메뉴 건너뛰기




Volumn 21, Issue 21, 2015, Pages 4753-4759

New strategies in sarcoma: Linking genomic and immunotherapy approaches to molecular subtype

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 CHLOROPHENYL) N (4 HYDROXYPHENYL) 2,3,9 TRIMETHYL 6H THIENO[3,2 F][1,2,4]TRIAZOLO[4,3 A][1,4]DIAZEPINE 6 ACETAMIDE; 6 (4 CHLOROPHENYL) N ETHYL 8 METHOXY 1 METHYL 4H [1,2,4]TRIAZOLO[4,3 A][1,4]BENZODIAZEPINE 4 ACETAMIDE; ABBV 075; ANTINEOPLASTIC AGENT; AZACITIDINE; BAY1238097; BSM 986158; CMB305; CPI 0610; CPI 1205; CYCLOPHOSPHAMIDE; DASATINIB; DEC 205; DECITABINE; E7438; FLUDARABINE; GSK 2816126; IPILIMUMAB; LV305; NIVOLUMAB; PACLITAXEL; PAZOPANIB; PEMBROLIZUMAB; RAPAMYCIN; SUNITINIB; TEN 010; TUMOR VACCINE; UNCLASSIFIED DRUG; HISTONE DEACETYLASE INHIBITOR;

EID: 84947207695     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-15-0831     Document Type: Article
Times cited : (37)

References (73)
  • 1
    • 84925221841 scopus 로고    scopus 로고
    • First-line anthracycline-based chemotherapy for angiosarcoma and other soft tissue sarcoma subtypes: Pooled analysis of eleven European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group trials
    • Young RJ, Natukunda A, Litiére S, Woll PJ, Wardelmann E, van der Graaf WT. First-line anthracycline-based chemotherapy for angiosarcoma and other soft tissue sarcoma subtypes: pooled analysis of eleven European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group trials. Eur J Cancer 2014;50:3178-86.
    • (2014) Eur J Cancer , vol.50 , pp. 3178-3186
    • Young, R.J.1    Natukunda, A.2    Litiére, S.3    Woll, P.J.4    Wardelmann, E.5    Van Der Graaf, W.T.6
  • 2
    • 84905586194 scopus 로고    scopus 로고
    • A phase 2 trial of R1507, a monoclonal antibody to the insulin-like growth factor-1 receptor (IGF-1R), in patients with recurrent or refractory rhabdomyosarcoma, osteosarcoma, synovial sarcoma, and other soft tissue sarcomas: Results of a Sarcoma Alliance for Research Through Collaboration study
    • Pappo AS, Vassal G, Crowley JJ, Bolejack V, Hogendoorn PC, Chugh R, et al. A phase 2 trial of R1507, a monoclonal antibody to the insulin-like growth factor-1 receptor (IGF-1R), in patients with recurrent or refractory rhabdomyosarcoma, osteosarcoma, synovial sarcoma, and other soft tissue sarcomas: results of a Sarcoma Alliance for Research Through Collaboration study. Cancer 2014;120:2448-56.
    • (2014) Cancer , vol.120 , pp. 2448-2456
    • Pappo, A.S.1    Vassal, G.2    Crowley, J.J.3    Bolejack, V.4    Hogendoorn, P.C.5    Chugh, R.6
  • 3
    • 84921342727 scopus 로고    scopus 로고
    • Phase II study of cixutumumab in combination with temsirolimus in pediatric patients and young adults with recurrent or refractory sarcoma: A report from the Children's Oncology Group
    • Wagner LM, Fouladi M, Ahmed A, Krailo MD, Weigel B, DuBois SG, et al. Phase II study of cixutumumab in combination with temsirolimus in pediatric patients and young adults with recurrent or refractory sarcoma: a report from the Children's Oncology Group. Pediatr Blood Cancer 2015;62:440-4.
    • (2015) Pediatr Blood Cancer , vol.62 , pp. 440-444
    • Wagner, L.M.1    Fouladi, M.2    Ahmed, A.3    Krailo, M.D.4    Weigel, B.5    DuBois, S.G.6
  • 5
    • 84907515188 scopus 로고    scopus 로고
    • Phase II study of the safety and antitumor activity of the hypoxia-activated prodrug TH-302 in combination with doxorubicin in patients with advanced soft tissue sarcoma
    • Chawla SP, Cranmer LD, Van Tine BA, Reed DR, Okuno SH, Butrynski JE, et al. Phase II study of the safety and antitumor activity of the hypoxia-activated prodrug TH-302 in combination with doxorubicin in patients with advanced soft tissue sarcoma. J Clin Oncol 2014;32:3299-306.
