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Bioorganic and Medicinal Chemistry

Volumn 23, Issue 17, 2015, Pages 5483-5488

Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1

(2) Lazarus, Michael B a Shokat, Kevan M a

a UNIVERSITY OF CALIFORNIA (United States)

Author keywords

Autophagy; Inhibitor; Kinase; Structure

Indexed keywords

BX 795; MRT 67307; N [3 [[4 [(3 AMINOPROPYL)AMINO] 5 IODOPYRIMIDIN 2 YL]AMINO]PHENYL]PYRROLIDINE 1 CARBOXAMIDE; N [3 [[4 [[3 (CYCLOPROPANECARBOXAMIDO)PROPYL]AMINO]5 IODOPYRIMIDIN 2 YL]AMINO]PHENYL]PYRROLIDINE 1 CARBOXAMIDE; NEW DRUG; PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; ULK1 INHIBITOR; ULK1 PROTEIN; UNCLASSIFIED DRUG; PROTEIN SERINE THREONINE KINASE; SERINE THREONINE PROTEIN KINASE ULK1; SIGNAL PEPTIDE; ULK1 PROTEIN, HUMAN;

ARTICLE; AUTOPHAGY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME BINDING; CHEMICAL STRUCTURE; GENETICS; HUMAN; METABOLISM;

AUTOPHAGY; AUTOPHAGY-RELATED PROTEIN-1 HOMOLOG; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MOLECULAR STRUCTURE; PROTEIN-SERINE-THREONINE KINASES;

EID: 84946500909 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2015.07.034 Document Type: Article

Times cited : (54)

References (34)

1
- 81055144784
- N. Mizushima, and M. Komatsu Cell 147 2011 728
- (2011) Cell , vol.147 , pp. 728
- Mizushima, N.¹ Komatsu, M.²

2
- 79952229430
- S. Yang, X. Wang, G. Contino, M. Liesa, E. Sahin, H. Ying, A. Bause, Y. Li, J.M. Stommel, G. Dell'antonio, J. Mautner, G. Tonon, M. Haigis, O.S. Shirihai, C. Doglioni, N. Bardeesy, and A.C. Kimmelman Genes Dev. 25 2011 717
- (2011) Genes Dev. , vol.25 , pp. 717
- Yang, S.¹ Wang, X.² Contino, G.³ Liesa, M.⁴ Sahin, E.⁵ Ying, H.⁶ Bause, A.⁷ Li, Y.⁸ Stommel, J.M.⁹ Dell'Antonio, G.¹⁰ Mautner, J.¹¹ Tonon, G.¹² Haigis, M.¹³ Shirihai, O.S.¹⁴ Doglioni, C.¹⁵ Bardeesy, N.¹⁶ Kimmelman, A.C.¹⁷

3
- 36448943299
- R. Mathew, V. Karantza-Wadsworth, and E. White Nat. Rev. Cancer 7 2007 961
- (2007) Nat. Rev. Cancer , vol.7 , pp. 961
- Mathew, R.¹ Karantza-Wadsworth, V.² White, E.³

4
- 84920463916
- X. Jiang, M. Overholtzer, and C.B. Thompson J. Clin. Invest. 125 2015 47
- (2015) J. Clin. Invest. , vol.125 , pp. 47
- Jiang, X.¹ Overholtzer, M.² Thompson, C.B.³

5
- 84866122688
- D.C. Rubinsztein, P. Codogno, and B. Levine Nat. Rev. Drug Discovery 11 2012 709
- (2012) Nat. Rev. Drug Discovery , vol.11 , pp. 709
- Rubinsztein, D.C.¹ Codogno, P.² Levine, B.³

6
- 35848947032
- V. Karantza-Wadsworth, and E. White Autophagy 3 2007 610
- (2007) Autophagy , vol.3 , pp. 610
- Karantza-Wadsworth, V.¹ White, E.²

7
- 39849109338
- N. Mizushima, B. Levine, A.M. Cuervo, and D.J. Klionsky Nature 451 2008 1069
- (2008) Nature , vol.451 , pp. 1069
- Mizushima, N.¹ Levine, B.² Cuervo, A.M.³ Klionsky, D.J.⁴

