Embryonic lethality in homozygous human Her-2 transgenic mice due to disruption of the Pds5b gene

PLoS ONE

Volumn 10, Issue 9, 2015, Pages

  Yong, Carmen S M ^a   Sharkey, Janelle ^a   Duscio, Belinda ^a   Venville, Ben ^a   Wei, Wei Zen ^b,c   Jones, Richard F ^b,c   Slaney, Clare Y ^a   Arnau, Gisela Mir ^d   Papenfuss, Anthony T ^a,d,e   Schröder, Jan ^a,d,e   Darcy, Phillip K ^a,f   Kershaw, Michael H ^a,f  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c KARMANOS CANCER INSTITUTE   (United States)

^d PETER MACCALLUM CANCER CENTRE   (Australia)

^e WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^f MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; DNA BINDING PROTEIN; PDS5B PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHROMOSOME 5; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO MORTALITY; EXON; GENE; GENE SEQUENCE; HOMOZYGOSITY; MOUSE; NONHUMAN; PDS5B GENE; PERINATAL DEATH; TRANSGENIC MOUSE; TUMOR GROWTH; ANIMAL; CHROMOSOMAL MAPPING; FETUS DEATH; GENETICS; HOMOZYGOTE; HUMAN; LETHAL GENE; PHENOTYPE; PROTO ONCOGENE; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CHROMOSOME MAPPING; DNA-BINDING PROTEINS; EXONS; FETAL DEATH; GENES, ERBB-2; GENES, LETHAL; HOMOZYGOTE; HUMANS; MICE; MICE, TRANSGENIC; PHENOTYPE; TRANSCRIPTION FACTORS;

EID: 84947461006     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0136817     Document Type: Article

References (51)

