Activation-induced cytidine deaminase in B cells of hepatits C virus-related cryoglobulinaemic vasculitis

Clinical and Experimental Immunology

Volumn 182, Issue 3, 2015, Pages 323-331

  Russi, S ^a   Dammacco, F ^a   Sansonno, S ^b   Pavone, F ^a   Sansonno, D ^a  

^a UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

^b UNIVERSITY OF FOGGIA   (Italy)

Author keywords

Cryoglobulinaemia; HCV infection; Immunoglobulin variable gene; Lymphoproliferation; Somatic hypermutation

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; ALANINE AMINOTRANSFERASE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; AICDA (ACTIVATION-INDUCED CYTIDINE DEAMINASE); CYTIDINE DEAMINASE;

ADULT; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; BLOOD ANALYSIS; CLINICAL FEATURE; CONTROLLED STUDY; CRYOGLOBULINEMIA; CRYOGLOBULINEMIC VASCULITIS; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; INFLAMMATORY CELL; ISOLATED LIVER; LASER CAPTURE MICRODISSECTION; LIVER BIOPSY; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PORTAL VEIN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOMATIC HYPERMUTATION; AGE; AGED; BIOSYNTHESIS; CELL SURVIVAL; CHRONIC HEPATITIS C; CLINICAL TRIAL; COMPLICATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; HEPACIVIRUS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MIDDLE AGED; PATHOLOGY; SIGNAL TRANSDUCTION; VASCULITIS;

AGE FACTORS; AGED; B-LYMPHOCYTES; CELL SURVIVAL; CRYOGLOBULINEMIA; CYTIDINE DEAMINASE; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; SIGNAL TRANSDUCTION; VASCULITIS;

EID: 84946479719     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/cei.12690     Document Type: Article

References (36)

1. Agnello V. The etiology and pathophysiology of mixed cryoglobulinemia secondary to hepatitis C virus infection. Springer Semin Immunopathol 1997; 19:111-29.
2. El-Serag HB, Hampel H, Yeh C, Rabeneck L. Extrahepatic manifestations of hepatitis C among United States male veterans. Hepatology 2002; 36:1439-45.
3. Sansonno D, Dammacco F. Hepatitis C virus, cryoglobulinaemia, and vasculitis: immune complex relations. Lancet Infect Dis 2005; 5:227-36.
4. Sansonno D, De Vita S, Iacobelli AR, Cornacchiulo V, Boiocchi M, Dammacco F. Clonal analysis of intrahepatic B cells from HCV-infected patients with and without mixed cryoglobulinemia. J Immunol 1998; 160:3594-601.
5. Racanelli V, Sansonno D, Piccoli C, D'Amore FP, Tucci FA, Dammacco F. Molecular characterization of B cell clonal expansions in the liver of chronically hepatitis C virus-infected patients. J Immunol 2001; 167:21-9.
6. Ivanovski M, Silvestri F, Pozzato G et al. Somatic hypermutation, clonal diversity, and preferential expression of the VH 51p1/VL kv325 immunoglobulin gene combination in hepatitis C virus-associated immunocytomas. Blood 1998; 91:2433-42.
7. Sansonno D, Lauletta G, De Re V et al. Intrahepatic B cell clonal expansions and extrahepatic manifestations of chronic HCV infection. Eur J Immunol 2004; 34:126-36.
8. Sansonno D, Tucci FA, Ghebrehiwet B et al. Role of the receptor for the globular domain of C1q protein in the pathogenesis of hepatitis C virus-related cryoglobulin vascular damage. J Immunol 2009; 183:6013-20.
9. Terrier B, Cacoub P. Cryoglobulinemia vasculitis: an update. Curr Opin Rheumatol 2013; 25:10-18.
10. Bartosch B, Vitelli A, Granier C et al. Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor. J Biol Chem 2003; 278:41624-30.
11. Hsu M, Zhang J, Flint M et al. Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles. Proc Natl Acad Sci USA 2003; 100:7271-7276.
12. Evans MJ, von Hahn T, Tscherne DM et al. Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry. Nature 2007; 446:801-5.
13. Dustin LB, Charles ED. Primary, post-primary and non-specific immunoglobulin M responses in HCV infection. Antivir Ther 2012; 17:1449-52.
14. Nakai M, Seya T, Matsumoto M, Shimotohno K, Sakamoto N, Aly HH. The J6JFH1 strain of hepatitis C virus infects human B-cells with low replication efficacy. Viral Immunol 2014; 27:285-94.
15. Sansonno D, Tucci FA, Lauletta G et al. Hepatitis C virus productive infection in mononuclear cells from patients with cryoglobulinaemia. Clin Exp Immunol 2007; 147:241-48.
16. Laskus T, Operskalski EA, Radkowski M et al. Negative-strand hepatitis C virus (HCV) RNA in peripheral blood mononuclear cells from anti-HCV-positive/HIV-infected women. J Infect Dis 2007; 195:124-33.
17. Oliviero B, Cerino A, Varchetta S et al. Enhanced B-cell differentiation and reduced proliferative capacity in chronic hepatitis C and chronic hepatitis B virus infections. J Hepatol 2011; 55:53-60.
18. Muto T, Okazaki IM, Yamada S et al. Negative regulation of activation-induced cytidine deaminase in B cells. Proc Natl Acad Sci USA 2006; 103:2752-7.
19. Muramatsu M, Sankaranand VS, Anant S et al. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J Biol Chem 1999; 274:18470-6.
20. Keim C, Kazadi D, Rothschild G, Basu U. Regulation of AID, the B-cell genome mutator. Genes Dev 2013; 27:1-17.
21. Crouch EE, Li Z, Takizawa M et al. Regulation of AID expression in the immune response. J Exp Med 2007; 204:1145-56.
22. Humby F, Bombardieri M, Manzo A et al. Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium. PLOS Med 2009; 6:e1.
23. Landau DA, Saadoun D, Calabrese LH, Cacoub P. The pathophysiology of HCV induced B-cell clonal disorders. Autoimmun Rev 2007; 6:581-7.
24. Laskov R, Yahud V, Hamo R, Steinitz M. Preferential targeting of somatic hypermutation to hotspot motifs and hypermutable sites and generation of mutational clusters in the IgVH alleles of a rheumatoid factor producing lymphoblastoid cell line. Mol Immunol 2011; 48:733-45.
25. Quartuccio L, Isola M, Corazza L et al. Validation of the classification criteria for cryoglobulinaemic vasculitis. Rheumatology (Oxf) 2014; 53:2209-13.
26. Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C. The French METAVIR Study Group. Hepatology 1994; 20:15-20.
27. Dammacco F, Sansonno D, Piccoli C, Tucci FA, Racanelli V. The cryoglobulins: an overview. Eur J Clin Invest 2001; 31:628-38.
28. Sansonno D, Tucci FA, De Re V et al. HCV-associated B cell clonalities in the liver do not carry the t(14;18) chromosomal translocation. Hepatology 2005; 42:1019-27.
29. