IsaB Inhibits Autophagic Flux to Promote Host Transmission of Methicillin-Resistant Staphylococcus aureus

Journal of Investigative Dermatology

Volumn 135, Issue 11, 2015, Pages 2714-2722

  Liu, Pei Feng ^a,b   Cheng, Jin Shiung ^a   Sy, Cheng Len ^a   Huang, Wei Chun ^a,c   Yang, Hsiu Chen ^a   Gallo, Richard L ^b,d   Huang, Chun Ming ^b   Shu, Chih Wen ^a  

^a KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNODOMINANT SURFACE ANTIGEN B; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; VIRULENCE FACTOR; BACTERIAL ANTIGEN; ISAB ANTIGEN, STAPHYLOCOCCUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BACTERIAL COLONIZATION; BACTERIAL SURVIVAL; BACTERIAL TRANSMISSION; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; CONTROLLED STUDY; DELETION MUTANT; FEMALE; HOST RESISTANCE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; CELL SURVIVAL; CROSS INFECTION; CYTOLOGY; DISEASE MODEL; IMMUNOLOGY; INSTITUTE FOR CANCER RESEARCH MOUSE; MICROBIOLOGY; PATHOGENICITY; RANDOMIZATION; SENSITIVITY AND SPECIFICITY; STAPHYLOCOCCUS AUREUS;

ANIMALS; ANTIGENS, BACTERIAL; AUTOPHAGY; CELL SURVIVAL; CROSS INFECTION; DISEASE MODELS, ANIMAL; FEMALE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICE; MICE, INBRED ICR; RANDOM ALLOCATION; SENSITIVITY AND SPECIFICITY; STAPHYLOCOCCUS AUREUS; VIRULENCE FACTORS;

EID: 84947029362     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2015.254     Document Type: Article

References (48)

