Uric acid enhances the antitumor immunity of dendritic cell-based vaccine

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Wang, Yihan ^a   Ma, Xuelei ^a   Su, Chao ^a   Peng, Bin ^a   Du, Jing ^a   Jia, Hongyuan ^a   Luo, Min ^a   Fang, Chunju ^a   Wei, Yuquan ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER VACCINE; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN; IMMUNOLOGICAL ADJUVANT; URIC ACID;

ADOPTIVE TRANSFER; ANIMAL; CD8+ T LYMPHOCYTE; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; DENDRITIC CELL; DISEASE MODEL; FEMALE; IMMUNIZATION; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MORTALITY; MOUSE; NATURAL KILLER CELL; NEOPLASMS; T LYMPHOCYTE SUBPOPULATION;

ADJUVANTS, IMMUNOLOGIC; ADOPTIVE TRANSFER; ANIMALS; CANCER VACCINES; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; FEMALE; IMMUNIZATION; IMMUNOGLOBULINS; INTERFERON-GAMMA; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MICE; NEOPLASMS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, CYTOTOXIC; URIC ACID;

EID: 84946893608     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep16427     Document Type: Article

References (47)

1. Mellman, I., Coukos, G. & Dranoff, G. Cancer immunotherapy comes of age. Nature. 480, 480-489 (2011)
2. Weiss, E. M. et al. Selected anti-tumor vaccines merit a place in multimodal tumor therapies. Front Oncol. 2, 132 (2012)
3. Finn, O. J. Cancer vaccines: between the idea and the reality. Nat Rev Immunol. 3, 630-641 (2003)
4. Steinman, R. M. The dendritic cell system and its role in immunogenicity. Annu Rev Immunol. 9, 271-296 (1991)
5. Hart, D. N. Dendritic cells: unique leukocyte populations which control the primary immune response. Blood. 90, 3245-3287 (1997)
6. Austyn, J. M., Kupiec-Weglinski, J. W., Hankins, D. F. & Morris, P. J. Migration patterns of dendritic cells in the mouse. Homing to T cell-dependent areas of spleen, and binding within marginal zone. J Exp Med. 167, 646-651 (1988)
7. Rock, K. L. A new foreign policy: MHC class I molecules monitor the outside world. Immunol Today. 17, 131-137 (1996)
8. Fields, R. C., Shimizu, K. & Mule, J. J. Murine dendritic cells pulsed with whole tumor lysates mediate potent antitumor immune responses in vitro and in vivo. ProcNatlAcadSci USA. 95, 9482-9487 (1998)
9. Feuerer, M., et al. Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow. Nat Med. 7, 452-458 (2001)
10. Asavaroengchai, W., Kotera, Y. & Mule, J. J. Tumor lysate-pulsed dendritic cells can elicit an effective antitumor immune response during early lymphoid recovery. ProcNatlAcadSci USA. 99, 931-936 (2002)
11. Hu, D. E., Moore, A. M., Thomsen, L. L. & Brindle, K. M. Uric acid promotes tumor immune rejection. Cancer Res. 64, 5059-5062 (2004)
12. Chen, C. J. et al. Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat Med. 13, 851-856 (2007)
13. Chen, C. J. et al. MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals. J Clin Invest. 116, 2262-2271 (2006)
14. Shi, Y., Evans, J. E. & Rock, K. L. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature. 425, 516-521 (2003)
15. Shi, Y., Galusha, S. A. & Rock, K. L. Cutting edge: elimination of an endogenous adjuvant reduces the activation of CD8 T lymphocytes to transplanted cells and in an autoimmune diabetes model. J Immunol. 176, 3905-3908 (2006)
16. Jerome, K. R. & Corey, L. The danger within. N Engl J Med. 350, 411-412 (2004)
17. Steinman, R. M. & Banchereau, J. Taking dendritic cells into medicine. Nature. 449, 419-426 (2007)
18. Dhodapkar, M. V., Dhodapkar, K. M. & Palucka, A. K. Interactions of tumor cells with dendritic cells: balancing immunity and tolerance. Cell Death Differ. 15, 39-50 (2008)
19. Banchereau, J. & Steinman, R. M. Dendritic cells and the control of immunity. Nature. 392, 245-252 (1998)
20. Figdor, C. G., de Vries I. J., Lesterhuis, W. J. & Melief, C. J. Dendritic cell immunotherapy: mapping the way. Nat Med. 10, 475-480 (2004)
21. Mayordomo, J. I. et al. Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity. Nat Med. 1, 1297-1302 (1995)
22. Paglia, P., Chiodoni, C., Rodolfo, M. & Colombo, M. P. Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo. J Exp Med. 183, 317-322 (1996)
