메뉴 건너뛰기




Volumn 39, Issue 11, 2015, Pages 1607-1618

Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance

Author keywords

[No Author keywords available]

Indexed keywords

BARICITINIB; CD11B ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; GLYCOPROTEIN P 15095; INSULIN; INTERLEUKIN 12P40; INTERLEUKIN 18; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUTRALIZING ANTIBODY; RANTES; STAT1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84947038680     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2015.104     Document Type: Article
Times cited : (137)

References (52)
  • 1
    • 77951918926 scopus 로고    scopus 로고
    • Macrophages, inflammation, and insulin resistance
    • Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol. 2010; 72: 219-246.
    • (2010) Annu Rev Physiol , vol.72 , pp. 219-246
    • Olefsky, J.M.1    Glass, C.K.2
  • 2
    • 35848961894 scopus 로고    scopus 로고
    • Associations between insulin resistance and TNF-Alpha in plasma, skeletal muscle and adipose tissue in humans with and without type 2 diabetes
    • Plomgaard P, Nielsen AR, Fischer CP, Mortensen OH, Broholm C, Penkowa M, et al. Associations between insulin resistance and TNF-Alpha in plasma, skeletal muscle and adipose tissue in humans with and without type 2 diabetes. Diabetologia. 2007; 50: 2562-2571.
    • (2007) Diabetologia , vol.50 , pp. 2562-2571
    • Plomgaard, P.1    Nielsen, A.R.2    Fischer, C.P.3    Mortensen, O.H.4    Broholm, C.5    Penkowa, M.6
  • 3
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest. 2007; 117: 175-184.
    • (2007) J Clin Invest , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 5
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest. 2003; 112: 1821-1830.
    • (2003) J Clin Invest , vol.112 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3    Tan, G.4    Yang, D.5    Chou, C.J.6
  • 6
    • 0027332738 scopus 로고
    • Tumor necrosis factoralpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates
    • Feinstein R, Kanety H, Papa MZ, Lunenfeld B, Karasik A. Tumor necrosis factoralpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates. J Biol Chem. 1993; 268: 26055-26058.
    • (1993) J Biol Chem , vol.268 , pp. 26055-26058
    • Feinstein, R.1    Kanety, H.2    Papa, M.Z.3    Lunenfeld, B.4    Karasik, A.5
  • 7
    • 33847280286 scopus 로고    scopus 로고
    • T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity
    • Wu H, Ghosh S, Perrard XD, Feng L, Garcia GE, Perrard JL, et al. T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity. Circulation. 2007; 115: 1029-1038.
    • (2007) Circulation , vol.115 , pp. 1029-1038
    • Wu, H.1    Ghosh, S.2    Perrard, X.D.3    Feng, L.4    Garcia, G.E.5    Perrard, J.L.6
  • 8
    • 38149142633 scopus 로고    scopus 로고
    • Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration
    • Rausch ME, Weisberg S, Vardhana P, Tortoriello DV. Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration. Int J Obes (Lond) 2008; 32: 451-463.
    • (2008) Int J Obes (Lond , vol.32 , pp. 451-463
    • Rausch, M.E.1    Weisberg, S.2    Vardhana, P.3    Tortoriello, D.V.4
  • 9
    • 46249117032 scopus 로고    scopus 로고
    • T-lymphocyte infiltration in visceral adipose tissue: A primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance
    • Kintscher U, Hartge M, Hess K, Foryst-Ludwig A, Clemenz M, Wabitsch M, et al. T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance. Arterioscler Thromb Vasc Biol. 2008; 28: 1304-1310.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1304-1310
    • Kintscher, U.1    Hartge, M.2    Hess, K.3    Foryst-Ludwig, A.4    Clemenz, M.5    Wabitsch, M.6
  • 10
    • 68349150756 scopus 로고    scopus 로고
    • CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
    • Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med. 2009; 15: 914-920.
    • (2009) Nat Med , vol.15 , pp. 914-920
    • Nishimura, S.1    Manabe, I.2    Nagasaki, M.3    Eto, K.4    Yamashita, H.5    Ohsugi, M.6
  • 11
    • 84875280888 scopus 로고    scopus 로고
    • Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation
    • Deng T, Lyon CJ, Minze LJ, Lin J, Zou J, Liu JZ, et al. Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation. Cell Metab. 2013; 17: 411-422.
