Bone and cartilage regeneration with the use of umbilical cord mesenchymal stem cells

Expert Opinion on Biological Therapy

Volumn 15, Issue 11, 2015, Pages 1541-1552

  Klontzas, Michail E ^a   Kenanidis, Eustathios I ^b   Heliotis, Manolis ^c   Tsiridis, Eleftherios ^a,b   Mantalaris, Athanasios ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ARISTOTLE UNIVERSITY MEDICAL SCHOOL   (Greece)

^c EALING HOSPITAL NHS TRUST   (United Kingdom)

Author keywords

bone; cartilage; mesenchymal; stem cells; tissue engineering; umbilical cord; Wharton's jelly

Indexed keywords

BONE DEVELOPMENT; BONE REGENERATION; CARTILAGE; CELL DIFFERENTIATION; CELL ISOLATION; CELL LINEAGE; HUMAN; MESENCHYMAL STEM CELL; NONHUMAN; PHENOTYPE; REVIEW; TISSUE ENGINEERING; TISSUE REGENERATION; UMBILICAL CORD; WHARTON JELLY; ANIMAL; CYTOLOGY; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMA CELL; METABOLISM; PHYSIOLOGY; REGENERATION;

SIGNAL PEPTIDE;

ANIMALS; BONE REGENERATION; CARTILAGE; CELL DIFFERENTIATION; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; REGENERATION; TISSUE ENGINEERING; UMBILICAL CORD;

EID: 84946490814     PISSN: 14712598     EISSN: 17447682     Source Type: Journal    
DOI: 10.1517/14712598.2015.1068755     Document Type: Review

References (81)