1. Amano A, Nakagawa I, Yoshimori T (2006) Autophagy in innate immunity against intracellular bacteria. J Biochem 140:161-6
2. Chatterjee SS, Otto M (2013) Improved understanding of factors driving methicillin-resistant Staphylococcus aureus epidemic waves. Clin Epidemiol 5:205-17
3. Dupont N, Jiang S, Pilli M et al. (2011) Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1beta. EMBO J 30: 4701-11
4. Fuchs S, Pane-Farre J, Kohler C et al. (2007) Anaerobic gene expression in Staphylococcus aureus. J Bacteriol 189:4275-89
5. Garzoni C, Francois P, Huyghe A et al. (2007) A global view of Staphylococcus aureus whole genome expression upon internalization in human epithelial cells. BMC Genomics 8:171
6. Gong L, Devenish RJ, Prescott M (2012) Autophagy as a macrophage response to bacterial infection. IUBMB Life 64:740-7
7. Haim M, Trost A, Maier CJ et al. (2010) Cytokeratin 8 interacts with clumping factor B: a new possible virulence factor target. Microbiology 156:3710-21
8. Han LL, McDougal LK, Gorwitz RJ et al. (2007) High frequencies of clindamycin and tetracycline resistance in methicillin-resistant Staphylococcus aureus pulsed-field type USA300 isolates collected at a Boston ambulatory health center. J Clin Microbiol 45:1350-2
9. Harris J, Hartman M, Roche C et al. (2011) Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation. J Biol Chem 286:9587-7
10. Hogea C, VANE T, Acosta CJ (2014) A basic dynamic transmission model of Staphylococcus aureus in the US population. Epidemiol Infect 142:468-78
11. Jappe U, Heuck D, Strommenger B et al. (2008) Staphylococcus aureus in dermatology outpatients with special emphasis on community-associated methicillin-resistant strains. J Invest Dermatol 128:2655-64
12. Kassegne K, Hu W, Ojcius DM et al. (2014) Identification of collagenase as a critical virulence factor for invasiveness and transmission of pathogenic Leptospira species. J Infect Dis 209:1105-5
13. Klionsky DJ, Elazar Z, Seglen PO et al. (2008) Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? Autophagy 4:849-50
14. Knodler LA, Celli J (2011) Eating the strangers within: host control of intracellular bacteria via xenophagy. Cell Microbiol 13:1319-27
15. Kraus D, Peschel A (2008) Staphylococcus aureus evasion of innate antimicrobial defense. Future Microbiol 3:437-51
16. Levine B, Mizushima N, Virgin HW (2011) Autophagy in immunity and inflammation. Nature 469:323-5
17. Liu PF, Leung CM, Chang YH et al. (2014) ATG4B promotes colorectal cancer growth independent of autophagic flux. Autophagy 10:1454-65
18. Liu PF, Lo CW, Chen CH et al. (2009) Use of nanoparticles as therapy for methicillin-resistant Staphylococcus aureus infections. Curr Drug Metab 10:875-4
19. Lo CW, Lai YK, Liu YT et al. (2011) Staphylococcus aureus hijacks a skin commensal to intensify its virulence: immunization targeting betahemolysin and CAMP factor. J Invest Dermatol 131:401-9
20. Mackey-Lawrence NM, Jefferson KK (2013a) Regulation of Staphylococcus aureus immunodominant antigen B (IsaB). Microbiol Res 168:113-8
21. Mackey-Lawrence NM, Jefferson KK (2013b) Regulation of Staphylococcus aureus immunodominant antigen B (IsaB). Microbiol Res 168:113-8
22. Mackey-Lawrence NM, Potter DE, Cerca N et al. (2009) Staphylococcus aureus immunodominant surface antigen B is a cell-surface associated nucleic acid binding protein. BMC Microbiol 9:61
23. Massey RC, Horsburgh MJ, Lina G et al. (2006) The evolution and maintenance of virulence in Staphylococcus aureus: a role for host-to-host transmission? Nat Rev Microbiol 4:953-8
24. Mauthe M, Yu W, Krut O et al. (2012) WIPI-1 positive autophagosome-like vesicles entrap pathogenic Staphylococcus aureus for lysosomal degradation. Int J Cell Biol 2012:179207
25. Mesquita FS, Thomas M, Sachse M et al. (2012) The Salmonella deubiquitinase SseL inhibits selective autophagy of cytosolic aggregates. PLoS Pathog 8: e1002743
26. Mizushima N, Levine B, Cuervo AM et al. (2008) Autophagy fights disease through cellular self-digestion. Nature 451:1069-75
27. Mizushima N, Yoshimori T, Levine B (2010) Methods in mammalian autophagy research. Cell 140:313-26
28. Ogawa M, Yoshikawa Y, Mimuro H et al. (2011) Autophagy targeting of Listeria monocytogenes and the bacterial countermeasure. Autophagy 7:310-4
29. Ogawa M, Yoshimori T, Suzuki T et al. (2005) Escape of intracellular Shigella from autophagy. Science 307:727-31
30. Orvedahl A, Levine B (2009) Eating the enemy within: autophagy in infectious diseases. Cell Death Differ 16:57-69
31. Otto M (2010) Looking toward basic science for potential drug discovery targets against community-associated MRSA. Med Res Rev 30:1-22
32. Otto M (2012) MRSA virulence and spread. Cell Microbiol 14:1513-21
33. Parihar SP, Guler R, Khutlang R et al. (2014) Statin therapy reduces the mycobacterium tuberculosis burden in human macrophages and in mice by enhancing autophagy and phagosome maturation. J Infect Dis 209: 754-63
34. Petruccioli E, Romagnoli A, Corazzari M et al. (2012) Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages. J Infect Dis 205:1425-35
35. Resch A, Rosenstein R, Nerz C et al. (2005) Differential gene expression profiling of Staphylococcus aureus cultivated under biofilm and planktonic conditions. Appl Environ Microb 71:2663-76
36. Schnaith A, Kashkar H, Leggio SA et al. (2007) Staphylococcus aureus subvert autophagy for induction of caspase-independent host cell death. J Biol Chem 282:2695-706
37. Sumpter R Jr, Levine B (2010) Autophagy and innate immunity: triggering, targeting and tuning. Semin Cell Dev Biol 21:699-711
38. Tarkowski A, Collins LV, Gjertsson I et al. (2001) Model systems: modeling human staphylococcal arthritis and sepsis in the mouse. Trends Microbiol 9:321-6
39. van Kessel KP, Bestebroer J, van Strijp JA (2014) Neutrophil-mediated phagocytosis of Staphylococcus aureus. Front Immunol 5:467
40. Voyich JM, Braughton KR, Sturdevant DE et al. (2005) Insights into mechanisms used by Staphylococcus aureus to avoid destruction by human neutrophils. J Immunol 175:3907-19
41. Westling K (2009) Cost-effectiveness analysis of treatment of methicillinresistant Staphylococcus aureus bacteremia and endocarditis is a difficult issue. Clin Infect Dis 49:699-701
42. Wickham ME, Brown NF, Boyle EC et al. (2007) Virulence is positively selected by transmission success between mammalian hosts. Curr Biol 17:783-8
43. Xia JF, Gao JJ, Kokudo N et al. (2013) Methicillin-resistant Staphylococcus aureus antibiotic resistance and virulence. Biosci Trends 7:113-21
44. Yamaguchi H, Nakagawa I, Yamamoto A et al. (2009) An initial step of GAScontaining autophagosome-like vacuoles formation requires Rab7. PLoS Pathog 5:e1000670
45. Yoshikawa Y, Ogawa M, Hain T et al. (2009) Listeria monocytogenes ActAmediated escape from autophagic recognition. Nat Cell Biol 11: 1233-40
46. Yuk JM, Jo EK (2013) Crosstalk between autophagy and inflammasomes. Mol Cells 36:393-9
47. Zhang L, Yu J, Pan H et al. (2007) Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci USA 104:19023-8
48. Zhou C, Zhong W, Zhou J et al. (2012) Monitoring autophagic flux by an improved tandem fluorescent-tagged LC3 (mTagRFP-mWasabi-LC3) reveals that high-dose rapamycin impairs autophagic flux in cancer cells. Autophagy 8:1215-26