The protective role of NAD(P)H:quinone oxidoreductase 1 on acetaminophen-induced liver injury is associated with prevention of adenosine triphosphate depletion and improvement of mitochondrial dysfunction

Archives of Toxicology

Volumn 89, Issue 11, 2015, Pages 2159-2166

  Hwang, Jung Hwan ^a   Kim, Yong Hoon ^a   Noh, Jung Ran ^a   Gang, Gil Tae ^a   Kim, Kyoung Shim ^a   Chung, Hyo Kyun ^b   Tadi, Surendar ^c   Yim, Yong Hyeon ^c   Shong, Minho ^b   Lee, Chul Ho ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Chungnam National University   (South Korea)

^c Korea Research Institute of Standards and Science   (South Korea)

Author keywords

Acetaminophen; Acute liver injury; Mitochondrial dysfunction; NAD(P)H:quinone oxidoreductase 1

Indexed keywords

3 NITROTYROSINE; ADENOSINE TRIPHOSPHATE; ALANINE AMINOTRANSFERASE; APOPTOSIS INDUCING FACTOR; ASPARTATE AMINOTRANSFERASE; CYTOCHROME C; DNA NUCLEOTIDYLEXOTRANSFERASE; ENDONUCLEASE G; N ACETYL 1,4 BENZOQUINONE IMINE; PARACETAMOL; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; NQO1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CLINICAL EVALUATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; KNOCKOUT MOUSE; LIVER CELL; LIVER CYTOSOL; LIVER INJURY; LIVER NECROSIS; LIVER PROTECTION; LIVER TOXICITY; MALE; MEMBRANE DEPOLARIZATION; MORTALITY; MOUSE; NONHUMAN; PRIMARY PREVENTION; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; SENSITIVITY ANALYSIS; WILD TYPE; ANIMAL; C57BL MOUSE; DOSE RESPONSE; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; GENETICS; LIVER MITOCHONDRION; METABOLISM; PATHOLOGY;

ACETAMINOPHEN; ADENOSINE TRIPHOSPHATE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; HEPATOCYTES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA, LIVER; NAD(P)H DEHYDROGENASE (QUINONE); REACTIVE OXYGEN SPECIES;

EID: 84947558324     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1340-5     Document Type: Article

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