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Volumn 21, Issue 6, 1996, Pages 621-635

Galanthamine derivatives for the treatment of Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINESTERASE; GALANTAMINE;

EID: 0029920219     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (52)

References (57)
  • 1
    • 0002173709 scopus 로고
    • Galanthamine in Alzheimer's disease
    • Giacobini E., Becker, R. (Eds.). Birkäuser: Boston
    • Kewitz, H., Wilcock, G., Davis, B. Galanthamine in Alzheimer's disease. In: Alzheimer Disease: Therapeutic Strategies. Giacobini E., Becker, R. (Eds.). Birkäuser: Boston 1994, 140-4.
    • (1994) Alzheimer Disease: Therapeutic Strategies , pp. 140-144
    • Kewitz, H.1    Wilcock, G.2    Davis, B.3
  • 2
    • 0025280479 scopus 로고
    • Galanthamine hydrobromide in a long-term treatment of Alzheimer's disease
    • Thomsen, T., Bickel, U., Fischer, J.P., Kewitz, H. Galanthamine hydrobromide in a long-term treatment of Alzheimer's disease. Dementia 1990, 1: 46-51.
    • (1990) Dementia , vol.1 , pp. 46-51
    • Thomsen, T.1    Bickel, U.2    Fischer, J.P.3    Kewitz, H.4
  • 3
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • Bartus, R.T., Dean, R.L., Beer, B., Lippa, A.S. The cholinergic hypothesis of geriatric memory dysfunction. Science 1982, 217: 408-17.
    • (1982) Science , vol.217 , pp. 408-417
    • Bartus, R.T.1    Dean, R.L.2    Beer, B.3    Lippa, A.S.4
  • 4
    • 0020686674 scopus 로고
    • Alzheimer's disease: A disorder of cortical cholinergic innervation
    • Coyle, J.T. Price, D.L., Delong, M.R. Alzheimer's disease: A disorder of cortical cholinergic innervation. Science 1983, 219: 1184-90.
    • (1983) Science , vol.219 , pp. 1184-1190
    • Coyle, J.T.1    Price, D.L.2    Delong, M.R.3
  • 5
    • 0019410162 scopus 로고
    • Alzheimer's disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis
    • Whitehouse, P.J., Price, D.L., Clark, A.W., Coyle, J.T., Delong, M.R. Alzheimer's disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis. Ann Neurol 1981, 10: 122.
    • (1981) Ann Neurol , vol.10 , pp. 122
    • Whitehouse, P.J.1    Price, D.L.2    Clark, A.W.3    Coyle, J.T.4    Delong, M.R.5
  • 7
    • 0023899578 scopus 로고
    • Mechanisms of ChE inhibition in senile dementia of the Alzheimer type: Clinical, pharmacological, and therapeutic aspects
    • Becker, R.E., Giacobini, E. Mechanisms of ChE inhibition in senile dementia of the Alzheimer type: Clinical, pharmacological, and therapeutic aspects. Drug Dev Res 1988, 12: 163-95.
    • (1988) Drug Dev Res , vol.12 , pp. 163-195
    • Becker, R.E.1    Giacobini, E.2
  • 8
    • 0024992639 scopus 로고
    • Present state and future development of the therapy of Alzheimer disease
    • Pomponi, M., Giacobini, E., Brufani, M. Present state and future development of the therapy of Alzheimer disease. Aging 1990, 2: 125-53.
    • (1990) Aging , vol.2 , pp. 125-153
    • Pomponi, M.1    Giacobini, E.2    Brufani, M.3
  • 9
    • 0026756286 scopus 로고
    • A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease
    • Davis, K.L., Thal, L.J., Gamzu, E.R. et al. A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease. New Engl J Med 1992, 327: 1253-9.
    • (1992) New Engl J Med , vol.327 , pp. 1253-1259
    • Davis, K.L.1    Thal, L.J.2    Gamzu, E.R.3
  • 11
    • 0001047396 scopus 로고
    • Alkaloids of Galanthus woronovi. II. Isolation of a new alkaloid
    • Proskurnina, N.F., Yakovleva, A.P. Alkaloids of Galanthus woronovi. II. Isolation of a new alkaloid. Zh Obshch Khim 1952, 22: 1899.
