Extended-spectrum-beta-lactamases, AmpC beta-lactamases and plasmid mediated quinolone resistance in Klebsiella spp. from companion animals in Italy

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Donati, Valentina ^a   Feltrin, Fabiola ^a   Hendriksen, Rene S ^b   Svendsen, Christina Aaby ^b   Cordaro, Gessica ^a   Garciá Fernández, Aurora ^c   Lorenzetti, Serena ^a   Lorenzetti, Raniero ^a   Battisti, Antonio ^a   Franco, Alessia ^a  

^a ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELLE REGIONI LAZIO E TOSCANA   (Italy)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE DERIVATIVE; AMPC BETA LACTAMASES; AMPC BETA-LACTAMASES; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAMASE; BETA LACTAMASE AMPC; BETA LACTAMASE CTX M; CEPHALOSPORIN; CHLORAMPHENICOL DERIVATIVE; EXTENDED SPECTRUM BETA LACTAMASE; PHARMACOLOGY; PLASMID VECTOR; QUINOLINE DERIVED ANTIINFECTIVE AGENT; QUINOLONE DERIVATIVE; SULFONAMIDE; TETRACYCLINE DERIVATIVE; TRIMETHOPRIM;

AAC IB CR GENE; AAC IB GENE; AADA2 GENE; AADB GENE; AMPC GENE; ANIMAL; ANIMAL DISEASE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL GENETICS; BACTERIUM ISOLATE; CAT; CAT GENE; CLUSTER ANALYSIS; CMY 2 GENE; CONTROLLED STUDY; CTX M 1 GENE; CTX M 15 GENE; CTX M 9 GENE; DFR GENE; DHA 1 GENE; DOG; DRUG EFFECT; DRUG THERAPY; ENZYMOLOGY; ESBL GENE; EXPRESSION VECTOR; GENE; GENE FUNCTION; GENE IDENTIFICATION; GENE INTERACTION; GENE TRANSFER; GENETICS; ISOLATION AND PURIFICATION; KLEBSIELLA; KLEBSIELLA INFECTION; KLEBSIELLA OXYTOCA; KLEBSIELLA PNEUMONIAE; MICROBIOLOGY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR CLONING; MULTIDRUG RESISTANCE; NONHUMAN; PLASMID; PMQR GENE; PULSED FIELD GEL ELECTROPHORESIS; SHV 12 GENE; SHV 28 GENE; SHV 2A GENE; STRA/B GENE; SUL GENE; TET GENE;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; CATS; DOGS; DRUG EFFECTS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; DRUG THERAPY; ENZYMOLOGY; GENES, BACTERIAL; GENETICS; ISOLATION AND PURIFICATION; KLEBSIELLA INFECTIONS; KLEBSIELLA OXYTOCA; KLEBSIELLA PNEUMONIAE; MICROBIOLOGY; PHARMACOLOGY; PLASMIDS; QUINOLONES; VETERINARY;

EID: 84897031029     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0090564     Document Type: Article

References (54)

1. Ko WC, Paterson DL, Sagnimeni AJ, Hansen DS, Von Gottberg A, et al. (2002) Community-acquired Klebsiella pneumoniae bacteremia: global differences in clinical patterns. Emerg Infect Dis. 8: 160-166. (Pubitemid 34202438)
2. Yu VL, Hansen DS, Ko WC, Sagnimeni A, Klugman KP, et al. (2007) Virulence characteristics of Klebsiella and clinical manifestations of K. pneumoniae bloodstream infections. Emerg Infect Dis. 13: 986-993. (Pubitemid 47048070)
3. Podschun R, Ullmann U (1998) Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin. Microbiol. Rev. 11: 589-603. (Pubitemid 28497563)
4. Jonas D, Spitzmüller B, Daschner FD, Verhoef J, Brisse S (2004) Discrimination of Klebsiella pneumoniae and Klebsiella oxytoca phylogenetic groups and other Klebsiella species by use of amplified fragment length polymorphism. Res Microbiol 155: 17-23. (Pubitemid 38167451)
5. Roberts DE, McClain HM, Hansen DS, Currin P, Howerth EW (2000) An outbreak of Klebsiella pneumoniae infection in dogs with severe enteritis and septicemia. J Vet Diagn Invest 12: 168-173.
