Genetic characterization of carbapenem-resistant enterobacteriaceae and the spread of carbapenem-resistant klebsiella pneumonia ST340 at a university hospital in Thailand

PLoS ONE

Volumn 10, Issue 9, 2015, Pages

  Netikul, Thidarat ^a   Kiratisin, Pattarachai ^a  

^a MAHIDOL UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; CARBAPENEM; CEFTAZIDIME; CIPROFLOXACIN; COTRIMOXAZOLE; DORIPENEM; ERTAPENEM; GENTAMICIN; IMIPENEM; MEROPENEM; NETILMICIN; TETRACYCLINE; TIGECYCLINE; ANTIINFECTIVE AGENT; CARBAPENEM DERIVATIVE;

ADOLESCENT; ADULT; AGED; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATE; BLAIMP14A GENE; BLAKPC13 GENE; CARBAPENEM RESISTANT ENTEROBACTERIACEAE; CARBAPENEM RESISTANT KLEBSIELLA PNEUMONIAE ST340; CHILD; CITROBACTER FREUNDII; CLINICAL ARTICLE; CONTROLLED STUDY; ENTEROBACTER CLOACAE; ESCHERICHIA COLI; FEMALE; GENE EXPRESSION; GENOTYPE; HUMAN; INFANT; KLEBSIELLA PNEUMONIAE; MALE; MOLECULAR CLONING; MOLECULAR EPIDEMIOLOGY; MOLECULAR TYPING; MULTILOCUS SEQUENCE TYPING; NONHUMAN; OMPK35 GENE; OMPK36 GENE; PHENOTYPE; PREVALENCE; PULSED FIELD GEL ELECTROPHORESIS; THAILAND; UNIVERSITY HOSPITAL; CROSS INFECTION; DRUG EFFECTS; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; GENETICS; KLEBSIELLA INFECTIONS; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MIDDLE AGED; PRESCHOOL CHILD; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BETA-LACTAM RESISTANCE; CARBAPENEMS; CHILD; CHILD, PRESCHOOL; CROSS INFECTION; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; FEMALE; HOSPITALS, UNIVERSITY; HUMANS; INFANT; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; MOLECULAR EPIDEMIOLOGY; THAILAND; YOUNG ADULT;

EID: 84947216619     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0139116     Document Type: Article

References (46)