1. Slamon DJ, GodolphinW, Jones LA, Holt JA, Wong SG, et al. (1989) Studies of the HER-2/neu protooncogene in human breast and ovarian cancer. Science 244: 707-712. PMID: 2470152
2. Burstein HJ (2005) The distinctive nature of HER2-positive breast cancers. N Engl J Med 353: 1652-1654. PMID: 16236735
3. Ross JS, Fletcher JA (1998) The HER-2/neu oncogene in breast cancer: prognostic factor, predictive factor, and target for therapy. Stem Cells 16: 413-428. PMID: 9831867
4. Matsuoka T, Yashiro M (2015) Recent advances in the HER2 targeted therapy of gastric cancer. World J Clin Cases 3: 42-51. doi: 10.12998/wjcc.v3.i1.42 PMID: 25610849
5. Mar N, Vredenburgh JJ, Wasser JS (2015) Targeting HER2 in the treatment of non-small cell lung cancer. Lung Cancer 87: 220-225. doi: 10.1016/j.lungcan.2014.12.018 PMID: 25601485
6. Pollock NI, Grandis JR (2015) HER2 as a Therapeutic Target in Head and Neck Squamous Cell Carcinoma. Clin Cancer Res 21: 526-533. doi: 10.1158/1078-0432.CCR-14-1432 PMID: 25424855
7. Morgan RA, Yang JC, Kitano M, Dudley ME, Laurencot CM, et al. (2010) Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. Mol Ther 18: 843-851. doi: 10.1038/mt.2010.24 PMID: 20179677
8. Restifo NP, Dudley ME, Rosenberg SA (2012) Adoptive immunotherapy for cancer: harnessing the T cell response. Nat Rev Immunol 12: 269-281. doi: 10.1038/nri3191 PMID: 22437939
9. Choi YW, Henrard D, Lee I, Ross SR (1987) The mouse mammary tumor virus long terminal repeat directs expression in epithelial and lymphoid cells of different tissues in transgenic mice. J Virol 61: 3013-3019. PMID: 3041021
10. Henrard D, Ross SR (1988) Endogenous mouse mammary tumor virus is expressed in several organs in addition to the lactating mammary gland. J Virol 62: 3046-3049. PMID: 2839721
11. Wen J, Kawamata Y, Tojo H, Tanaka S, Tachi C (1995) Expression of whey acidic protein (WAP) genes in tissues other than the mammary gland in normal and transgenic mice expressing mWAP/hGH fusion gene. Mol Reprod Dev 41: 399-406. PMID: 7576607
12. Wagner KU, McAllister K, Ward T, Davis B, Wiseman R, et al. (2001) Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice. Transgenic Res 10: 545-553. PMID: 11817542
13. Zerafa N, Westwood JA, Cretney E, Mitchell S, Waring P, et al. (2005) Cutting edge: TRAIL deficiency accelerates hematological malignancies. J Immunol 175: 5586-5590. PMID: 16237043
14. Hanker AB, Pfefferle AD, Balko JM, Kuba MG, Young CD, et al. (2013) Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies. Proc Natl Acad Sci U S A 110: 14372-14377. doi: 10.1073/pnas.1303204110 PMID: 23940356
15. Finkle D, Quan ZR, Asghari V, Kloss J, Ghaboosi N, et al. (2004) HER2-targeted therapy reduces incidence and progression of midlife mammary tumors in female murine mammary tumor virus huHER2-transgenic mice. Clin Cancer Res 10: 2499-2511. PMID: 15073130
16. Yamamoto T, Ikawa S, Akiyama T, Semba K, Nomura N, et al. (1986) Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. Nature 319: 230-234. PMID: 3003577
17. Pupa SM, Invernizzi AM, Forti S, Di Carlo E, Musiani P, et al. (2001) Prevention of spontaneous neuexpressing mammary tumor development in mice transgenic for rat proto-neu by DNA vaccination. Gene Ther 8: 75-79. PMID: 11402305
18. Piechocki MP, Ho YS, Pilon S, Wei WZ (2003) Human ErbB-2 (Her-2) transgenic mice: a model system for testing Her-2 based vaccines. J Immunol 171: 5787-5794. PMID: 14634087
19. Pittius CW, Hennighausen L, Lee E, Westphal H, Nicols E, et al. (1988) A milk protein gene promoter directs the expression of human tissue plasminogen activator cDNA to the mammary gland in transgenic mice. Proc Natl Acad Sci U S A 85: 5874-5878. PMID: 2842753
20. Zhang M, Shi Y, Magit D, Furth PA, Sager R (2000) Reduced mammary tumor progression in WAPTAg/WAP-maspin bitransgenic mice. Oncogene 19: 6053-6058. PMID: 11146557
21. Tessier CR, Doyle GA, Clark BA, Pitot HC, Ross J (2004) Mammary tumor induction in transgenic mice expressing an RNA-binding protein. Cancer Res 64: 209-214. PMID: 14729626
22. Wang LX, Westwood JA, Moeller M, Duong CP, Wei WZ, et al. (2010) Tumor ablation by gene-modified T cells in the absence of autoimmunity. Cancer Res 70: 9591-9598. doi: 10.1158/0008-5472.CAN-10-2884 PMID: 21098715
23. John LB, Devaud C, Duong CP, Yong CS, Beavis PA, et al. (2013) Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells. Clin Cancer Res 19: 5636-5646. doi: 10.1158/1078-0432.CCR-13-0458 PMID: 23873688
24. Shintomi K, Hirano T (2009) Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1. Genes Dev 23: 2224-2236. doi: 10.1101/gad.1844309 PMID: 19696148
25. Zhang B, Jain S, Song H, Fu M, Heuckeroth RO, et al. (2007) Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome. Development 134: 3191-3201. PMID: 17652350
26. Carretero M, Ruiz-Torres M, Rodriguez-Corsino M, Barthelemy I, Losada A (2013) Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres. EMBO J 32: 2938-2949. doi: 10.1038/emboj.2013.230 PMID: 24141881