6. Carter GR, Wise DJ (2004) Essentials in Veterinary Bacteriology and Mycology 290 pages. Iowa State University Press.
7. Quinn PJ, Carter ME, Markey B, Carter GR (2004) Clinical Veterinary Microbiology, 684 pages Elsevier Ltd.
8. Paterson DL, Hujer KM, Hujer AM, Yeiser B, Bonomo MD, et al. (2003) International Klebsiella Study Group. Extended-spectrum beta-lactamases in Klebsiella pneumoniae bloodstream isolates from seven countries: dominance and widespread prevalence of SHV- and CTX-M-type beta-lactamases. Antimicrob Agents Chemother 47: 3554-3560. (Pubitemid 37345719)
9. Pfeifer Y, Cullik A, Witte W (2010) Resistance to cephalosporins and carbapenems in Gram-negative bacterial pathogens. International Journal of Medical Microbiology 300: 371-379.
10. Yang J, Luo Y, Cui S, Wang W, Han L (2011) Diverse phenotypic and genotypic characterization among clinical Klebsiella pneumoniae and Escherichia coli isolates carrying plasmid-mediated quinolone resistance determinants. Microb Drug Resist 17: 363-367.
11. Vo AT, van Duijkeren E, Fluit AC, Gaastra W (2007) Characteristics of extended-spectrum cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae isolates from horses. Vet Microbiol 124: 248-255. (Pubitemid 47268675)
12. Ma J, Zeng Z, Chen Z, Xu X, Wang X, et al. (2009) High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6′)-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals. Antimicrob Agents Chemother 53(2): 519-524.
13. Fontana C, Favaro M, Pelliccioni M, Pistoia ES, Favalli C (2005) Use of the MicroSeq 500 16S rRNA gene-based sequencing for identification of bacterial isolates that commercial automated systems failed to identify correctly. J Clin Microbiol 43: 615-619. (Pubitemid 40256009)
14. Diancourt L, Passet V, Verhoef J, Grimont PAD, Brisse S (2005) Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates. J Clin Microbiol 43: 4178-4182. (Pubitemid 41129719)
15. Durmaz R, Otlu B, Koksal F, Hosoglu S, Ozturk R, et al. (2009) The optimization of a rapid pulsed-field gel electrophoresis protocol for the typing of Acinetobacter baumannii, Escherichia coli and Klebsiella spp. Jpn J Infect Dis 62: 372-377.
16. Clinical laboratory Standard Institute (2013) Performance standards for antimicrobial susceptibility testing; twenty-third informational supplement. CLSI document M100-S23. Supplemental table 2A-S1. Screening and confirmatory tests for ESBLs. CLSI, Wayne, PA.
17. Woodford N, Fagan EJ, Ellington MJ (2006) Multiplex PCR for rapid detection of genes encoding CTX-M extended-spectrum (beta)-lactamases. J Antimicrob Chemother 57: 154-155.Epub 2005 Nov 10.
18. Hujer AM, Page MG, Helfand MS, Yeiser B, Bonomo RA (2002) Development of a sensitive and specific enzyme-linked immunosorbent assay for detecting and quantifying CMY-2 and SHV beta-lactamases. J Clin Microbiol 40: 1947-1957. (Pubitemid 34596367)
19. Arlet G, Brami G, Décrè D, Flippo A, Gaillot O, et al. (1995) Molecular characterisation by PCR-restriction fragment length polymorphism of TEM beta-lactamases. FEMS Microbiol Lett 134: 203-208.
20. Lavollay M, Mamlouk K, Frank T, Akpabie A, Burghoffer B, et al. (2006) Clonal dissemination of a CTX-M-15 beta-lactamase-producing Escherichia coli strain in the Paris area, Tunis, and Bangui. Antimicrob Agents Chemother 50: 2433-2438. (Pubitemid 43993183)
21. Pérez-Pérez FJ, Hanson ND (2002) Detection of plasmid-mediated AmpC beta-lactamase genes in clinical isolates by using multiplex PCR. J Clin Microbiol 40: 2153-2162. (Pubitemid 34596400)
22. Park CH, Robicsek A, Jacoby GA, Sahm D, Hooper DC (2006) Prevalence in the United States of aac(69)-Ib-cr encoding a ciprofloxacin-modifying enzyme. Antimicrob Agents Chemother 50: 3953-5955.
