Disruption of the 5S RNP-Mdm2 interaction significantly improves the erythroid defect in a mouse model for Diamond-Blackfan anemia

Leukemia

Volumn 29, Issue 11, 2015, Pages 2221-2229

  Jaako, P ^a   Debnath, S ^a   Olsson, K ^a   Zhang, Y ^a   Flygare, J ^b   Lindstrom M S ^c   Bryder, D ^a   Karlsson, S ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

5S RIBONUCLEOPROTEIN; PROTEIN MDM2; PROTEIN P53; RIBONUCLEOPROTEIN; UNCLASSIFIED DRUG; DOXYCYCLINE; MDM2 PROTEIN, MOUSE; RIBOSOME PROTEIN; RNA 5S; RPS19 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLACKFAN DIAMOND ANEMIA; CELL DAMAGE; CONTROLLED STUDY; ERYTHROID CELL; ERYTHROID PRECURSOR CELL; ERYTHROPOIESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN HOMEOSTASIS; PROTEIN PROTEIN INTERACTION; RECEPTOR DOWN REGULATION; TRANSGENIC MOUSE; ANEMIA, DIAMOND-BLACKFAN; ANIMAL; C57BL MOUSE; DISEASE MODEL; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANEMIA, DIAMOND-BLACKFAN; ANIMALS; DISEASE MODELS, ANIMAL; DOXYCYCLINE; ERYTHROID PRECURSOR CELLS; ERYTHROPOIESIS; MICE; MICE, INBRED C57BL; PROTO-ONCOGENE PROTEINS C-MDM2; RIBONUCLEOPROTEINS; RIBOSOMAL PROTEINS; RNA, RIBOSOMAL, 5S; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84946496523     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2015.128     Document Type: Article

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