27. Shiloni E, Karp SE, Custer MC, Shilyansky J, Restifo NP, et al. (1993) Retroviral transduction of interferon-gamma cDNA into a nonimmunogenic murine fibrosarcoma: generation of T cells in draining lymph nodes capable of treating established parental metastatic tumor. Cancer Immunol Immunother 37: 286-292. PMID: 8402732
28. Kershaw MH, Jackson JT, Haynes NM, Teng MW, Moeller M, et al. (2004) Gene-engineered T cells as a superior adjuvant therapy for metastatic cancer. J Immunol 173: 2143-2150. PMID: 15265951
29. Langmead B, Trapnell C, Pop M, Salzberg SL (2009) Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol 10: R25. doi: 10.1186/gb-2009-10-3-r25 PMID: 19261174
30. Schroder J, Hsu A, Boyle SE, Macintyre G, Cmero M, et al. (2014) Socrates: identification of genomic rearrangements in tumour genomes by re-aligning soft clipped reads. Bioinformatics.
31. Boeva V, Popova T, Bleakley K, Chiche P, Cappo J, et al. (2012) Control-FREEC: a tool for assessing copy number and allelic content using next-generation sequencing data. Bioinformatics 28: 423-425. doi: 10.1093/bioinformatics/btr670 PMID: 22155870
32. Peters JM, Tedeschi A, Schmitz J (2008) The cohesin complex and its roles in chromosome biology. Genes Dev 22: 3089-3114. doi: 10.1101/gad.1724308 PMID: 19056890
33. Geck P, Maffini MV, Szelei J, Sonnenschein C, Soto AM (2000) Androgen-induced proliferative quiescence in prostate cancer cells: the role of AS3 as its mediator. Proc Natl Acad Sci U S A 97: 10185-10190. PMID: 10963680
34. Losada A, Yokochi T, Hirano T (2005) Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts. J Cell Sci 118: 2133-2141. PMID: 15855230
35. Zhang B, Chang J, Fu M, Huang J, Kashyap R, et al. (2009) Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies. PLoS One 4: e5232. doi: 10.1371/journal.pone.0005232 PMID: 19412548
36. Singer T, Burke E (2003) High-throughput TAIL-PCR as a tool to identify DNA flanking insertions. Methods Mol Biol 236: 241-272. PMID: 14501069
37. Chen ZY, Yant SR, He CY, Meuse L, Shen S, et al. (2001) Linear DNAs concatemerize in vivo and result in sustained transgene expression in mouse liver. Mol Ther 3: 403-410. PMID: 11273783
38. Yan B, Li D, Gou K (2010) Homologous illegitimate random integration of foreign DNA into the X chromosome of a transgenic mouse line. BMC Mol Biol 11: 58. doi: 10.1186/1471-2199-11-58 PMID: 20707910
39. Hamada T, Sasaki H, Seki R, Sakaki Y (1993) Mechanism of chromosomal integration of transgenes in microinjected mouse eggs: sequence analysis of genome-transgene and transgene-transgene junctions at two loci. Gene 128: 197-202. PMID: 8390388
40. Bishop JO, Smith P (1989) Mechanism of chromosomal integration of microinjected DNA. Mol Biol Med 6: 283-298. PMID: 2695741
41. Brinster RL, Chen HY, Trumbauer M, Senear AW, Warren R, et al. (1981) Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs. Cell 27: 223-231. PMID: 6276022
42. Folger KR, Wong EA, Wahl G, Capecchi MR (1982) Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules. Mol Cell Biol 2: 1372-1387. PMID: 6298598
43. Panizza S, Tanaka T, Hochwagen A, Eisenhaber F, Nasmyth K (2000) Pds5 cooperates with cohesin in maintaining sister chromatid cohesion. Curr Biol 10: 1557-1564. PMID: 11137006
44. Stead K, Aguilar C, Hartman T, Drexel M, Meluh P, et al. (2003) Pds5p regulates the maintenance of sister chromatid cohesion and is sumoylated to promote the dissolution of cohesion. J Cell Biol 163: 729-741. PMID: 14623866
45. Wang SW, Read RL, Norbury CJ (2002) Fission yeast Pds5 is required for accurate chromosome segregation and for survival after DNA damage or metaphase arrest. J Cell Sci 115: 587-598. PMID: 11861765
46. Singer SM, Umetsu DT, McDevitt HO (1996) High copy number I-Ab transgenes induce production of IgE through an interluekin 4-dependent mechanism. Proc Natl Acad Sci U S A 93: 2947-2952. PMID: 8610148
47. Wang B, Biron C, She J, Higgins K, Sunshine MJ, et al. (1994) A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3E gene. Proc Natl Acad Sci U S A 91: 9402-9406. PMID: 7937778
48. Wang SH, Lu L, Fan Y, Wicha MS, Cao Z, et al. (2013) Characterization of a novel transgenic mouse tumor model for targeting HER2+ cancer stem cells. Int J Biol Sci 10: 25-32. doi: 10.7150/ijbs.6309 PMID: 24391448
49. Jacob JB, Quaglino E, Radkevich-Brown O, Jones RF, Piechocki MP, et al. (2010) Combining human and rat sequences in her-2 DNA vaccines blunts immune tolerance and drives antitumor immunity. Cancer Res 70: 119-128. doi: 10.1158/0008-5472.CAN-09-2554 PMID: 20048073
50. Radkevich-Brown O, Jacob J, Kershaw M, Wei W-Z (2009) Genetic Regulation of the Response to Her-2 DNA Vaccination in Human Her-2 Transgenic Mice. Cancer Research 69: 212-218. doi: 10.1158/0008-5472.CAN-08-3092 PMID: 19118005
51. De Giovanni C, Nicoletti G, Quaglino E, Landuzzi L, Palladini A, et al. (2014) Vaccines against human HER2 prevent mammary carcinoma in mice transgenic for human HER2. Breast Cancer Res 16: R10. doi: 10.1186/bcr3602 PMID: 24451168