23. Cattoir V, Poirel L, Rotini V, Soussy CJ, Nordmann P (2007) Multiplex PCR for detection of plasmid-medianted quinolone resistance qnr genes in ESBL-producing enterobacterial isolates. J Antimicrob Chemother 60: 394-397. (Pubitemid 47243891)
24. Périchon B, Courvalin P, Galimand M (2007) Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. Antimicrob Agents Chemother 51: 2464-2469. (Pubitemid 47047325)
25. Cavaco LM, Frimodt-MØller N, Hasman H, Guardabassi L, Nielsen L, et al. (2008) Prevalence of quinolone resistance mechanism and associations to minimum inhibitory concentrations in quinolone-resistant Escherichia coli isolated from humans and swine in Denmark. Microb Drug Resist 14: 163-169.
26. Cavaco LM, Hasman H, Xia S, Aarestrup FM (2009) QnrD, a novel gene conferring trasferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin. Antimicrob Agents Chemother 53: 603-608.
27. Poirel L, Walsh TR, Cuvilliera V, Nordmann P (2011) Multiplex PCR for detection of acquired carbapenemase genes. Diagnostic Microbiology and Infectious Diseases 70: 119-123.
28. Carattoli A, Bertini A, Villa L, Falbo V, Hopkins KL, et al. (2005) Identification of plasmids by PCR-based replicon typing. J Microbiol Methods 63: 219-228. (Pubitemid 41597366)
29. García-Fernández A, Fortini D, Veldman K, Mevius D, Carattoli A (2009) Characterization of plasmids harbouring qnrS1, qnrB2 and qnrB19 genes in Salmonella. Journal of Antimicrobial Chemotherapy 63: 274-281.
30. Villa L, García-Fernández A, Fortini D, Carattoli A (2010) Replicon sequence typing of IncF plasmids carrying virulence and resistance determinants. J Antimicrob Chemother 65: 2518-2529.
31. Haenni M, Ponsin C, Métayer V, Médaille C, Madec JY (2011) Veterinary hospital-acquired infections in pets with a ciprofloxacin-resistant CTX-M-15-producing Klebsiella pneumoniae ST15 clone. J Antimicrob Chemother 67: 770-771. doi: 10.1093/jac/dkr527.
32. Jemima SA, Verghese S (2009) SHV-28, an extended-spectrum beta-lactamase produced by a clinical isolate of Klebsiella pneumoniae in south India. Indian Journal of Medical Microbiology, 27: 51-54.
33. Nielsen JB, Skov MN, Jørgensen RL, Heltberg O, Hansen DS, et al. (2011) Identification of CTX-M15-, SHV-28-producing Klebsiella pneumoniae ST15 as an epidemic clone in the Copenhagen area using a semi-automated Rep-PCR typing assay. European Journal of Clinical Microbiology & Infectious Diseases 6: 773-778.
34. Carattoli A (2009) Resistance Plasmid Families in Enterobacteriaceae. Antimicrob Agents Chemother 53: 2227-2238.
35. Coelho A, González-López JJ, Miró E, Alonso-Tarrés C, Mirelis B, et al. (2010) Characterisation of the CTX-M-15-encoding gene in Klebsiella pneumoniae strains from the Barcelona metropolitan area: plasmid diversity and chromosomal integration. Int J Antimicrob Agents 36: 73-78.
36. Hidalgo L, Gutierrez B, Ovejero CM, Carrilero L, Matrat S, et al. (2013). Klebsiella pneumoniae sequence type 11 from companion animals bearing ArmA methyltransferase, DHA-1 b-lactamase, and QnrB4. Antimicrob Agents Chemother 57:4532-4534.
37. Fontana C, Favaro M, Sarmati L, Natoli S, Altieri A, et al. (2010) Emergence of KPC-producing Klebsiella pneumoniae in Italy. BMC Res Notes 23: 3-40.
38. Qi Y, Wei Z, Ji S, Du X, Shen P, et al. (2011) ST11, the dominant clone of KPC-producing Klebsiella pneumoniae in China. J Antimicrob Chemother 66: 307-312.
39. Österblad M, Kirveskari J, Hakanen AJ, Tissari P, Vaara M, et al. (2012) Carbapenemase-producing Enterobacteriaceae in Finland: the first years (2008-11). J Antimicrob Chemother 67: 2860-2864.
40. Voulgari E, Zarkotou O, Ranellou K, Karageorgopoulos DE, Vrioni G, et al. (2013) Outbreak of OXA-48 carbapenemase-producing Klebsiella pneumoniae in Greece involving an ST11 clone. J Antimicrob Chemother 68: 84-88.
