Methanolic extract of ganoderma lucidum induces autophagy of AGS human gastric tumor cells

Molecules

Volumn 20, Issue 10, 2015, Pages 17872-17882

  Reis, Filipa S ^a,b,c,d   Lima, Raquel T ^a,b,e   Morales, Patricia ^c   Ferreira, Isabel C F R ^d   Vasconcelos, M Helena ^a,b  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^d INSTITUTO POLITÉCNICO DE BRAGANÇA   (Portugal)

^e University of Porto   (Portugal)

Author keywords

Antitumor potential; Autophagy; Ganoderma lucidum; Methanolic extract; Programmed cell death (pcd)

Indexed keywords

ANTINEOPLASTIC AGENT; HYDROXYBENZOIC ACID DERIVATIVE; PHENOLIC ACID;

ADENOCARCINOMA; AUTOPHAGY; CHEMISTRY; DRUG EFFECTS; GANODERMA LUCIDUM; HUMAN; METABOLISM; STOMACH TUMOR; TUMOR CELL LINE;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; AUTOPHAGY; CELL LINE, TUMOR; HUMANS; HYDROXYBENZOATES; REISHI; STOMACH NEOPLASMS;

EID: 84946934938     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules201017872     Document Type: Article

References (29)

1. Hanahan, D.; Weinberg, R.A. Hallmarks of cancer: The next generation. Cell 2011, 144, 646-674.
2. Tan, M.L.; Ooi, J.P.; Ismail, N.; Moad, A.I.H.; Muhammad, T.S.T. Programmed cell death pathways and current antitumor targets. Pharm. Res. 2009, 26, 1547-1560.
3. Yang, Z.J.; Chee, C.E.; Huang, S.; Sinicrop, F.A. The role of autophagy in cancer: Therapeutic implications. Mol. Cancer Ther. 2011, 10, 1533-1541.
4. Ferreira, I.C.F.R.; Vaz, J.A.; Vasconcelos, M.H.; Martins, A. Compounds from wild mushrooms with antitumor potential. Anticancer Agents Med. Chem. 2010, 10, 424-436.
5. Patel, S.; Goyal, A. Recent developments in mushrooms as anti-cancer therapeutics: A review.3 Biotech 2012, 2, 1-15.
6. Reis, F.S.; Morales, P.; Ferreira, I.C.F.R.; Vasconcelos, M.H. Mushrooms as a source of compounds that induce programmed cell death in tumor cells. In Recent Progress in Medicinal Plants Govil, J.N., Ed.; Studium Press LLC: Houston, TX, USA, 2015; Volume 43-Phytotherapeutics II, in press.
7. Harhaji Trajkoví , L.M.; Mijatoví , S.A.; Maksimoví -Ivaní , D.D.; Stojanoví , I.D.; Momečiloví , M.B.; Tufegdžć , S.J.; Maksimovi, V.M.; Marjanovi, Zcaron;.S.; Stoší -Grujiečić , S.D. Anticancer properties of Ganoderma lucidum methanol extracts in vitro and in vivo. Nutr. Cancer 2009, 61, 696-707.
8. Calviño, E.; Manjón, J.L.; Sancho, P.; Tejedor, M.C.; Herráez, A.; Diez, J.C. Ganoderma lucidum induced apoptosis in NB4 human leukemia cells: Involvement of Akt and Erk. J. Ethnopharmacol. 2010, 128, 71-78.
9. Ferreira, I.C.F.R.; Heleno, S.A.; Reis, F.S.; Stojkoví , D.; Queiroz, M.J.R.P.; Vasconcelos, M.H.; Sokoví , M. Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities. Phytochemistry 2015, 114, 38-55.
10. Thyagarajan, A.; Jedinak, A.; Nguyen, H.; Terry, C.; Baldridge, L.A.; Jiang, J.; Sliva, D. Triterpenes from Ganoderma lucidum induce autophagy in colon cancer through the inhibition of p38 mitogen-activated kinase (p38 MAPK). Nutr. Cancer 2010, 62, 630-640.
11. Hossain, A.; Radwan, F.F.Y.; Doonan, B.P.; God, J.M.; Zhang, L.; Bell, P.D.; Haque, A. A possible cross-talk between autophagy and apoptosis in generating an immune response in melanoma. Apoptosis 2012, 17, 1066-1078.
12. Liang, C.; Li, H.; Zhou, H.; Zhang, S.; Liu, Z.; Zhou, Q.; Sun, F. Recombinant Lz-8 from Ganoderma lucidum induces endoplasmic reticulum stress-mediated autophagic cell death in SGC-7901 human gastric cancer cells. Oncol. Rep. 2012, 27, 1079-1089.
13. Oliveira, M.; Reis, F.S.; Sousa, D.; Tavares, C.; Lima, R.T.; Ferreira, I.C.F.R.; dos Santos, T.; Vasconcelos, M.H. A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cycle. Food Funct. 2014, 5, 1389-1394.
