Clitocybe alexandri extract induces cell cycle arrest and apoptosis in a lung cancer cell line: Identification of phenolic acids with cytotoxic potential

Food Chemistry

Volumn 132, Issue 1, 2012, Pages 482-486

  Vaz, Josiana A ^a,b   Almeida, Gabriela M ^a   Ferreira, Isabel C F R ^b   Martins, Anabela ^b   Vasconcelos, M Helena ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b INSTITUTO POLITÉCNICO DE BRAGANÇA   (Portugal)

Author keywords

Apoptosis; Cell cycle; Citotoxicity; Clitocybe alexandri; Phenolic acids

Indexed keywords

BIOACTIVITY; BIOLOGICAL ORGANS; CELL CULTURE; CELL DEATH; CELL GROWTH; CYTOTOXICITY; DISEASES; FLOW CYTOMETRY; GROWTH KINETICS; ORGANIC ACIDS;

APOPTOTIC CELLS; BIOLOGICALLY ACTIVE COMPOUNDS; CASPASE-3; CELL CYCLE; CELL-CYCLE ARREST; CINNAMIC ACIDS; CITOTOXICITY; CLITOCYBE ALEXANDRI; CYTOTOXIC; DRUG DISCOVERY; ETHANOLIC EXTRACTS; EXPRESSION LEVELS; GROWTH INHIBITION; HPLC-DAD; INHIBITORY ACTIVITY; LUNG CANCER CELLS; MAIN COMPONENT; MECHANISM OF ACTION; PHENOLIC ACIDS; PHENOLIC COMPOSITION; POLY(ADP-RIBOSE) POLYMERASE; POTENT COMPOUNDS; S-PHASE; SULFORHODAMINE B; VIABLE CELLS; WESTERN BLOTS;

PHENOLS;

4 HYDROXYBENZOIC ACID; ANTINEOPLASTIC AGENT; CASPASE 3; CINNAMIC ACID; CLITOCYBE ALEXANDRI EXTRACT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHENOL; PLANT EXTRACT; PROTEIN P53; PROTOCATECHUIC ACID; SULFORHODAMINE B; TRYPAN BLUE; UNCLASSIFIED DRUG; BIOLOGICAL PRODUCT; HYDROXYBENZOIC ACID DERIVATIVE; PHENOLIC ACID;

APOPTOSIS; ARTICLE; CANCER CELL; CELL COUNT; CELL CYCLE ARREST; CELL CYCLE S PHASE; CELL GROWTH; CELL STRAIN; CELL STRAIN MCF 7; CHEMICAL COMPOSITION; CLITOCYBE ALEXANDRI; CONTROLLED STUDY; CYTOTOXICITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LUNG CANCER; MEDICINAL PLANT; MUSHROOM; PROTEIN EXPRESSION; WESTERN BLOTTING; AGARICALES; CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE; CELL CYCLE CHECKPOINT; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; GENETICS; LUNG NEOPLASMS; METABOLISM; MORTALITY; SURVIVAL RATE; TUMOR CELL LINE;

BASIDIOMYCOTA; CLITOCYBE;

AGARICALES; APOPTOSIS; BIOLOGICAL PRODUCTS; CARCINOMA, NON-SMALL-CELL LUNG; CASPASE 3; CELL CYCLE; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOTOXICITY, IMMUNOLOGIC; HUMANS; HYDROXYBENZOATES; LUNG NEOPLASMS; SURVIVAL RATE;

EID: 84355166472     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2011.11.031     Document Type: Article

References (22)

1. A.T. Borchers, C.L. Keen, and M.E. Gershwin Mushrooms, tumours, and immunity: An update Experimental Biology and Medicine 229 2004 393 406
2. L. Bravo Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance Nutrition Reviews 56 1998 317 333 (Pubitemid 28532456)
3. F.J. Brescia Lung cancer - A philosophical, ethical and personal perspective Critical Reviews in Oncology/Hematology 40 2001 139 148 (Pubitemid 33001598)
4. Y.-L. Cheng, W.-L. Chang, S.-C. Lee, Y.-G. Liu, C.-J. Chen, and S.-Z. Lin Acetone extract of Angelica sinensis inhibits proliferation of human cancer cells via inducing cell cycle arrest and apoptosis Life Sciences 75 2011 1579 1594
5. I.C.F.R. Ferreira, L. Barros, and R.M.V. Abreu Antioxidants in wild mushrooms Current Medicinal Chemistry 16 2009 1543 1560
6. I.C.F.R. Ferreira, J.A. Vaz, M.H. Vasconcelos, and A. Martins Compounds from wild mushrooms with antitumour potential Anti-cancer Agents in Medicinal Chemistry 10 2010 424 436
7. S.C. Hsu, C.L. Kuo, J.P. Lin, J.H. Lee, C.C. Lin, and C.C. Su Crude extracts of Euchresta formosana radix induce cytotoxicity and apoptosis in human hepatocellular carcinoma cell line (Hep3B) Anticancer Research 27 2007 2415 2425
8. A. Monks, D. Scudiero, P. Skehan, R. Shoemaker, K. Paull, and D. Vistica Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumour cell lines Journal of the National Cancer Institute 83 1991 757 766
9. M.-F. Moradali, H. Mostafavi, S. Ghods, and G.-A. Hedjaroude Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi) International Immunopharmacology 7 2007 701 724 (Pubitemid 46635272)
10. A.C. Moreno Setas y hongos de la Rioja 2005 Fundación CajaRioja. [pp. 324]
11. A. Palmeira, A. Paiva, E. Sousa, H. Seca, G.M. Almeida, and R.T. Lima Insights into the in vitro antitumour mechanism of action of a new pyranoxanthone Chemical Biology and Drug Design 76 2010 43 58
12. C. Poleri, J.L. Morero, B. Nieva, M.F. Vazquez, C. Rodriguez, and E. Titto Risk of recurrence in patients with surgically resected stage I non small cell lung cancer Chest 123 2003 1858 1867
13. M.J. Queiroz, R.C. Calhelha, L.A. Vale-Silva, E. Pinto, G.M. Almeida, and M.H. Vasconcelos Synthesis and evaluation of tumour cell growth inhibition of methyl 3-amino-6-[(hetero)arylethynyl]thieno[3,2-b]pyridine-2-carboxylates. Structure-activity relationships, effects on the cell cycle and apoptosis European Journal of Medicinal Chemistry 46 2011 236 240
14. D. Renzi, M. Valtolina, and R. Foster The evaluation of a multiendpoint cytotoxicity assay system Alternatives to Laboratory Animals 21 1993 89 96
15. P. Skehan, R. Storeng, D. Scudiero, A. Monks, J. MacMahon, and D. Vistica New colorimetric cytotoxicity assay for anticancer-drug screening Journal of the National Cancer Institute 82 1990 1107 1112 (Pubitemid 20213250)
16. M.H. Vasconcelos, S.S. Beleza, C. Quirk, L.F. Maia, C. Sambade, and J.E. Guimarães Limited synergistic effect of antisense oligonucleotides against BCR-ABL and transferrin receptor mRNA in leukemic cells in culture Cancer Letters 52 2000 135 143 (Pubitemid 30201494)
17. J.A. Vaz, S.A. Heleno, A. Martins, G.M. Almeida, M.H. Vasconcelos, and I.C.F.R. Ferreira Wild mushrooms Clitocybe alexandri and Lepista inversa: In vitro antioxidant activity and growth inhibition of human tumour cell lines Food and Chemical Toxicology 48 2010 2881 2884
18. J.A. Vaz, L. Barros, A. Martins, J.S. Morais, M.H. Vasconcelos, and I.C.F.R. Ferreira Phenolic profile of seventeen Portuguese wild mushrooms LWT - Food Science and Technology 44 2011 343 346
19. S.P. Wasser Medicinal mushrooms as a source of antitumour and immunomodulating polysaccharides Applied Microbiology and Biotechnology 60 2002 258 274
20. World Health Organization. (2010). WHO Library Cataloguing-in-Publication Data World health statistics 2010. 1. Health status indicators. 2. World health. 3. Health services-statistics. 4. Mortality. 5. Morbidity. 6. Life expectancy.7. Demography. 8. Statistics. I. World Health Organization. ISBN 978 92 4 156398 7 [NLM classification: WA 900.1].
21. B.-Z. Zaidman, M. Yassin, J. Mahajana, and S.P. Wasser Medicinal mushroom modulators of molecular targets as cancer therapeutics Applied Microbiology and Biotechnology 67 2005 453 468 (Pubitemid 40909591)
22. M. Zhang, S.W. Cui, P.C.K. Cheung, and Q. Wang Antitumour polysaccharides from mushrooms: A review on their isolation process, structural characteristics and antitumour activity Trends in Food Science and Technology 18 2007 4 19 (Pubitemid 44827599)