EHMT2 inhibitor BIX-01294 induces apoptosis through PMAIP1-USP9X-MCL1 axis in human bladder cancer cells

Cancer Cell International

Volumn 15, Issue 1, 2015, Pages

  Cui, Jing ^a   Sun, Wendong ^a   Hao, Xuexi ^a   Wei, Minli ^a   Su, Xiaonan ^a   Zhang, Yajing ^a   Su, Ling ^a   Liu, Xiangguo ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BH3 PROTEIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; N (1 BENZYL 4 PIPERIDINYL) 2 (HEXAHYDRO 4 METHYL 1H 1,4 DIAZEPIN 1 YL) 6,7 DIMETHOXY 4 QUINAZOLINAMINE; PEPTIDASE; PMAIP1 PROTEIN; PROTEIN MCL 1; UBIQUITIN SPECIFIC PEPTIDASE 9X; UNCLASSIFIED DRUG;

A549 CELL LINE; APOPTOSIS; ARTICLE; BLADDER CANCER CELL LINE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; UPREGULATION;

EID: 84924060693     PISSN: None     EISSN: 14752867     Source Type: Journal    
DOI: 10.1186/s12935-014-0149-x     Document Type: Article

References (41)

1. Milner CM, Campbell RD. The EHMT2 gene in the human major histocompatibility complex encodes a novel protein containing ankyrin-like repeats. Biochem J. 1993;290(3):811-8.
2. Tachibana M, Sugimoto K, Fukushima T, Shinkai Y. Set domain-containing protein, EHMT2, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3. Biol Chem. 2001;276(27):25309-17.
3. Huang J, Dorsey J, Chuikov S, Pérez-Burgos L, Zhang X, Jenuwein T, et al. G9a and Glpmethylate lysine 373 in the tumor suppressor p53. Biol Chem. 2010;285:9636-41.
4. Kondo Y, Shen L, Ahmed S, Boumber Y, Sekido Y, Haddad BR, et al. Downregulation of histone H3lysine 9 methyltransferase G9a induces centrosome disruption and chromosome instability in cancer cells. PLoS One. 2008;3(4):e2037.
5. Mund C, Lyko F. Epigenetic cancer therapy: proof of concept and remaining challenges. Bioessays. 2010;32(11):949-57.
6. Cho HS, Kelly JD, Hayami S, Toyokawa G, Takawa M, Yoshimatsu M, et al. Enhanced expression of EHMT2 is involved in the proliferation of cancer cells through negative regulation of SIAH1. Neoplasia. 2011;13(8):676-84.
7. Kim Y, Kim YS, Kim DE, Lee JS, Kim CS, Koh JY, et al. BIX-01294 induces autophagy-associated cell death via EHMT2/EHMT2 dysfunction and intracellular reactive oxygen species production. Autophagy. 2013;9(12):2126-39.
8. Shi Y, Desponts C, Do JT, Hahm HS, Schöler HR, Ding S. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell. 2008;3(5):568-74.
9. Lu Z, Tian Y, Salwen HR, Chlenski A, Godley LA, Raj JU, et al. Histone-lysine methyltransferase EHMT2 is involved in proliferation, apoptosis, cell invasion, and DNA methylation of human neuroblastoma cells. Anticancer Drugs. 2013;24(5):484-93.
10. Chen MW, Hua KT, Kao HJ, Chi CC, Wei LH, Johansson G, et al. H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM. Cancer Res. 2010;70(20):7830-40.
11. Ding J, Li T, Wang X, Zhao E, Choi JH, Yang L, et al. The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustaincancer cell survival and proliferation. Cell Metab. 2013;18(6):896-907.
12. Kubicek S, O'Sullivan RJ, August EM, Hickey ER, Zhang Q, Teodoro ML, et al. Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell. 2007;25(3):473-81.
13. Vedadi M, Barsyte-Lovejoy D, Liu F, Rival-Gervier S, Allali-Hassani A, Labrie V, et al. A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol. 2011;7(8):566-74.
14. Kaneko M. Molecular pharmacological studies on the protection mechanism against endoplasmic reticulum stress-induced neurodegenerative disease. Yakugaku Zasshi. 2012;132(12):1437-42.
15. Kim SJ, Hong EH, Lee BR, Park MH, Kim JW, Pyun AR, et al. α-Mangostin reduced ER stress-mediated tumor growth through autophagy activation. Immune Netw. 2012;12(6):253-60.
16. Chen X, Li M, Chen D, Gao W, Guan JL, Komatsu M, et al. Autophagy induced by calcium phosphate precipitates involves endoplasmic reticulum membranes inautophagosome biogenesis. PLoS One. 2012;7(12):e52347.
17. Patra A, Deb M, Dahiya R, Patra SK. 5-Aza-2'-deoxycytidine stress response andapoptosis in prostate cancer. Clin Epigenetics. 2011;2(2):339-48.
18. Austgen K, Johnson ET, Park TJ, Curran T, et al. The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress. Nat Cell Biol. 2011;14(1):87-92.