    • (2013) Cell Metab , vol.17 , pp. 411-422
    • Deng, T.1    Lyon, C.J.2    Minze, L.J.3    Lin, J.4    Zou, J.5    Liu, J.Z.6
  • 14
    • 68349148211 scopus 로고    scopus 로고
    • Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
    • Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A, et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med. 2009; 15: 930-939.
    • (2009) Nat Med , vol.15 , pp. 930-939
    • Feuerer, M.1    Herrero, L.2    Cipolletta, D.3    Naaz, A.4    Wong, J.5    Nayer, A.6
  • 15
    • 68349137821 scopus 로고    scopus 로고
    • Normalization of obesity-Associated insulin resistance through immunotherapy
    • Winer S, Chan Y, Paltser G, Truong D, Tsui H, Bahrami J, et al. Normalization of obesity-Associated insulin resistance through immunotherapy. Nat Med. 2009; 15: 921-929.
    • (2009) Nat Med , vol.15 , pp. 921-929
    • Winer, S.1    Chan, Y.2    Paltser, G.3    Truong, D.4    Tsui, H.5    Bahrami, J.6
  • 16
    • 70450277113 scopus 로고    scopus 로고
    • Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway
    • McGillicuddy FC, Chiquoine EH, Hinkle CC, Kim RJ, Shah R, Roche HM, et al. Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway. J Biol Chem. 2009; 284: 31936-31944.
    • (2009) J Biol Chem , vol.284 , pp. 31936-31944
    • McGillicuddy, F.C.1    Chiquoine, E.H.2    Hinkle, C.C.3    Kim, R.J.4    Shah, R.5    Roche, H.M.6
  • 17
    • 0033543754 scopus 로고    scopus 로고
    • Transmembrane tumor necrosis factor (TNF)-Alpha inhibits adipocyte differentiation by selectively activating TNF receptor 1
    • Xu H, Sethi JK, Hotamisligil GS. Transmembrane tumor necrosis factor (TNF)-Alpha inhibits adipocyte differentiation by selectively activating TNF receptor 1. J Biol Chem. 1999; 274: 26287-26295.
    • (1999) J Biol Chem , vol.274 , pp. 26287-26295
    • Xu, H.1    Sethi, J.K.2    Hotamisligil, G.S.3
  • 18
    • 0041568670 scopus 로고    scopus 로고
    • TNF-Alpha induction of lipolysis is mediated through activation of the extracellular signal related kinase pathway in 3T3-L1 adipocytes
    • Souza SC, Palmer HJ, Kang YH, Yamamoto MT, Muliro KV, Paulson KE, et al. TNF-Alpha induction of lipolysis is mediated through activation of the extracellular signal related kinase pathway in 3T3-L1 adipocytes. J Cell Biochem. 2003; 89: 1077-1086.
    • (2003) J Cell Biochem , vol.89 , pp. 1077-1086
    • Souza, S.C.1    Palmer, H.J.2    Kang, Y.H.3    Yamamoto, M.T.4    Muliro, K.V.5    Paulson, K.E.6
  • 19
    • 42449097289 scopus 로고    scopus 로고
    • Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
    • Guilherme A, Virbasius JV, Puri V, Czech MP. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol. 2008; 9: 367-377.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 367-377
    • Guilherme, A.1    Virbasius, J.V.2    Puri, V.3    Czech, M.P.4
  • 20
    • 84874543773 scopus 로고    scopus 로고
    • Cross-Talk between skeletal muscle and immune cells: Muscle-derived mediators and metabolic implications
    • Pillon NJ, Bilan PJ, Fink LN, Klip A. Cross-Talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications. Am J Physiol Endocrinol Metab. 2013; 304: E453-E465.
    • (2013) Am J Physiol Endocrinol Metab , vol.304 , pp. E453-E465
    • Pillon, N.J.1    Bilan, P.J.2    Fink, L.N.3    Klip, A.4
  • 21
    • 75549085755 scopus 로고    scopus 로고
    • Skeletal muscle insulin resistance is the primary defect in type 2 diabetes
    • DeFronzo RA, Tripathy D. Skeletal muscle insulin resistance is the primary defect in type 2 diabetes. Diabetes Care. 2009; 32: S157-S163.
    • (2009) Diabetes Care , vol.32 , pp. S157-S163
    • DeFronzo, R.A.1    Tripathy, D.2
  • 22
    • 0035256412 scopus 로고    scopus 로고
    • Skeletal muscle and insulin sensitivity: Pathophysiological alterations
    • Ryder JW, Gilbert M, Zierath JR. Skeletal muscle and insulin sensitivity: pathophysiological alterations. Front Biosci. 2001; 6: D154-D163.