    • (2014) J Clin Oncol , vol.32 , pp. 3299-3306
    • Chawla, S.P.1    Cranmer, L.D.2    Van Tine, B.A.3    Reed, D.R.4    Okuno, S.H.5    Butrynski, J.E.6
  • 7
    • 84905457348 scopus 로고    scopus 로고
    • The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation
    • Brohl AS, Solomon DA, Chang W, Wang J, Song Y, Sindiri S, et al. The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation. PLoS Genet 2014;10:e1004475.
    • (2014) PLoS Genet , vol.10
    • Brohl, A.S.1    Solomon, D.A.2    Chang, W.3    Wang, J.4    Song, Y.5    Sindiri, S.6
  • 10
    • 79958065572 scopus 로고    scopus 로고
    • Specific sites in the C terminus of CTCF interact with the SA2 subunit of the cohesin complex and are required for cohesin-dependent insulation activity
    • Xiao T, Wallace J, Felsenfeld G. Specific sites in the C terminus of CTCF interact with the SA2 subunit of the cohesin complex and are required for cohesin-dependent insulation activity. Mol Cell Biol 2011;31:2174-83.
    • (2011) Mol Cell Biol , vol.31 , pp. 2174-2183
    • Xiao, T.1    Wallace, J.2    Felsenfeld, G.3
  • 11
    • 84875466344 scopus 로고    scopus 로고
    • Chromosome instability accounts for reverse metastatic outcomes of pediatric and adult synovial sarcomas
    • Lagarde P, Przybyl J, Brulard C, Pérot G, Pierron G, Delattre O, et al. Chromosome instability accounts for reverse metastatic outcomes of pediatric and adult synovial sarcomas. J Clin Oncol 2013;31:608-15.
    • (2013) J Clin Oncol , vol.31 , pp. 608-615
    • Lagarde, P.1    Przybyl, J.2    Brulard, C.3    Pérot, G.4    Pierron, G.5    Delattre, O.6
  • 13
    • 84919936242 scopus 로고    scopus 로고
    • Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma
    • Perry JA, Kiezun A, Tonzi P, Van Allen EM, Carter SL, Baca SC, et al. Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma. Proc Natl Acad Sci U S A 2014;111:E5564-73.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. E5564-E5573
    • Perry, J.A.1    Kiezun, A.2    Tonzi, P.3    Van Allen, E.M.4    Carter, S.L.5    Baca, S.C.6
  • 17
    • 84912064689 scopus 로고    scopus 로고
    • EWS-FLI1 utilizes divergent chromatin remodelingmechanisms to directly activate or repress enhancer elements in Ewing sarcoma
    • Riggi N, Knoechel B, Gillespie SM, Rheinbay E, Boulay G, Suvà ML, et al. EWS-FLI1 utilizes divergent chromatin remodelingmechanisms to directly activate or repress enhancer elements in Ewing sarcoma. Cancer Cell 2014;26:668-81.
    • (2014) Cancer Cell , vol.26 , pp. 668-681
    • Riggi, N.1    Knoechel, B.2    Gillespie, S.M.3    Rheinbay, E.4    Boulay, G.5    Suvà, M.L.6
  • 18
    • 84863337645 scopus 로고    scopus 로고
    • Deconstruction of the SS18-SSX fusion oncoprotein complex: Insights into disease etiology and therapeutics
    • Su L, Sampaio AV, Jones KB, Pacheco M, Goytain A, Lin S, et al. Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics. Cancer Cell 2012;21:333-47.
    • (2012) Cancer Cell , vol.21 , pp. 333-347
    • Su, L.1    Sampaio, A.V.2    Jones, K.B.3    Pacheco, M.4    Goytain, A.5    Lin, S.6
  • 19
    • 84886558872 scopus 로고    scopus 로고
    • Classification of rhabdomyosarcoma and its molecular basis
    • Parham DM, Barr FG. Classification of rhabdomyosarcoma and its molecular basis. Adv Anat Pathol 2013;20:387-97.
    • (2013) Adv Anat Pathol , vol.20 , pp. 387-397
    • Parham, D.M.1    Barr, F.G.2
  • 20
    • 77952299529 scopus 로고    scopus 로고
    • Fusion gene-negative alveolar rhabdomyosarcoma is clinically and molecularly indistinguishable from embryonal rhabdomyosarcoma
    • Williamson D, Missiaglia E, de Reyniès A, Pierron G, Thuille B, Palenzuela G, et al. Fusion gene-negative alveolar rhabdomyosarcoma is clinically and molecularly indistinguishable from embryonal rhabdomyosarcoma. J Clin Oncol 2010;28:2151-8.
