Galantamine derivatives with indole moiety: Docking, design, synthesis and acetylcholinesterase inhibitory activity

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 17, 2015, Pages 5382-5389

  Atanasova, Mariyana ^a   Stavrakov, Georgi ^a   Philipova, Irena ^b   Zheleva, Dimitrina ^a   Yordanov, Nikola ^a   Doytchinova, Irini ^a  

^a MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

^b INSTITUTE OF ORGANIC CHEMISTRY   (Bulgaria)

Author keywords

Acetylcholinesterase inhibitors; Amyloid beta peptide; Galantamine; GoldScore; Indole; Molecular docking

Indexed keywords

11 [6 (1H INDOL 5 YLOXY)HEXYL] 3 METHOXY 5,6,9,10,11,12 HEXA HYDRO 4AH BENZO[2,3]BENZOFURO[4,3 CD]AZEPIN 6 OL; 11 [6 [4 [(1H INDOL 5 YLAMINO)METHYL]PHENOXY]HEXYL] 3 METHOXY 5,6,9,10,11,12 HEXAHYDRO 4AH BENZO[2,3]BENZOFURO[4,3 CD]AZEPIN 6 OL; ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN; CHOLINESTERASE INHIBITOR; GALANTAMINE; GALANTAMINE DERIVATIVE; INDOLE DERIVATIVE; METHYL 3 (1H INDOL 3 YL) 2 [6 (6 HYDROXY 3 METHOXY 5,6,9,10 TETRAHYDRO 4AH BENZO[2,3]BENZOFURO[4,3 CD]AZEPIN 11(12H)YL)HEXANAMIDO]PROPANOATE; N (1H INDOL 5 YL) 6 (6 HYDROXY 3 METHOXY 5,6,9,10 TETRAHYDRO 4AH BENZO[2,3] BENZOFURO[4,3 CD]AZEPIN 11(12H) YL)HEXANAMIDE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; INDOLE;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; IC50; MOLECULAR DOCKING; PREDICTION; PROTEIN LOCALIZATION; ALZHEIMER DISEASE; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CHEMISTRY; ENZYMOLOGY; HUMAN; LILIACEAE; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; CHOLINESTERASE INHIBITORS; DRUG DESIGN; GALANTAMINE; HUMANS; INDOLES; LILIACEAE; MOLECULAR DOCKING SIMULATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84946496608     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.07.058     Document Type: Article

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