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Volumn 10, Issue 9, 2015, Pages

G9a inhibition induces autophagic cell death via AMPK/mTOR pathway in bladder transitional cell carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLADENINE; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; COMPOUND C; ENZYME INHIBITOR; G9A PROTEIN; HISTONE METHYLTRANSFERASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; RHEB PROTEIN; UNCLASSIFIED DRUG; EHMT2 PROTEIN, HUMAN; HISTOCOMPATIBILITY ANTIGEN; HISTONE LYSINE METHYLTRANSFERASE; TARGET OF RAPAMYCIN KINASE;

EID: 84946924390     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0138390     Document Type: Article
Times cited : (50)

References (50)
  • 2
    • 84894420746 scopus 로고    scopus 로고
    • EAU guidelines on muscleinvasive and metastatic bladder cancer: Summary of the 2013 guidelines
    • PMID: 24373477
    • Witjes JA, Comperat E, Cowan NC, De Santis M, Gakis G, Lebret T, et al. EAU guidelines on muscleinvasive and metastatic bladder cancer: summary of the 2013 guidelines. Eur Urol 2014; 65(4):778-92. doi: 10.1016/j.eururo.2013.11.046 PMID: 24373477
    • (2014) Eur Urol , vol.65 , Issue.4 , pp. 778-792
    • Witjes, J.A.1    Comperat, E.2    Cowan, N.C.3    De Santis, M.4    Gakis, G.5    Lebret, T.6
  • 3
    • 84883813935 scopus 로고    scopus 로고
    • EAU guidelines on nonmuscle- invasive urothelial carcinoma of the bladder: Update 2013
    • PMID: 23827737
    • Babjuk M, Burger M, Zigeuner R, Shariat SF, van Rhijn BW, Comperat E, et al. EAU guidelines on nonmuscle- invasive urothelial carcinoma of the bladder: update 2013. Eur Urol 2013; 64(4):639-53. doi: 10.1016/j.eururo.2013.06.003 PMID: 23827737
    • (2013) Eur Urol , vol.64 , Issue.4 , pp. 639-653
    • Babjuk, M.1    Burger, M.2    Zigeuner, R.3    Shariat, S.F.4    Van Rhijn, B.W.5    Comperat, E.6
  • 4
    • 32944465832 scopus 로고    scopus 로고
    • Predicting recurrence and progression in individual patients with stage Ta T1 bladder cancer using EORTC risk tables: A combined analysis of 2596 patients from seven EORTC trials
    • discussion 475-7. PMID: 16442208
    • Sylvester RJ, van der Meijden AP, OosterlinckW, Witjes JA, Bouffioux C, Denis L, et al. Predicting recurrence and progression in individual patients with stage Ta T1 bladder cancer using EORTC risk tables: a combined analysis of 2596 patients from seven EORTC trials. Eur Urol 2006; 49(3):466-5; discussion 475-7. PMID: 16442208
    • (2006) Eur Urol , vol.49 , Issue.3 , pp. 466-475
    • Sylvester, R.J.1    Van Der Meijden, A.P.2    Oosterlinckw Witjes, J.A.3    Bouffioux, C.4    Denis, L.5
  • 5
    • 67650401369 scopus 로고    scopus 로고
    • Bladder cancer
    • PMID: 19520422
    • Kaufman DS, Shipley WU, Feldman AS. Bladder cancer. Lancet 2009; 374(9685):239-49. doi:10. 1016/S0140-6736(09)60491-8 PMID: 19520422
    • (2009) Lancet , vol.374 , Issue.9685 , pp. 239-249
    • Kaufman, D.S.1    Shipley, W.U.2    Feldman, A.S.3
  • 6
  • 7
    • 80051543424 scopus 로고    scopus 로고
    • Enhanced expression of EHMT2 is involved in the proliferation of cancer cells through negative regulation of SIAH1
    • PMID: 21847359
