Micro 3D cell culture systems for cellular behavior studies: Culture matrices, devices, substrates, and in-situ sensing methods

Biotechnology Journal

Volumn 10, Issue 11, 2015, Pages 1682-1688

  Choi, Jonghoon ^a   Lee, Eun Kyu ^a   Choo, Jaebum ^a   Yuh, Junhan ^b   Hong, Jong Wook ^a  

^a Hanyang University   (South Korea)

^b POSCO   (South Korea)

Author keywords

3D cell culture microsystem; Bionanotechnology; Cellular biosensing; Functionalized hydrogels; Spheroid cell culture

Indexed keywords

CELL CULTURE; CELL MEMBRANES; DIAGNOSIS; DRUG PRODUCTS; HYDROGELS; MEDICAL APPLICATIONS; MICROANALYSIS; MICROFABRICATION; MICROSYSTEMS; SUBSTRATES; TISSUE REGENERATION;

3-D CELL CULTURE; BIOMEDICAL APPLICATIONS; BIONANOTECHNOLOGY; CELLULAR BIOSENSING; FUNCTIONALIZED; HIGH THROUGHPUT SCREENING; MICROFABRICATED SYSTEMS; MICROFABRICATION METHODS;

CELL ENGINEERING;

GLASS; POLYMER; SILICON; HYDROGEL;

CELL AGGREGATION; CELL CULTURE; CELL FUNCTION; CELL STRUCTURE; CELL SURFACE; EXTRACELLULAR MATRIX; HIGH THROUGHPUT SCREENING; HUMAN; HYDROGEL; METASTASIS; MICROENVIRONMENT; MICROTECHNOLOGY; NANOBIOTECHNOLOGY; NANOPROBE; PAPER; PRIORITY JOURNAL; REGENERATIVE MEDICINE; SHORT SURVEY; SPHEROID CELL; TARGET CELL; TISSUE ENGINEERING; WOUND HEALING; ANIMAL; BIOTECHNOLOGY; CELL CULTURE TECHNIQUE; DEVICES; GENETIC PROCEDURES; MICROFLUIDIC ANALYSIS; MOUSE; TUMOR CELL LINE;

ANIMALS; BIOSENSING TECHNIQUES; BIOTECHNOLOGY; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; HUMANS; HYDROGELS; MICE; MICROFLUIDIC ANALYTICAL TECHNIQUES;

EID: 84947030200     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201500092     Document Type: Review

References (48)