    • (1952) Zh Obshch Khim , vol.22 , pp. 1899
    • Proskurnina, N.F.1    Yakovleva, A.P.2
  • 12
    • 8944221265 scopus 로고
    • Lycoris alkaloids. XXIV. Isolation and characterization of lycoremine
    • Uyeo, S., Kobayashi, S. Lycoris alkaloids. XXIV. Isolation and characterization of lycoremine. Pharm Bull 1953, 1: 139.
    • (1953) Pharm Bull , vol.1 , pp. 139
    • Uyeo, S.1    Kobayashi, S.2
  • 13
    • 0004816232 scopus 로고
    • Structure of galanthamine and lycoramine
    • Kobayashi, S., Shingu, T., Uyeo, S. Structure of galanthamine and lycoramine. Chem Ind 1956, 177.
    • (1956) Chem Ind , pp. 177
    • Kobayashi, S.1    Shingu, T.2    Uyeo, S.3
  • 14
    • 8944252876 scopus 로고
    • The activity of galanthamine and related compounds on muscle
    • Irwin, R.L., Smith, H.J. The activity of galanthamine and related compounds on muscle. Arch Int Pharmacodyn 1960, 127: 314.
    • (1960) Arch Int Pharmacodyn , vol.127 , pp. 314
    • Irwin, R.L.1    Smith, H.J.2
  • 15
    • 0017102448 scopus 로고
    • Molecular mechanism of action of galanthamine, a curare antagonist
    • Schuh, F.T. Molecular mechanism of action of galanthamine, a curare antagonist. Anaesthetist 1976, 25: 444-8.
    • (1976) Anaesthetist , vol.25 , pp. 444-448
    • Schuh, F.T.1
  • 16
    • 0024331940 scopus 로고
    • Galanthamine, an acetylChE inhibitor: A time course of the effects on performance and neurochemical parameters in mice
    • Sweeney, J.E., Puttfarcken, P.S., Coyle, J.T. Galanthamine, an acetylChE inhibitor: A time course of the effects on performance and neurochemical parameters in mice. Pharmacol Biochem Behav 1989, 34: 129-37.
    • (1989) Pharmacol Biochem Behav , vol.34 , pp. 129-137
    • Sweeney, J.E.1    Puttfarcken, P.S.2    Coyle, J.T.3
  • 17
    • 0007836439 scopus 로고
    • Comparison of acetyl- and butyrylChE inhibition as due to reversible enzyme inhibitors
    • Thomsen, T., Kewitz, H. Comparison of acetyl- and butyrylChE inhibition as due to reversible enzyme inhibitors. Clin Biochem 1989, 22: 411.
    • (1989) Clin Biochem , vol.22 , pp. 411
    • Thomsen, T.1    Kewitz, H.2
  • 18
    • 0026086023 scopus 로고
    • In vitro effects of various ChE inhibitors on acetyl- and butyrylChE of healthy volunteers
    • Thomsen, T., Zendeh, B., Fischer, J.P., Kewitz, H. In vitro effects of various ChE inhibitors on acetyl- and butyrylChE of healthy volunteers. Biochem Pharmacol 1991, 41: 139-41.
    • (1991) Biochem Pharmacol , vol.41 , pp. 139-141
    • Thomsen, T.1    Zendeh, B.2    Fischer, J.P.3    Kewitz, H.4
  • 19
    • 0008080162 scopus 로고
    • A novel medication for the treatment of myasthenia gravis and muscular dystrophy: Nivalin®
    • Pestel, M. A novel medication for the treatment of myasthenia gravis and muscular dystrophy: Nivalin®. Nouv Presse Med 1961, 69: 182.
    • (1961) Nouv Presse Med , vol.69 , pp. 182
    • Pestel, M.1
  • 20
    • 0025953079 scopus 로고
    • Pharmacokinetics of galanthamine in humans and corresponding ChE inhibition
    • Bickel, U., Thomsen, T., Weber, W. et al. Pharmacokinetics of galanthamine in humans and corresponding ChE inhibition. Clin Pharmacol Ther 1991, 50: 420-8.
    • (1991) Clin Pharmacol Ther , vol.50 , pp. 420-428
    • Bickel, U.1    Thomsen, T.2    Weber, W.3
  • 21
    • 0024372802 scopus 로고
    • Pharmacokinetics of galanthamine hydrobromide after single subcutaneous and oral dosage in humans
    • Mihailova, D., Yamboliev, I., Zhivkova, Z., Tencheva, J., Jovovich, V. Pharmacokinetics of galanthamine hydrobromide after single subcutaneous and oral dosage in humans. Pharmacology 1989, 39: 50-8.