14. Funderburk, S.F.; Wang, Q.J.; Yue, Z. The Beclin 1-VPS34 complex-At the crossroads of autophagy and beyond. Trends Cell. Biol. 2010, 20, 355-362.
15. Mizushima, N.; Yoshimori, T.; Levine, B. Methods in mammalian autophagy research. Cell 2010, 140, 313-326.
16. Seca, H.; Lima, R.T.; Lopes-Rodrigues, V.; Guimarães, J.E.; Almeida, G.M.; Vasconcelos, M.H. Targeting miR-21 induces autophagy and chemosensitivity of leukemia cells. Curr. Cancer Drug Targets 2013, 14, 1135-1143.
17. Ichimura, Y.; Komatsu, M. Selective degradation of p62 by autophagy. Semin. Immunopathol. 2010, 32, 431-436.
18. Cerniglia, G.J.; Karar, J.; Tyagi, S.; Christofidou-Solomidou, M.; Rengan, R.; Koumenis, C.; Maity, A. Inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235. Mol. Pharmacol. 2012, 82, 1230-1240.
19. Heleno, S.A.; Ferreira, I.C.F.R.; Esteves, A.P.; irí , A.; Glamoèlija, J.; Martins, A.; Sokoví , M.; Queiroz, M.J.R.P. Antimicrobial and demelanizing activity of Ganoderma lucidum extract, p-hydroxybenzoic and cinnamic acids and their synthetic acetylated glucuronide methyl esters. Food Chem. Toxicol. 2013, 58, 95-100.
20. Cai, S.; Wang, O.; Wang, M.; He, J.; Wang, Y.; Zhang, D.; Zhou, F.; Ji, B. In vitro inhibitory effect on pancreatic lipase activity of subfractions from ethanol extracts of fermented oats (Avena sativa L.) and synergistic effect of three phenolic acids. J. Agric. Food Chem. 2012, 60, 7245-7251.
21. Lin, C.-J.; Lee, C.-C.; Shih, Y.-L.; Lin, T.-Y.; Wang, S.-H.; Lin, Y.-F.; Shih, C.-M. Resveratrol enhances the therapeutic effect of temozolomide against malignant glioma in vitro and in vivo by inhibiting autophagy. Free Radic. Biol. Med. 2012, 52, 377-391.
22. Vaz, J.A.; Almeida, G.M.; Ferreira, I.C.F.R.; Martins, A.; Vasconcelos, M.H. Clitocybe alexandri extract induces cell cycle arrest and apoptosis in a lung cancer cell line: Identification of phenolic acids with cytotoxic potential. Food Chem. 2012, 132, 482-486.
23. Weng, C.-J.; Yen, G.-C. Chemopreventive effects of dietary phytochemicals against cancer invasion and metastasis: Phenolic acids, monophenol, polyphenol, and their derivatives. Cancer Treat. Rev. 2012, 38, 76-87.
24. Gonzáles-Vallinas, M.; Gonzáles-Catejón, M.; Rodríguez-Casado, A.; de Molina, A.R. Dietary phytochemicals in cancer prevention and therapy: A complementary approach with promising perspectives. Nutr Rev. 2013, 71, 585-599.
25. Heleno, S.A.; Barros, L.; Martins, A.; Queiroz, M.J.R.P.; Santos-Buelga, C.; Ferreira, I.C.F.R. Fruiting body, spores and in vitro produced mycelium of Ganoderma lucidum from Northeast Portugal: A comparative study of the antioxidant potential of phenolic and polysaccharidic extracts. Food Res. Int. 2012, 46, 135-140.
26. Monks, A.; Scudiero, D.; Skehan, P.; Shoemaker, R.; Paull, K.; Vistica, D.; Hose, C.; Langley, J.; Cronise, P.; Vaigro-Wolff, A.; et al. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J. Natl. Cancer Inst. 1991, 83, 757-766.
27. Pankiv, S.; Clausen, T.H.; Lamark, T.; Brech, A.; Bruun, J.A.; Outzen, H.; Overvatn, A.; Bjorkoy, G.; Johansen, T. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J. Biol. Chem. 2007, 282, 24131-24145.
28. Birame, B.M.; Jigui, W.; Fuxian, Y.; Shuang, W.; Li, Y.D.; Jiazeng, S.; Zhili, L.; Bao, Y.; Weiquan, L. Co-expression of apoptin (VP3) and antibacterial peptide cecropin B mutant (ABPS1) genes induce higher rate of apoptosis in HepG2 and A375 cell lines. Afr. J. Biotechnol. 2012, 11, 10981-10988.
29. Lima, R.T.; Barron, G.A.; Grabowska, J.A.; Bermano, G.; Kaur, S.; Roy, N.; Vasconcelos, M.H.; Lin, P.K.T. Cytotoxicity and cell death mechanisms induced by a novel bisnaphthalimidopropyl derivative against the NCI-H460 non-small lung cancer cell line. Anticancer Agents Med. Chem. 2013, 13, 414-421.