    • (2010) J Clin Oncol , vol.28 , pp. 2151-2158
    • Williamson, D.1    Missiaglia, E.2    De Reyniès, A.3    Pierron, G.4    Thuille, B.5    Palenzuela, G.6
  • 21
    • 84896691170 scopus 로고    scopus 로고
    • Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors
    • Shern JF, Chen L, Chmielecki J, Wei JS, Patidar R, Rosenberg M, et al. Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors. Cancer Discov 2014;4:216-31.
    • (2014) Cancer Discov , vol.4 , pp. 216-231
    • Shern, J.F.1    Chen, L.2    Chmielecki, J.3    Wei, J.S.4    Patidar, R.5    Rosenberg, M.6
  • 22
    • 84910108437 scopus 로고    scopus 로고
    • A study of alveolar rhabdomyosarcoma copy number alterations by single nucleotide polymorphism analysis
    • Lynn M, Shah N, Conroy J, Ennis S, Morris T, Betts D, et al. A study of alveolar rhabdomyosarcoma copy number alterations by single nucleotide polymorphism analysis. Diagn Mol Pathol 2014;22:213-21.
    • (2014) Diagn Mol Pathol , vol.22 , pp. 213-221
    • Lynn, M.1    Shah, N.2    Conroy, J.3    Ennis, S.4    Morris, T.5    Betts, D.6
  • 23
    • 84879431387 scopus 로고    scopus 로고
    • PAX-FOXO1 fusion status drives unfavorable outcome for children with rhabdomyosarcoma: A children's oncology group report
    • Skapek SX, Anderson J, Barr FG, Bridge JA, Gastier-Foster JM, Parham DM, et al. PAX-FOXO1 fusion status drives unfavorable outcome for children with rhabdomyosarcoma: a children's oncology group report. Pediatr Blood Cancer 2013;60:1411-7.
    • (2013) Pediatr Blood Cancer , vol.60 , pp. 1411-1417
    • Skapek, S.X.1    Anderson, J.2    Barr, F.G.3    Bridge, J.A.4    Gastier-Foster, J.M.5    Parham, D.M.6
  • 24
    • 84863748866 scopus 로고    scopus 로고
    • PAX3/FOXO1 fusion gene status is the key prognostic molecular marker in rhabdomyosarcoma and significantly improves current risk stratification
    • Missiaglia E, Williamson D, Chisholm J, Wirapati P, Pierron G, Petel F, et al. PAX3/FOXO1 fusion gene status is the key prognostic molecular marker in rhabdomyosarcoma and significantly improves current risk stratification. J Clin Oncol 2012;30:1670-7.
    • (2012) J Clin Oncol , vol.30 , pp. 1670-1677
    • Missiaglia, E.1    Williamson, D.2    Chisholm, J.3    Wirapati, P.4    Pierron, G.5    Petel, F.6
  • 25
    • 84904332096 scopus 로고    scopus 로고
    • Recurrent MYOD1 mutations in pediatric and adult sclerosing and spindle cell rhabdomyosarcomas: Evidence for a common pathogenesis
    • Agaram NP, Chen CL, Zhang L, LaQuaglia MP, Wexler L, Antonescu CR. Recurrent MYOD1 mutations in pediatric and adult sclerosing and spindle cell rhabdomyosarcomas: evidence for a common pathogenesis. Genes Chromosomes Cancer 2014;53:779-87.
    • (2014) Genes Chromosomes Cancer , vol.53 , pp. 779-787
    • Agaram, N.P.1    Chen, C.L.2    Zhang, L.3    LaQuaglia, M.P.4    Wexler, L.5    Antonescu, C.R.6
  • 26
    • 84892399017 scopus 로고    scopus 로고
    • Transactivating mutation of the MYOD1 gene is a frequent event in adult spindle cell rhabdomyosarcoma
    • Szuhai K, de Jong D, Leung WY, Fletcher CD, Hogendoorn PC. Transactivating mutation of the MYOD1 gene is a frequent event in adult spindle cell rhabdomyosarcoma. J Pathol 2014;232:300-7.
    • (2014) J Pathol , vol.232 , pp. 300-307
    • Szuhai, K.1    De Jong, D.2    Leung, W.Y.3    Fletcher, C.D.4    Hogendoorn, P.C.5
  • 27
    • 84901687144 scopus 로고    scopus 로고
    • A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations
    • Kohsaka S, Shukla N, Ameur N, Ito T, Ng CK, Wang L, et al. A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations. Nat Genet 2014;46:595-600.