    • (2001) Front Biosci , vol.6 , pp. D154-D163
    • Ryder, J.W.1    Gilbert, M.2    Zierath, J.R.3
  • 24
    • 0026087478 scopus 로고
    • Influence of dietary fat composition on development of insulin resistance in rats Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid
    • Storlien LH, Jenkins AB, Chisholm DJ, Pascoe WS, Khouri S, Kraegen EW. Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid. Diabetes. 1991; 40: 280-289.
    • (1991) Diabetes , vol.40 , pp. 280-289
    • Storlien, L.H.1    Jenkins, A.B.2    Chisholm, D.J.3    Pascoe, W.S.4    Khouri, S.5    Kraegen, E.W.6
  • 25
    • 0030765908 scopus 로고    scopus 로고
    • Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat
    • Goodpaster BH, Thaete FL, Simoneau JA, Kelley DE. Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes. 1997; 46: 1579-1585.
    • (1997) Diabetes , vol.46 , pp. 1579-1585
    • Goodpaster, B.H.1    Thaete, F.L.2    Simoneau, J.A.3    Kelley, D.E.4
  • 26
    • 0032934826 scopus 로고    scopus 로고
    • Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: A 1H NMR spectroscopy study
    • Krssak M, Falk Petersen K, Dresner A, DiPietro L, Vogel SM, Rothman DL, et al. Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia. 1999; 42: 113-116.
    • (1999) Diabetologia , vol.42 , pp. 113-116
    • Krssak, M.1    Falk Petersen, K.2    Dresner, A.3    DiPietro, L.4    Vogel, S.M.5    Rothman, D.L.6
  • 27
    • 0032764784 scopus 로고    scopus 로고
    • Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: A 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents
    • Perseghin G, Scifo P, De Cobelli F, Pagliato E, Battezzati A, Arcelloni C, et al. Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes. 1999; 48: 1600-1606.
    • (1999) Diabetes , vol.48 , pp. 1600-1606
    • Perseghin, G.1    Scifo, P.2    De Cobelli, F.3    Pagliato, E.4    Battezzati, A.5    Arcelloni, C.6
  • 28
    • 38949161524 scopus 로고    scopus 로고
    • Determinants of intramyocellular triglyceride turnover: Implications for insulin sensitivity
    • Moro C, Bajpeyi S, Smith SR. Determinants of intramyocellular triglyceride turnover: implications for insulin sensitivity. Am J Physiol Endocrinol Metab. 2008; 294: E203-E213.
    • (2008) Am J Physiol Endocrinol Metab , vol.294 , pp. E203-E213
    • Moro, C.1    Bajpeyi, S.2    Smith, S.R.3
  • 29
    • 0036224883 scopus 로고    scopus 로고
    • Assessment of skeletal muscle triglyceride content by 1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: Relationships to insulin sensitivity, total body fat, and central adiposity
    • Sinha R, Dufour S, Petersen KF, LeBon V, Enoksson S, Ma YZ, et al. Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity. Diabetes. 2002; 51: 1022-1027.
    • (2002) Diabetes , vol.51 , pp. 1022-1027
    • Sinha, R.1    Dufour, S.2    Petersen, K.F.3    LeBon, V.4    Enoksson, S.5    Ma, Y.Z.6
  • 30
    • 0034107084 scopus 로고    scopus 로고
    • Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus
    • Goodpaster BH, Thaete FL, Kelley DE. Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus. Am J Clin Nutr. 2000; 71: 885-892.
    • (2000) Am J Clin Nutr , vol.71 , pp. 885-892
    • Goodpaster, B.H.1    Thaete, F.L.2    Kelley, D.E.3
  • 31
    • 84869487754 scopus 로고    scopus 로고
    • Insulin sensitivity is associated with thigh adipose tissue distribution in healthy postmenopausal women
    • Goss AM, Gower BA. Insulin sensitivity is associated with thigh adipose tissue distribution in healthy postmenopausal women. Metabolism. 2012; 61: 1817-1823.
    • (2012) Metabolism , vol.61 , pp. 1817-1823
    • Goss, A.M.1    Gower, B.A.2
  • 32
    • 66849093697 scopus 로고    scopus 로고
    • Muscle inflammatory response and insulin resistance: Synergistic interaction between macrophages and fatty acids leads to impaired insulin action
    • Varma V, Yao-Borengasser A, Rasouli N, Nolen GT, Phanavanh B, Starks T, et al. Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action. Am J Physiol Endocrinol Metab. 2009; 296: E1300-E1310.
