Synthetic fatty acids prevent plasmid-mediated horizontal gene transfer

mBio

Volumn 6, Issue 5, 2015, Pages

  Getino, María ^a   Sanabria Ríos, David J ^b   Fernández López, Raúl ^a   Campos Gómez, Javier ^a,d   Sánchez López, José M ^c   Fernández, Antonio ^c   Carballeira, Néstor M ^b   De La Cruz, Fernando ^a  

^a University of Cantabria   (Spain)

^b UNIVERSITY OF PUERTO RICO   (Puerto Rico)

^c Instituto Biomar SA   (Spain)

^d SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 ALKYNOIC FATTY ACID; 2 HEXADECYNOIC ACID; FATTY ACID; UNCLASSIFIED DRUG;

ACINETOBACTER; ARTICLE; BACTERIUM CONJUGATION; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; CONTROLLED STUDY; ESCHERICHIA; FATTY ACID ANALYSIS; FATTY ACID DESATURATION; HORIZONTAL GENE TRANSFER; NONHUMAN; PLASMID; PRIORITY JOURNAL; PSEUDOMONAS; SALMONELLA; DRUG EFFECTS; GENETICS; GRAM NEGATIVE BACTERIUM; METABOLISM; SYNTHESIS;

CONJUGATION, GENETIC; FATTY ACIDS; GENE TRANSFER, HORIZONTAL; GRAM-NEGATIVE BACTERIA; PLASMIDS;

EID: 84946569568     PISSN: 21612129     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.01032-15     Document Type: Article

References (40)

