [(TRIETHYLAMMONIO)METHYL]PYRIDIN 1 IUM DIBROMIDE; 3' HYDROXY 4' (HYDROXYMETHYL) 2' METHYL 5',7' DIHYDROSPIRO[MORPHOLINE 4,6' PYRROLO[3,4 B]PYRIDINE] 1',4 DIIUM DICHLORIDE; 3' HYDROXY 4' (HYDROXYMETHYL) 2' METHYL 5',7' DIHYDROSPIRO[PIPERIDINE 4,6' PYRROLO[3,4 B]PYRIDINE] 1,1' DIIUM DICHLORIDE; 3,3,5 TRIMETHYL 7,9 DIHYDRO 1H SPIRO[[1,3]DIOXINO[5,4 D]PYRROLO[3,4 B]PYRIDINE 8,1' PIPERIDIN] 1 IUM CHLORIDE; 3,3,5 TRIMETHYL 7,9 DIHYDRO 1H SPIRO[[1,3]DIOXINO[5,4D]PYRROLO[3,4 B]PYRIDINE 8,4' MORPHOLIN] 4' IUM CHLORIDE; 3,3,5 TRIMETHYL 8,8 DIOCTYL 1,7,8,9 TETRAHYDRO [1,3]DIOXINO[5,4 D]PYRROLO[3,4 B]PYRIDIN 8 IUM CHLORIDE; 3,3,5,8,8 PENTAMETHYL 1,7,8,9 TETRAHYDRO [1,3]DIOXINO[5,4D]PYRROLO[3,4 B]PYRIDIN IUM CHLORIDE; 5 [(DIMETHYL(OCTADECYL)AMMONIO)METHYL] 3 HYDROXY 4 (HYDROXYMETHYL) 2 METHYLPYRIDIN 1 IUM DICHLORIDE; 5 [(DIMETHYL(OCTYL)AMMONIO)METHYL] 3 HYDROXY 4 (HYDROXYMETHYL) 2 METHYLPYRIDIN 1 IUM DICHLORIDE; 6,6 DIBENZYL 3 HYDROXY 4 (HYDROXYMETHYL) 2 METHYL 6,7 DIHYDRO 5H PYRROLO[3,4 B]PYRIDINE 1,6 DIIUM DICHLORIDE; 6,6 DIBUTYL 3 HYDROXY 4 (HYDROXYMETHYL) 2 METHYL 6,7 DIHYDRO 5H PYRROLO[3,4 B]PYRIDINE 1,6 DIIUM DICHLORIDE; 6,6 DIETHYL 3 HYDROXY 4 (HYDROXYMETHYL) 2 METHYL 6,7 DIHYDRO 5H PYRROLO[3,4 B]PYRIDINE 1,6 DIIUM DICHLORIDE; 8,8 DIBENZYL 3,3,5 TRIMETHYL 1,7,8,9 TETRAHYDRO [1,3]DIOXINO[5,4 D]PYRROLO[3,4 B]PYRIDIN 8 IUM CHLORIDE; 8,8 DIBUTYL 3,3,5 TRIMETHYL 1,7,8,9 TETRAHYDRO [1,3]DIOXINO [5,4 D]PYRROLO[3,4 B]PYRIDIN 8 IUM CHLORIDE; 8,8 DIETHYL 3,3,5 TRIMETHYL 1,7,8,9 TETRAHYDRO [1,3]DIOXINO [5,4 D]PYRROLO[3,4 B]PYRIDIN 8 IUM CHLORIDE; ANTIBIOTIC AGENT; N [(5 (HYDROXYMETHYL) 2,2,8 TRIMETHYL 4H [1,3]DIOXINO [4,5 C]PYRIDIN 6 YL)METHYL] N,N DIMETHYLOCTAN 1 AMINIUM BROMIDE; N [(5 (HYDROXYMETHYL) 2,2,8 TRIMETHYL 4H [1,3]DIOXINO[4, 5 C]PYRIDIN 6 YL)METHYL] N,N DIMETHYLOCTADECAN 1 AMINIUM BROMIDE; N,N DIETHYL N [(5 (HYDROXYMETHYL) 2,2,8 TRIMETHYL 4H [1,3]DIOXINO[4,5 C]PYRIDIN 6 YL)METHYL]ETHANAMINIUM BROMIDE; N,N DIMETHYL N [(2,2,8 TRIMETHYL 4H [1,3]DIOXINO[4,5 C]PYRIDIN 5 YL)METHYL]OCTADECAN 1 AMINIUM; N,N DIMETHYL N [(2,2,8 TRIMETHYL 4H [1,3]DIOXINO[4,5 C]PYRIDIN 5 YL)METHYL]OCTAN 1 AMINIUM CHLORIDE; N,N' [(2,2,8 TRIMETHYL 4H [1,3]DIOXINO[4,5 C]PYRIDINE 5,6 DIYL)BIS(METHYLENE)]BIS(N,N DIMETHYLOCTAN 1 AMINIUM)DICHLORIDE; PYRIDOXINE DERIVATIVE; QUATERNARY AMMONIUM DERIVATIVE; UNCLASSIFIED DRUG; VANCOMYCIN; ANTIINFECTIVE AGENT; PYRIDOXINE;

ANTIBACTERIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SYNTHESIS; ESCHERICHIA COLI K 12; FIBROBLAST; GENOTOXICITY; HEK293 CELL LINE; HUMAN; HUMAN CELL; HYDROLYSIS; IN VITRO STUDY; LIPOPHILICITY; MICROCOCCUS LUTEUS; MINIMUM INHIBITORY CONCENTRATION; MTT ASSAY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; STAPHYLOCOCCUS AUREUS; BACTERIUM; CHEMICAL PHENOMENA; CHEMISTRY; DRUG EFFECTS; MICROBIAL SENSITIVITY TEST; MUTAGEN TESTING; SYNTHESIS;

ANTI-BACTERIAL AGENTS; BACTERIA; CHEMISTRY TECHNIQUES, SYNTHETIC; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICROBIAL SENSITIVITY TESTS; MUTAGENICITY TESTS; PYRIDOXINE; QUATERNARY AMMONIUM COMPOUNDS;

EID: 84947809883     PISSN: 15734064     EISSN: 18756638     Source Type: Journal    
DOI: 10.2174/1573406411666150504122930     Document Type: Article

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