    • (2009) Am J Physiol Endocrinol Metab , vol.296 , pp. E1300-E1310
    • Varma, V.1    Yao-Borengasser, A.2    Rasouli, N.3    Nolen, G.T.4    Phanavanh, B.5    Starks, T.6
  • 33
    • 34249907880 scopus 로고    scopus 로고
    • Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones
    • Hevener AL, Olefsky JM, Reichart D, Nguyen MT, Bandyopadyhay G, Leung HY, et al. Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest. 2007; 117: 1658-1669.
    • (2007) J Clin Invest , vol.117 , pp. 1658-1669
    • Hevener, A.L.1    Olefsky, J.M.2    Reichart, D.3    Nguyen, M.T.4    Bandyopadyhay, G.5    Leung, H.Y.6
  • 34
    • 52749092267 scopus 로고    scopus 로고
    • Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals
    • Patsouris D, Li PP, Thapar D, Chapman J, Olefsky JM, Neels JG. Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab. 2008; 8: 301-309.
    • (2008) Cell Metab , vol.8 , pp. 301-309
    • Patsouris, D.1    Li, P.P.2    Thapar, D.3    Chapman, J.4    Olefsky, J.M.5    Neels, J.G.6
  • 35
    • 84895820360 scopus 로고    scopus 로고
    • Pro-inflammatory macrophages increase in skeletal muscle of high fat-fed mice and correlate with metabolic risk markers in humans
    • Fink LN, Costford SR, Lee YS, Jensen TE, Bilan PJ, Oberbach A, et al. Pro-inflammatory macrophages increase in skeletal muscle of high fat-fed mice and correlate with metabolic risk markers in humans. Obesity (Silver Spring) 2013; 22: 747-757.
    • (2013) Obesity (Silver Spring , vol.22 , pp. 747-757
    • Fink, L.N.1    Costford, S.R.2    Lee, Y.S.3    Jensen, T.E.4    Bilan, P.J.5    Oberbach, A.6
  • 36
    • 70350561703 scopus 로고    scopus 로고
    • Interleukin-10 prevents dietinduced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle
    • Hong EG, Ko HJ, Cho YR, Kim HJ, Ma Z, Yu TY, et al. Interleukin-10 prevents dietinduced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle. Diabetes. 2009; 58: 2525-2535.
    • (2009) Diabetes , vol.58 , pp. 2525-2535
    • Hong, E.G.1    Ko, H.J.2    Cho, Y.R.3    Kim, H.J.4    Ma, Z.5    Yu, T.Y.6
  • 37
    • 33646397556 scopus 로고    scopus 로고
    • Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects
    • Bruun JM, Helge JW, Richelsen B, Stallknecht B. Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. Am J Physiol Endocrinol Metab. 2006; 290: E961-E967.
    • (2006) Am J Physiol Endocrinol Metab , vol.290 , pp. E961-E967
    • Bruun, J.M.1    Helge, J.W.2    Richelsen, B.3    Stallknecht, B.4
  • 39
    • 84896267299 scopus 로고    scopus 로고
    • Attenuated adipose tissue and skeletal muscle inflammation in obese mice with combined CD4+ and CD8+ T cell deficiency
    • Khan IM, Dai Perrard XY, Perrard JL, Mansoori A, Wayne Smith C, Wu H, et al. Attenuated adipose tissue and skeletal muscle inflammation in obese mice with combined CD4+ and CD8+ T cell deficiency. Atherosclerosis. 2014; 233: 419-428.
    • (2014) Atherosclerosis , vol.233 , pp. 419-428
    • Khan, I.M.1    Dai Perrard, X.Y.2    Perrard, J.L.3    Mansoori, A.4    Wayne Smith, C.5    Wu, H.6
  • 40
    • 2942748411 scopus 로고    scopus 로고
    • Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes
    • Wu H, Rodgers JR, Perrard XY, Perrard JL, Prince JE, Abe Y, et al. Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes. J Immunol. 2004; 173: 297-306.
