Evaluation of MTHFR genetic polymorphism as a risk factor in Egyptian autistic children and mothers

African Journal of Psychiatry (South Africa)

Volumn 18, Issue 1, 2015, Pages

  Meguid, Nagwa ^a   Khalil, Rehab ^a   Gebril, Ola ^a   El Fishawy, Paul ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Autism; Folate; MTHFR; Polymorphism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); GENOMIC DNA;

ARTICLE; AUTISM; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; EGYPTIAN; ENZYME ACTIVITY; FEMALE; GENE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MALE; MTHFR GENE; MUTATIONAL ANALYSIS; PRESCHOOL CHILD; PREVALENCE; RISK FACTOR; SCHOOL CHILD;

EID: 84946829323     PISSN: 19948220     EISSN: None     Source Type: Journal    
DOI: 10.4172/Psychiatry.1000179     Document Type: Article

References (28)

1. American Psychiatric Association (2000) Diagnostic and Statistical Manual-Text Revision. 4th ed. Washington, DC: American Psychiatric Association.
2. Main PA, Angley MT, O'Doherty CE, Thomas P, Fenech M (2012) The potential role of the antioxidant and detoxification properties of glutathione in autism spectrum disorders: a systematic review and meta-analysis. Nutrition and Metabolism 9: 35-45.
3. Al-Farsi YM, Al-Sharbati MM, Al-Farsi OA, Al-Shafaee MS, Brooks DR, et al. (2011) Brief report: Prevalence of autistic spectrum disorders in the Sultanate of Oman. J Autism Dev Disord 41: 821-5.
4. Eapen V, Mabrouk AA, Zoubeidi T, Yunis F (2007) Prevalence of pervasive developmental disorders in preschool children in the UAE. J Trop Pediatr 53: 202-5.
5. Lyall K, Schmidt RJ, Hertz-Picciotto I (2014) Maternal lifestyle and environmental risk factors for autism spectrum disorders. Int J Epidemiol 11.
6. Banerjee S, Riordan M, Bhat MA (2014) Genetic aspects of autism spectrum disorders: insights from animal models. Front Cell Neurosci 24: 8-58.
7. Geier DA, Kern JK, Garver CR, Adams JB, Audhya T, et al. (2009) A prospective study of transsulfuration biomarkers in autistic disorders. Neurochem Res 34: 386-93.
8. Sugden (2006) One-carbon metabolism in psychiatric illness. Nutr Res Rev 19: 117-136.
9. Trimmer EE (2003) Methylenetetrahydrofolate reductase: biochemical characterization and medical significance. Curr Pharm Des 19: 2574-93.
10. Van der Put NM, Gabreëls F, Stevens EM, Smeitink JA, Trijbels FJ, et al. (1998) A second common mutation in the methylenetetrahydrofolate reductase gene: An additional risk factor for neural-tube defects? American Journal of Human Genetics; 62: 1044-1051.
11. Pasca SP, Dronca E, Kaucsár T, Craciun EC, Endreffy E, et al. (1998) One carbon metabolism disturbances and the C677T MTHFR gene polymorphism in children with autism spectrum disorders. J Cell Mol Med 13: 4229-4238.
12. Dos Santos PA, Longo D, Brandalize AP, Schüler-Faccini L (2010) MTHFR C677T is not a risk factor for autism spectrum disorders in South Brazil. Psychiatric Genetics 20: 187-189.
13. Guo T, Chen H, Liu B, Ji W, Yang C (2012) Methylenetetrahydrofolate reductase polymorphisms C677T and risk of autism in the Chinese Han population. Genet Test Mol Biomarkers 16: 968-73.
14. Mohammad NS, Jain JM, Chintakindi KP, Singh RP, Naik U, et al. (2009) Aberrations in folate metabolic pathway and altered susceptibility to autism. Psychiatric Genetics 19: 171-176.
15. James SJ, Melnyk S, Jernigan S, Pavliv O, Trusty T, et al. (2010) A functional polymorphism in the reduced folate carrier gene and DNA hypomethylation in mothers of children with autism. Am J Med Genet B Neuropsychiatr Genet 153B: 1209-20.
16. Liu X, Solehdin F, Cohen IL, Gonzalez MG, Jenkins EC, et al. (2011) Population- and Family-Based Studies Associate the MTHFR. Gene with Idiopathic Autism in Simplex Families. J Autism Dev Disord 41: 938-944.
17. Schopler E, Reichler RJ, Renner BR (1993) Childhood Autism Rating Scale. Los Angeles, CA: Western Psychological Services.
18. Rutter M, Couteur A, Lord C (2009) Autism Diagnostic Interview Revised (ADI-R).
19. Frosst P, Blom HJ, Milos R (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nature Genet 10: 111-113.
20. Miyake K, Hirasawa T, Koide T, Kubota T (2012) Epigenetics in autism and other neurodevelopmental diseases. Adv. Exp. Med. Biol 724: 91-98.
21. Mansoori N, Tripathi M, Luthra K, Alam R, Lakshmy R, et al. (2012) MTHFR (677 and 1298) and IL-6-174 G/C genes in pathogenesis of Alzheimer's and vascular dementia and their epistatic interaction. Neurobiol Aging 33: 1003.
22. Kim SG, Song JY, Joo EJ, Jeong SH, Kim SH, et al. (2011) No association of functional polymorphisms in methlylenetetrahydrofolate reductase and the risk and minor physical anomalies of schizophrenia in Korean population. J Korean Med Sci 26: 1356-63.
23. Ergul E, Sazci A, Kara I (2012) Methylenetetrahydrofolate reductase gene polymorphisms in Turkish children with attention-deficit/hyperactivity disorder. Genet Test Mol Biomarker 16: 67-9.
24. Gebril OH, Meguid NA (2011) HFE gene polymorphisms and the risk for autism in Egyptian children and impact on the effect of oxidative stress. Dis Markers 31: 289-94.
25. Liu SY, Zeng FF, Chen ZW, Wang CY, Zhao B, et al. (2013) Vascular endothelial growth factor gene promoter polymorphisms and Alzheimer's disease risk: a meta-analysis. CNS Neurosci Ther 19: 469-76.
26. Gebril OH, Kirby J, Savva G, Brayne C, Ince PG (2011) HFE H63D, C282Y and AGTR1 A1166C polymorphisms and brain white matter lesions in the aging brain. J Neurogenet 25: 7-14.
27. Gebril OH, Meguid NA (2014) Iron-regulated transporter SLC40A1 gene polymorphism and autism: A pilot study. World Journal of Cell Biology and Genetics 1: 2-5.
28. Park J, Ro M, Pyun JA, Nam M, Bang HJ, et al. (2013) MTHFR 1298A>C is a risk factor for autism spectrum disorder in the Korean population. Psychiatry Res 215: 258-9.