Vascular endothelial growth factor gene promoter polymorphisms and alzheimer's disease risk: A meta-analysis

CNS Neuroscience and Therapeutics

Volumn 19, Issue 7, 2013, Pages 469-476

  Liu, Sheng Yuan ^a,b   Zeng, Fang Fang ^c   Chen, Zhong Wei ^b   Wang, Chang Yi ^b,c   Zhao, Bin ^a   Li, Ke Shen ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

^b Shenzhen Nanshan Center for Chronic Disease Control   (China)

^c SUN YAT SEN UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Meta analysis; Polymorphism; Promoter; Vascular endothelial growth factor

Indexed keywords

VASCULOTROPIN;

ALZHEIMER DISEASE; ARTICLE; DNA POLYMORPHISM; ETHNIC DIFFERENCE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC RISK; HUMAN; META ANALYSIS (TOPIC); MOLECULAR DIAGNOSIS; OBSERVATIONAL STUDY; PROMOTER REGION; RISK ASSESSMENT; SENSITIVITY ANALYSIS; SYSTEMATIC REVIEW;

ALZHEIMER DISEASE; APOLIPOPROTEINS E; CONFIDENCE INTERVALS; DATA INTERPRETATION, STATISTICAL; HUMANS; ODDS RATIO; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84879006648     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12093     Document Type: Article

References (38)

