Anticancer properties of ganoderma lucidum methanol extracts in vitro and in vivo

Nutrition and Cancer

Volumn 61, Issue 5, 2009, Pages 696-707

  Harhaji Trajkovic, Ljubica M ^a   Mijatovic, Sanja A ^a   Maksimovic Ivanic, Danijela D ^a   Stojanovic, Ivana D ^a   Momcilovic, Miljana B ^a   Tufegdzic, Srdjan J ^b   Maksimovic, Vuk M ^c   Marjanovi, Zaklina S ^c   Stosic Grujicic, Stanislava D ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

^c UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; GANODERMA LUCIDUM EXTRACT; METHANOL; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; TERPENOID DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG PURIFICATION; FIBROSARCOMA; IN VITRO STUDY; IN VIVO STUDY; INOCULATION; MELANOMA; MELANOMA CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RAT; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; ASTROCYTES; CASPASES; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; CELLS, CULTURED; DRUGS, CHINESE HERBAL; GENE EXPRESSION REGULATION, NEOPLASTIC; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; NECROSIS; NEOPLASM TRANSPLANTATION; OXIDATIVE STRESS; RATS; REACTIVE OXYGEN SPECIES; REISHI; SERBIA; TERPENES; TUMOR BURDEN;

BASIDIOMYCOTA; GANODERMA LUCIDUM; MUS; RATTUS; RODENTIA;

EID: 70449625691     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1080/01635580902898743     Document Type: Article

References (50)

