Bis-phosphonium salts of pyridoxine: The relationship between structure and antibacterial activity

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 23, 2013, Pages 7330-7342

  Pugachev, Mikhail V ^a   Shtyrlin, Nikita V ^a   Sapozhnikov, Sergey V ^a   Sysoeva, Lubov P ^a   Iksanova, Alfiya G ^a   Nikitina, Elena V ^a   Musin, Rashid Z ^b   Lodochnikova, Olga A ^b   Berdnikov, Eugeny A ^a   Shtyrlin, Yurii G ^a  

^a KAZAN FEDERAL UNIVERSITY   (Russian Federation)

^b A E ARBUZOV INSTITUTE OF ORGANIC AND PHYSICAL CHEMISTRY   (Russian Federation)

Author keywords

Antibacterial activity; Lipophilicity; Pyridoxine; Quaternary phosphonium salts; Structure activity relationship

Indexed keywords

2,3 BIS[(TRI 3 TOLYLPHOSPHONIO)METHYL] 5 HYDROXY 4 (HYDROXYMETHYL) 6 METHYLPYRIDINE 1 IUM TRICHLORIDE; 2,3 BIS[(TRI 4 TOLYLPHOSPHONIO)METHYL] 5 HYDROXY 4 (HYDROXYMETHYL) 6 METHYLPYRIDINE 1 IUM TRICHLORIDE; 2,3 BIS[[TRIS(4 FLUOROPHENYL)PHOSPHONIO]METHYL] 5 HYDROXY 4 (HYDROXYMETHYL) 6 METHYLPYRIDINE 1 IUM TRICHLORIDE; 2,3 BIS[[TRIS(THIOPHEN 2 YL)PHOSPHONIO]METHYL] 5 HYDROXY 4 (HYDROXYMETHYL) 6 METHYLPYRIDINE 1 IUM TRICHLORIDE; 2,3 BIS[TRIBUTYLPHOSPHONIO(METHYL)] 5 HYDROXY 4 (HYDROXYMETHYL) 6 METHYLPYRIDINE 1 IUM TRICHLORIDE; 3 HYDROXY 4 (HYDROXYMETHYL) 2 METHYL 6,6,9,9 TETRAPHENYL 5,6,7,8,9,10 HEXAHYDRO[1,4]DIPHOSPHOCINO[6,7 B]PYRIDINE 1,6,9 TRIIUM TRICHLORIDE; 3,3,5 TRIMETHYL 8,8,11,11 TETRAPHENYL 7,8,9,10,11,12 HEXAHYDRO 1H [1,3]DIOXINO[5,4 D][1,4]DIPHOSPHOCINO[6,7 B]PYRIDINE 8,11 DIIUM DICHLORIDE; 5,6 BIS[(TRI 3 TOLYLPHOSPHONIO)METHYL] 2,2,8 TRIMETHYL 4H [1,3]DIOXINO[4,5 C]PYRIDINE DICHLORIDE; 5,6 BIS[(TRI 4 TOLYLPHOSPHONIO)METHYL] 2,2,8 TRIMETHYL 4H [1,3]DIOXINO[4,5 C]PYRIDINE DICHLORIDE; 5,6 BIS[(TRI 4 TOLYLPHOSPHONIO)METHYL] 8 METHYL 2 PROPYL 4H [1,3]DIOXINO[4,5 C]PYRIDINE DICHLORIDE; 5,6 BIS[[TRIS(4 FLUOROPHENYL)PHOSPHONIO]METHYL] 2,2,8 TRIMETHYL 4H [1,3]DIOXINO[4,5 C]PYRIDINE DICHLORIDE; 5,6 BIS[[TRIS(THIOPHEN 2 YL)PHOSPHONIO]METHYL] 2,2,8 TRIMETHYL 4H [1,3]DIOXINO[4,5 C]PYRIDINE DICHLORIDE; 5,6 BIS[TRIBUTYLPHOSPHONIO(METHYL)] 2,2,8 TRIMETHYL 4H [1,3]DIOXINO[4,5 C]PYRIDINE DICHLORIDE; 5,6 BIS[TRIPHENYLPHOSPHONIO(METHYL)] 2 BUTYL 8 METHYL 4H [1,3]DIOXINO[4,5 C]PYRIDINE DICHLORIDE; 5,6 BIS[TRIPHENYLPHOSPHONIO(METHYL)] 2 ETHYL 8 METHYL 4H [1,3]DIOXINO[4,5 C]PYRIDINE DICHLORIDE; 5,6 BIS[TRIPHENYLPHOSPHONIO(METHYL)] 2 HEPTYL 8 METHYL 4H [1,3]DIOXINO[4,5 C]PYRIDINE DICHLORIDE; 5,6 BIS[TRIPHENYLPHOSPHONIO(METHYL)] 2 ISOPROPYL 8 METHYL 4H [1,3]DIOXINO[4,5 C]PYRIDINE DICHLORIDE; 5,6 BIS[TRIPHENYLPHOSPHONIO(METHYL)] 2,2,8 TRIMETHYL 4H [1,3]DIOXINO[4,5 C]PYRIDINE DIBROMIDE; 5,6 BIS[TRIPHENYLPHOSPHONIO(METHYL)] 2,2,8 TRIMETHYL 4H [1,3]DIOXINO[4,5 C]PYRIDINE DICHLORIDE; 5,6 BIS[TRIPHENYLPHOSPHONIO(METHYL)] 2,2,8 TRIMETHYL 4H [1,3]DIOXINO[4,5 C]PYRIDINE DIIODIDE; 5,6 BIS[TRIPHENYLPHOSPHONIO(METHYL)] 2,2,8 TRIMETHYL 4H [1,3]DIOXINO[4,5 C]PYRIDINE DINITRATE; 5,6 BIS[TRIPHENYLPHOSPHONIO(METHYL)] 2,8 DIMETHYL 4H [1,3]DIOXINO[4,5 C]PYRIDINE DICHLORIDE; 5,6 BIS[TRIPHENYLPHOSPHONIO(METHYL)] 8 METHYL 2 PENTYL 4H [1,3]DIOXINO[4,5 C]PYRIDINE DICHLORIDE; 5,6 BIS[TRIPHENYLPHOSPHONIO(METHYL)] 8 METHYL 2 PROPYL 4H [1,3]DIOXINO[4,5 C]PYRIDINE DICHLORIDE; 6 [TRIPHENYLPHOSPHONIO(METHYL)] 5 (HYDROXYMETHYL) 2,2,8 TRIMETHYL 4H [1,3]DIOXINO[4,5 C]PYRIDIN BROMIDE; ANTIINFECTIVE AGENT; PHOSPHONIUM DERIVATIVE; PYRIDOXINE; UNCLASSIFIED DRUG; VANCOMYCIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; CELL STRAIN HEK293; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTEUS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STRUCTURE ACTIVITY RELATION;

NEGIBACTERIA; POSIBACTERIA; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

ANTIBACTERIAL ACTIVITY; LIPOPHILICITY; PYRIDOXINE; QUATERNARY PHOSPHONIUM SALTS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANTI-BACTERIAL AGENTS; HEK293 CELLS; HUMANS; MICROBIAL SENSITIVITY TESTS; ORGANOPHOSPHORUS COMPOUNDS; PYRIDOXINE; SALTS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84886954100     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.09.056     Document Type: Article

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