8
- 79251587803
- D.F. Egan, D.B. Shackelford, M.M. Mihaylova, S. Gelino, R.A. Kohnz, W. Mair, D.S. Vasquez, A. Joshi, D.M. Gwinn, R. Taylor, J.M. Asara, J. Fitzpatrick, A. Dillin, B. Viollet, M. Kundu, M. Hansen, and R.J. Shaw Science 331 2011 456
- (2011) Science , vol.331 , pp. 456
- Egan, D.F.¹ Shackelford, D.B.² Mihaylova, M.M.³ Gelino, S.⁴ Kohnz, R.A.⁵ Mair, W.⁶ Vasquez, D.S.⁷ Joshi, A.⁸ Gwinn, D.M.⁹ Taylor, R.¹⁰ Asara, J.M.¹¹ Fitzpatrick, J.¹² Dillin, A.¹³ Viollet, B.¹⁴ Kundu, M.¹⁵ Hansen, M.¹⁶ Shaw, R.J.¹⁷

9
- 79551598347
- J. Kim, M. Kundu, B. Viollet, and K.L. Guan Nat. Cell Biol. 13 2011 132
- (2011) Nat. Cell Biol. , vol.13 , pp. 132
- Kim, J.¹ Kundu, M.² Viollet, B.³ Guan, K.L.⁴

10
- 66449083078
- I.G. Ganley, H. Lam du, J. Wang, X. Ding, S. Chen, and X. Jiang J. Biol. Chem. 284 2009 12297
- (2009) J. Biol. Chem. , vol.284 , pp. 12297
- Ganley, I.G.¹ Lam Du, H.² Wang, J.³ Ding, X.⁴ Chen, S.⁵ Jiang, X.⁶

11
- 34548482499
- E.Y. Chan, S. Kir, and S.A. Tooze J. Biol. Chem. 282 2007 25464
- (2007) J. Biol. Chem. , vol.282 , pp. 25464
- Chan, E.Y.¹ Kir, S.² Tooze, S.A.³

12
- 84873675067
- P.M. Wong, C. Puente, I.G. Ganley, and X. Jiang Autophagy 9 2013 124
- (2013) Autophagy , vol.9 , pp. 124
- Wong, P.M.¹ Puente, C.² Ganley, I.G.³ Jiang, X.⁴

13
- 80054025654
- N. Mizushima, T. Yoshimori, and Y. Ohsumi Annu. Rev. Cell Dev. Biol. 27 2011 107
- (2011) Annu. Rev. Cell Dev. Biol. , vol.27 , pp. 107
- Mizushima, N.¹ Yoshimori, T.² Ohsumi, Y.³

14
- 84901986623
- Y. Fujioka, S.W. Suzuki, H. Yamamoto, C. Kondo-Kakuta, Y. Kimura, H. Hirano, R. Akada, F. Inagaki, Y. Ohsumi, and N.N. Noda Nat. Struct. Mol. Biol. 21 2014 513
- (2014) Nat. Struct. Mol. Biol. , vol.21 , pp. 513
- Fujioka, Y.¹ Suzuki, S.W.² Yamamoto, H.³ Kondo-Kakuta, C.⁴ Kimura, Y.⁵ Hirano, H.⁶ Akada, R.⁷ Inagaki, F.⁸ Ohsumi, Y.⁹ Noda, N.N.¹⁰

15
- 0028800171
- T.M. Harding, K.A. Morano, S.V. Scott, and D.J. Klionsky J. Cell Biol. 131 1995 591
- (1995) J. Cell Biol. , vol.131 , pp. 591
- Harding, T.M.¹ Morano, K.A.² Scott, S.V.³ Klionsky, D.J.⁴

16
- 84930188743
- J. Kofinger, M.J. Ragusa, I.H. Lee, G. Hummer, and J.H. Hurley Structure 23 2015 809
- (2015) Structure , vol.23 , pp. 809
- Kofinger, J.¹ Ragusa, M.J.² Lee, I.H.³ Hummer, G.⁴ Hurley, J.H.⁵

17
- 84907228043
- G. Stjepanovic, C.W. Davies, R.E. Stanley, M.J. Ragusa, J. Kim do, and J.H. Hurley Proc. Natl. Acad. Sci. U.S.A. 111 2014 12793
- (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. 12793
- Stjepanovic, G.¹ Davies, C.W.² Stanley, R.E.³ Ragusa, M.J.⁴ Kim Do, J.⁵ Hurley, J.H.⁶