23. Boczkowski, D., Nair, S. K., Snyder, D. & Gilboa, E. Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo. J Exp Med. 184, 465-472 (1996)
24. Manickan, E., Kanangat, S., Rouse, R. J., Yu, Z. & Rouse, B. T. Enhancement of immune response to naked DNA vaccine by immunization with transfected dendritic cells. J Leukoc Biol. 61, 125-132 (1997)
25. Mackensen, A. et al. Phase I study in melanoma patients of a vaccine with peptide-pulsed dendritic cells generated in vitro from CD34(+ ) hematopoietic progenitor cells. Int J Cancer. 86, 385-392 (2000)
26. Banchereau, J. et al. Immune and clinical responses in patients with metastatic melanoma to CD34(+ ) progenitor-derived dendritic cell vaccine. Cancer Res. 61, 6451-6458 (2001)
27. Schuler-Thurner, B. et al. Rapid induction of tumor-specific type 1 T helper cells in metastatic melanoma patients by vaccination with mature, cryopreserved, peptide-loaded monocyte-derived dendritic cells. J Exp Med. 195, 1279-1288 (2002)
28. deVries I. J. et al. Maturation of dendritic cells is a prerequisite for inducing immune responses in advanced melanoma patients. Clin Cancer Res. 9, 5091-5100 (2003)
29. Dhodapkar, M. V. et al. Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells. J Clin Invest. 104, 173-180 (1999)
30. Behrens, M. D. et al. The endogenous danger signal, crystalline uric acid, signals for enhanced antibody immunity. Blood. 111, 1472-1479 (2008)
31. Kuhn, S. et al. Increased numbers of monocyte-derived dendritic cells during successful tumor immunotherapy with immuneactivating agents. J Immunol. 191, 1984-1992 (2013)
32. Martinon, F., Petrilli, V., Mayor, A., Tardivel, A. & Tschopp, J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 440, 237-241 (2006)
33. Nishioka, Y., Nishimura, N., Suzuki, Y. & Sone, S. Human monocyte-derived and CD83(+ ) blood dendritic cells enhance NK cell-mediated cytotoxicity. Eur J Immunol. 31, 2633-2641 (2001)
34. Yu, Y. et al. Enhancement of human cord blood CD34+ cell-derived NK cell cytotoxicity by dendritic cells. J Immunol. 166, 1590-1600 (2001)
35. Trinchieri, G. Natural killer cells wear different hats: effector cells of innate resistance and regulatory cells of adaptive immunity and of hematopoiesis. SeminImmunol. 7, 83-88 (1995)
36. Hamzah, J. et al. Targeted liposomal delivery of TLR9 ligands activates spontaneous antitumor immunity in an autochthonous cancer model. J Immunol. 183, 1091-1098 (2009)
37. Broomfield, S. A. et al. Locally administered TLR7 agonists drive systemic antitumor immune responses that are enhanced by anti-CD40 immunotherapy. J Immunol. 182, 5217-5224 (2009)
38. Hsu, F. J. et al. Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nat Med. 2, 52-58 (1996)
39. Maier, T. et al. Vaccination of patients with cutaneous T-cell lymphoma using intranodal injection of autologous tumor-lysatepulsed dendritic cells. Blood. 102, 2338-2344 (2003)
40. Nestle, F. O. et al. Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nat Med. 4, 328-332 (1998)
41. Kandalaft, L. E. et al. A Phase I vaccine trial using dendritic cells pulsed with autologous oxidized lysate for recurrent ovarian cancer. J Transl Med. 11, 149 (2013)
42. Gitlitz, B. J. et al. A pilot trial of tumor lysate-loaded dendritic cells for the treatment of metastatic renal cell carcinoma. J Immunother. 26, 412-9 (2003)
43. Inaba, K. et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/ macrophage colony-stimulating factor. J Exp Med. 176, 1693-1702 (1992)
44. Hodgkins, S. R. et al. NO2 inhalation induces maturation of pulmonary CD11c+ cells that promote antigenspecific CD4+ T cell polarization. Respir Res. 11, 102 (2010)
45. Horton, H. M. et al. A gene therapy for cancer using intramuscular injection of plasmid DNA encoding interferon alpha. ProcNatlAcadSci USA. 96, 1553-1558 (1999)
46. Wei, Y. Q. et al. Immunogene therapy of tumors with vaccine based on Xenopus homologous vascular endothelial growth factor as a model antigen. ProcNatlAcadSci USA. 98, 11545-11550 (2001)
47. Wei, Y. et al. Induction of autologous tumor killing by heat treatment of fresh human tumor cells: involvement of gamma delta T cells and heat shock protein 70. Cancer Res. 56, 1104-1110 (1996)