    • (2014) Nat Genet , vol.46 , pp. 595-600
    • Kohsaka, S.1    Shukla, N.2    Ameur, N.3    Ito, T.4    Ng, C.K.5    Wang, L.6
  • 28
    • 84908498652 scopus 로고    scopus 로고
    • BCOR-CCNB3 (Ewing-like) sarcoma: A clinicopathologic analysis of 10 cases, in comparison with conventional Ewing sarcoma
    • Puls F, Niblett A, Marland G, Gaston CL, Douis H, Mangham DC, et al. BCOR-CCNB3 (Ewing-like) sarcoma: a clinicopathologic analysis of 10 cases, in comparison with conventional Ewing sarcoma. Am J Surg Pathol 2014;38:1307-18.
    • (2014) Am J Surg Pathol , vol.38 , pp. 1307-1318
    • Puls, F.1    Niblett, A.2    Marland, G.3    Gaston, C.L.4    Douis, H.5    Mangham, D.C.6
  • 29
    • 84911478067 scopus 로고    scopus 로고
    • Ewing-like sarcomas with BCOR-CCNB3 fusion transcript: A clinical, radiological and pathological retrospective study from the Societe Francaise des Cancers de L'Enfant
    • Cohen-Gogo S, Cellier C, Coindre JM, Mosseri V, Pierron G, Guillemet C, et al. Ewing-like sarcomas with BCOR-CCNB3 fusion transcript: a clinical, radiological and pathological retrospective study from the Societe Francaise des Cancers de L'Enfant. Pediatr Blood Cancer 2014;61:2191-8.
    • (2014) Pediatr Blood Cancer , vol.61 , pp. 2191-2198
    • Cohen-Gogo, S.1    Cellier, C.2    Coindre, J.M.3    Mosseri, V.4    Pierron, G.5    Guillemet, C.6
  • 31
    • 84899963751 scopus 로고    scopus 로고
    • Distinct transcriptional signature and immunoprofile of CIC-DUX4 fusion-positive round cell tumors compared to EWSR1-rearranged Ewing sarcomas: Further evidence toward distinct pathologic entities
    • Specht K, Sung YS, Zhang L, Richter GH, Fletcher CD, Antonescu CR. Distinct transcriptional signature and immunoprofile of CIC-DUX4 fusion-positive round cell tumors compared to EWSR1-rearranged Ewing sarcomas: further evidence toward distinct pathologic entities. Genes Chromosomes Cancer 2014;53:622-33.
    • (2014) Genes Chromosomes Cancer , vol.53 , pp. 622-633
    • Specht, K.1    Sung, Y.S.2    Zhang, L.3    Richter, G.H.4    Fletcher, C.D.5    Antonescu, C.R.6
  • 32
    • 84920685825 scopus 로고    scopus 로고
    • CIC-DUX sarcomas demonstrate frequent MYC amplification and ETS-family transcription factor expression
    • Smith SC, Buehler D, Choi EY, McHugh JB, Rubin BP, Billings SD, et al. CIC-DUX sarcomas demonstrate frequent MYC amplification and ETS-family transcription factor expression. Mod Pathol 2015;28:57-68.
    • (2015) Mod Pathol , vol.28 , pp. 57-68
    • Smith, S.C.1    Buehler, D.2    Choi, E.Y.3    McHugh, J.B.4    Rubin, B.P.5    Billings, S.D.6
  • 33
    • 84914814609 scopus 로고    scopus 로고
    • A novel CIC-FOXO4 gene fusion in undifferentiated small round cell sarcoma: A genetically distinct variant of Ewing-like sarcoma
    • Sugita S, Arai Y, Tonooka A, Hama N, Totoki Y, Fujii T, et al. A novel CIC-FOXO4 gene fusion in undifferentiated small round cell sarcoma: a genetically distinct variant of Ewing-like sarcoma. Am J Surg Pathol 2014;38:1571-6.
    • (2014) Am J Surg Pathol , vol.38 , pp. 1571-1576
    • Sugita, S.1    Arai, Y.2    Tonooka, A.3    Hama, N.4    Totoki, Y.5    Fujii, T.6
  • 34
    • 84914684943 scopus 로고    scopus 로고
    • Clinicopathologic features of a second patient with Ewing-like sarcoma harboring CIC-FOXO4 gene fusion
    • Solomon DA, Brohl AS, Khan J, Miettinen M. Clinicopathologic features of a second patient with Ewing-like sarcoma harboring CIC-FOXO4 gene fusion. Am J Surg Pathol 2014;38:1724-5.