1. Roco, M. C., Nanotechnology: Convergence with modern biology and medicine. Curr. Opin. Biotechnol. 2003, 14, 337-346.
2. Jain, K., Nanobiotechnology, Jain PharmaBiotech Report 2010.
3. Whitesides, G. M., The 'right' size in nanobiotechnology. Nat. Biotechnol. 2003, 21, 1161-1165.
4. Svendsen, W. E., Castillo-León, J., Lange, J. M., Sasso, L. et al., Micro and nano-platforms for biological cell analysis. Sens. Actuators, A 2011, 172, 54-60.
5. Lowe, S. B., Tan, V. T. G., Soeriyadi, A. H., Davis, T. P., Gooding, J. J., Synthesis and high-throughput processing of polymeric hydrogels for 3D cell culture. Bioconjugate Chem. 2014, 25, 1581-1601.
6. Taskin, M. B., Sasso, L., Dimaki, M., Svendsen, W. E., Castillo-León, J., Combined cell culture-biosensing platform using vertically aligned patterned peptide nanofibers for cellular studies. ACS Appl. Mater. Interfaces 2013, 5, 3323-3328.
7. Dionigi, C., Bianchi, M., D'Angelo, P., Chelli, B. et al., Control of neuronal cell adhesion on single-walled carbon nanotube 3D patterns. J. Mater. Chem. 2010, 20, 2213-2218.
8. Nur-E-Kamal, A., Ahmed, I., Kamal, J., Schindler, M., Meiners, S., Three-dimensional nanofibrillar surfaces promote self-renewal in mouse embryonic stem cells. Stem Cells 2006, 24, 426-433.
9. Schindler, M., Nur-E-Kamal, A., Ahmed, I., Kamal, J. et al., Living in three dimensions: 3D nanostructured environments for cell culture and regenerative medicine. Cell Biochem. Biophys. 2006, 45, 215-227.
10. Kuo, C. T., Chiang, C. L., Chang, C. H., Liu, H. K. et al., Modeling of cancer metastasis and drug resistance via biomimetic nano-cilia and microfluidics. Biomaterials 2013, 35, 1562-1571.
11. Bradshaw, M., Ho, D., Fear, M. W., Gelain, F. et al., Designer self-assembling hydrogel scaffolds can impact skin cell proliferation and migration. Sci. Rep. 2014, 4, 6903.
12. Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M. et al., Reconstituting organ-level lung functions on a chip. Science 2010, 328, 1662-1668.
13. Lovitt, C. J., Shelper, T. B., Avery, V. M., Miniaturized three-dimensional cancer model for drug evaluation. Assay Drug Dev. Technol. 2013, 11, 435-448.
14. Wu, L., Ma, C., Ge, L., Kong, Q. et al., Paper-based electrochemiluminescence origami cyto-device for multiple cancer cells detection using porous AuPd alloy as catalytically promoted nanolabels. Biosens. Bioelectron. 2015, 63, 450-457.
15. Derda, R., Tang, S. K. Y., Laromaine, A., Mosadegh, B. et al., Multizone paper platform for 3D cell cultures. PLoS One 2011, 6, e18940.
16. Kraning-Rush, C. M., Carey, S. P., Lampi, M. C., Reinhart-King, C. A., Microfabricated collagen tracks facilitate single cell metastatic invasion in 3D. Integr. Biol. 2013, 5, 606-616.
17. Purcell, B. P., Lobb, D., Charati, M. B., Dorsey, S. M. et al., Injectable and bioresponsive hydrogels for on-demand matrix metalloproteinase inhibition. Nat. Mater. 2014, 13, 653-661.
18. Atefi, E., Lemmo, S., Fyffe, D., Luker, G. D., Tavana, H., High throughput, polymeric aqueous two-phase printing of tumor spheroids. Adv. Funct. Mater. 2014, 24, 6509-6515.
19. Tung, Y. C., Hsiao, A. Y., Allen, S. G., Torisawa, Y. S. et al., High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array. Analyst 2011, 136, 473-478.
20. Hamon, M., Hong, J. W., New tools and new biology: Recent miniaturized systems for molecular and cellular biology. Mol. Cells 2013, 36, 485-506.
21. Hamon, M., Jambovane, S., Bradley, L., Khademhosseini, A., Hong, J. W., Cell-based dose responses from open-well microchambers. Anal. Chem. 2013, 85, 5249-5254.
22. Montanez-Sauri, S. I., Sung, K. E., Puccinelli, J. P., Pehlke, C., Beebe, D. J., Automation of three-dimensional cell culture in arrayed microfluidic devices. J. Lab. Autom. 2011, 16, 171-185.
23. Kunze, A., Giugliano, M., Valero, A., Renaud, P., Micropatterning neural cell cultures in 3D with a multi-layered scaffold. Biomaterials 2011, 32, 2088-2098.
24. Shin, Y., Han, S., Jeon, J. S., Yamamoto, K. et al., Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels. Nat. Protoc. 2012, 7, 1247-1259.
