A novel Dock8 gene mutation confers diabetogenic susceptibility in the LEW.1AR1/Ztm-iddm rat, an animal model of human type 1 diabetes

Diabetologia

Volumn 58, Issue 12, 2015, Pages 2800-2809

  Arndt, Tanja ^a   Wedekind, Dirk ^a   Jörns, Anne ^a   Tsiavaliaris, Georgios ^a   Cuppen, Edwin ^b   Hedrich, Hans Jürgen ^a   Lenzen, Sigurd ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b HUBRECHT INSTITUTE   (Netherlands)

Author keywords

Animal model; Mutation; T cells; Type 1 diabetes

Indexed keywords

ARGININE; DEDICATOR OF CYTOKINESIS 8 PROTEIN; GENOMIC DNA; GLUTAMIC ACID; GLUTAMINE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; TRYPTOPHAN; UNCLASSIFIED DRUG; DOCK8 PROTEIN, RAT; LYMPHOCYTE ANTIGEN RECEPTOR; VON WILLEBRAND FACTOR;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACKCROSSING; BROWN NORWAY RAT; CHROMOSOME 1; CONTROLLED STUDY; CYTOKINESIS; DIABETOGENESIS; DISEASE PREDISPOSITION; EXON; GENE IDENTIFICATION; GENE MAPPING; GENE MUTATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC SUSCEPTIBILITY; IMMUNOCOMPETENT CELL; INSULIN DEPENDENT DIABETES MELLITUS; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; SINGLE NUCLEOTIDE POLYMORPHISM; ALLELE; ANIMAL; CHEMICAL STRUCTURE; DISEASE MODEL; GENETICS; HUMAN; LEWIS RAT; MUTATION; NATURAL KILLER CELL;

ALLELES; AMINO ACID SUBSTITUTION; ANIMALS; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; DISEASE SUSCEPTIBILITY; EXONS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; KILLER CELLS, NATURAL; MODELS, MOLECULAR; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; RATS; RATS, INBRED LEW; RECEPTOR-CD3 COMPLEX, ANTIGEN, T-CELL; VON WILLEBRAND FACTOR;

EID: 84946492391     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3757-7     Document Type: Article

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