18
- 84905706340
- H. Maes, A. Kuchnio, A. Peric, S. Moens, K. Nys, K. De Bock, A. Quaegebeur, S. Schoors, M. Georgiadou, J. Wouters, S. Vinckier, H. Vankelecom, M. Garmyn, A.C. Vion, F. Radtke, C. Boulanger, H. Gerhardt, E. Dejana, M. Dewerchin, B. Ghesquiere, W. Annaert, P. Agostinis, and P. Carmeliet Cancer Cell 26 2014 190
- (2014) Cancer Cell , vol.26 , pp. 190
- Maes, H.¹ Kuchnio, A.² Peric, A.³ Moens, S.⁴ Nys, K.⁵ De Bock, K.⁶ Quaegebeur, A.⁷ Schoors, S.⁸ Georgiadou, M.⁹ Wouters, J.¹⁰ Vinckier, S.¹¹ Vankelecom, H.¹² Garmyn, M.¹³ Vion, A.C.¹⁴ Radtke, F.¹⁵ Boulanger, C.¹⁶ Gerhardt, H.¹⁷ Dejana, E.¹⁸ Dewerchin, M.¹⁹ Ghesquiere, B.²⁰ more..

19
- 0032512636
- T. Noda, and Y. Ohsumi J. Biol. Chem. 273 1998 3963
- (1998) J. Biol. Chem. , vol.273 , pp. 3963
- Noda, T.¹ Ohsumi, Y.²

20
- 78149475478
- Q.W. Fan, C. Cheng, C. Hackett, M. Feldman, B.T. Houseman, T. Nicolaides, D. Haas-Kogan, C.D. James, S.A. Oakes, J. Debnath, K.M. Shokat, and W.A. Weiss Sci. Signal. 3 2010 ra81
- (2010) Sci. Signal. , vol.3 , pp. ra81
- Fan, Q.W.¹ Cheng, C.² Hackett, C.³ Feldman, M.⁴ Houseman, B.T.⁵ Nicolaides, T.⁶ Haas-Kogan, D.⁷ James, C.D.⁸ Oakes, S.A.⁹ Debnath, J.¹⁰ Shokat, K.M.¹¹ Weiss, W.A.¹²

21
- 84907966806
- L. Yu, C. Gu, D. Zhong, L. Shi, Y. Kong, Z. Zhou, and S. Liu Cancer Lett. 355 2014 34
- (2014) Cancer Lett. , vol.355 , pp. 34
- Yu, L.¹ Gu, C.² Zhong, D.³ Shi, L.⁴ Kong, Y.⁵ Zhou, Z.⁶ Liu, S.⁷

22
- 84921417671
- M.B. Lazarus, C.J. Novotny, and K.M. Shokat ACS Chem. Biol. 10 2015 257
- (2015) ACS Chem. Biol. , vol.10 , pp. 257
- Lazarus, M.B.¹ Novotny, C.J.² Shokat, K.M.³

23
- 21244435590
- R.I. Feldman, J.M. Wu, M.A. Polokoff, M.J. Kochanny, H. Dinter, D. Zhu, S.L. Biroc, B. Alicke, J. Bryant, S. Yuan, B.O. Buckman, D. Lentz, M. Ferrer, M. Whitlow, M. Adler, S. Finster, Z. Chang, and D.O. Arnaiz J. Biol. Chem. 280 2005 19867
- (2005) J. Biol. Chem. , vol.280 , pp. 19867
- Feldman, R.I.¹ Wu, J.M.² Polokoff, M.A.³ Kochanny, M.J.⁴ Dinter, H.⁵ Zhu, D.⁶ Biroc, S.L.⁷ Alicke, B.⁸ Bryant, J.⁹ Yuan, S.¹⁰ Buckman, B.O.¹¹ Lentz, D.¹² Ferrer, M.¹³ Whitlow, M.¹⁴ Adler, M.¹⁵ Finster, S.¹⁶ Chang, Z.¹⁷ Arnaiz, D.O.¹⁸