1. Hawkey PM, Jones AM. 2009. The changing epidemiology of resistance. J Antimicrob Chemother 64(Suppl 1):i3-i10. http://dx.doi.org/10.1093/ jac/dkp256.
2. WHO. 2014. Antimicrobial resistance: global report on surveillance 2014. World Health Organization, Geneva, Switzerland.
3. Pitout JD. 2010. Infections with extended-spectrum beta-lactamaseproducing enterobacteriaceae: changing epidemiology and drug treatment choices. Drugs 70:313-333. http://dx.doi.org/10.2165/11533040-000000000-00000.
4. Smith PA, Romesberg FE. 2007. Combating bacteria and drug resistance by inhibiting mechanisms of persistence and adaptation. Nat Chem Biol 3:549-556. http://dx.doi.org/10.1038/nchembio.2007.27.
5. Baquero F, Coque TM, de la Cruz F. 2011. Ecology and evolution as targets: the need for novel eco-evo drugs and strategies to fight antibiotic resistance. Antimicrob Agents Chemother 55:3649-3660. http://dx.doi.org/10.1128/AAC.00013-11.
6. Lujan SA, Guogas LM, Ragonese H, Matson SW, Redinbo MR. 2007. Disrupting antibiotic resistance propagation by inhibiting the conjugative DNA relaxase. Proc Natl Acad Sci U S A 104:12282-12287. http://dx.doi.org/10.1073/pnas.0702760104.
7. Nash RP, McNamara DE, Ballentine WK, III, Matson SW, Redinbo MR. 2012. Investigating the impact of bisphosphonates and structurally related compounds on bacteria containing conjugative plasmids. Biochem Biophys Res Commun 424:697-703. http://dx.doi.org/10.1016/j.bbrc.2012.07.012.
8. Garcillán-Barcia MP, Jurado P, González-Pérez B, Moncalián G, Fernández LA, de la Cruz F. 2007. Conjugative transfer can be inhibited by blocking relaxase activity within recipient cells with intrabodies. Mol Microbiol 63:404-416. http://dx.doi.org/10.1111/j.1365-2958.2006.05523.x.
9. Lin A, Jimenez J, Derr J, Vera P, Manapat ML, Esvelt KM, Villanueva L, Liu DR, Chen IA. 2011. Inhibition of bacterial conjugation by phage M13 and its protein g3p: quantitative analysis and model. PLoS One 6:e19991. http://dx.doi.org/10.1371/journal.pone.0019991.
10. Hooper DC, Wolfson JS, Tung C, Souza KS, Swartz MN. 1989. Effects of inhibition of the B subunit ofDNAgyrase on conjugation in Escherichia coli. J Bacteriol 171:2235-2237.
11. Michel-Briand Y, Laporte JM. 1985. Inhibition of conjugal transfer of R plasmids by nitrofurans. J Gen Microbiol 131:2281-2284. http://dx.doi.org/10.1099/00221287-131-9-2281.
12. Conter A, Sturny R, Gutierrez C, Cam K. 2002. The RcsCB His-Asp phosphorelay system is essential to overcome chlorpromazine-induced stress in Escherichia coli. J Bacteriol 184:2850-2853. http://dx.doi.org/10.1128/JB.184.10.2850-2853.2002.
13. Fernandez-Lopez R, Machón C, Longshaw CM, Martin S, Molin S, Zechner EL, Espinosa M, Lanka E, de la Cruz F. 2005. Unsaturated fatty acids are inhibitors of bacterial conjugation. Microbiology 151: 3517-3526. http://dx.doi.org/10.1099/mic.0.28216-0.
14. Gussoni M, Greco F, Pegna M, Bianchi G, Zetta L. 1994. Solid state and microscopyNMRstudy of the chemical constituents of Afzelia cuanzensis seeds. Magn Reson Imaging 12:477-486. http://dx.doi.org/10.1016/0730-725X(94)92542-9.
15. Carballeira NM, Cartagena M, Sanabria D, Tasdemir D, Prada CF, Reguera RM, Balaña-Fouce R. 2012. 2-Alkynoic fatty acids inhibit topoisomerase IB from Leishmania donovani. Bioorg Med Chem Lett 22: 6185-6189. http://dx.doi.org/10.1016/j.bmcl.2012.08.019.
16. Sanabria-Ríos DJ, Rivera-Torres Y, Maldonado-Domínguez G, Domínguez I, Ríos C, Díaz D, Rodríguez JW, Altieri-Rivera JS, Ríos-Olivares E, Cintrón G, Montano N, Carballeira NM. 2014. Antibacterial activity of 2-alkynoic fatty acids against multidrug-resistant bacteria. Chem Phys Lipids 178:84-91. http://dx.doi.org/10.1016/j.chemphyslip.2013.12.006.
17. Tasdemir D, Sanabria D, Lauinger IL, Tarun A, Herman R, Perozzo R, Zloh M, Kappe SH, Brun R, Carballeira NM. 2010. 2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage plasmodium infections. Bioorg Med Chem 18:7475-7485. http://dx.doi.org/10.1016/j.bmc.2010.08.055.
18. Francia MV, Varsaki A, Garcillán-Barcia MP, Latorre A, Drainas C, de la Cruz F. 2004. A classification scheme for mobilization regions of bacterial plasmids. FEMS Microbiol Rev 28:79-100. http://dx.doi.org/10.1016/j.femsre.2003.09.001.