1. Moradali MF, Mostafavi H, Ghods S, and Hedjaroude GA: Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi). Int Immunopharmacol 7, 701-724, 2007.
2. Paterson RR: Ganoderma-a therapeutic fungal biofactory. Phytochemistry 67, 1985-2001, 2006.
3. Niu JF, Fang Z, Wang HJ, and Wang GC: The research advance on the effective constituents of Ganoderma spp. J Agric Univ Hebei 25, 51-54, 2002.
4. Zhou X, Lin J, Yin Y, Zhao J, Sun X, et al.: Ganodermataceae: natural products and their related pharmacological functions. Am J Chin Med 35, 559-574, 2007.
5. Sliva D: Ganoderma lucidum in cancer research. Leuk Res 30, 767-768, 2006.
6. Lei LS and Lin ZB: Effect of Ganoderma polysaccharides on T cell subpopulations and production of interleukin 2 in mixed lymphocyte response. Yao Xue Xue Bao 27, 331-335, 1992.
7. Won SJ, Lin MT, and Wu WL: Ganoderma tsugae mycelium enhances splenic natural killer cell activity and serum interferon production in mice. Jpn J Pharmacol 59, 171-176, 1992.
8. TangW, Liu JW, Zhao WM,Wei DZ, and Zhong JJ: Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells. Life Sci 80, 205-211, 2006.
9. Lin SB, Li CH, Lee SS, and Kan LS: Triterpene-enriched extracts from Ganoderma lucidum inhibit growth of hepatoma cells via suppressing protein kinase C, activating mitogen-activated protein kinases and G2-phase cell cycle arrest. Life Sci 72, 2381-2390, 2003.
10. Thyagarajan A, Jiang J, Hopf A, Adamec J, and Sliva D: Inhibition of oxidative stress-induced invasiveness of cancer cells by Ganoderma lucidum is mediated through the suppression of interleukin-8 secretion. Int J Mol Med 18, 657-664, 2006.
11. Kimura Y, Taniguchi M, and Baba K: Antitumor and antimetastatic effects on liver of triterpenoid fractions of Ganoderma lucidum: mechanism of action and isolation of an active substance. Anticancer Res 22, 3309-3318, 2002.
12. Huie CW and Di X: Chromatographic and electrophoretic methods for Lingzhi pharmacologically active components. J Chromatogr B Analyt Technol Biomed Life Sci 812, 241-257, 2004.
13. Su HJ, Fann YF, Chung MI, Won SJ, and Lin CN: New lanostanoids of Ganoderma tsugae. J Nat Prod 63, 514-516, 2000.
14. Ma J, Ye Q, Hua Y, Zhang D, Cooper R, et al.: New lanostanoids from the mushroom Ganoderma lucidum. J Nat Prod 65, 72-75, 2002.
15. Luo J, Zhao YY, and Li ZB: A new lanostane-type triterpene from the fruiting bodies of Ganoderma lucidum. J Asian Nat Prod Res 4, 129-134, 2002.
16. Al-Fatimi M, Wurster M, Kreisel H, and Lindenquist U: Antimicrobial, cytotoxic and antioxidant activity of selected basidiomycetes from Yemen. Pharmazie 60, 776-780, 2005.
17. Folch J, Lees M, and Sloane Stanley GH: A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226, 497-509, 1957.
18. McCarthy KD and de Vellis J: Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol 85, 890-902, 1980.
19. Buhtoiarov IN, Lum HE, Berke G, Sondel PM, and Rakhmilevich AL: Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent anti-tumor effects. J Immunol 176, 308-318, 2006.
20. Harhaji Lj, Mijatovíc S, Maksimovíc-Ivaníc D, Stojanovíc I, Momcilovíc M, et al.: Anti-tumor effect of Coriolus versicolor methanol extract against mouse B16 melanoma cells: in vitro and in vivo study. Food Chem Toxicol 46, 1825-1833, 2008.
21. Mosmann T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65, 55-63, 1983.
22. Cheon GJ, Chung HK, Choi JA, Lee SJ, Ahn SH, et al. : Cellular metabolic responses of PET radiotracers to (188)Re radiation in an MCF7 cell line containing dominant-negative mutant p53. Nucl Med Biol 34, 425-432, 2007.
23. Decker T and Lohmann-Matthes ML: A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity. J Immunol Methods 115, 61-69, 1988.
24. Mijatovic S, Maksimovic-Ivanic D, Radovic J, Miljkovic D, Kaludjerovic GN, et al.: Aloe emodin decreases the ERK-dependent anticancer activity of cisplatin. Cell Mol Life Sci 62, 1275-1282, 2005.
25. Kaludjerovíc GN, Miljkovíc D, Momcilovíc M, Djinovíc VM, Mostarica Stojkovíc M, et al.: Novel platinum(IV) complexes induce rapid tumor cell death in vitro. Int J Cancer 116, 479-486, 2005.
26. Flick DA and Gifford GE: Comparison of in vitro cell cytotoxic assays for tumor necrosis factor. J Immunol Methods 68, 167-175, 1984.
27. Versteeg HH, Nijhuis E, van den Brink GR, Evertzen M, Pynaert GN, et al.: A new phosphospecific cell-based ELISA for p42/p44 mitogen-activated protein kinase (MAPK), p38 MAPK, protein kinase B and cAMP-responseelement- binding protein. Biochem J 3, 717-722, 2000.
28. Han X, Wang F, Yao W, Xing H, Weng D, et al.: Heat shock proteins and p53 play a critical role in K+ channel-mediated tumor cell proliferation and apoptosis. Apoptosis 12, 1837-1846, 2007.
29. Higuchi Y: Chromosomal DNA fragmentation in apoptosis and necrosis induced by oxidative stress. Biochem Pharmacol 66, 1527-1535, 2003.
30. Min BS, Gao JJ, Nakamura N, and Hattori M: Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against meth-A and LLC tumor cells. Chem Pharm Bull (Tokyo) 48, 1026-1033, 2000.
31. Linksel-Mekkawy S, Meselhy MR, Nakamura N, Tezuka Y, Hattori M, et al.: Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum. Phytochemistry 49, 1651-1657, 1998.
32. Hirotani M, Ino C, and Furuya T: Comparative study on the strain-specific triterpenoid components of Ganoderma lucidum. Phytochemistry 33, 379-382, 1993.
33. Huie CW: A review of modern sample preparation techniques for the extraction and analysis of medicinal plants. Anal Bioanal Chem 373, 23-30, 2002.
34. Williamson EM: Synergy and other interactions in phytomedicines. Phytomedicine 8, 401-409, 2001.
35. Gonźalez AG, Léon F, Rivera A, Padŕon JI, Gonźalez-Plata J, et al.: New lanostanoids from the fungus Ganoderma concinna. J Nat Prod 65, 417-421, 2002.
36. Jiang J, Slivova V, Valachovicova T, Harvey K, and Sliva D: Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3. Int J Oncol 24, 1093-1099, 2004.
37. Zhang SS, Zhang HQ, Li D, Sun LH, Ma CP, et al.: A novel benzotriazole derivative inhibits proliferation of human hepatocarcinoma cells by increasing oxidative stress concomitant mitochondrial damage. Eur J Pharmacol 584, 144-152, 2008.
38. Lai KN, Chan LY, Tang SC, and Leung JC: Ganoderma extract prevents albumin-induced oxidative damage and chemokines synthesis in cultured human proximal tubular epithelial cells. Nephrol Dial Transplant 21, 1188-1197, 2006.
39. Sun J, He H, and Xie BJ: Novel antioxidant peptides from fermented mushroom Ganoderma lucidum. J Agric Food Chem 52, 6646-6652, 2004.
40. Lee JM, Kwon H, Jeong H, Lee JW, Lee SY, et al.: Inhibition of lipid peroxidation and oxidative DNA damage by Ganoderma lucidum. Phytother Res 15, 245-249, 2001.
41. Zhao HB, Wang SZ, He QH, Yuan L, Chen AF, et al.: Ganoderma total sterol (GS) and GS1 protect rat cerebral cortical neurons from hypoxia/ reoxygenation injury. Life Sci 76, 1027-1037, 2005.
42. Zhu M, Chang Q,Wong LK, Chong FS, and Li RC: Triterpene antioxidants from Ganoderma lucidum. Phytother Res 13, 529-531, 1999.
43. Brown NS and Bicknell R: Hypoxia and oxidative stress: its effects on growth, metastatic potential and response to therapy of breast cancer. Breast Cancer Res 3, 323-327, 2001.
44. Yang HL: Ganoderic acid produced from submerged culture of Ganoderma lucidum induces cell cycle arrest and cytotoxicity in human hepatoma cell line BEL7402. Biotechnol Lett 27, 835-838, 2005.
45. Kuerbitz SJ, Plunkett BS, Walsh WV, and Kastan MB: Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc Natl Acad Sci USA 89, 7491-7495, 1992.
46. Muret J, Yacoub M, Terrier P, Drusch F, Laplanche A, et al.: p53 status correlates with histopathological response in patients with soft tissue sarcomas treated using isolated limb perfusion with TNF-alpha and melphalan. Ann Oncol 19, 793-800 2008.
47. Soengas MS and Lowe SW: Apoptosis and melanoma chemoresistance. Oncogene 22, 3138-3151, 2003.
48. Jendrossek V, Kugler W, Erdlenbruch B, Eibl H, Lang F, et al.: Erucylphosphocholine-induced apoptosis in chemoresistant glioblastoma cell lines: involvement of caspase activation and mitochondrial alterations. Anticancer Res 21, 3389-3396, 2001.
49. Melcher A, Todryk S, Hardwick N, Ford M, Jacobson M, et al.: Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression. Nat Med 4, 581-587, 1998.
50. Wang G, Zhao J, Liu J, Huang Y, Zhong JJ, et al.: Enhancement of IL-2 and IFN-gamma expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo. Int Immunopharmacol 7, 864-870, 2007.