Low macrophage accumulation in skeletal muscle of obese type 2 diabetics and elderly subjects

Obesity

Volumn 20, Issue 7, 2012, Pages 1530-1533

  Tam, Charmaine S ^a   Sparks, Lauren M ^a   Johannsen, Darcy L ^a   Covington, Jeffrey D ^a   Church, Timothy S ^a   Ravussin, Eric ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BODY FAT; BODY MASS; BODY SURFACE; CD206 GENE; CD68 GENE; CELL COUNT; FEMALE; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; MUSCLE CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; SKELETAL MUSCLE; VASTUS LATERALIS MUSCLE;

ADULT; AGED; AGED, 80 AND OVER; AGING; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; BLOOD GLUCOSE; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; EXERCISE THERAPY; FEMALE; GENE EXPRESSION; GLUCOSE TOLERANCE TEST; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MACROPHAGES; MALE; MIDDLE AGED; MUSCLE, SKELETAL; OBESITY; YOUNG ADULT;

EID: 84862904269     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2012.24     Document Type: Article

References (13)

1. Varma V, Yao-Borengasser A, Rasouli N et al. Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action. Am J Physiol Endocrinol Metab 2009;296:E1300-E1310.
2. Weisberg SP, McCann D, Desai M et al. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003;112:1796-1808.
3. Kewalramani G, Bilan PJ, Klip A. Muscle insulin resistance: assault by lipids, cytokines and local macrophages. Curr Opin Clin Nutr Metab Care 2010;13:382-390.
4. Kim TH, Choi SE, Ha ES et al. IL-6 induction of TLR-4 gene expression via STAT3 has an effect on insulin resistance in human skeletal muscle. Acta Diabetol 2011; e-pub ahead of print 4 February 2011.
5. Nguyen MT, Favelyukis S, Nguyen AK et al. A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem 2007;282:35279-35292.
6. Bruun JM, Helge JW, Richelsen B, Stallknecht B. Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. Am J Physiol Endocrinol Metab 2006;290:E961-E967.
7. Di Gregorio GB, Yao-Borengasser A, Rasouli N et al. Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone. Diabetes 2005;54:2305-2313.
8. Peake J, Della Gatta P, Cameron-Smith D. Aging and its effects on inflammation in skeletal muscle at rest and following exercise-induced muscle injury. Am J Physiol Regul Integr Comp Physiol 2010;298: R1485-R1495.
9. Przybyla B, Gurley C, Harvey JF et al. Aging alters macrophage properties in human skeletal muscle both at rest and in response to acute resistance exercise. Exp Gerontol 2006;41:320-327.
10. Church TS, Blair SN, Cocreham S et al. Effects of aerobic and resistance training on hemoglobin A1c levels in patients with type 2 diabetes: a randomized controlled trial. JAMA 2010;304:2253-2262.
11. Johannsen DL, Conley KE, Bajpeyi S et al. Ectopic lipid accumulation and reduced glucose tolerance in elderly adults are accompanied by altered skeletal muscle mitochondrial activity. J Clin Endocrinol Metab 2012;97:242-250.
12. Bilan PJ, Samokhvalov V, Koshkina A et al. Direct and macrophagemediated actions of fatty acids causing insulin resistance in muscle cells. Arch Physiol Biochem 2009;115:176-190.
13. Pedersen M, Bruunsgaard H, Weis N et al. Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes. Mech Ageing Dev 2003;124:495-502.