19. Fernández-González E, de Paz HD, Alperi A, Agúndez L, Faustmann M, Sangari FJ, Dehio C, Llosa M. 2011. Transfer of R388 derivatives by a pathogenesis-associated type IV secretion system into both bacteria and human cells. J Bacteriol 193:6257-6265. http://dx.doi.org/10.1128/JB.05905-11.
20. Draper O, César CE, Machón C, de la Cruz F, Llosa M. 2005. Sitespecific recombinase and integrase activities of a conjugative relaxase in recipient cells. Proc Natl Acad Sci U S A 102:16385-16390. http://dx.doi.org/10.1073/pnas.0506081102.
21. Stewart FM, Levin BR. 1977. The population biology of bacterial plasmids: a priori conditions for the existence of conjugationally transmitted factors. Genetics 87:209-228.
22. Niki E, Yoshida Y, Saito Y, Noguchi N. 2005. Lipid peroxidation: mechanisms, inhibition, and biological effects. Biochem Biophys Res Commun 338:668-676. http://dx.doi.org/10.1016/j.bbrc.2005.08.072.
23. Morbidoni HR, Vilchèze C, Kremer L, Bittman R, Sacchettini JC, Jacobs WR, Jr. 2006. Dual inhibition of mycobacterial fatty acid biosynthesis and degradation by 2-alkynoic acids. Chem Biol 13:297-307. http://dx.doi.org/10.1016/j.chembiol.2006.01.005.
24. Swarts HG, Schuurmans Stekhoven FM, De Pont JJ. 1990. Binding of unsaturated fatty acids to Na+, K(+)-ATPase leading to inhibition and inactivation. Biochim Biophys Acta 1024:32-40. http://dx.doi.org/10.1016/0005-2736(90)90205-3.
25. Yung BY, Kornberg A. 1988. Membrane attachment activates dnaA protein, the initiation protein of chromosome replication in Escherichia coli. Proc Natl Acad Sci U S A 85:7202-7205. http://dx.doi.org/10.1073/ pnas.85.19.7202.
26. Mahmmoud YA, Christensen SB. 2011. Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E(2)P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump. Biochim Biophys Acta 1808:2413-2420. http://dx.doi.org/10.1016/j.bbamem.2011.06.025.
27. Haag M, Vermeulen F, Magada O, Kruger MC. 1999. Polyunsaturated fatty acids inhibit Mg2_-ATPase in basolateral membranes from rat enterocytes. Prostaglandins Leukot Essent Fatty Acids 61:25-27. http://dx.doi.org/10.1054/plef.1999.0068.
28. Cabezón E, Ripoll-Rozada J, Peña A, de la Cruz F, Arechaga I. 2015. Towards an integrated model of bacterial conjugation. FEMS Microbiol Rev 39:81-95. http://dx.doi.org/10.1111/1574-6976.12085.
29. Machon C. 2004. Ph.D. thesis. University of Cantabria, Santander, Spain.
30. Ripoll-Rozada J, Zunzunegui S, de la Cruz F, Arechaga I, Cabezón E. 2013. Functional interactions of VirB11 traffic ATPases with VirB4 and VirD4 molecular motors in type IV secretion systems. J Bacteriol 195: 4195-4201. http://dx.doi.org/10.1128/JB.00437-13.
31. Carattoli A. 2009. Resistance plasmid families in Enterobacteriaceae. Antimicrob Agents Chemother 53:2227-2238. http://dx.doi.org/10.1128/AAC.01707-08.
32. Levin BR. 1996. The evolution and maintenance of virulence in microparasites. Emerg Infect Dis 2:93-102. http://dx.doi.org/10.3201/eid0202.960203.
33. Haft RJ, Mittler JE, Traxler B. 2009. Competition favours reduced cost of plasmids to host bacteria. ISME J 3:761-769. http://dx.doi.org/10.1038/ismej.2009.22.
34. Datta N, Hedges RW. 1972. Trimethoprim resistance conferred by W plasmids in Enterobacteriaceae. J Gen Microbiol 72:349-355. http://dx.doi.org/10.1099/00221287-72-2-349.
35. Carballeira NM, Sanabria D, Cruz C, Parang K, Wan B, Franzblau S. 2006. 2,6-Hexadecadiynoic acid and 2,6-nonadecadiynoic acid: novel synthesized acetylenic fatty acids as potent antifungal agents. Lipids 41: 507-511. http://dx.doi.org/10.1007/s11745-006-5124-4.
36. Sanabria-Ríos D. 2007. Ph.D. thesis. University of Puerto Rico, San Juan, Puerto Rico.
37. Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S. 2011. MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol 28:2731-2739. http://dx.doi.org/10.1093/molbev/msr121.
38. Taylor DE, Gibreel A, Lawley TD, Tracz DM. 2004. Antibiotic resistance plasmids, p 473-491. In Funnel BE, Phillips GJ (ed), Plasmid biology. ASM Press, Washington, DC.
39. Garcillán-Barcia MP, Francia MV, de la Cruz F. 2009. The diversity of conjugative relaxases and its application in plasmid classification. FEMS Microbiol Rev 33:657-687. http://dx.doi.org/10.1111/j.1574-6976.2009.00168.x.
40. Guglielmini J, Quintais L, Garcillán-Barcia MP, de la Cruz F, Rocha EP. 2011. The repertoire of ICE in prokaryotes underscores the unity, diversity, and ubiquity of conjugation. PLoS Genet 7:e1002222. http://dx.doi.org/10.1371/journal.pgen.1002222.