1. Vardakas KZ, Tansarli GS, Rafailidis PI, Falagas ME (2012) Carbapenems versus alternative antibiotics for the treatment of bacteraemia due to Enterobacteriaceae producing extended-spectrum β-lactamases: a systematic review and meta-analysis. J Antimicrob Chemother 67:2793-2803. doi: 10.1093/jac/dks301 PMID: 22915465
2. Gupta N, Limbago BM, Patel JB, Kallen AJ (2011) Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention. Clin Infect Dis 53:60-67. doi: 10.1093/cid/cir202 PMID: 21653305
3. Falagas ME, Tansarli GS, Karageorgopoulos DE, Vardakas KZ (2014) Deaths attributable to carbapenem-resistant Enterobacteriaceae infections. Emerg Infect Dis 20:1170-1175. doi: 10.3201/eid2007. 121004 PMID: 24959688
4. Correa L, Martino MDV, Siqueira I, Pasternak J, Gales AC, Camargo TZ, et al. (2013) A hospital-based matched case-control study to identify clinical outcome and risk factors associated with carbapenemresistant Klebsiella pneumoniae infection. BMC Infect Dis 13:80. doi: 10.1186/1471-2334-13-80 PMID: 23398691
5. Tumbarello M, Viale P, Viscoli C, Trecarichi EM, Tumietto F, Marchese A, et al. (2012) Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: importance of combination therapy. Clin Infect Dis 55:943-950. doi: 10.1093/cid/cis588 PMID: 22752516
6. Lubbert C, Rodloff AC, Laudi S, Simon P, Busch T, Mössner J, et al. (2014) Lessons learned from excess mortality associated with Klebsiella pneumoniae carbapenemase 2-producing K. pneumoniae in liver transplant recipients. Liver transpl 20:736-738. doi: 10.1002/lt.23858 PMID: 24677425
7. Tzouvelekis LS, Markogiannakis A, Psichogiou M, Tassios PT, Daikos GL (2012) Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensions. Clin Microbiol Rev 25:682-707. doi: 10.1128/CMR.05035-11 PMID: 23034326
8. Nordmann P, Naas T, Poirel L (2011) Global spread of carbapenemase-producing Enterobacteriaceae. Emerg Infect Dis 17:1791-1798. doi: 10.3201/eid1710.110655 PMID: 22000347
9. Geffen Y, Adler A, Paikin S, Khabra E, Gorenshtein S, Aronov R, et al. (2013) Detection of the plasmidmediated KPC-2 carbapenem-hydrolysing enzyme in three unusual species of the Enterobacteriaceae family in Israel. J Antimicrob Chemother 68:719-729. doi: 10.1093/jac/dks443 PMID: 23134657
10. Cuzon G, Naas T, Truong H, Villegas MV, Wisell KT, Carmeli Y, et al. (2010) Worldwide diversity of Klebsiella pneumoniae that produce beta-lactamase blaKPC-2 gene. Emerg Infect Dis 16:1349-1356. doi: 10.3201/eid1609.091389 PMID: 20735917
11. Poirel L, Hombrouck-Alet C, Freneaux C, Bernabeu S, Nordmann P (2010) Global spread of New Delhi metallo-β-lactamase-1. Lancet Infect Dis 10:832. doi: 10.1016/S1473-3099(10)70279-6 PMID: 21109172
12. Munoz-Price LS, Poirel L, Bonomo RA, Schwaber MJ, Daikos GL, Cormican M, et al. (2013) Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Lancet Infect Dis 13:785-796. doi: 10.1016/S1473-3099(13)70190-7 PMID: 23969216
13. Patel G, Bonomo RA (2013) "Stormy waters ahead": global emergence of carbapenemases. Front Microbiol 4:48. doi: 10.3389/fmicb.2013.00048 PMID: 23504089
14. Tsai YK, Fung CP, Lin JC, Chen JH, Chang FY, Chen TL, et al. (2011) Klebsiella pneumoniae outer membrane porins OmpK35 and OmpK36 play roles in both antimicrobial resistance and virulence. Antimicrob Agents Chemother 55:1485-1493. doi: 10.1128/AAC.01275-10 PMID: 21282452
15. Novais Â, Rodrigues C, Branquinho R, Antunes P, Grosso F, Boaventura L, et al. (2012) Spread of an OmpK36-modified ST15 Klebsiella pneumoniae variant during an outbreak involving multiple carbapenem-resistant Enterobacteriaceae species and clones. Eur J Clin Microbiol Infect Dis 31:3057-3063. doi: 10.1007/s10096-012-1665-z PMID: 22706513
16. Doménech-Sánchez A, Martínez-Martínez L, Hernández-Allés S, del Carmen Conejo M, Pascual A, Tomás JM, et al. (2003) Role of Klebsiella pneumoniae OmpK35 porin porin in antimicrobial resistance. Antimicrob Agents Chemother 47:3332-3335. PMID: 14506051