    • Cho HS, Kelly JD, Hayami S, Toyokawa G, Takawa M, Yoshimatsu M, et al. Enhanced expression of EHMT2 is involved in the proliferation of cancer cells through negative regulation of SIAH1. Neoplasia 2011; 13(8):676-84. PMID: 21847359
    • (2011) Neoplasia , vol.13 , Issue.8 , pp. 676-684
    • Cho, H.S.1    Kelly, J.D.2    Hayami, S.3    Toyokawa, G.4    Takawa, M.5    Yoshimatsu, M.6
  • 8
    • 0037099413 scopus 로고    scopus 로고
    • G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis
    • PMID: 12130538
    • Tachibana M, Sugimoto K, Nozaki M, Ueda J, Ohta T, Ohki M, et al. G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev 2002; 16(14):1779-91. PMID: 12130538
    • (2002) Genes Dev , vol.16 , Issue.14 , pp. 1779-1791
    • Tachibana, M.1    Sugimoto, K.2    Nozaki, M.3    Ueda, J.4    Ohta, T.5    Ohki, M.6
  • 9
    • 84890834128 scopus 로고    scopus 로고
    • BIX-01294 induces autophagy-associated cell death via EHMT2/G9a dysfunction and intracellular reactive oxygen species production
    • PMID: 24322755
    • Kim Y, Kim YS, Kim DE, Lee JS, Song JH, Kim HG, et al. BIX-01294 induces autophagy-associated cell death via EHMT2/G9a dysfunction and intracellular reactive oxygen species production. Autophagy 2013; 9(12):2126-39. doi: 10.4161/auto.26308 PMID: 24322755
    • (2013) Autophagy , vol.9 , Issue.12 , pp. 2126-2139
    • Kim, Y.1    Kim, Y.S.2    Kim, D.E.3    Lee, J.S.4    Song, J.H.5    Kim, H.G.6
  • 10
    • 84923311761 scopus 로고    scopus 로고
    • Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation
    • PMID: 25595900
    • Zhang J, He P, Xi Y, Geng M, Chen Y, Ding J. Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation. Oncotarget 2015; 6(5):2917-27. PMID: 25595900
    • (2015) Oncotarget , vol.6 , Issue.5 , pp. 2917-2927
    • Zhang, J.1    He, P.2    Xi, Y.3    Geng, M.4    Chen, Y.5    Ding, J.6
  • 11
    • 84896714854 scopus 로고    scopus 로고
    • H3K9 histone methyltransferase G9a-mediated transcriptional activation of p21
    • PMID: 24492005
    • Oh ST, Kim KB, Chae YC, Kang JY, Hahn Y, Seo SB. H3K9 histone methyltransferase G9a-mediated transcriptional activation of p21. FEBS Lett 2014; 588(5):685-91. doi: 10.1016/j.febslet.2014.01.039 PMID: 24492005
    • (2014) FEBS Lett , vol.588 , Issue.5 , pp. 685-691
    • Oh, S.T.1    Kim, K.B.2    Chae, Y.C.3    Kang, J.Y.4    Hahn, Y.5    Seo, S.B.6
  • 12
    • 84904078487 scopus 로고    scopus 로고
    • Inhibition of G9a induces DUSP4-dependent autophagic cell death in head and neck squamous cell carcinoma
    • PMID: 25027955
    • Li KC, Hua KT, Lin YS, Su CY, Ko JY, Hsiao M, et al. Inhibition of G9a induces DUSP4-dependent autophagic cell death in head and neck squamous cell carcinoma. Mol Cancer 2014; 13:172. doi:10. 1186/1476-4598-13-172 PMID: 25027955
    • (2014) Mol Cancer , vol.13 , pp. 172
    • Li, K.C.1    Hua, K.T.2    Lin, Y.S.3    Su, C.Y.4    Ko, J.Y.5    Hsiao, M.6
  • 13
    • 84930181780 scopus 로고    scopus 로고
    • Inhibition of H3K9 methyltransferase G9a induces autophagy and apoptosis in oral squamous cell carcinoma
    • Ren A, Qiu Y, Cui H, Fu G. Inhibition of H3K9 methyltransferase G9a induces autophagy and apoptosis in oral squamous cell carcinoma. Biochem Biophys Res Commun 2015.
