AZ17: A new bispecific drug targeting IL-6 and IL-23 with potential clinical use - Improves psoriasis in a human xenograft transplantation model

Protein Engineering, Design and Selection

Volumn 28, Issue 10, 2015, Pages 467-479

  Stenderup, Karin ^a   Rosada, Cecilia ^a   Shanebeck, Kurt ^b   Brady, William ^b   Van Brunt, Michael P ^b   King, Gordon ^b   Marelli, Marcello ^b   Slagle, Paul ^b   Xu, Hengyu ^b   Nairn, Natalie W ^b   Johnson, Jeffrey ^b   Wang, Aijun A ^b   Li, Gary ^b   Thornton, Kenneth C ^b   Dam, Tomas N ^c   Grabstein, Kenneth H ^b  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b Allozyne   (United States)

^c ROSKILDE HOSPITAL   (Denmark)

Author keywords

bispecific antibody; IL 23; IL 6; psoriasis; xenograft model

Indexed keywords

ESCHERICHIA COLI; ETHYLENE; ETHYLENE GLYCOL; IMMUNOLOGY; MAMMALS; MOLECULES; MONOCLONAL ANTIBODIES;

CELL DEVELOPMENT; HIGH AFFINITY BINDING; IL-23; IL-6; INFLAMMATORY DISEASE; MULTIFACTORIAL DISEASE; PSORIASIS; THERAPEUTIC EFFICACY;

DERMATOLOGY;

AZ 17; BISPECIFIC ANTIBODY; INTERLEUKIN 23; INTERLEUKIN 23 ANTIBODY; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; MACROGOL; MONOCLONAL ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG; USTEKINUMAB; IL6 PROTEIN, HUMAN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSOCIATION CONSTANT; CHIMERA; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG CONJUGATION; DRUG STABILITY; DRUG TARGETING; EC50; FEMALE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIGHT CHAIN; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSORIASIS; RESTRICTION SITE; SKIN BIOPSY; TH17 CELL; TIME TO MAXIMUM PLASMA CONCENTRATION; XENOGRAFT; ANIMAL; ANTIBODY SPECIFICITY; DISEASE MODEL; IMMUNOLOGY; MOLECULARLY TARGETED THERAPY; RAT;

ANIMALS; ANTIBODIES, BISPECIFIC; ANTIBODY SPECIFICITY; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; INTERLEUKIN-23; INTERLEUKIN-6; MICE; MOLECULAR TARGETED THERAPY; PSORIASIS; RATS; TRANSPLANTATION, HETEROLOGOUS;

EID: 84947718742     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzv034     Document Type: Article

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