The effect of siRNA-mediated lymphocyte-specific protein tyrosine kinase (Lck) inhibition on pulmonary inflammation in a mouse model of asthma

International Journal of Clinical and Experimental Medicine

Volumn 8, Issue 9, 2015, Pages 15146-15154

  Zhang, Shikui ^a   Yang, Rongjia ^a   Zheng, Yonghua ^b  

^a GANSU PROVINCIAL HOSPITAL   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

IgE; IL 4; In vivo transfection; T lymphocyte

Indexed keywords

IMMUNOGLOBULIN E; INTERLEUKIN 4; OVALBUMIN; PROTEIN KINASE LCK; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BLOOD ANALYSIS; CELL CULTURE; CELL ISOLATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENETIC TRANSFECTION; HISTOPATHOLOGY; MOUSE; NONHUMAN; PNEUMONIA; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE ACTIVATION; WESTERN BLOTTING;

EID: 84946546359     PISSN: None     EISSN: 19405901     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Fitzgerald JM, Bateman E, Hurd S, Boulet LP, Haahtela T, Cruz AA, Levy ML. The GINA Asthma Challenge: reducing asthma hospitalisations. Eur Respir J 2011; 38: 997-8.
2. Anderson GP. Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. Lancet 2008; 372: 1107-19.
3. Robinson DS. The role of the T cell in asthma. J Allergy ClinImmunol 2010; 126: 1081-91; quiz 1092-3.
4. Kemp KL, Levin SD, Bryce PJ, Stein PL. Lck mediates Th2 differentiation through effects on T-bet and GATA-3. J Immunol 2010; 184: 4178-84.
5. Robinson DS. The role of the T cell in asthma. J Allergy ClinImmunol 2010; 126: 1081-91; quiz 1092-3.
6. McRae BL, Wallace C, Dixon KF, Roux A, Mohan S, Jia Y, Presky DH, Tracey DE, Hirst GC. Suppression of CD4+ T cell activation by a novel inhibitor of Src family kinases. IntImmunopharmacol 2005; 5: 667-77.
7. Shin IS, Shin NR, Jeon CM, Kwon OK, Sohn KY, Lee TS, Kim JW, Ahn KS, Oh SR. EC-18, a synthetic monoacetyldiglyceride (1-palmitoyl-2-linoleoyl-3-acetylglycerol), attenuates the asthmatic response in an aluminum hydroxide/ovalbumin-induced model of asthma. IntImmunopharmacol 2014; 18: 116-23.
8. Finiasz M, Otero C, Bezrodnik L, Fink S. The role of cytokines in atopic asthma. Curr Med Chem 2011; 18: 1476-87.
9. Davis SJ, van der Merwe PA. Lck and the nature of the T cell receptor trigger. Trends Immunol 2011; 32: 1-5.
10. Shalaby KH, Martin JG. Overview of asthma; the place of the T cell. Curr Opin Pharmacol 2010; 10: 218-25.
11. Nika K, Soldani C, Salek M, Paster W, Gray A, Etzensperger R, Fugger L, Polzella P, Cerundolo V, Dushek O, Höfer T, Viola A, Acuto O. Constitutively active Lck kinase in T cells drives antigen receptor signal transduction. Immunity 2010; 32: 766-77.
12. Stephen TL, Wilson BS, Laufer TM. Subcellular distribution of Lck during CD4 T-cell maturation in the thymic medulla regulates the T-cell activation threshold. Proc Natl Acad Sci U S A 2012; 109: 7415-20.
13. Kittipatarin C, Tschammer N, Khaled AR. The interaction of LCK and the CD4 co-receptor alters the dose response of T-cells to interleukin-7. Immunol Lett 2010; 131: 170-81.
14. Mahon RN, Sande OJ, Rojas RE, Levine AD, Harding CV, Boom WH. Mycobacterium tuberculosis ManLAM inhibits T-cell-receptor signaling by interference with ZAP-70, Lck and LAT phosphorylation. Cell Immunol 2012; 275: 98-105.
15. Boldizsar F, Szabo M, Kvell K, Czompoly T, Talaber G, Bjorkan J, Bartis D, Nemeth P, Berki T. ZAP-70 tyrosines 315 and 492 transmit nongenomic glucocorticoid (GC) effects in T cells. MolImmunol 2013; 53: 111-7.
16. Ramakrishna L, de Vries VC, deLafaille MA C. Cross-roads in the lung: immune cells and tissue interactions as determinants of allergic asthma. Immunol Res 2012; 53: 213-28.