    • (2015) Biochem Biophys Res Commun
    • Ren, A.1    Qiu, Y.2    Cui, H.3    Fu, G.4
  • 14
    • 84889684498 scopus 로고    scopus 로고
    • The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation
    • PMID: 24315373
    • Ding J, Li T, Wang X, Zhao E, Choi JH, Yang L, et al. The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation. Cell Metab 2013; 18(6):896-907. doi: 10.1016/j.cmet.2013.11.004 PMID: 24315373
    • (2013) Cell Metab , vol.18 , Issue.6 , pp. 896-907
    • Ding, J.1    Li, T.2    Wang, X.3    Zhao, E.4    Choi, J.H.5    Yang, L.6
  • 15
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • PMID: 18305538
    • Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008; 451(7182):1069-75. doi: 10.1038/nature06639 PMID: 18305538
    • (2008) Nature , vol.451 , Issue.7182 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 16
    • 77950994646 scopus 로고    scopus 로고
    • Autophagy: Cellular and molecular mechanisms
    • PMID: 20225336
    • Glick D, Barth S, Macleod KF. Autophagy: cellular and molecular mechanisms. J Pathol 2010; 221 (1):3-12. doi: 10.1002/path.2697 PMID: 20225336
    • (2010) J Pathol , vol.221 , Issue.1 , pp. 3-12
    • Glick, D.1    Barth, S.2    Macleod, K.F.3
  • 17
    • 84907212907 scopus 로고    scopus 로고
    • Cell biology. Metabolic control of cell death
    • PMID: 25237106
    • Green DR, Galluzzi L, Kroemer G. Cell biology. Metabolic control of cell death. Science 2014; 345 (6203):1250256. doi: 10.1126/science.1250256 PMID: 25237106
    • (2014) Science , vol.345 , Issue.6203
    • Green, D.R.1    Galluzzi, L.2    Kroemer, G.3
  • 19
    • 84897143522 scopus 로고    scopus 로고
    • To be or not to be? How selective autophagy and cell death govern cell fate
    • PMID: 24679527
    • Green DR, Levine B. To be or not to be? How selective autophagy and cell death govern cell fate. Cell 2014; 157(1):65-75. doi: 10.1016/j.cell.2014.02.049 PMID: 24679527
    • (2014) Cell , vol.157 , Issue.1 , pp. 65-75
    • Green, D.R.1    Levine, B.2
  • 20
    • 84924060693 scopus 로고    scopus 로고
    • EHMT2 inhibitor BIX-01294 induces apoptosis through PMAIP1-USP9X-MCL1 axis in human bladder cancer cells
    • PMID: 25685062
    • Cui J, Sun W, Hao X, Wei M, Su X, Zhang Y, et al. EHMT2 inhibitor BIX-01294 induces apoptosis through PMAIP1-USP9X-MCL1 axis in human bladder cancer cells. Cancer Cell Int 2015; 15(1):4. doi: 10.1186/s12935-014-0149-x PMID: 25685062
    • (2015) Cancer Cell Int , vol.15 , Issue.1 , pp. 4
    • Cui, J.1    Sun, W.2    Hao, X.3    Wei, M.4    Su, X.5    Zhang, Y.6
  • 21
    • 34548077575 scopus 로고    scopus 로고
    • Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3
    • PMID: 17534139
    • Kimura S, Noda T, Yoshimori T. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 2007; 3(5):452-60. PMID: 17534139
    • (2007) Autophagy , vol.3 , Issue.5 , pp. 452-460
    • Kimura, S.1    Noda, T.2    Yoshimori, T.3
  • 22
    • 84905164867 scopus 로고    scopus 로고
    • MiR-145 inhibits invasion of bladder cancer cells by targeting PAK1
    • PMID: 24954107
    • Kou B, Gao Y, Du C, Shi Q, Xu S, Wang CQ, et al. miR-145 inhibits invasion of bladder cancer cells by targeting PAK1. Urol Oncol 2014; 32(6):846-54. doi: 10.1016/j.urolonc.2014.01.003 PMID: 24954107
    • (2014) Urol Oncol , vol.32 , Issue.6 , pp. 846-854
    • Kou, B.1    Gao, Y.2    Du, C.3    Shi, Q.4    Xu, S.5    Wang, C.Q.6
  • 23
    • 2542565666 scopus 로고    scopus 로고
    • Gene expression in the urinary bladder: A common carcinoma in situ gene expression signature exists disregarding histopathological classification
    • PMID: 15173019
    • Dyrskjot L, Kruhoffer M, Thykjaer T, Marcussen N, Jensen JL, Moller K, et al. Gene expression in the urinary bladder: a common carcinoma in situ gene expression signature exists disregarding histopathological classification. Cancer Res 2004; 64(11):4040-8. PMID: 15173019
    • (2004) Cancer Res , vol.64 , Issue.11 , pp. 4040-4048
    • Dyrskjot, L.1    Kruhoffer, M.2    Thykjaer, T.3    Marcussen, N.4    Jensen, J.L.5    Moller, K.6
  • 24
    • 84864886861 scopus 로고    scopus 로고
    • Autophagic cell death exists
    • Clarke PGH, Puyal J. Autophagic cell death exists. Autophagy 2014; 8(6):867-869.