    • (2004) J Immunol , vol.173 , pp. 297-306
    • Wu, H.1    Rodgers, J.R.2    Perrard, X.Y.3    Perrard, J.L.4    Prince, J.E.5    Abe, Y.6
  • 43
    • 57849127155 scopus 로고    scopus 로고
    • In vivo quantification of subcutaneous and visceral adiposity by micro-computed tomography in a small animal model
    • Luu YK, Lublinsky S, Ozcivici E, Capilla E, Pessin JE, Rubin CT, et al. In vivo quantification of subcutaneous and visceral adiposity by micro-computed tomography in a small animal model. Med Eng Phys. 2009; 31: 34-41.
    • (2009) Med Eng Phys , vol.31 , pp. 34-41
    • Luu, Y.K.1    Lublinsky, S.2    Ozcivici, E.3    Capilla, E.4    Pessin, J.E.5    Rubin, C.T.6
  • 44
    • 84878833173 scopus 로고    scopus 로고
    • Expression of anti-inflammatory macrophage genes within skeletal muscle correlates with insulin sensitivity in human obesity and type 2 diabetes
    • Fink LN, Oberbach A, Costford SR, Chan KL, Sams A, Bluher M, et al. Expression of anti-inflammatory macrophage genes within skeletal muscle correlates with insulin sensitivity in human obesity and type 2 diabetes. Diabetologia. 2013; 56: 1623-1628.
    • (2013) Diabetologia , vol.56 , pp. 1623-1628
    • Fink, L.N.1    Oberbach, A.2    Costford, S.R.3    Chan, K.L.4    Sams, A.5    Bluher, M.6
  • 45
    • 77954531991 scopus 로고    scopus 로고
    • Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: Preclinical characterization of INCB028050
    • Fridman JS, Scherle PA, Collins R, Burn TC, Li Y, Li J, et al. Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050. J Immunol. 2010; 184: 5298-5307.
    • (2010) J Immunol , vol.184 , pp. 5298-5307
    • Fridman, J.S.1    Scherle, P.A.2    Collins, R.3    Burn, T.C.4    Li, Y.5    Li, J.6
  • 47
    • 0030641529 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 is sufficient for the chemotaxis of monocytes and lymphocytes in transgenic mice but requires an additional stimulus for inflammatory activation
    • Gunn MD, Nelken NA, Liao X, Williams LT. Monocyte chemoattractant protein-1 is sufficient for the chemotaxis of monocytes and lymphocytes in transgenic mice but requires an additional stimulus for inflammatory activation. J Immunol. 1997; 158: 376-383.
    • (1997) J Immunol , vol.158 , pp. 376-383
    • Gunn, M.D.1    Nelken, N.A.2    Liao, X.3    Williams, L.T.4
  • 48
    • 0025038599 scopus 로고
    • Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES
    • Schall TJ, Bacon K, Toy KJ, Goeddel DV. Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature. 1990; 347: 669-671.
    • (1990) Nature , vol.347 , pp. 669-671
    • Schall, T.J.1    Bacon, K.2    Toy, K.J.3    Goeddel, D.V.4
  • 49
    • 34548230927 scopus 로고    scopus 로고
    • Getting to the site of inflammation: The leukocyte adhesion cascade updated
    • Ley K, Laudanna C, Cybulsky MI, Nourshargh S. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol. 2007; 7: 678-689.
    • (2007) Nat Rev Immunol , vol.7 , pp. 678-689
    • Ley, K.1    Laudanna, C.2    Cybulsky, M.I.3    Nourshargh, S.4
  • 50
    • 54049086276 scopus 로고    scopus 로고
    • Interferongamma, a Th1 cytokine, regulates fat inflammation: A role for adaptive immunity in obesity
    • Rocha VZ, Folco EJ, Sukhova G, Shimizu K, Gotsman I, Vernon AH, et al. Interferongamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity. Circ Res. 2008; 103: 467-476.
    • (2008) Circ Res , vol.103 , pp. 467-476
    • Rocha, V.Z.1    Folco, E.J.2    Sukhova, G.3    Shimizu, K.4    Gotsman, I.5    Vernon, A.H.6
  • 51
    • 65549118531 scopus 로고    scopus 로고
    • Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12
    • Schulz EG, Mariani L, Radbruch A, Hofer T. Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12. Immunity. 2009; 30: 673-683.
    • (2009) Immunity , vol.30 , pp. 673-683
    • Schulz, E.G.1    Mariani, L.2    Radbruch, A.3    Hofer, T.4
  • 52
    • 84857883847 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization: In vivo veritas
    • Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J Clin Invest. 2012; 122: 787-795.
    • (2012) J Clin Invest , vol.122 , pp. 787-795
    • Sica, A.1    Mantovani, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.