    • (2014) Am J Surg Pathol , vol.38 , pp. 1724-1725
    • Solomon, D.A.1    Brohl, A.S.2    Khan, J.3    Miettinen, M.4
  • 35
    • 84884211534 scopus 로고    scopus 로고
    • Multiplexed gene expression and fusion transcript analysis to detect ALK fusions in lung cancer
    • Lira ME, Kim TM, Huang D, Deng S, Koh Y, Jang B, et al. Multiplexed gene expression and fusion transcript analysis to detect ALK fusions in lung cancer. J Mol Diagn 2013;15:51-61.
    • (2013) J Mol Diagn , vol.15 , pp. 51-61
    • Lira, M.E.1    Kim, T.M.2    Huang, D.3    Deng, S.4    Koh, Y.5    Jang, B.6
  • 37
    • 84875727068 scopus 로고    scopus 로고
    • Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma
    • Kadoch C, Crabtree GR. Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma. Cell 2013;153:71-85.
    • (2013) Cell , vol.153 , pp. 71-85
    • Kadoch, C.1    Crabtree, G.R.2
  • 38
    • 84905868284 scopus 로고    scopus 로고
    • The Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx)
    • Ciarapica R, De Salvo M, Carcarino E, Bracaglia G, Adesso L, Leoncini PP, et al. The Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx). Oncogene 2014;33:4173-84.
    • (2014) Oncogene , vol.33 , pp. 4173-4184
    • Ciarapica, R.1    De Salvo, M.2    Carcarino, E.3    Bracaglia, G.4    Adesso, L.5    Leoncini, P.P.6
  • 39
    • 84908700635 scopus 로고    scopus 로고
    • Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors
    • Zhang M, Wang Y, Jones S, Sausen M, McMahon K, Sharma R, et al. Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors. Nat Genet 2014;46:1170-2.
    • (2014) Nat Genet , vol.46 , pp. 1170-1172
    • Zhang, M.1    Wang, Y.2    Jones, S.3    Sausen, M.4    McMahon, K.5    Sharma, R.6
  • 40
    • 84908666344 scopus 로고    scopus 로고
    • PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors
    • Lee W, Teckie S, Wiesner T, Ran L, Prieto Granada CN, Lin M, et al. PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors. Nat Genet 2014;46:1227-32.
    • (2014) Nat Genet , vol.46 , pp. 1227-1232
    • Lee, W.1    Teckie, S.2    Wiesner, T.3    Ran, L.4    Prieto Granada, C.N.5    Lin, M.6
  • 41
    • 84883187700 scopus 로고    scopus 로고
    • A phase II trial of panobinostat in patients with advanced pretreated soft tissue sarcoma. A study from the French Sarcoma Group
    • Cassier PA, Lefranc A, Amela EY, Chevreau C, Bui BN, Lecesne A, et al. A phase II trial of panobinostat in patients with advanced pretreated soft tissue sarcoma. A study from the French Sarcoma Group. Br J Cancer 2013;109:909-14.
    • (2013) Br J Cancer , vol.109 , pp. 909-914
    • Cassier, P.A.1    Lefranc, A.2    Amela, E.Y.3    Chevreau, C.4    Bui, B.N.5    Lecesne, A.6
  • 42
    • 84929085702 scopus 로고    scopus 로고
    • A phase II study of SB939, a novel pan-histone deacetylase inhibitor, in patients with translocation-associated recurrent/metastatic sarcomas-NCIC-CTG IND 200dagger
    • Chu QS, Nielsen TO, Alcindor T, Gupta A, Endo M, Goytain A, et al. A phase II study of SB939, a novel pan-histone deacetylase inhibitor, in patients with translocation-associated recurrent/metastatic sarcomas-NCIC-CTG IND 200dagger. Ann Oncol 2015;26:973-81.
    • (2015) Ann Oncol , vol.26 , pp. 973-981
    • Chu, Q.S.1    Nielsen, T.O.2    Alcindor, T.3    Gupta, A.4    Endo, M.5    Goytain, A.6
  • 43
    • 84947267216 scopus 로고    scopus 로고
    • CD8/FOXP3-ratio in osteosarcoma microenvironment separates survivors from non-survivors: A multicenter validated retrospective study
    • Fritzsching B, Fellenberg J, Moskovszky L, Sápi Z, Krenacs T, Machado I, et al. CD8/FOXP3-ratio in osteosarcoma microenvironment separates survivors from non-survivors: a multicenter validated retrospective study. Oncoimmunology 2015;4:e990800.