24
- 67649823926
- K. Clark, L. Plater, M. Peggie, and P. Cohen J. Biol. Chem. 284 2009 14136
- (2009) J. Biol. Chem. , vol.284 , pp. 14136
- Clark, K.¹ Plater, L.² Peggie, M.³ Cohen, P.⁴

25
- 84862233012
- X. Ma, E. Helgason, Q.T. Phung, C.L. Quan, R.S. Iyer, M.W. Lee, K.K. Bowman, M.A. Starovasnik, and E.C. Dueber Proc. Natl. Acad. Sci. U.S.A. 109 2012 9378
- (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 9378
- Ma, X.¹ Helgason, E.² Phung, Q.T.³ Quan, C.L.⁴ Iyer, R.S.⁵ Lee, M.W.⁶ Bowman, K.K.⁷ Starovasnik, M.A.⁸ Dueber, E.C.⁹

26
- 84928806944
- K.J. Petherick, O.J. Conway, C. Mpamhanga, S.A. Osborne, A. Kamal, B. Saxty, and I.G. Ganley J. Biol. Chem. 290 2015 11376
- (2015) J. Biol. Chem. , vol.290 , pp. 11376
- Petherick, K.J.¹ Conway, O.J.² Mpamhanga, C.³ Osborne, S.A.⁴ Kamal, A.⁵ Saxty, B.⁶ Ganley, I.G.⁷

27
- 0034329418
- Y. Kabeya, N. Mizushima, T. Ueno, A. Yamamoto, T. Kirisako, T. Noda, E. Kominami, Y. Ohsumi, and T. Yoshimori EMBO J. 19 2000 5720
- (2000) EMBO J. , vol.19 , pp. 5720
- Kabeya, Y.¹ Mizushima, N.² Ueno, T.³ Yamamoto, A.⁴ Kirisako, T.⁵ Noda, T.⁶ Kominami, E.⁷ Ohsumi, Y.⁸ Yoshimori, T.⁹

28
- 45049087900
- T. Tamguney, C. Zhang, D. Fiedler, K. Shokat, and D. Stokoe Exp. Cell Res. 314 2008 2299
- (2008) Exp. Cell Res. , vol.314 , pp. 2299
- Tamguney, T.¹ Zhang, C.² Fiedler, D.³ Shokat, K.⁴ Stokoe, D.⁵

29
- 70349597601
- N.W. Moriarty, R.W. Grosse-Kunstleve, and P.D. Adams Biol. Crystallogr. 65 2009 1074
- (2009) Biol. Crystallogr. , vol.65 , pp. 1074
- Moriarty, N.W.¹ Grosse-Kunstleve, R.W.² Adams, P.D.³

30
- 65349129758
- T.C. Terwilliger, R.W. Grosse-Kunstleve, P.V. Afonine, N.W. Moriarty, P.H. Zwart, L.W. Hung, R.J. Read, and P.D. Adams Biol. Crystallogr. 64 2008 61
- (2008) Biol. Crystallogr. , vol.64 , pp. 61
- Terwilliger, T.C.¹ Grosse-Kunstleve, R.W.² Afonine, P.V.³ Moriarty, N.W.⁴ Zwart, P.H.⁵ Hung, L.W.⁶ Read, R.J.⁷ Adams, P.D.⁸

31
- 23844520061
- J. Painter, and E.A. Merritt Biol. Crystallogr. 61 2005 465
- (2005) Biol. Crystallogr. , vol.61 , pp. 465
- Painter, J.¹ Merritt, E.A.²

32
- 33646260450
- J. Painter, and E.A. Merritt Biol. Crystallogr. 62 2006 439
- (2006) Biol. Crystallogr. , vol.62 , pp. 439
- Painter, J.¹ Merritt, E.A.²

33
- 77949535720
- P. Emsley, B. Lohkamp, W.G. Scott, and K. Cowtan Biol. Crystallogr. 66 2010 486
- (2010) Biol. Crystallogr. , vol.66 , pp. 486
- Emsley, P.¹ Lohkamp, B.² Scott, W.G.³ Cowtan, K.⁴

34
- 78449264099
- Schrodinger, LLC, The PyMOL Molecular Graphics System, 2010.
- (2010) The PyMOL Molecular Graphics System
- Schrodinger, L.L.C.¹

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