17. Zhang Y, Jiang X, Wang Y, Li G, Tian Y, Liu H, et al. (2014) Contribution of β-lactamases and porin proteins OmpK35 and OmpK36 to carbapenem resistance in clinical isolates of KPC-2-producing Klebsiella pneumoniae. Antimicrob Agents Chemother 58:1214-1217. doi: 10.1128/AAC.02045-12 PMID: 24277031
18. Kitchel B, Rasheed JK, Patel JB, Srinivasan A, Navon-Venezia S, Carmeli Y, et al. (2009) Molecular epidemiology of KPC-producing Klebsiella pneumonia isolates in the United States: clonal expansion of multilocus sequence type 258. Antimicrob. Agents Chemother 53:3365-3370. doi: 10.1128/AAC. 00126-09 PMID: 19506063
19. Giakkoupi P, Papagiannitsis CC, Miriagou V, Pappa O, Polemis M, Tryfinopoulou K, et al. (2011) An update of the evolving epidemic of blaKPC-2-carrying Klebsiella pneumoniae in Greece (2009-10). J Antimicrob Chemother 66:1510-1513. doi: 10.1093/jac/dkr166 PMID: 21543359
20. Chiu SK, Wu TL, Chuang YC, Lin JC, Fung CP, Lu PL, et al. (2013) National surveillance study on carbapenem non-susceptible Klebsiella pneumonia in Taiwan: the emergence and rapid dissemination of KPC-2 carbapenemase. PLOS ONE 8:e69428. doi: 10.1371/journal.pone.0069428 PMID: 23894478
21. Giske CG, Fröding I, Hasan CM, Turlej-Rogacka A, Toleman M, Livermore D, et al. (2012) Diverse sequence types of Klebsiella pneumoniae contribute to the dissemination of blaNDM-1 in India, Sweden, and the United Kingdom. Antimicrob Agents Chemother 56:2735-2738. doi: 10.1128/AAC.06142-11 PMID: 22354295
22. Pereira PS, de Araujo CF, Seki LM, Zahner V, Carvalho-Assef AP, Asensi MD (2013) Update of the molecular epidemiology of KPC-2-producing Klebsiella pneumoniae in Brazil: spread of clonal complex 11 (ST11, ST437 and ST340). J Antimicrob Chemother 68:312-316. doi: 10.1093/jac/dks396 PMID: 23070735
23. Kim SY, Shin J, Shin SY, Ko KS (2013) Characteristics of carbapenem-resistant Enterobacteriaceae isolates from Korea. Diagn Microbiol Infect Dis 76:486-490. doi: 10.1016/j.diagmicrobio.2013.04.006 PMID: 23688521
24. Chen L, Mathema B, Chavda KD, DeLeo FR, Bonomo RA, Kreiswirth BN (2014) Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decoding. Trends Microbiol 22:686-696. doi: 10. 1016/j.tim.2014.09.003 PMID: 25304194
25. Ageevets VA, Partina IV, Lisitsyna ES, Ilina EN, Lobzin YV, Shlyapnikov SA, et al. (2014) Emergence of carbapenemase-producing Gram-negative bacteria in Saint Petersburg, Russia. Int J Antimicrob Agents 44:152-155. doi: 10.1016/j.ijantimicag.2014.05.004 PMID: 25059447
26. Clinical and Laboratory Standards Institute (2012) Performance Standards for Antimicrobial Susceptibility Testing: Twenty-second Informational Supplement M100-S22. CLSI, Wayne, PA, USA.
27. European Committee on Antimicrobial Susceptibility Testing (2014) Breakpoint Tables for Interpretation of MICs and Zone Diameters, Version 4.0. Available: http://www.eucast.org/clinical-breakpoints. Accessed 31 October 2014.
28. Hæggman S., Löfdahl S., Paauw A., Verhoef J., Brisse S. (2004) Diversity and evolution of the Class A chromosomal beta-lactamase gene in Klebsiella pneumoniae. Antimicrob Agents Chemother 48:2400-2408. PMID: 15215087
29. Kiratisin P, Apisarnthanarak A, Laesripa C, Saifon P (2008) Molecular characterization and epidemiology of extended-spectrum-β-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic. Antimicrob Agents Chemother 52:2818-2824. doi: 10.1128/AAC.00171-08 PMID: 18505851
30. Poirel L, Walsh TR, Cuvillier V, Nordmann P (2011) Multiplex PCR for detection of acquired carbapenemase genes. Diagn Microbiol Infect Dis 70:119-123. doi: 10.1016/j.diagmicrobio.2010.12.002 PMID: 21398074
31. Perez-Perez FJ, Hanson ND (2002) Detection of plasmid-mediated AmpC β-lactamase genes in clinical isolates by using multiplex PCR. J Clin Microbiol 40:2153-2162. PMID: 12037080
