Lessons learned from excess mortality associated with Klebsiella pneumoniae carbapenemase 2-producing k. pneumoniae in liver transplant recipients

Liver Transplantation

Volumn 20, Issue 6, 2014, Pages 736-738

  Lübbert, Christoph ^a   Rodloff, Arne C ^a   Laudi, Sven ^a   Simon, Philipp ^a   Busch, Thilo ^a   Mössner, Joachim ^a   Bartels, Michael ^a   Kaisers, Udo X ^a  

^a UNIVERSITY HOSPITAL LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; CARBAPENEM; CARBAPENEMASE; CARBAPENEMASE 2; COLISTIMETHATE; COLISTIN; GENTAMICIN; TIGECYCLINE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAMASE; CARBAPENEMASE-2, KLEBSIELLA PNEUMONIAE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; APACHE; BLOODSTREAM INFECTION; BROTH DILUTION; CARBAPENEMASE 2 PRODUCING KLEBSIELLA PNEUMONIAE; CARBAPENEMASE PRODUCING ENTEROBACTERIACEAE; CLINICAL EFFECTIVENESS; DEATH; DISEASE ASSOCIATION; DISEASE SEVERITY; GRAFT RECIPIENT; HAND WASHING; HUMAN; INFECTION CONTROL; KLEBSIELLA OXYTOCA; KLEBSIELLA PNEUMONIAE; LETTER; LIVER TRANSPLANTATION; MINIMUM INHIBITORY CONCENTRATION; MORTALITY; PNEUMONIA; PRIORITY JOURNAL; SCREENING; SURGICAL INFECTION; SURVIVAL; ADULT; CROSS INFECTION; DRUG EFFECTS; ENZYMOLOGY; EPIDEMIC; FEMALE; GERMANY; KAPLAN MEIER METHOD; KLEBSIELLA INFECTIONS; MALE; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MIDDLE AGED; PATIENT SELECTION; RETROSPECTIVE STUDY; RISK FACTOR; TIME; TREATMENT OUTCOME; UNIVERSITY HOSPITAL;

ADULT; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; CROSS INFECTION; DISEASE OUTBREAKS; DRUG RESISTANCE, BACTERIAL; FEMALE; GERMANY; HOSPITALS, UNIVERSITY; HUMANS; KAPLAN-MEIER ESTIMATE; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; LIVER TRANSPLANTATION; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; PATIENT SELECTION; RETROSPECTIVE STUDIES; RISK FACTORS; TIME FACTORS; TREATMENT OUTCOME;

EID: 84901632631     PISSN: 15276465     EISSN: 15276473     Source Type: Journal    
DOI: 10.1002/lt.23858     Document Type: Letter

References (10)

1. Nordmann P, Cuzon G, Naas T,. The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect Dis 2009; 9: 228-236.
2. Kalpoe JS, Sonnenberg E, Factor SH, del Rio Martin J, Schiano T, Patel G, Huprikar S,. Mortality associated with carbapenem-resistant Klebsiella pneumoniae infections in liver transplant recipients. Liver Transpl 2012; 18: 468-474.
3. Bergamasco MD, Barroso Barbosa M, de Oliveira Garcia D, Cipullo R, Moreira JC, Baia C, et al. Infection with Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae in solid organ transplantation. Transpl Infect Dis 2012; 14: 198-205.
4. Snitkin ES, Zelazny AM, Thomas PJ, Stock F, NISC Comparative Sequencing Program Group, Henderson DK, et al. Tracking a hospital outbreak of carbapenem-resistant Klebsiella pneumoniae with whole-genome sequencing. Sci Transl Med 2012; 4: 148ra116.
5. Cicora F, Mos F, Paz M, Allende NG, Roberti J,. Infections with blaKPC-2-producing Klebsiella pneumoniae in renal transplant patients: a retrospective study. Transplant Proc 2013; 45: 3389-3393.
6. Lübbert C, Becker-Rux D, Rodloff AC, Laudi S, Busch T, Bartels M, Kaisers UX,. Colonization of liver transplant recipients with KPC-producing Klebsiella pneumoniae is associated with high infection rates and excess mortality: a case-control analysis. Infection; doi: 10.1007/s15010-013-0547-3.
7. Lübbert C, Faucheux S, Becker-Rux D, Laudi S, Dürrbeck A, Busch T, et al. Rapid emergence of secondary resistance to gentamicin and colistin following selective digestive decontamination in patients with KPC-2-producing Klebsiella pneumoniae: a single-centre experience. Int J Antimicrob Agents 2013; 42: 565-570.
8. Ben-David D, Kordevani R, Keller N, Tal I, Marzel A, Gal-Mor O, et al. Outcome of carbapenem resistant Klebsiella pneumoniae bloodstream infections. Clin Microbiol Infect 2012; 18: 54-60.
9. Lübbert C, Lippmann N, Busch T, Kaisers UX, Ducomble T, Eckmanns T, Rodloff AC,. Long-term carriage of Klebsiella pneumoniae carbapenemase-2- producing K. pneumoniae after a large single-center outbreak in Germany. Am J Infect Control; doi: 10.1016/j.ajic.2013.12.001.
10. Satlin MJ, Jenkins SG, Walsh TJ,. The Global Challenge of Carbapenem-Resistant Enterobacteriaceae in Transplant Recipients and Patients With Hematologic Malignancies. Clin Infect Dis; doi: 10.1093/cid/ciu052.