    • (1989) Pharmacology , vol.39 , pp. 50-58
    • Mihailova, D.1    Yamboliev, I.2    Zhivkova, Z.3    Tencheva, J.4    Jovovich, V.5
  • 22
    • 0000730810 scopus 로고
    • Galanthamine hydrobromide in the treatment of senile dementia of Alzheimer's type
    • Kewitz, H., Bickel, U. (Eds.). W Zuckschwerdt Verlag: München
    • Rainer, M., Mark, T., Haushofer, A. Galanthamine hydrobromide in the treatment of senile dementia of Alzheimer's type. In: Pharmacological Interventions on Central Cholinergic Mechanisms in Senile Dementia. Kewitz, H., Bickel, U. (Eds.). W Zuckschwerdt Verlag: München 1989, 233-7.
    • (1989) Pharmacological Interventions on Central Cholinergic Mechanisms in Senile Dementia , pp. 233-237
    • Rainer, M.1    Mark, T.2    Haushofer, A.3
  • 23
    • 0013947161 scopus 로고
    • Galanthamine chemistry, VII. Synthesis of analogues of galanthamine
    • Uyeo, S., Shirai, H., Koshiro, A., Yashiro, T., Kagei, K. Galanthamine chemistry, VII. Synthesis of analogues of galanthamine. Chem Pharm Bull 1966, 14: 1033-9.
    • (1966) Chem Pharm Bull , vol.14 , pp. 1033-1039
    • Uyeo, S.1    Shirai, H.2    Koshiro, A.3    Yashiro, T.4    Kagei, K.5
  • 24
    • 8944255685 scopus 로고    scopus 로고
    • Sticht Biomedical Research. New 6-demethylgalanthamine derivatives useful as antiChE agents. NL 8800350-A
    • Sticht Biomedical Research. New 6-demethylgalanthamine derivatives useful as antiChE agents. NL 8800350-A.
  • 25
    • 0026472718 scopus 로고
    • Chemical and pharmacological characterization of galanthamine, an acetylChE inhibitor, and its derivatives. A potential application in Alzheimer's disease
    • Han, S.Y., Sweeney, J.E., Bachman, E.S. et al. Chemical and pharmacological characterization of galanthamine, an acetylChE inhibitor, and its derivatives. A potential application in Alzheimer's disease. Eur J Med Chem 1992, 27: 673-87.
    • (1992) Eur J Med Chem , vol.27 , pp. 673-687
    • Han, S.Y.1    Sweeney, J.E.2    Bachman, E.S.3
  • 26
    • 8944225570 scopus 로고    scopus 로고
    • A convenient, high yield procedure for the O-demethylation of galanthamine
    • in press
    • Kosley, R.W. Jr., Rauckman, B.S., Wolf, V., Wong, G. A convenient, high yield procedure for the O-demethylation of galanthamine. J Org Chem, in press.
    • J Org Chem
    • Kosley Jr., R.W.1    Rauckman, B.S.2    Wolf, V.3    Wong, G.4
  • 27
    • 0028024493 scopus 로고
    • Asymmetric transformations of either enantiomer of narwedine via total spontaneous resolution process, a concise solution to the synthesis of galanthamine
    • Shieh, W-C., Carlson, J. Asymmetric transformations of either enantiomer of narwedine via total spontaneous resolution process, a concise solution to the synthesis of galanthamine. J Org Chem 1994, 59: 5463-5.
    • (1994) J Org Chem , vol.59 , pp. 5463-5465
    • Shieh, W.-C.1    Carlson, J.2
  • 28
    • 37049065522 scopus 로고
    • Phenol oxidation and biosynthesis. Part V. The synthesis of galanthamine
    • Barton, D.H.R., Kirby, G. Phenol oxidation and biosynthesis. Part V. The synthesis of galanthamine. J Chem Soc 1962, 806.
