Azithromycin protects mice against ischemic stroke injury by promoting macrophage transition towards M2 phenotype

Experimental Neurology

Volumn 275, Issue , 2016, Pages 116-125

  Amantea, Diana ^a   Certo, Michelangelo ^a   Petrelli, Francesco ^a   Tassorelli, Cristina ^b,c   Micieli, Giuseppe ^b   Corasaniti, Maria Tiziana ^d   Puccetti, Paolo ^e   Fallarino, Francesca ^e   Bagetta, Giacinto ^a  

^a UNIVERSITY OF CALABRIA   (Italy)

^b C MONDINO NATIONAL NEUROLOGICAL INSTITUTE   (Italy)

^c UNIVERSITY OF PAVIA   (Italy)

^d UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^e UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Azithromycin; Drug repurposing; Immune system; Macrophage polarization; Stroke

Indexed keywords

ARGINASE; ARGINASE 1; AZITHROMYCIN; SECRETORY PROTEIN; UNCLASSIFIED DRUG; YM1 PROTEIN; ANTIINFECTIVE AGENT; NEUROPROTECTIVE AGENT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BONE MARROW CELL; BRAIN BLOOD FLOW; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL INFILTRATION; CONTROLLED STUDY; DISEASE MODEL; DOSE RESPONSE; DRUG DOSE COMPARISON; ENZYME ACTIVITY; ENZYME INHIBITION; MACROPHAGE; MACROPHAGE MIGRATION; MALE; MEMBRANE DAMAGE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROPROTECTION; NEUTROPHIL; NONHUMAN; PERITONEAL EXUDATE CELL; PHENOTYPE; POLARIZATION; PRIORITY JOURNAL; REPERFUSION; SINGLE DRUG DOSE; TREATMENT OUTCOME; ANIMAL; C57BL MOUSE; DRUG EFFECTS; MACROPHAGE ACTIVATION; METABOLISM; PATHOLOGY; STROKE;

ANIMALS; ANTI-BACTERIAL AGENTS; AZITHROMYCIN; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; MACROPHAGE ACTIVATION; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; NEUROPROTECTIVE AGENTS; STROKE;

EID: 84946888241     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2015.10.012     Document Type: Article

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