1. Campana V, Milano G, Pagano E, et al. Bone substitutes in orthopaedic surgery: from basic science to clinical practice. J Mater Sci Mater Med 2014;25(10):2445-61
2. Ringe J, Häupl T, Sittinger M. Future of tissue engineering in rheumatic diseases. Expert Opin Biol Ther 2007;7(3):283-7
3. Wei C, Lin AB, Hung S. Mesenchymal stem cells in regenerative medicine for musculoskeletal diseases: bench, bedside, and industry. Cell Transpl 2014;23(4-5):505-12
4. Dawson JI, Kanczler J, Tare R, et al. Bridging the Gap: Bone Regeneration Using Skeletal Stem Cell-Based Strategies - Where Are We Now? Stem Cells 2014;32(1):35-44
5. Sponer P, Kučera T, Diaz-Garcia D, Filip S. The role of mesenchymal stem cells in bone repair and regeneration. Eur J Orthop Surg Traumatol 2014;24(3):257-62
6. Mueller SM, Glowacki J. Age-related decline in the osteogenic potential of human bone marrow cells cultured in three-dimensional collagen sponges. J Cell Biochem 2001;82(4):583-90
7. Erickson IE, van Veen SC, Sengupta S, et al. Cartilage matrix formation by bovine mesenchymal stem cells in three-dimensional culture is age-dependent. Clin Orthop Relat Res 2011;469(10):2744-53
8. Kim D-W, Staples M, Shinozuka K, et al. Wharton's jelly-derived mesenchymal stem cells: phenotypic characterization and optimizing their therapeutic potential for clinical applications. Int J Mol Sci 2013;14(6):11692-712
9. Wang L, Ott L, Seshareddy K, et al. Musculoskeletal tissue engineering with human umbilical cord mesenchymal stromal cells. Regen Med 2011;6(1):95-109
10. Nanaev AK, Kohnen G, Milovanov AP, et al. Stromal differentiation and architecture of the human umbilical cord. Placenta 1997;18(1):53-64
11. Jeschke MG, Gauglitz GG, Phan TT, et al. Umbilical cord lining membrane and Wharton's jelly-derived mesenchymal stem cells: the similarities and differences. Open Tissue Eng Regen Med J 2011;4(1):21-7
12. Baksh D, Yao R, Tuan RS. Comparison of proliferative and multilineage differentiation potential of human mesenchymal stem cells derived from umbilical cord and bone marrow. Stem Cells 2007;25(6):1384-92
13. Lu L-L, Liu Y-J, Yang S-G, et al. Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials. Haematologica 2006;91(8):1017-26
14. Pereira WC, Khushnooma I, Madkaikar M, Ghosh K. Reproducible methodology for the isolation of mesenchymal stem cells from human umbilical cord and its potential for cardiomyocyte generation. J Tissue Eng Regen Med 2008;2(7):394-9
15. De Bruyn C, Najar M, Raicevic G, et al. A rapid, simple, and reproducible method for the isolation of mesenchymal stromal cells from Wharton's jelly without enzymatic treatment. Stem Cells Dev 2011;20(3):547-57
16. Anzalone R, Farina F, Zummo G, Rocca G. La. Recent patents and advances on isolation and cellular therapy applications of mesenchymal stem cells from human umbilical cord Wharton's jelly. Recent Pat Regen Med 2011;1(3):216-27
17. Hendijani F, Sadeghi-Aliabadi H, Javanmard SH. Comparison of human mesenchymal stem cells isolated by explant culture method from entire umbilical cord and Wharton's jelly matrix. Cell Tissue Bank 2014;15(4):555-65
18. Iftimia-Mander A, Hourd P, Dainty R, Thomas RJ. Mesenchymal stem cell isolation from human umbilical cord tissue: understanding and minimizing variability in cell yield for process optimization. Biopreserv Biobank 2013;11(5):291-8
19. Sarugaser R, Lickorish D, Baksh D, et al. Human umbilical cord perivascular (HUCPV) cells: a source of mesenchymal progenitors. Stem Cells 2005;23(2):220-9
20. Lee OK, Kuo TK, Chen W-M, et al. Isolation of multipotent mesenchymal stem cells from umbilical cord blood. Blood 2004;103(5):1669-75
21. Lee MW, Yang MS, Park JS, et al. Isolation of mesenchymal stem cells from cryopreserved human umbilical cord blood. Int J Hematol 2005;81(2):126-30
22. Hutson EL, Boyer S, Genever PG. Rapid Isolation, Expansion, and Differentiation of Osteoprogenitors from Full-Term Umbilical Cord Blood. Tissue Eng 2005;11(9/10):1407-20
23. Gang EJ, Hong SH, Jeong JA, et al. In vitro mesengenic potential of human umbilical cord blood-derived mesenchymal stem cells. Biochem Biophys Res Commun 2004;321(1):102-8
24. Secco M, Zucconi E, Vieira NM, et al. Multipotent stem cells from umbilical cord: cord is richer than blood!. Stem Cells 2008;26(1):146-50
25. Donaldson C, Armitage WJ, Laundy V, et al. Impact of obstetric factors on cord blood donation for transplantation. Br J Hematol 1999;106(1):128-32
26. Surbek D V, Steinmann C, Tichelli A, et al. Decreased cord blood yield in postterm pregnancy: a comparative study. Br J Haematol 2000;110(1):235-7
27. Secunda R, Vennila R, Mohanashankar a M, et al. Isolation, expansion and characterisation of mesenchymal stem cells from human bone marrow, adipose tissue, umbilical cord blood and matrix: a comparative study. Cytotechnology 2014. [Epub ahead of print]
28. Zeddou M, Briquet A, Relic B, et al. The umbilical cord matrix is a better source of mesenchymal stem cells (MSC) than the umbilical cord blood. Cell Biol Int 2010;34(7):693-701