    • (1962) J Chem Soc , pp. 806
    • Barton, D.H.R.1    Kirby, G.2
  • 29
    • 0001418316 scopus 로고
    • Studies on the synthesis of heterocyclic compounds. CCCXCVI. An alternative total synthesis of (±)-galanthamine
    • Kametani, T., Shishido, K., Hayashi, E. et al. Studies on the synthesis of heterocyclic compounds. CCCXCVI. An alternative total synthesis of (±)-galanthamine. J Org Chem 1971, 36: 1295.
    • (1971) J Org Chem , vol.36 , pp. 1295
    • Kametani, T.1    Shishido, K.2    Hayashi, E.3
  • 30
    • 0001617383 scopus 로고
    • A biogenetic-type asymmetric synthesis of optically active amaryllidaceae alkaloids: (+)- and (-)-galanthamine from L-tyrosine
    • Shimizu, K., Tomioka, K., Yamada, S., Koga, K. A biogenetic-type asymmetric synthesis of optically active amaryllidaceae alkaloids: (+)- and (-)-galanthamine from L-tyrosine. Heterocycles 1977, 8: 277.
    • (1977) Heterocycles , vol.8 , pp. 277
    • Shimizu, K.1    Tomioka, K.2    Yamada, S.3    Koga, K.4
  • 32
    • 0001666469 scopus 로고
    • Synthesis of galanthamine and related alkaloids - New approaches. I
    • Vlahov, R., Krikorian, D., Spassov, G. et al. Synthesis of galanthamine and related alkaloids - New approaches. I. Tetrahedron 1989, 45: 3329.
    • (1989) Tetrahedron , vol.45 , pp. 3329
    • Vlahov, R.1    Krikorian, D.2    Spassov, G.3
  • 33
    • 0001094404 scopus 로고
    • Palladium-mediatedbiomimetic synthesis of narwedine
    • Holton, R., Sibi, M., Murphy, W. Palladium-mediatedbiomimetic synthesis of narwedine. J Amer Chem Soc 1988, 110: 314.
    • (1988) J Amer Chem Soc , vol.110 , pp. 314
    • Holton, R.1    Sibi, M.2    Murphy, W.3
  • 34
    • 8944225084 scopus 로고    scopus 로고
    • Production of new or known galanthamine compounds from benzaldehyde and phenethylamine derivatives. WO 383279/50
    • Czollner, L., Froehlich, J., Jordis, U., Kueenburg, B. Production of new or known galanthamine compounds from benzaldehyde and phenethylamine derivatives. WO 383279/50.
    • Czollner, L.1    Froehlich, J.2    Jordis, U.3    Kueenburg, B.4
  • 36
    • 12644273785 scopus 로고    scopus 로고
    • Pharmacological evaluation of novel Alzheimer disease therapeutics: AcetylChE inhibitors related to galanthamine
    • Bores, G.M., Huger, F.P., Petko, W. et al. Pharmacological evaluation of novel Alzheimer disease therapeutics: AcetylChE inhibitors related to galanthamine. JPET 1996, 277: 728-38.
    • (1996) JPET , vol.277 , pp. 728-738
    • Bores, G.M.1    Huger, F.P.2    Petko, W.3
  • 37
    • 8944262905 scopus 로고
    • Galanthamine derivatives as agents for the treatment of Alzheimer's disease
    • Abst MEDI 91
    • Davis, L., Fink, D., Rauckman, B. et al. Galanthamine derivatives as agents for the treatment of Alzheimer's disease. 209th ACS Natl Meet 1995, Abst MEDI 91.
    • (1995) 209th ACS Natl Meet
    • Davis, L.1    Fink, D.2    Rauckman, B.3
  • 39
    • 0025339542 scopus 로고
    • Selective inhibition of human acetylChE by galanthamine in vitro and in vivo
    • Thomsen, T., Kewitz, H. Selective inhibition of human acetylChE by galanthamine in vitro and in vivo. Life Sci 1990, 46: 1553-8.
    • (1990) Life Sci , vol.46 , pp. 1553-1558
    • Thomsen, T.1    Kewitz, H.2
  • 40
    • 0023755529 scopus 로고
    • Estimation of ChE activity (EC3.1.1.7;3.1.1.8) in undiluted plasma and erythrocytes as a tool for measuring in vivo effects of reversible inhibitors
    • Thomsen, T., Kewitz, H., Pleul, O. Estimation of ChE activity (EC3.1.1.7;3.1.1.8) in undiluted plasma and erythrocytes as a tool for measuring in vivo effects of reversible inhibitors. J Clin Chem Clin Biochem 1988, 26: 469-75.