    • (2015) Oncoimmunology , vol.4
    • Fritzsching, B.1    Fellenberg, J.2    Moskovszky, L.3    Sápi, Z.4    Krenacs, T.5    Machado, I.6
  • 44
    • 84895928445 scopus 로고    scopus 로고
    • CD8(+) tumor-infiltrating lymphocytes at primary sites as a possible prognostic factor of cutaneous angiosarcoma
    • Fujii H, Arakawa A, Utsumi D, Sumiyoshi S, Yamamoto Y, Kitoh A, et al. CD8(+) tumor-infiltrating lymphocytes at primary sites as a possible prognostic factor of cutaneous angiosarcoma. Int J Cancer 2014;134:2393-402.
    • (2014) Int J Cancer , vol.134 , pp. 2393-2402
    • Fujii, H.1    Arakawa, A.2    Utsumi, D.3    Sumiyoshi, S.4    Yamamoto, Y.5    Kitoh, A.6
  • 45
    • 85027926398 scopus 로고    scopus 로고
    • Expression of cancer-testis antigens MAGEA1, MAGEA3, ACRBP, PRAME, SSX2, and CTAG2 in myxoid and round cell liposarcoma
    • Hemminger JA, Toland AE, Scharschmidt TJ, Mayerson JL, Guttridge DC, Iwenofu OH. Expression of cancer-testis antigens MAGEA1, MAGEA3, ACRBP, PRAME, SSX2, and CTAG2 in myxoid and round cell liposarcoma. Mod Pathol 2014;27:1238-45.
    • (2014) Mod Pathol , vol.27 , pp. 1238-1245
    • Hemminger, J.A.1    Toland, A.E.2    Scharschmidt, T.J.3    Mayerson, J.L.4    Guttridge, D.C.5    Iwenofu, O.H.6
  • 47
    • 84908070945 scopus 로고    scopus 로고
    • Cross-sectional and longitudinal analysis of cancer vaccination trials registered on the US Clinical Trials Database demonstrates paucity of immunological trial endpoints and decline in registration since 2008
    • Lu L, Yan H, Shyam-Sundar V, Janowitz T. Cross-sectional and longitudinal analysis of cancer vaccination trials registered on the US Clinical Trials Database demonstrates paucity of immunological trial endpoints and decline in registration since 2008. Drug Des Devel Ther 2014;8:1539-53.
    • (2014) Drug Des Devel Ther , vol.8 , pp. 1539-1553
    • Lu, L.1    Yan, H.2    Shyam-Sundar, V.3    Janowitz, T.4
  • 48
    • 84928912377 scopus 로고    scopus 로고
    • A pilot trial using lymphocytes genetically engineered with an NY-ESO-1-reactive T-cell receptor: Long-term follow-up and correlates with response
    • Robbins PF, Kassim SH, Tran TL, Crystal JS, Morgan RA, Feldman SA, et al. A pilot trial using lymphocytes genetically engineered with an NY-ESO-1-reactive T-cell receptor: long-term follow-up and correlates with response. Clin Cancer Res 2015;21:1019-27.
    • (2015) Clin Cancer Res , vol.21 , pp. 1019-1027
    • Robbins, P.F.1    Kassim, S.H.2    Tran, T.L.3    Crystal, J.S.4    Morgan, R.A.5    Feldman, S.A.6
  • 49
    • 84977111467 scopus 로고    scopus 로고
    • Combined immune checkpoint protein blockade and low dose whole body irradiation as immunotherapy for myeloma
    • Jing W, Gershan JA, Weber J, Tlomak D, McOlash L, Sabatos-Peyton C, et al. Combined immune checkpoint protein blockade and low dose whole body irradiation as immunotherapy for myeloma. J Immunother Cancer 2015;3:2.
    • (2015) J Immunother Cancer , vol.3 , pp. 2
    • Jing, W.1    Gershan, J.A.2    Weber, J.3    Tlomak, D.4    McOlash, L.5    Sabatos-Peyton, C.6
  • 50
    • 84921448324 scopus 로고    scopus 로고
    • The evolution of checkpoint blockade as a cancer therapy: What's here, what's next?
    • Shin DS, Ribas A. The evolution of checkpoint blockade as a cancer therapy: what's here, what's next? Curr Opin Immunol 2015;33:23-35.
    • (2015) Curr Opin Immunol , vol.33 , pp. 23-35
    • Shin, D.S.1    Ribas, A.2
  • 51
    • 84997606253 scopus 로고    scopus 로고
    • Combination immunotherapy with alpha-CTLA-4 and alpha-PD-L1 antibody blockade prevents immune escape and leads to complete control of metastatic osteosarcoma
    • Lussier DM, Johnson JL, Hingorani P, Blattman JN. Combination immunotherapy with alpha-CTLA-4 and alpha-PD-L1 antibody blockade prevents immune escape and leads to complete control of metastatic osteosarcoma. J Immunother Cancer 2015;3:21.
