Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 7, 2010, Pages 3002-3006

  Leavitt, Azita ^a   Carmeli, Yehuda ^a   Chmelnitsky, Inna ^a   Goren, Moran G ^a   Ofek, Itzhak ^b   Navon Venezia, Shiri ^a  

^a TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; BETA LACTAMASE; CARBAPENEM; GENTAMICIN; KPC 2 BETA LACTAMASE; KPC 3 BETA LACTAMASE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; BETA-LACTAMASE KPC-2, KLEBSIELLA PNEUMONIAE; BETA-LACTAMASE KPC-3, KLEBSIELLA PNEUMONIAE; CARBAPENEM DERIVATIVE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATION; CONTROLLED STUDY; ESCHERICHIA COLI; ISRAEL; KLEBSIELLA PNEUMONIAE; MOLECULAR EPIDEMIOLOGY; MOLECULAR EVOLUTION; MULTILOCUS SEQUENCE TYPING; NONHUMAN; PLASMID; PRIORITY JOURNAL; CLASSIFICATION; DRUG EFFECTS; ENZYMOLOGY; EPIDEMIOLOGY; GENETICS; HUMAN; KLEBSIELLA INFECTIONS; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; PHYLOGENY; POLYMERASE CHAIN REACTION; PROCEDURES;

BACTERIAL PROTEINS; BETA-LACTAMASES; CARBAPENEMS; DRUG RESISTANCE, BACTERIAL; HUMANS; ISRAEL; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; MOLECULAR EPIDEMIOLOGY; PHYLOGENY; PLASMIDS; POLYMERASE CHAIN REACTION;

EID: 77953773166     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01818-09     Document Type: Article

References (18)

1. Baraniak, A., R. Izdebski, M. Herda, J. Fiett, W. Hryniewicz, M. Gniadkowski, I. Kern-Zdanowicz, K. Filczak, and U. Lopaciuk. 2009. Emergence of Klebsiella pneumoniae ST258 with KPC-2 in Poland. Antimicrob. Agents Chemother. 53:4565-4567.
2. Chmelnitsky, I., S. Navon-Venezia, J. Strahilevitz, and Y. Carmeli. 2008. Plasmid-mediated qnrB2 and carbapenemase gene blaKPC-2 carried on the same plasmid in carbapenem-resistant ciprofloxacin-susceptible Enterobacter cloacae isolates. Antimicrob. Agents Chemother. 52:2962-2965.
3. Chmelnitsky, I., O. Hermesh, S. Navon-Venezia, J. Strahilevitz, and Y. Carmeli. 2009. First detection of aac (6′)-Ib-cr in KPC-producing Klebsiella pneumoniae isolates. J. Antimicrob. Chemother. 64:718-722.
4. Clinical and Laboratory Standards Institute. 2010. Performance standards for antimicrobial susceptibility testing; 20th informational supplement. M100-S20. Clinical and Laboratory Standards Institute, Wayne, PA.
5. Giani, T., M. M. D'Andrea, P. Pecile, L. Borgianni, P. Nicoletti, F. Tonelli, A. Bartoloni, and G. M. Rossolini. 2009. Emergence in Italy of Klebsiella pneumoniae sequence type 258 producing KPC-3 carbapenemase. J. Clin. Microbiol. 47:3793-3794.
6. Goren, M. G., S. Navon-Venezia, I. Chmelnitsky, and Y. Carmeli. 2010. Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. Antimicrob. Agents Chemother. 54:2687-2691.
7. Hussein, K., H. Sprecher, T. Mashiach, I. Oren, I. Kassis, and R. Finkelstein. 2009. Carbapenem resistance among Klebsiella pneumoniae isolates: risk factors, molecular characteristics, and susceptibility patterns. Infect. Control Hosp. Epidemiol. 30:666-671.
8. Kitchel, B., J. K. Rasheed, J. B. Patel, A. Srinivasan, S. Navon-Venezia, Y. Carmeli, A. Brolund, and C. G. Giske. 2009. Molecular epidemiology of KPC-producing Klebsiella pneumoniae isolates in the United States: clonal expansion of multilocus sequence type 258. Antimicrob. Agents Chemother. 53:3365-3370.
9. Leavitt, A., S. Navon-Venezia, I. Chmelnitsky, M. J. Schwaber, and Y. Carmeli. 2007. Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital. Antimicrob. Agents Chemother. 51:3026-3029.
10. Leavitt, A., I. Chmelnitsky, I. Ofek, Y. Carmeli, and S. Navon-Venezia. 24 November 2009. Plasmid pKpQIL encoding KPC-3 and TEM-1 confers carbapenem resistance in an extremely drug resistant epidemic Klebsiella pneumoniae strain. J. Antimicrob. Chemother. 65:243-248. [Epub ahead of print.]
11. Navon-Venezia, S., I. Chmelnitsky, A. Leavitt, M. J. Schwaber, D. Schwartz, and Y. Carmeli. 2006. Plasmid-mediated imipenem-hydrolyzing enzyme KPC-2 among multiple carbapenem-resistant Escherichia coli clones in Israel. Antimicrob. Agents Chemother. 50:3098-3101.
12. Navon-Venezia, S., A. Leavitt, M. J. Schwaber, J. K. Rasheed, A. Srinivasan, J. B. Patel, Y. Carmeli, and Israeli KPC Kpn Study Group. 2009. First report on a hyperepidemic clone of KPC-3-producing Klebsiella pneumoniae in Israel genetically related to a strain causing outbreaks in the United States. Antimicrob. Agents Chemother. 53:818-820.
13. Nordmann, P., G. Cuzon, and T. Naas. 2009. The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect. Dis. 9:228-236.
14. Osterblad, M., J. Kirveskari, S. Koskela, P. Tissari, K. Vuorenoja1, A. J. Hakanen, M. Vaara, and J. Jalava1. 2009. First isolations of KPC-2-carrying ST258 Klebsiella pneumoniae strains in Finland, June and August 2009. Euro Surveill. 14(40):pii=19349.
15. Samuelsen, Ø., U. Naseer, S. Tofteland, D. H. Skutlaberg, A. Onken, R. Hjetland, A. Sundsfjord, and G. G. Giske. 2009. Emergence of clonally related Klebsiella pneumoniae isolates of sequence type 258 producing plasmid-mediated KPC carbapenemase in Norway and Sweden. J. Antimicrob. Chemother. 63:654-658.
16. Schwaber, M. J., and Y. Carmeli. 2008. Carbapenem-resistant Enterobacteriaceae: a potential threat. JAMA 300:2911-2913.
17. Schwaber, M. J., S. Klarfeld-Lidji, S. Navon-Venezia, D. Schwartz, A. Leavitt, and Y. Carmeli. 2008. Predictors of carbapenem-resistant Klebsiella pneumoniae acquisition among hospitalized adults and effect of acquisition on mortality. Antimicrob. Agents Chemother. 52:1028-1033.
18. Woodford, N., J. Zhang, M. Warner, M. E. Kaufmann, J. Matos, A. MacDonald, D. Brudney, D. Sompolinsky, S. Navon-Venezia, and D. M. Livermore. 2008. Arrival of Klebsiella pneumoniae producing KPC carbapenemase in the United Kingdom. J. Antimicrob. Chemother. 62:1261-1264.