Spontaneous epileptic seizures in transgenic rats harboring a human ADNFLE missense mutation in the β2-subunit of the nicotinic acetylcholine receptor

Neuroscience Research

Volumn 100, Issue , 2015, Pages 46-54

  Shiba, Yuko ^a   Mori, Fumiaki ^a   Yamada, Junko ^a   Migita, Keisuke ^a   Nikaido, Yoshikazu ^a   Wakabayashi, Koichi ^a   Kaneko, Sunao ^a,b   Okada, Motohiro ^c   Hirose, Shinichi ^d   Ueno, Shinya ^a  

^a HIROSAKI UNIVERSITY   (Japan)

^b North Tohoku Epilepsy Center   (Japan)

^c MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d FUKUOKA UNIVERSITY   (Japan)

Author keywords

Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE); Epilepsy; Nicotinic acetylcholine receptor (nAChR) mutation; Seizures; Transgenic rat; 2 Subunit

Indexed keywords

NICOTINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BETA2; PROTEIN SUBUNIT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL DOMINANT NOCTURNAL FRONTAL LOBE EPILEPSY; BRAIN CORTEX; CEREBELLUM; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; EPILEPSY; GENE; GENE EXPRESSION; HIPPOCAMPUS; IN SITU HYBRIDIZATION; MALE; MISSENSE MUTATION; MOTOR ACTIVITY; NICOTINIC RECEPTOR BETA2 GENE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RESPONSE TIME; TRANSGENE; TRANSGENIC RAT; WILD TYPE; ANIMAL; BRAIN; CHEMICALLY INDUCED; DISEASE MODEL; ELECTROENCEPHALOGRAPHY; FRONTAL LOBE EPILEPSY; GENETICS; METABOLISM; PATHOPHYSIOLOGY; PROTEIN SUBUNIT; RAT; SENSORIMOTOR CORTEX;

ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; ELECTROENCEPHALOGRAPHY; EPILEPSY; EPILEPSY, FRONTAL LOBE; MALE; MUTATION, MISSENSE; NICOTINE; PROTEIN SUBUNITS; RATS; RATS, TRANSGENIC; RECEPTORS, NICOTINIC; SENSORIMOTOR CORTEX;

EID: 84946481321     PISSN: 01680102     EISSN: 18728111     Source Type: Journal    
DOI: 10.1016/j.neures.2015.06.003     Document Type: Article

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