29. Zhang X, Hirai M, Cantero S, et al. Isolation and characterization of mesenchymal stem cells from human umbilical cord blood: reevaluation of critical factors for successful isolation and high ability to proliferate and differentiate to chondrocytes as compared to mesenchymal stem cells fro. J Cell Biochem 2011;112(4):1206-18
30. Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science (80-) 1999;284(5411):143-7
31. Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006;8(4):315-17
32. Conconi MT, Di Liddo R, Tommasini M, et al. Phenotype and differentiation potential of stromal populations obtained from various zones of human umbilical cord: an overview. Open Tissue Eng Regen Med J 2011;4(1):6-20
33. Cardoso TC, Ferrari HF, Garcia AF, et al. Isolation and characterization of Wharton's jelly-derived multipotent mesenchymal stromal cells obtained from bovine umbilical cord and maintained in a defined serum-free three-dimensional system. BMC Biotechnol 2012;12(1):18
34. La Rocca G, Anzalone R, Corrao S, et al. Isolation and characterization of Oct-4+/HLA-G+ mesenchymal stem cells from human umbilical cord matrix: differentiation potential and detection of new markers. Histochem Cell Biol 2009;131(2):267-82
35. Liu S, Yuan M, Hou K, et al. Immune characterization of mesenchymal stem cells in human umbilical cord Wharton's jelly and derived cartilage cells. Cell Immunol 2012;278(1-2):35-44
36. Prasajak P, Rattananinsruang P, Chotinantakul K, et al. Embryonic stem cells conditioned medium enhances Wharton's jelly-derived mesenchymal stem cells expansion under hypoxic condition. Cytotechnology 2015;67(3):493-505
37. Erices A, Conget P, Minguell JJ. Mesenchymal progenitor cells in human umbilical cord blood. Br J Hematol 2000;109(1):235-42
38. Campagnoli C, Roberts IAG, Kumar S, et al. Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow. Blood 2001;98(8):2396-402
39. Wexler SA, Donaldson C, Denning-Kendall P, et al. Adult bone marrow is a rich source of human mesenchymal 'stem' cells but umbilical cord and mobilized adult blood are not. Br J Hematol 2003;121(2):368-74
40. Romanov YA, Veronika SA, Smirnov VN. Searching for alternative sources of postnatal human mesenchymal stem cells: candidate MSC-like cells from umbilical cord. Stem Cells 2003;21(1):105-10
41. Ciavarella S, Dammacco F, De Matteo M, et al. Umbilical cord mesenchymal stem cells: role of regulatory genes in their differentiation to osteoblasts. Stem Cells Dev 2009;18(8):1211-20
42. Hou T, Xu J, Wu X, et al. Umbilical cord Wharton's jelly: a new potential cell source. Tissue Eng Part A 2009;15(9):2325-34
43. Schneider RK, Puellen A, Kramann R, et al. The osteogenic differentiation of adult bone marrow and perinatal umbilical mesenchymal stem cells and matrix remodelling in three-dimensional collagen scaffolds. Biomaterials 2010;31(3):467-80
44. Penolazzi L, Tavanti E, Vecchiatini R, et al. Encapsulation of mesenchymal stem cells from Wharton's jelly in alginate microbeads. Tissue Eng Part C 2010;16(1):141-55
45. Penolazzi L, Mazzitelli S, Vecchiatini R, et al. Human mesenchymal stem cells seeded on extracellular matrix-scaffold: viability and osteogenic potential. J Cell Physiol 2012;227(2):857-66
46. Mueller AA, Forraz N, Gueven S, et al. Osteoblastic differentiation of Wharton jelly biopsy specimens and their mesenchymal stromal cells after serum-free culture. Plast Reconstr Surg 2014;134(1):59e-69e
47. Karadas O, Yucel D, Kenar H, et al. Collagen scaffolds with in situ -grown calcium phosphate for osteogenic differentiation of Wharton's jelly and menstrual blood stem cells. J Tissue Eng Regen Med 2014;8(7):534-45
48. Baba K, Yamazaki Y, Ishiguro M, et al. Osteogenic potential of human umbilical cord-derived mesenchymal stromal cells cultured with umbilical cord blood-derived fibrin: a preliminary study. J Cranio Maxill Surg 2013;41(8):775-82
49. Gauthaman K, Venugopal JR, Yee FC, et al. Osteogenic differentiation of human Wharton's jelly stem cells on nanofibrous substrates in vitro. Tissue Eng Part A 2011;17(1-2):71-81
50. Hsieh J, Fu Y-S, Chang S-J, et al. Functional module analysis reveals differential osteogenic and stemness potentials in human mesenchymal stem cells from bone marrow and Wharton's jelly of umbilical cord. Stem Cells Dev 2010;19(12):1895-910
51. Sudo K, Kanno M, Miharada K, et al. Mesenchymal progenitors able to differentiate into osteogenic, chondrogenic, and/or adipogenic cells in vitro are present in most primary fibroblast-like cell populations. Stem Cells 2007;25(7):1610-17
52. Capelli C, Gotti E, Morigi M, et al. Minimally manipulated whole human umbilical cord is a rich source of clinical-grade human mesenchymal stromal cells expanded in human platelet lysate. Cytotherapy 2011;13(7):786-801
53. Wang L, Zhao L, Detamore MS. Human umbilical cord mesenchymal stromal cells in a sandwich approach for osteochondral tissue engineering. J Tissue Eng Regen Med 2011;5(9):712-21
54. Kuo H-C, Chiu C-C, Chang W-C, et al. Use of proteomic differential displays to assess functional discrepancies and adjustments of human bone marrow- and Wharton jelly-derived mesenchymal stem cells. J Proteome Res 2011;10(3):1305-15
55. Farias VA, Linares-Fernández JL, Peñalver JL, et al. Human umbilical cord stromal stem cell express CD10 and exert contractile properties. Placenta 2011;32(1):86-95
