1H NMR based metabolomic profiling revealed doxorubicin-induced systematic alterations in a rat model

Journal of Pharmaceutical and Biomedical Analysis

Volumn 118, Issue , 2016, Pages 338-348

  Niu, Qian Yun ^a   Li, Zhen Yu ^a   Du, Guan Hua ^a,b   Qin, Xue Mei ^a  

^a SHANXI UNIVERSITY   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Doxorubicin; Metabolomic; Multivariate data analysis; NMR; Rats; Toxicity

Indexed keywords

2 OXOGLUTARIC ACID; ACETIC ACID; ACETOACETIC ACID; ACETONE; ALANINE; ALLANTOIN; BENZOIC ACID; BIOLOGICAL MARKER; CITRIC ACID; CREATINE; DIMETHYLGLYCINE; DOXORUBICIN; DRUG METABOLITE; GLUCOSE; GLUTAMIC ACID; GLYCEROL; HIPPURIC ACID; INOSITOL; LACTIC ACID; LEUCINE; LIPID; LYSINE; MALIC ACID; METHYLAMINE; PHOSPHORYLCHOLINE; PYRUVIC ACID; SUCCINIC ACID; TRIMETHYLAMINE OXIDE; UNINDEXED DRUG; XANTHINE; HYDROGEN;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CARDIOTOXICITY; CONTROLLED STUDY; DRUG EXPOSURE; ECHOCARDIOGRAPHY; ENERGY METABOLISM; EXPOSURE; FATTY ACID OXIDATION; HEART LEFT VENTRICLE CONTRACTILITY; HISTOPATHOLOGY; INTESTINE FLORA; MALE; METABOLOMICS; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PURINE METABOLISM; RAT; URINE LEVEL; ANIMAL; ANIMAL MODEL; CARDIAC MUSCLE; DRUG EFFECTS; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PATHOLOGY; PHYSIOLOGY; PROCEDURES; SPRAGUE DAWLEY RAT;

ANIMALS; DOXORUBICIN; ENERGY METABOLISM; HYDROGEN; MALE; METABOLOMICS; MODELS, ANIMAL; MYOCARDIUM; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84947244213     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2015.10.026     Document Type: Article

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