41. Migliavacca R, Nucleo E, Asticcioli S, Casari E, Bracco S, et al. (2013) Multifocal diffusion of a KPC-3 producing ST512 K. pneumoniae clone in Northern Italy. New Microbiol. 36(1):109-110.
42. García-Fernández A, Villa L, Carta C, Venditti C, Giordano A, et al. (2012) Klebsiella pneumoniae ST258 producing KPC-3 identified in Italy carries novel plasmids and OmpK36/OmpK35 porin variants. Antimicrob Agents Chemother. 56(4):2143-2145.
43. Mammina C, Bonura C, Aleo A, Fasciana T, Brunelli T, et al. (2012) Sequence type 101 (ST101) as the predominant carbapenem-non-susceptible Klebsiella pneumoniae clone in an acute general hospital in Italy. Int J Antimicrob Agents. 39(6):543-545.
44. Boccia D, D'Ancona F, Salmaso S, Monaco M, Del Grosso M, et al. (2005) Antibiotic-resistance in Italy: activity of the first year of the surveillance project AR-ISS. Ann Ig. Mar-Apr 17: 95-110.
45. García-Fernández A, Miriagou V, Papagiannitsis CC, Giordano A, Venditti M, et al. (2010) An Ertapenem-Resistant Extended-Spectrum--- Lactamase-Producing Klebsiella pneumoniae Clone Carries a Novel OmpK36 Porin Variant. Antimicrob Agents Chemother p. 4178-4184.
46. Mammina C, Bonura C, Di Bernardo F, Aleo A, Fasciana T, et al. (2012) Ongoing spread of colistin-resistant Klebsiella pneumoniae in different wards of an acute general hospital, Italy, June to December 2011. Euro Surveill 16:17(33)
47. D'Andrea MM, Arena F, Pallecchi L, Rossolini GM (2013) CTX-M-type β-lactamases: a successful story of antibiotic resistance. Int J Med Microbiol. doi:pii: S1438-4221(13)00023-4.
48. Briales A, Rodríguez-Martínez JM, Velasco C, de Alba PD, Rodríguez-Baño J, et al. (2012) Prevalence of plasmid-mediated quinolone resistance determinants qnr and aac(6′)-Ib-cr in Escherichia coli and Klebsiella pneumoniae producing extended-spectrum β-lactamases in Spain. Int J Antimicrob Agents 39(5):431-4.
49. Lavilla S, González-López JJ, Sabaté M, García-Fernández A, Larrosa MN, et al. (2008) Prevalence of qnr genes among extended-spectrum beta-lactamase-producing enterobacterial isolates in Barcelona, Spain. J Antimicrob Chemother 61(2):291-5.
50. Ode T, Saito R, Kumita W, Sato K, Okugawa S, et al. (2009) Analysis of plasmid-mediated multidrug resistance in Escherichia coli and Klebsiella oxytoca isolates from clinical specimens in Japan. Int J Antimicrob Agents 34(4):347-50.
51. Miró E, Segura C, Navarro F, Sorlí L, Coll P, et al. (2010) Spread of plasmids containing the bla(VIM-1) and bla(CTX-M) genes and the qnr determinant in Enterobacter cloacae, Klebsiella pneumoniae and Klebsiella oxytoca isolates. J Antimicrob Chemother 65: 661-665.
52. Frank T, Gautier V, Talarmin A, Bercion R, Arlet G (2007) Characterization of sulphonamide resistance genes and class 1 integron gene cassettes in Enterobacteriaceae, Central African Republic (CAR). J Antimicrob Chemother 59: 742-745. (Pubitemid 47073410)
53. Roy Chowdhury P, Ingold A, Vanegas N, Martínez E, Merlino J, et al. (2011) Dissemination of Multiple Drug Resistance Genes by Class 1 Integrons in Klebsiella pneumoniae Isolates from Four Countries: a Comparative Study. Antimicrob Agents Chemother 55: 3140-3149.
54. Roh KH, Uh Y, Kim JS, Kim HS, Shin DH, et al. (2008) First outbreak of multidrug-resistant Klebsiella pneumoniae producing both SHV-12-type extended-spectrum beta-lactamase and DHA-1-type AmpC beta-lactamase at a Korean hospital. Yonsei Med J 49: 53-57. (Pubitemid 351513645)