56. Girdlestone J, Limbani VA, Cutler AJ, Navarrete C V. Efficient expansion of mesenchymal stromal cells from umbilical cord under low serum conditions. Cytotherapy 2009;11(6):738-48
57. Rebelatto CK, Aguiar AM, Moretão MP, et al. Dissimilar differentiation of mesenchymal stem cells from bone marrow, umbilical cord blood, and adipose tissue. Exp Biol Med 2008;233(7):901-13
58. Wagner W, Wein F, Seckinger A, et al. Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. Exp Hematol 2005;33(11):1402-16
59. Khorshied MM, Gouda HM, Shaheen IA, Al Bolkeny TN. The osteogenic differentiation potentials of umbilical cord blood hematopoietic stem cells. Comp Clin Path 2012;21(4):441-7
60. Handschel J, Naujoks C, Langenbach F, et al. Comparison of ectopic bone formation of embryonic stem cells and cord blood stem cells in vivo. Tissue Eng Part A 2010;16(8):2475-83
61. Hildebrandt C, Büth H, Thielecke H. Influence of cell culture media conditions on the osteogenic differentiation of cord blood-derived mesenchymal stem cells. Ann Anat 2009;191(1):23-32
62. Bosch J, Houben AP, Radke TF, et al. Distinct differentiation potential of 'MSC' derived from cord blood and umbilical cord: are cord-derived cells true mesenchymal stromal cells? Stem Cells Dev 2012;21(11):1977-88
63. Bosch J, Houben AP, Hennicke T, et al. Comparing the gene expression profile of stromal cells from human cord blood and bone marrow: lack of the typical 'bone' signature in cord blood cells. Stem Cells Int 2013;2013:631984
64. Behery O, Siston R a, Harris JD, Flanigan DC. Treatment of cartilage defects of the knee: expanding on the existing algorithm. Clin J Sport Med 2014;24(1):21-30
65. Khan WS, Johnson DS, Hardingham TE. The potential of stem cells in the treatment of knee cartilage defects. Knee 2010;17(6):369-74
66. Liu S, Hou KD, Yuan M, et al. Characteristics of mesenchymal stem cells derived from Wharton's jelly of human umbilical cord and for fabrication of non-scaffold tissue-engineered cartilage. J Biosci Bioeng 2014;117(2):229-35
67. Chen X, Zhang F, He X, et al. Chondrogenic differentiation of umbilical cord-derived mesenchymal stem cells in type I collagen-hydrogel for cartilage engineering. Injury 2013;44(4):540-9
68. La Rocca G, Lo Iacono M, Corsello T, et al. Human Wharton's jelly mesenchymal stem cells maintain the expression of key immunomodulatory molecules when subjected to osteogenic, adipogenic and chondrogenic differentiation in vitro: new perspectives for cellular therapy. Curr Stem Cell Res Ther 2013;8(1):100-13
69. Wang L, Tran I, Seshareddy K, et al. A comparison of human bone marrow-derived mesenchymal stem cells and human umbilical cord-derived mesenchymal stromal cells for cartilage tissue engineering. Tissue Eng Part A 2009;15(8):2259-66
70. Fong C-Y, Subramanian A, Gauthaman K, et al. Human umbilical cord Wharton's jelly stem cells undergo enhanced chondrogenic differentiation when grown on nanofibrous scaffolds and in a sequential two-stage culture medium environment. Stem Cell Rev 2012;8(1):195-209
71. Hildner F, Wolbank S, Redl H, et al. How chondrogenic are human umbilical cord matrix cells? A comparison to adipose-derived stem cells. J Tissue Eng Regen Med 2010;4(3):242-5
72. Wang L, Seshareddy K, Weiss ML, Detamore MS. Effect of initial seeding density on human umbilical cord mesenchymal stromal cells for fibrocartilage tissue engineering. Tissue Eng Part A 2009;15(5):1009-17
73. Bailey MM, Wang L, Bode CJ, et al. A comparison of human umbilical cord matrix stem cells and temporomandibular joint condylar chondrocytes for tissue engineering temporomandibular joint condylar cartilage. Tissue Eng 2007;13(8):2003-10
74. Wang J-F, Wang L-J, Wu Y-F, et al. Mesenchymal stem/progenitor cells in human umbilical cord blood as support for ex vivo expansion of CD34+ hematopoietic stem cells and for chondrogenic differentiation. Haematologica 2004;89(7):837-44
75. De Mara CS, Duarte ASS, Sartori-Cintra AR, et al. Chondrogenesis from umbilical cord blood cells stimulated with BMP-2 and BMP-6. Rheumatol Int 2013;33(1):121-8
76. Chung JY, Song M, Ha C-W, et al. Comparison of articular cartilage repair with different hydrogel-human umbilical cord blood-derived mesenchymal stem cell composites in a rat model. Stem Cell Res Ther 2014;5(2):39
77. Kunisaki SM, Fuchs JR, Steigman SA, Fauza DO. A comparative analysis of cartilage engineered from different perinatal mesenchymal progenitor cells. Tissue Eng 2007;13(11):2633-44
78. Zheng P, Ju L, Jiang B, et al. Chondrogenic differentiation of human umbilical cord blood-derived mesenchymal stem cells by co-culture with rabbit chondrocytes. Mol Med Rep 2013;8(4):1169-82
79. Jay KE, Rouleau A, Underhill TM, Bhatia M. Identification of a novel population of human cord blood cells with hematopoietic and chondrocytic potential. Cell Res 2004;14(4):268-82
80. Yan H, Yu C. Repair of full-thickness cartilage defects with cells of different origin in a rabbit model. Arthroscopy 2007;23(2):178-87
81. Pagkalos J, Cha JM, Kang Y, et al. Simvastatin induces osteogenic differentiation of murine embryonic stem cells. J Bone Min Res 2010;25(11):2470-8