Practical method development for the separation of monoclonal antibodies and antibody-drug-conjugate species in hydrophobic interaction chromatography, part 1: Optimization of the mobile phase

Journal of Pharmaceutical and Biomedical Analysis

Volumn 118, Issue , 2016, Pages 393-403

  Rodriguez Aller, Marta ^a   Guillarme, Davy ^a   Beck, Alain ^b   Fekete, Szabolcs ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b Centre d'Immunologie Pierre Fabre   (France)

Author keywords

Antibody drug conjugate; Brentuximab vedotin; Hydrophobic interaction chromatography; Method development; Monoclonal antibody

Indexed keywords

2 PROPANOL; ANTIBODY CONJUGATE; ANTIBODY DRUG CONJUGATE; BRENTUXIMAB VEDOTIN; SODIUM CHLORIDE; UNCLASSIFIED DRUG; CAC10-VCMMAE; MONOCLONAL ANTIBODY;

ADDITION REACTION; ARTICLE; COMPUTER PROGRAM; CONTROLLED STUDY; ELUTION; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; PH; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SEPARATION TECHNIQUE; CHEMICAL PHENOMENA; ION EXCHANGE CHROMATOGRAPHY; MEDICINAL CHEMISTRY; PROCEDURES; TRENDS;

ANTIBODIES, MONOCLONAL; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, ION EXCHANGE; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IMMUNOCONJUGATES;

EID: 84947730438     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2015.11.011     Document Type: Article

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