    • (1988) J Clin Chem Clin Biochem , vol.26 , pp. 469-475
    • Thomsen, T.1    Kewitz, H.2    Pleul, O.3
  • 41
    • 47249137703 scopus 로고
    • Comparative study of some pharmacological properties of epigalanthamine and galanthamine
    • Zakirov, U., Umarova, S. Comparative study of some pharmacological properties of epigalanthamine and galanthamine. Farmakol Alkaloidov Serdech Glikozidov 1971, 96-100.
    • (1971) Farmakol Alkaloidov Serdech Glikozidov , pp. 96-100
    • Zakirov, U.1    Umarova, S.2
  • 42
    • 8944255236 scopus 로고
    • HP 290: A potent, orally active ChE inhibitor for the treatment of Alzheimer's disease
    • Abst 274.3
    • Bores, G.M., Huger, F.P., Usu, R.S. et al. HP 290: A potent, orally active ChE inhibitor for the treatment of Alzheimer's disease. 21st Soc Neurosci Meet 1991, 17: Abst 274.3.
    • (1991) 21st Soc Neurosci Meet , vol.17
    • Bores, G.M.1    Huger, F.P.2    Usu, R.S.3
  • 43
    • 0025765379 scopus 로고
    • Galanthamine: Pharmacokinetics, tissue distribution and ChE inhibition in brain of mice
    • Bickel, U., Thomsen, T., Fischer, J.P., Weber, W., Kewitz, H. Galanthamine: Pharmacokinetics, tissue distribution and ChE inhibition in brain of mice. Neuropharmacology 1991, 30: 447-54.
    • (1991) Neuropharmacology , vol.30 , pp. 447-454
    • Bickel, U.1    Thomsen, T.2    Fischer, J.P.3    Weber, W.4    Kewitz, H.5
  • 45
    • 0019202705 scopus 로고
    • A study of the ChEs of the canine pancreatic sphincters and the relationship between reduced butyrylChE activity and pancreatic ductal hypertension
    • Dressel, T.D., Goodale, R.L., Borner, J.W., Etani, S.E. A study of the ChEs of the canine pancreatic sphincters and the relationship between reduced butyrylChE activity and pancreatic ductal hypertension. Ann Surg 1980, 192: 614-8.
    • (1980) Ann Surg , vol.192 , pp. 614-618
    • Dressel, T.D.1    Goodale, R.L.2    Borner, J.W.3    Etani, S.E.4
  • 46
    • 0023200838 scopus 로고
    • Iso-OMPA-induced potentiation of soman toxicity in rat
    • Gupta, R.C., Dettbarn, W.D. Iso-OMPA-induced potentiation of soman toxicity in rat. Arch Toxicol 1987, 61: 58-62.
    • (1987) Arch Toxicol , vol.61 , pp. 58-62
    • Gupta, R.C.1    Dettbarn, W.D.2
  • 47
    • 0017154203 scopus 로고
    • Effects of persistent selective suppression of ganglionic butyrylChE on steady state and regenerating levels of acetylChE: Implications regarding function of butyrylChE and regulation of protein synthesis
    • Koelle, W.A., Koelle, G.B., Smyrl, E.G. Effects of persistent selective suppression of ganglionic butyrylChE on steady state and regenerating levels of acetylChE: Implications regarding function of butyrylChE and regulation of protein synthesis. Proc Natl Acad Sci USA 1976, 73: 2936-8.
    • (1976) Proc Natl Acad Sci USA , vol.73 , pp. 2936-2938
    • Koelle, W.A.1    Koelle, G.B.2    Smyrl, E.G.3
  • 48
    • 0024494147 scopus 로고
    • De novo amplification within a 'silent' human ChE gene in a family subjected to prolonged exposure to organophosphorous insecticides
    • Prody, C.A., Dreyfus, P., Zamir, R., Zakut, H., Soreq, H. De novo amplification within a 'silent' human ChE gene in a family subjected to prolonged exposure to organophosphorous insecticides. Proc Natl Acad Sci USA 1989, 86: 690-4.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 690-694
    • Prody, C.A.1    Dreyfus, P.2    Zamir, R.3    Zakut, H.4    Soreq, H.5
  • 49
    • 0028142915 scopus 로고
    • Thermoregulation in laboratory mammals and humans exposed to antiChE agents
    • Gordon, C.J. Thermoregulation in laboratory mammals and humans exposed to antiChE agents. Neurotoxicol Teratol 1994, 16: 427-53.