19. Jwa M, Chang P. PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK and IRE1α-mediated unfolded protein response. Nat Cell Biol. 2012;14(11):1223-30.
20. Szegezdi E, Logue SE, Gorman AM, Samali A. Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep. 2006;7(9):880-5.
21. Kim I, Xu W, Reed JC. Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat Rev Drug Discov. 2008;7(12):1013-30.
22. Sun SY, Liu X, Zou W, Yue P, Marcus AI, Khuri FR. The farnesyltransferase inhibitor lonafarnib induces CCAAT/enhancer-binding protein homologous protein-dependent expression of death receptor 5, leading to induction of apoptosis in human cancer cells. J Biol Chem. 2007;282(26):18800-9.
23. Yoshida T, Shiraishi T, Nakata S, Horinaka M, Wakada M, Mizutani Y, et al. Proteasome inhibitor MG132 induces death receptor 5 through CCAAT/enhancer-binding protein homologous protein. Cancer Res. 2005;65(13):5662-7.
24. Zou W, Yue P, Khuri FR, Sun SY. Coupling of endoplasmic reticulum stress to CDDO-Me-induced up-regulation of death receptor 5 via a CHOP-dependent mechanism involving JNK activation. Cancer Res. 2008;68(18):7484-92.
25. Jürgensmeier JM, Xie Z, Deveraux Q, Ellerby L, Bredesen D, Reed JC. Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci U S A. 1998;95(9):4997-5002.
26. Lomonosova E, Chinnadurai G. BH3-only proteins in apoptosis and beyond: an overview. Oncogene. 2008;Suppl 1:S2-19.
27. Scull C, Tabas I. Mechanisms of ER stress-induced apoptosis in the atherosclerosis. Arterioscler Thromb Vasc Biol. 2011;31(12):2792-97.
28. Gomez-Bougie P, Ménoret E, Juin P, Dousset C, Pellat-Deceunynck C, Amiot M. Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1/USP9X interaction. Biochem Biophys Res Commun. 2011;413(3):460-4.
29. Peddaboina C, Jupiter D, Fletcher S, Yap JL, Rai A, Tobin RP, et al. The downregulation of MCL-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition. BMC Cancer. 2012;12(1):541.
30. Yan J, Zhong N, Liu G, Chen K, Liu X, Su L, et al. Usp9x- and Noxa-mediated Mcl-1 downregulation contributes to pemetrexed-induced apoptosis in human non-small-cell lung cancer cells. Cell Death Dis. 2014;281(5):e1316.
31. Ning Q, Hou L, Meng M, Pan BR, Zhao XH. TNF related apoptosis -inducing ligand and its receptors in ocular tumors. Int J Ophthalmol. 2011;4(5):552-7.
32. Li T, Su L, Zhong N, Hao X, Zhong D, Singhal S, et al. Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells. Autophagy. 2013;9(7):1057-68.
33. Sun SY, Yue P, Dawson MI, Shroot B, Michel S, Lamph WW, et al. Differential effects of synthetic nuclear retinoid receptor-selective retinoids on the growth of human non-small cell lung carcinoma cells. Cancer Res. 1997;57:4931-9.
34. Weber A, Kirejczyk Z, Potthoff S, Ploner C, Häcker G. Endogenous Noxa Determines the Strong Proapoptotic Synergism of the BH3-Mimetic ABT-373 with Chemotherapeutic Agents in Human Melanoma Cells. Transl Oncol. 2009;2(2):73-83.
35. Yan J, Zhong N, Liu G, Chen K, Liu X, Su L, et al. Usp9x- and Noxa-mediated Mcl-1 downregulation contributes to pemetrexed-induced apoptosis in human non-small-cell lung cancer cells. Cell Death Dis. 2014;5:e1316.
36. Verfaillie T, van Vliet A, Garg AD, Dewaele M, Rubio N, Gupta S, et al. Pro-apoptotic signaling induced by photo-oxidative ER stress is amplified by Noxa, not Bim. Biochem Biophys Res Commun. 2013;438(3):500-6.
37. Liu G, Su L, Hao X, Zhong N, Zhong D, Singhal S, et al. Salermide up-regulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cells. J Cell Mol Med. 2012;16(7):1618-28.
38. Miura S, Maesawa C, Shibazaki M, Yasuhira S, Kasai S, Tsunoda K, et al. Immunohistochemistry for histone h3 lysine 9 methyltransferase and demethylase proteins in human melanomas. Am J Dermatopathol. 2014;36(3):211-6.
39. Guan X, Zhong X, Men W, Gong S, Zhang L, Han Y. Analysis of EHMT1 expression and its correlations with clinical significance in esophageal squamous cell cancer. Mol Clin Oncol. 2014;2(1):76-80.
40. Lehnertz B, Pabst C, Su L, Miller M, Liu F, Yi L, et al. The methyltransferase G9a regulates HoxA9-dependent transcription in AML. Genes Dev. 2014;28(4):317-27.
41. Schwickart M, Huang X, Lill JR, Liu J, Ferrando R, French DM, et al. Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature. 2010;463:103-7.