32. Vourli S, Giakkoupi P, Miriagou V, Tzelepi E, Vatopoulos AC, Tzouvelekis LS (2004) Novel GES/IBC extended-spectrum beta-lactamase variants with carbapenemase activity in clinical enterobacteria. FEMS Microbiol Lett 234:209-213. PMID: 15135524
33. Doumith M, Ellington MJ, Livermore DM, Woodford N (2009) Molecular mechanisms disrupting porin expression in ertapenem-resistant Klebsiella and Enterobacter spp. clinical isolates from the UK. J Antimicrob Chemother 63:659-667. doi: 10.1093/jac/dkp029 PMID: 19233898
34. Ribot EM, Fair MA, Gautom R, Cameron DN, Hunter SB, Swaminathan B, et al. (2006) Standardization of pulsed-field gel electrophoresis protocols for the subtyping of Escherichia coli O157:H7, Salmonella, and Shigella for PulseNet. Foodborne Pathog Dis 3:59-67. PMID: 16602980
35. Tenover FC, Arbeit RD, Goering RV, Mickelsen PA, Murray BE, Persing DH, et al. (1995) Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 33:2233-2239. PMID: 7494007
36. Hsueh PR, Badal RE, Hawser SP, Hoban DJ, Bouchillon SK, Ni Y, et al. (2010) Epidemiology and antimicrobial susceptibility profiles of aerobic and facultative Gram-negative bacilli isolated from patients with intra-abdominal infections in the Asia-Pacific region: 2008 results from SMART (Study for Monitoring Antimicrobial Resistance Trends). Int J Antimicrob Agents 36:408-414. doi: 10.1016/j.ijantimicag. 2010.07.002 PMID: 20728316
37. Kiratisin P, Chongthaleong A, Tan TY, Lagamayo E, Roberts S, Garcia J, et al. (2012) Comparative in vitro activity of carbapenems against major Gram-negative pathogens: results of Asia-Pacific surveillance from the COMPACT II study. Int J Antimicrob Agents 39:311-316. doi: 10.1016/j. ijantimicag.2012.01.002 PMID: 22386743
38. Carvalhaes CG, Picao RC, Nicoletti AG, Xavier DE, Gales AC (2010) Cloverleaf test (modified Hodge test) for detecting carbapenemase production in Klebsiella pneumoniae: be aware of false positive results. J Antimicrob Chemother 65:249-251. doi: 10.1093/jac/dkp431 PMID: 19996141
39. Girlich D, Poirel L, Nordmann P (2012) Value of the modified Hodge test for detection of emerging carbapenemases in Enterobacteriaceae. J Clin Microbiol 50:477-479. doi: 10.1128/JCM.05247-11 PMID: 22116154
40. Yang FC, Yan JJ, Hung KH, Wu JJ (2012) Characterization of ertapenem-resistant Enterobacter cloacae in a Taiwanese university hospital. J Clin Microbiol 50:223-226. doi: 10.1128/JCM.01263-11 PMID: 22135256
41. Netikul T, Sidjabat H, Paterson D, Kiratisin P (2014) Emergence of novel blaKPC-13 among carbapenem-resistant Enterobacteriaceae in Thailand. Int J Antimicrob Agents 44:568-569. doi: 10.1016/j. ijantimicag.2014.08.005 PMID: 25443891
42. Rimrang B, Chanawong A, Lulitanond A, Wilailuckana C, Charoensri N, Sribenjalux P, et al. (2012) Emergence of NDM-1-and IMP-14a-producing Enterobacteriaceae in Thailand. J Antimicrob Chemother 67:2626-2630. doi: 10.1093/jac/dks267 PMID: 22796889
43. Hernández-Allés S, Conejo Md, Pascual A, Tomás JM, Benedí VJ, Martínez-Martínez L (2000) Relationship between outer membrane alterations and susceptibility to antimicrobial agents in isogenic strains of Klebsiella pneumoniae. J Antimicrob Chemother 46:273-277. PMID: 10933652
44. Leavitt A, Carmeli Y, Chmelnitsky I, Goren MG, Ofek I, Navon-Venezia S (2010) Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel. Antimicrob Agents Chemother 54:3002-3006. doi: 10.1128/AAC.01818-09 PMID: 20350950
45. Donati V, Feltrin F, Hendriksen RS, Svendsen CA, Cordaro G, García-Fernández A, et al. (2014) Extended-spectrum-beta-lactamases, AmpC beta-lactamases and plasmid mediated quinolone resistance in Klebsiella spp. from companion animals in Italy. PLOS ONE 9:e90564. doi: 10.1371/journal. pone.0090564 PMID: 24595207
46. Bushnell G, Mitrani-Gold F, Mundy LM (2013) Emergence of New Delhi metallo-β-lactamase type 1-producingEnterobacteriaceae and non-Enterobacteriaceae: global case detection and bacterial surveillance. Int J Infect Dis 17:e325-e333. doi: 10.1016/j.ijid.2012.11.025 PMID: 23332300