    • (2015) J Immunother Cancer , vol.3 , pp. 21
    • Lussier, D.M.1    Johnson, J.L.2    Hingorani, P.3    Blattman, J.N.4
  • 53
    • 84961994266 scopus 로고    scopus 로고
    • The coordinated actions of TIM-3 on cancer and myeloid cells in the regulation of tumorigenicity and clinical prognosis in clear cell renal cell carcinomas
    • Komohara Y, Morita T, Annan DA, Horlad H, Ohnishi K, Yamada S, et al. The coordinated actions of TIM-3 on cancer and myeloid cells in the regulation of tumorigenicity and clinical prognosis in clear cell renal cell carcinomas. Cancer Immunol Res 2015;3:999-1007.
    • (2015) Cancer Immunol Res , vol.3 , pp. 999-1007
    • Komohara, Y.1    Morita, T.2    Annan, D.A.3    Horlad, H.4    Ohnishi, K.5    Yamada, S.6
  • 54
    • 84942887332 scopus 로고    scopus 로고
    • Differential expression of immune-regulatory genes associated with PD-L1 display in melanoma: Implications for PD-1 pathway blockade
    • Taube JM, Young GD, McMiller TL, Chen S, Salas JT, Pritchard TS, et al. Differential expression of immune-regulatory genes associated with PD-L1 display in melanoma: implications for PD-1 pathway blockade. Clin Cancer Res 2015;21:3969-76.
    • (2015) Clin Cancer Res , vol.21 , pp. 3969-3976
    • Taube, J.M.1    Young, G.D.2    McMiller, T.L.3    Chen, S.4    Salas, J.T.5    Pritchard, T.S.6
  • 56
    • 84926419753 scopus 로고    scopus 로고
    • Myeloid cells in cancer-related inflammation
    • Caronni N, Savino B, Bonecchi R. Myeloid cells in cancer-related inflammation. Immunobiology 2015;220:249-53.
    • (2015) Immunobiology , vol.220 , pp. 249-253
    • Caronni, N.1    Savino, B.2    Bonecchi, R.3
  • 58
    • 84964284448 scopus 로고    scopus 로고
    • Tumour-associated macrophages correlate with poor prognosis in myxoid liposarcoma and promote cell motility and invasion via the HB-EGF-EGFR-PI3K/Akt pathways
    • Nabeshima A, Matsumoto Y, Fukushi J, Iura K, Matsunobu T, Endo M, et al. Tumour-associated macrophages correlate with poor prognosis in myxoid liposarcoma and promote cell motility and invasion via the HB-EGF-EGFR-PI3K/Akt pathways. Br J Cancer 2015;112:547-55.
    • (2015) Br J Cancer , vol.112 , pp. 547-555
    • Nabeshima, A.1    Matsumoto, Y.2    Fukushi, J.3    Iura, K.4    Matsunobu, T.5    Endo, M.6
  • 61
    • 80053373081 scopus 로고    scopus 로고
    • Inhibition of fms-like tyrosine kinase 3 alleviates experimental arthritis by reducing formation of dendritic cells and antigen presentation
    • Dehlin M, Andersson S, Erlandsson M, Brisslert M, Bokarewa M. Inhibition of fms-like tyrosine kinase 3 alleviates experimental arthritis by reducing formation of dendritic cells and antigen presentation. J Leukoc Biol 2011;90:811-7.
    • (2011) J Leukoc Biol , vol.90 , pp. 811-817
    • Dehlin, M.1    Andersson, S.2    Erlandsson, M.3    Brisslert, M.4    Bokarewa, M.5
  • 62
    • 84898642115 scopus 로고    scopus 로고
    • Cutting edge: Flt3 ligand mediates STAT3-independent expansion but STAT3-dependent activation of myeloid-derived suppressor cells
    • Rosborough BR, Mathews LR, Matta BM, Liu Q, Raïch-Regué D, Thomson AW, et al. Cutting edge: Flt3 ligand mediates STAT3-independent expansion but STAT3-dependent activation of myeloid-derived suppressor cells. J Immunol 2014;192:3470-3.