25. Bian, W., Jackman, C. P., Bursac, N., Controlling the structural and functional anisotropy of engineered cardiac tissues. Biofabrication 2014, 6, 024109.
26. Yamada, M., Utoh, R., Ohashi, K., Tatsumi, K. et al., Controlled formation of heterotypic hepatic micro-organoids in anisotropic hydrogel microfibers for long-term preservation of liver-specific functions. Biomaterials 2012, 33, 8304-8315.
27. Annabi, N., Nichol, J. W., Zhong, X., Ji, C. et al., Controlling the porosity and microarchitecture of hydrogels for tissue engineering. Tissue Eng. Part B 2010, 16, 371-383.
28. Arcaute, K., Mann, B. K., Wicker, R. B., Stereolithography of three-dimensional bioactive poly(ethylene glycol) constructs with encapsulated cells. Ann. Biomed. Eng. 2006, 34, 1429-1441.
29. Kloxin, A. M., Kasko, A. M., Salinas, C. N., Anseth, K. S., Photodegradable hydrogels for dynamic tuning of physical and chemical properties. Science 2009, 324, 59-63.
30. Huang, G. Y., Zhou, L. H., Zhang, Q. C., Chen, Y. M. et al., Microfluidic hydrogels for tissue engineering. Biofabrication 2011, 3, 012001.
31. Ota, H., Miki, N., Microtechnology-based three-dimensional spheroid formation. Front. Biosci. (Elite Ed) 2013, 5, 37-48.
32. Lee, W., Lee, V., Polio, S., Keegan, P. et al., On-demand three-dimensional freeform fabrication of multi-layered hydrogel scaffold with fluidic channels. Biotechnol. Bioeng. 2010, 105, 1178-1186.
33. Ling, Y., Rubin, J., Deng, Y., Huang, C. et al., A cell-laden microfluidic hydrogel. Lab Chip 2007, 7, 756-762.
34. Ziolkowska, K., Jedrych, E., Kwapiszewski, R., Lopacinska, J. et al., PDMS/glass microfluidic cell culture system for cytotoxicity tests and cells passage. Sens. Actuators, B 2010, 145, 533-542.
35. Sun, D., Lu, J., Chen, Z., Yu, Y., Li, Y., A novel three-dimensional microfluidic platform for on chip multicellular tumor spheroid formation and culture. Microfluid. Nanofluid. 2014, 17, 831-842.
36. Ni, M., Tong, W. H., Choudhury, D., Rahim, N. A. A. et al., Cell culture on MEMS platforms: A review. Int. J. Mol. Sci. 2009, 10, 5411-5441.
37. Elliott, N., Lee, T., You, L., Yuan, F., Proliferation behavior of E. coli in a three-dimensional in vitro tumor model. Integr. Biol. 2011, 3, 696-705.
38. Schütte, J., Hagmeyer, B., Holzner, F., Kubon, M. et al., "Artificial micro organs" - a microfluidic device for dielectrophoretic assembly of liver sinusoids. Biomed. Microdevices 2011, 13, 493-501.
39. Chen, S. Y. C., Hung, P. J., Lee, P. J., Microfluidic array for three-dimensional perfusion culture of human mammary epithelial cells. Biomed. Microdevices 2011, 13, 753-758.
40. Shinohara, M., Kimura, H., Montagne, K., Komori, K. et al., Combination of microwell structures and direct oxygenation enables efficient and size-regulated aggregate formation of an insulin-secreting pancreatic β-cell line. Biotechnol. Progr. 2014, 30, 178-187.
41. Derda, R., Laromaine, A., Mammoto, A., Tang, S. K. Y. et al., Paper-supported 3D cell culture for tissue-based bioassays. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 18457-18462.
42. Lidke, D. S., Lidke, K. A., Advances in high-resolution imaging - techniques for three-dimensional imaging of cellular structures. J. Cell Sci. 2012, 125, 2571-2580.
43. Wang, Y., Fruhwirth, G., Cai, E., Ng, T., Selvin, P. R., 3D super-resolution imaging with blinking quantum dots. Nano Lett. 2013, 13, 5233-5241.
44. McAughtrie, S., Lau, K., Faulds, K., Graham, D., 3D optical imaging of multiple SERS nanotags in cells. Chem. Sci. 2013, 4, 3566-3572.
45. Huang, K. C., Bando, K., Ando, J., Smith, N. I. et al., 3D SERS (surface enhanced Raman scattering) imaging of intracellular pathways. Methods 2014, 68, 348-353.
46. Kloxin, A. M., Kloxin, C. J., Bowman, C. N., Anseth, K. S., Mechanical properties of cellularly responsive hydrogels and their experimental determination. Adv. Mater. 2010, 22, 3484-3494.
47. Zhang, J., Campbell, R. E., Ting, A. Y., Tsien, R. Y., Creating new fluorescent probes for cell biology. Nat. Rev. Mol. Cell Biol. 2002, 3, 906-918.
48. Wirtz, D., Particle-tracking microrheology of living cells: Principles and applications. Annu. Rev. Biophys. 2009, 38, 301-326.