    • (1994) Neurotoxicol Teratol , vol.16 , pp. 427-453
    • Gordon, C.J.1
  • 50
    • 0029147282 scopus 로고
    • Research overview of animal models of dementia
    • Porsolt, R.D., Roux, S., Wettstein, J.G. Research overview of animal models of dementia. Drug Dev Res 1995, 35: 214-29.
    • (1995) Drug Dev Res , vol.35 , pp. 214-229
    • Porsolt, R.D.1    Roux, S.2    Wettstein, J.G.3
  • 51
    • 0026792734 scopus 로고
    • Effects of four non-cholinergic cognitive enhancers in comparison with tacrine and galanthamine on scopolamine-induced amnesia in rats
    • Chopin, P., Briley, M. Effects of four non-cholinergic cognitive enhancers in comparison with tacrine and galanthamine on scopolamine-induced amnesia in rats. Psychopharmacology 1992, 106: 26-30.
    • (1992) Psychopharmacology , vol.106 , pp. 26-30
    • Chopin, P.1    Briley, M.2
  • 52
    • 0025079538 scopus 로고
    • Effects of different doses of galanthamine, a long-acting acetylChE inhibitor, on memory in mice
    • Sweeney, J.E., Bachman, E.S., Coyle, J.T. Effects of different doses of galanthamine, a long-acting acetylChE inhibitor, on memory in mice. Psychopharmacology 1990, 102: 191-200.
    • (1990) Psychopharmacology , vol.102 , pp. 191-200
    • Sweeney, J.E.1    Bachman, E.S.2    Coyle, J.T.3
  • 53
    • 0029970479 scopus 로고    scopus 로고
    • 2-Adrenoceptor antagonists potentiate acetylcholinesterase inhibitor effects on passive avoidance learning in the rat
    • 2-Adrenoceptor antagonists potentiate acetylcholinesterase inhibitor effects on passive avoidance learning in the rat. Psychopharmacology 1996, 124: 347-54.
    • (1996) Psychopharmacology , vol.124 , pp. 347-354
    • Camacho, F.1    Smith, C.P.2    Vargas, H.M.3    Winslow, J.T.4
  • 54
    • 0026571391 scopus 로고
    • Memory modulation with peripherally acting cholinergic drugs
    • Rush, D.K., Streit, K. Memory modulation with peripherally acting cholinergic drugs. Psychopharmacology 1992, 106: 375-82.
    • (1992) Psychopharmacology , vol.106 , pp. 375-382
    • Rush, D.K.1    Streit, K.2
  • 55
    • 0027223702 scopus 로고
    • D-Cycloserine attenuates scopolamine-induced learning and memory deficits in rats
    • Fishkin, R.J., Ince, E.S., Carlezon, W.A. Jr., Dunn, R.W. D-Cycloserine attenuates scopolamine-induced learning and memory deficits in rats. Behav Neural Biol 1993, 59: 150-7.
    • (1993) Behav Neural Biol , vol.59 , pp. 150-157
    • Fishkin, R.J.1    Ince, E.S.2    Carlezon Jr., W.A.3    Dunn, R.W.4
  • 56
    • 0028899957 scopus 로고
    • The behavioral effects of heptylphysostigmine on rats lesioned in the nucleus basalis
    • Waite, J.J., Thal, L.J. The behavioral effects of heptylphysostigmine on rats lesioned in the nucleus basalis. Neurosci Res 1995, 21: 251-9.
    • (1995) Neurosci Res , vol.21 , pp. 251-259
    • Waite, J.J.1    Thal, L.J.2
  • 57
    • 0022453239 scopus 로고
    • Pharmacokinetics of galanthamine hydrobromide (Nivalin®) following single intravenous and oral administration in rats
    • Mihailova, D., Yamboliev, I. Pharmacokinetics of galanthamine hydrobromide (Nivalin®) following single intravenous and oral administration in rats. Pharmacology 1986, 32: 301-6.
    • (1986) Pharmacology , vol.32 , pp. 301-306
    • Mihailova, D.1    Yamboliev, I.2


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