    • (2014) J Immunol , vol.192 , pp. 3470-3473
    • Rosborough, B.R.1    Mathews, L.R.2    Matta, B.M.3    Liu, Q.4    Raïch-Regué, D.5    Thomson, A.W.6
  • 63
    • 84928588528 scopus 로고    scopus 로고
    • Intratumoral myeloid cells regulate responsiveness and resistance to antiangiogenic therapy
    • Rivera LB, Meyronet D, Hervieu V, Frederick MJ, Bergsland E, Bergers G. Intratumoral myeloid cells regulate responsiveness and resistance to antiangiogenic therapy. Cell Rep 2015;11:577-91.
    • (2015) Cell Rep , vol.11 , pp. 577-591
    • Rivera, L.B.1    Meyronet, D.2    Hervieu, V.3    Frederick, M.J.4    Bergsland, E.5    Bergers, G.6
  • 65
    • 84922999148 scopus 로고    scopus 로고
    • The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation
    • DuPage M, Chopra G, Quiros J, Rosenthal WL, Morar MM, Holohan D, et al. The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation. Immunity 2015;42:227-38.
    • (2015) Immunity , vol.42 , pp. 227-238
    • DuPage, M.1    Chopra, G.2    Quiros, J.3    Rosenthal, W.L.4    Morar, M.M.5    Holohan, D.6
  • 66
    • 84887549060 scopus 로고    scopus 로고
    • The polycomb protein Ezh2 regulates differentiation and plasticity of CD4(+) T helper type 1 and type 2 cells
    • Tumes DJ, Onodera A, Suzuki A, Shinoda K, Endo Y, Iwamura C, et al. The polycomb protein Ezh2 regulates differentiation and plasticity of CD4(+) T helper type 1 and type 2 cells. Immunity 2013;39:819-32.
    • (2013) Immunity , vol.39 , pp. 819-832
    • Tumes, D.J.1    Onodera, A.2    Suzuki, A.3    Shinoda, K.4    Endo, Y.5    Iwamura, C.6
  • 69
    • 84898025518 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 inhibitors induce the canonical WNT/beta-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma
    • Chen EY, DeRan MT, Ignatius MS, Grandinetti KB, Clagg R, McCarthy KM, et al. Glycogen synthase kinase 3 inhibitors induce the canonical WNT/beta-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma. Proc Natl Acad Sci U S A 2014;111:5349-54.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 5349-5354
    • Chen, E.Y.1    DeRan, M.T.2    Ignatius, M.S.3    Grandinetti, K.B.4    Clagg, R.5    McCarthy, K.M.6
  • 70
    • 84926081430 scopus 로고    scopus 로고
    • Sorafenib and everolimus for patients with unresectable high-grade osteosarcoma progressing after standard treatment: A non-randomised phase 2 clinical trial
    • Grignani G, Palmerini E, Ferraresi V, D'Ambrosio L, Bertulli R, Asaftei SD, et al. Sorafenib and everolimus for patients with unresectable high-grade osteosarcoma progressing after standard treatment: a non-randomised phase 2 clinical trial. Lancet Oncol 2015;16:98-107.
    • (2015) Lancet Oncol , vol.16 , pp. 98-107
    • Grignani, G.1    Palmerini, E.2    Ferraresi, V.3    D'Ambrosio, L.4    Bertulli, R.5    Asaftei, S.D.6
  • 71
    • 0036189675 scopus 로고    scopus 로고
    • Progression-free rate as the principal end-point for phase II trials in soft-tissue sarcomas
    • Van Glabbeke M, Verweij J, Judson I, Nielsen OS EORTC Soft Tissue and Bone Sarcoma Group. Progression-free rate as the principal end-point for phase II trials in soft-tissue sarcomas. Eur J Cancer 2002;38:543-9.
    • (2002) Eur J Cancer , vol.38 , pp. 543-549
    • Van Glabbeke, M.1    Verweij, J.2    Judson, I.3
  • 72
    • 84920855943 scopus 로고    scopus 로고
    • Phase II study of olaparib in patients with refractory Ewing sarcoma following failure of standard chemotherapy
    • Choy E, Butrynski JE, Harmon DC, Morgan JA, George S, Wagner AJ, et al. Phase II study of olaparib in patients with refractory Ewing sarcoma following failure of standard chemotherapy. BMC Cancer 2014;14:813.
    • (2014) BMC Cancer , vol.14 , pp. 813
    • Choy, E.1    Butrynski, J.E.2    Harmon, D.C.3    Morgan, J.A.4    George, S.5    Wagner, A.J.6
  • 73
    • 84880991913 scopus 로고    scopus 로고
    • 'Basket studies' will hold intricate data for cancer drug approvals
    • Willyard C. 'Basket studies' will hold intricate data for cancer drug approvals. Nat Med 2013;19:655.
    • (2013) Nat Med , vol.19 , pp. 655
    • Willyard, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.