    • (2014) Autophagy , vol.8 , Issue.6 , pp. 867-869
    • Clarke, P.G.H.1    Puyal, J.2
  • 26
    • 77954935974 scopus 로고    scopus 로고
    • Rheb G-Proteins and the Activation of mTORC1
    • PMID: 25429186
    • Parmar N, Tamanoi F. Rheb G-Proteins and the Activation of mTORC1. Enzymes 2010; 27:39-56. PMID: 25429186
    • (2010) Enzymes , vol.27 , pp. 39-56
    • Parmar, N.1    Tamanoi, F.2
  • 27
    • 63849149937 scopus 로고    scopus 로고
    • LKB1 and AMP-activated protein kinase control of mTOR signalling and growth
    • PMID: 19245654
    • Shaw RJ. LKB1 and AMP-activated protein kinase control of mTOR signalling and growth. Acta Physiologica 2009; 196(1):65-80. doi: 10.1111/j.1748-1716.2009.01972.x PMID: 19245654
    • (2009) Acta Physiologica , vol.196 , Issue.1 , pp. 65-80
    • Shaw, R.J.1
  • 28
    • 84923637078 scopus 로고    scopus 로고
    • Cancer metabolism: Strategic diversion from targeting cancer drivers to targeting cancer suppliers
    • Kim SY. Cancer metabolism: strategic diversion from targeting cancer drivers to targeting cancer suppliers. Biomol Ther (Seoul) 2015; 23(2):99-109.
    • (2015) Biomol Ther (Seoul) , vol.23 , Issue.2 , pp. 99-109
    • Kim, S.Y.1
  • 29
    • 78649464206 scopus 로고    scopus 로고
    • Autophagy is a therapeutic target in anticancer drug resistance
    • PMID: 20637264
    • Chen S, Rehman SK, Zhang W, Wen A, Yao L, Zhang J. Autophagy is a therapeutic target in anticancer drug resistance. Biochim Biophys Acta 2010; 1806(2):220-9. doi: 10.1016/j.bbcan.2010.07.003 PMID: 20637264
    • (2010) Biochim Biophys Acta , vol.1806 , Issue.2 , pp. 220-229
    • Chen, S.1    Rehman, S.K.2    Zhang, W.3    Wen, A.4    Yao, L.5    Zhang, J.6
  • 30
    • 84946903349 scopus 로고    scopus 로고
    • PAWR-mediated suppression of BCL2 promotes switching of 3-azido withaferin A (3-AWA)-induced autophagy to apoptosis in prostate cancer cells
    • PMID: 25803782
    • Rah B, Ur RR, Nayak D, Yousuf SK, Mukherjee D, Kumar LD, et al. PAWR-mediated suppression of BCL2 promotes switching of 3-azido withaferin A (3-AWA)-induced autophagy to apoptosis in prostate cancer cells. Autophagy 2015; 11(2):314-31. doi: 10.1080/15548627.2015.1017182 PMID: 25803782
    • (2015) Autophagy , vol.11 , Issue.2 , pp. 314-331
    • Rah, B.1    Ur, R.R.2    Nayak, D.3    Yousuf, S.K.4    Mukherjee, D.5    Kumar, L.D.6
  • 31
    • 84886927142 scopus 로고    scopus 로고
    • Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells
    • PMID: 23807219
    • Yuan Y, Tang AJ, Castoreno AB, Kuo SY, Wang Q, Kuballa P, et al. Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. Cell Death Dis 2013; 4:e690. doi:10. 1038/cddis.2013.191 PMID: 23807219
    • (2013) Cell Death Dis , vol.4 , pp. e690
    • Yuan, Y.1    Tang, A.J.2    Castoreno, A.B.3    Kuo, S.Y.4    Wang, Q.5    Kuballa, P.6
  • 32
    • 84908635321 scopus 로고    scopus 로고
    • Inhibition of H3K9 methyltransferase G9a repressed cell proliferation and induced autophagy in neuroblastoma cells
    • PMID: 25198515
    • Ke XX, Zhang D, Zhu S, Xia Q, Xiang Z, Cui H. Inhibition of H3K9 methyltransferase G9a repressed cell proliferation and induced autophagy in neuroblastoma cells. PLoS One 2014; 9(9):e106962. doi: 10.1371/journal.pone.0106962 PMID: 25198515
    • (2014) PLoS One , vol.9 , Issue.9
    • Ke, X.X.1    Zhang, D.2    Zhu, S.3    Xia, Q.4    Xiang, Z.5    Cui, H.6
  • 33
    • 84922355342 scopus 로고    scopus 로고
    • ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis
    • PMID: 25484082
    • Xiong Y, Yepuri G, Forbiteh M, Yu Y, Montani JP, Yang Z, et al. ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis. Autophagy 2014; 10(12):2223-38. doi: 10.4161/15548627.2014.981789 PMID: 25484082
    • (2014) Autophagy , vol.10 , Issue.12 , pp. 2223-2238
    • Xiong, Y.1    Yepuri, G.2    Forbiteh, M.3    Yu, Y.4    Montani, J.P.5    Yang, Z.6
  • 34
    • 84927916541 scopus 로고    scopus 로고
    • Autophagy Induction by Silibinin Positively Contributes to Its Anti-Metastatic Capacity via AMPK/mTOR Pathway in Renal Cell Carcinoma
    • PMID: 25884331
    • Li F, Ma Z, Guan Z, Chen Y, Wu K, Guo P, et al. Autophagy Induction by Silibinin Positively Contributes to Its Anti-Metastatic Capacity via AMPK/mTOR Pathway in Renal Cell Carcinoma. International Journal of Molecular Sciences 2015; 16(4):8415-8429. doi: 10.3390/ijms16048415 PMID: 25884331
    • (2015) International Journal of Molecular Sciences , vol.16 , Issue.4 , pp. 8415-8429
    • Li, F.1    Ma, Z.2    Guan, Z.3    Chen, Y.4    Wu, K.5    Guo, P.6
  • 35
    • 65249119430 scopus 로고    scopus 로고
    • Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy
    • PMID: 19211835
    • Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, et al. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell 2009; 20 (7):1981-91. doi: 10.1091/mbc.E08-12-1248 PMID: 19211835
    • (2009) Mol Biol Cell , vol.20 , Issue.7 , pp. 1981-1991
    • Hosokawa, N.1    Hara, T.2    Kaizuka, T.3    Kishi, C.4    Takamura, A.5    Miura, Y.6
  • 36
    • 42949139481 scopus 로고    scopus 로고
    • AMPK phosphorylation of raptor mediates a metabolic checkpoint
    • PMID: 18439900
    • Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 2008; 30(2):214-26. doi: 10.1016/j.molcel. 2008.03.003 PMID: 18439900
    • (2008) Mol Cell , vol.30 , Issue.2 , pp. 214-226
    • Gwinn, D.M.1    Shackelford, D.B.2    Egan, D.F.3    Mihaylova, M.M.4    Mery, A.5    Vasquez, D.S.6
  • 37
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • PMID: 14651849
    • Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003; 115(5):577-90. PMID: 14651849
    • (2003) Cell , vol.115 , Issue.5 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 38
    • 79953211917 scopus 로고    scopus 로고
    • Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK
    • PMID: 21383122
    • Shang L, Chen S, Du F, Li S, Zhao L, Wang X. Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK. Proc Natl Acad Sci U S A 2011; 108(12):4788-93. doi: 10.1073/pnas.1100844108 PMID: 21383122
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.12 , pp. 4788-4793
    • Shang, L.1    Chen, S.2    Du, F.3    Li, S.4    Zhao, L.5    Wang, X.6
  • 39
    • 77951231349 scopus 로고    scopus 로고
    • MTOR and cancer: Many loops in one pathway
    • PMID: 19945836
    • Efeyan A, Sabatini DM. mTOR and cancer: many loops in one pathway. Curr Opin Cell Biol 2010; 22 (2):169-76. doi: 10.1016/j.ceb.2009.10.007 PMID: 19945836
    • (2010) Curr Opin Cell Biol , vol.22 , Issue.2 , pp. 169-176
    • Efeyan, A.1    Sabatini, D.M.2
  • 40
    • 84856800302 scopus 로고    scopus 로고
    • Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: Cross talk shortcuts and feedbacks
    • PMID: 22025673
    • Alers S, Loffler AS, Wesselborg S, Stork B. Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks. Mol Cell Biol 2012; 32(1):2-11. doi: 10.1128/MCB.06159-11 PMID: 22025673