1. Alzheimer's disease International. World Alzheimer Report 2009-2011. 2012. Available at: http://www.alz.co.uk/research/world-report (accessed on 15 November 2012).
2. Berchtold NC, Cotman CW. Evolution in the conceptualization of dementia and Alzheimer's disease: Greco-Roman period to the 1960s. Neurobiol Aging 1998;19:173-189.
3. Ferrara N, Henzel WJ. Pltubry follicuiar cells secrete a VEGF in femoral head of growing rat novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 1989;161:851-858.
4. Gospodarowicz D, Abraham JA, Schilling J. Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculostellate cells. Proc Natl Acad Sci USA 1989;86:7311-7315.
5. Shibuya M. Vascular endothelial growth factor-dependent and -independent regulation of angiogenesis. BMB Rep 2008;41:278-286.
6. Mateo I, Llorca J, Infante J, et al. Low serum VEGF levels are associated with Alzheimer's disease. Acta Neurol Scand 2007;116:56-58.
7. Provias J, Jeynes B. Neurofibrillary tangles and senile plaques in Alzheimer's brains are associated with reduced capillary expression of vascular endothelial growth factor and endothelial nitric oxide synthase. Curr Neurovasc Res 2008;5:199-205.
8. Tarkowski E, Issa R, Sjogren M, et al. Increased intrathecal levels of the angiogenic factors VEGF and TGFbeta in Alzheimer's disease and vascular dementia. Neurobiol Aging 2002;23:237-243.
9. Thirumangalakudi L, Samany PG, Owoso A, Wiskar B, Grammas P. Angiogenic proteins are expressed by brain blood vessels in Alzheimer's disease. J Alzheimers Dis 2006;10:111-118.
10. Kalaria RN, Cohen DL, Premkumar DR, Nag S, LaManna JC, Lust WD. Vascular endothelial growth factor in Alzheimer's disease and experimental ischemia. Brain Res Mol Brain Res 1998;62:101-105.
11. Blacker D, Bertram L, Saunders AJ, et al. Results of a high-resolution genome screen of 437 Alzheimer's disease families. Hum Mol Genet 2003;12:23-32.
12. Tischer E, Mitchell R, Hartman T, et al. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J Biol Chem 1991;266:11947-11954.
13. Stevens A, Soden J, Brenchley PE, Ralph S, Ray DW. Haplotype analysis of the polymorphic human vascular endothelial growth factor gene promoter. Cancer Res 2003;63:812-816.
14. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000;283:2008-2012.
15. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 2010;25:603-605.
16. Tobias A. Assessing the influence of a single study in the meta-analysis estimate. Stata Tech Bull 1999;8:15-17.
17. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ (Clinical researched) 2003;327:557-560.
18. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959;22:719-748.
19. DerSimonian R, Kacker R. Random-effects model for meta-analysis of clinical trials: an update. Contemp Clin Trials 2007;28:105-114.
20. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994;50:1088-1101.
21. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629-634.
22. Del Bo R, Scarlato M, Ghezzi S, et al. Vascular endothelial growth factor gene variability is associated with increased risk for AD. Ann Neurol 2005;57:373-380.
23. Chapuis J, Tian J, Shi J, et al. Association study of the vascular endothelial growth factor gene with the risk of developing Alzheimer's disease. Neurobiol Aging 2006;27:1212-1215.
24. Chiappelli M, Borroni B, Archetti S, et al. VEGF gene and phenotype relation with Alzheimer's disease and mild cognitive impairment. Rejuvenation Res 2006;9:485-493.
25. Mateo I, Llorca J, Infante J, et al. Case-control study of vascular endothelial growth factor (VEGF) genetic variability in Alzheimer's disease. Neurosci Lett 2006;401:171-173.
26. Giedraitis V, Kilander L, Degerman-Gunnarsson M, et al. Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men. Dement Geriatr Cogn Disord 2009;27:59-68.
27. Yuan Q, Zuo X, Jia J. Association between promoter polymorphisms of vascular endothelial growth factor gene and sporadic Alzheimer's disease among Northern Chinese Han. Neurosci Lett 2009;457:133-136.
28. Landgren S, Palmer MS, Skoog I, et al. No association of VEGF polymorphism with Alzheimer's disease. Neuromolecular Med 2010;12:224-228.
29. Smach MA, Charfeddine B, Othman LB, et al. -1154G/A and -2578C/A polymorphisms of the vascular endothelial growth factor gene in Tunisian Alzheimer patients in relation to beta-amyloid (1-42) and total tau protein. Neurosci Lett 2010;472:139-142.
30. Leoni V. The effect of apolipoprotein E (ApoE) genotype on biomarkers of amyloidogenesis, tau pathology and neurodegeneration in Alzheimer's disease. Clin Chem Lab Med 2011;49:375-383.
31. Lin KP, Chen SY, Lai LC, et al. Genetic polymorphisms of a novel vascular susceptibility gene, Ninjurin2 (NINJ2), are associated with a decreased risk of Alzheimer's disease. PLoS ONE 2011;6:e20573.
32. Cellini E, Tedde A, Bagnoli S, et al. Implication of sex and SORL1 variants in italian patients with Alzheimer disease. Arch Neurol 2009;66:1260-1266.
33. Shahbazi M, Fryer AA, Pravica V, et al. Vascular endothelial growth factor gene polymorphisms are associated with acute renal allograft rejection. J Am Soc Nephrol 2002;13:260-264.
34. Oosthuyse B, Moons L, Storkebaum E, et al. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat Genet 2001;28:131-138.
35. Sanchez A, Tripathy D, Luo J, Yin X, Martinez J, Grammas P. Neurovascular unit and the effects of dosage in VEGF toxicity: role for oxidative stress and thrombin. J Alzheimers Dis 2013;34:281-291.
36. Combarros O, Rodero L, Infante J, et al. Age-dependent association between the Q7R polymorphism in the Saitohin gene and sporadic Alzheimer's disease. Dement Geriatr Cogn Disord 2003;16:132-135.
37. Zou F, Gopalraj RK, Lok J, et al. Sex-dependent association of a common low-density lipoprotein receptor polymorphism with RNA splicing efficiency in the brain and Alzheimer's disease. Hum Mol Genet 2008;17:929-935.
38. Wollmer MA, Kapaki E, Hersberger M, et al. Ethnicity-dependent genetic association of ABCA2 with sporadic Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet 2006;141B:534-536.