    • (2012) Mol Cell Biol , vol.32 , Issue.1 , pp. 2-11
    • Alers, S.1    Loffler, A.S.2    Wesselborg, S.3    Stork, B.4
  • 41
    • 79959963047 scopus 로고    scopus 로고
    • Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop
    • PMID: 21460634
    • Loffler AS, Alers S, Dieterle AM, Keppeler H, Franz-Wachtel M, Kundu M, et al. Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. Autophagy 2011; 7(7):696-706. PMID: 21460634
    • (2011) Autophagy , vol.7 , Issue.7 , pp. 696-706
    • Loffler, A.S.1    Alers, S.2    Dieterle, A.M.3    Keppeler, H.4    Franz-Wachtel, M.5    Kundu, M.6
  • 42
    • 84875537133 scopus 로고    scopus 로고
    • Epigenetic reprogramming in cancer
    • PMID: 23539597
    • Suva ML, Riggi N, Bernstein BE. Epigenetic reprogramming in cancer. Science 2013; 339 (6127):1567-70. doi: 10.1126/science.1230184 PMID: 23539597
    • (2013) Science , vol.339 , Issue.6127 , pp. 1567-1570
    • Suva, M.L.1    Riggi, N.2    Bernstein, B.E.3
  • 43
    • 79957895563 scopus 로고    scopus 로고
    • P53 signaling and autophagy in cancer: A revolutionary strategy could be developed for cancer treatment
    • PMID: 21099252
    • Sui X, Jin L, Huang X, Geng S, He C, Hu X. p53 signaling and autophagy in cancer: a revolutionary strategy could be developed for cancer treatment. Autophagy 2011; 7(6):565-71. PMID: 21099252
    • (2011) Autophagy , vol.7 , Issue.6 , pp. 565-571
    • Sui, X.1    Jin, L.2    Huang, X.3    Geng, S.4    He, C.5    Hu, X.6
  • 44
    • 85018218312 scopus 로고    scopus 로고
    • Combined HDAC1 and HDAC2 Depletion Promotes Retinal Ganglion Cell Survival after Injury Through Reduction of p53 Target Gene Expression
    • Lebrun-Julien F, Suter U. Combined HDAC1 and HDAC2 Depletion Promotes Retinal Ganglion Cell Survival After Injury Through Reduction of p53 Target Gene Expression. ASN Neuro 2015;7(3).
    • (2015) ASN Neuro , vol.7 , Issue.3
    • Lebrun-Julien, F.1    Suter, U.2
  • 45
    • 84877324373 scopus 로고    scopus 로고
    • Involvement of autophagy in the response of tumor cells to PtdIns3K inhibitors: Therapeutic implications
    • PMID: 23324613
    • Arcaro A. Involvement of autophagy in the response of tumor cells to PtdIns3K inhibitors: therapeutic implications. Autophagy 2013; 9(4):607-8. doi: 10.4161/auto.23461 PMID: 23324613
    • (2013) Autophagy , vol.9 , Issue.4 , pp. 607-608
    • Arcaro, A.1
  • 46
    • 84924903322 scopus 로고    scopus 로고
    • Epigenetic modifications as regulatory elements of autophagy in cancer
    • PMID: 25687886
    • Sui X, Zhu J, Zhou J, Wang X, Li D, Han W, et al. Epigenetic modifications as regulatory elements of autophagy in cancer. Cancer Lett 2015; 360(2):106-13. doi: 10.1016/j.canlet.2015.02.009 PMID: 25687886
    • (2015) Cancer Lett , vol.360 , Issue.2 , pp. 106-113
    • Sui, X.1    Zhu, J.2    Zhou, J.3    Wang, X.4    Li, D.5    Han, W.6
  • 47
    • 84886920194 scopus 로고    scopus 로고
    • Epigenetic regulation of autophagy by the methyltransferase G9a
    • PMID: 23918802
    • Artal-Martinez DNA, Gomez TS, Zhang JS, Mann AO, Taoda Y, Gorman JA, et al. Epigenetic regulation of autophagy by the methyltransferase G9a. Mol Cell Biol 2013; 33(20):3983-93. doi: 10.1128/MCB. 00813-13 PMID: 23918802
    • (2013) Mol Cell Biol , vol.33 , Issue.20 , pp. 3983-3993
    • Artal-Martinez, D.N.A.1    Gomez, T.S.2    Zhang, J.S.3    Mann, A.O.4    Taoda, Y.5    Gorman, J.A.6
  • 49


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.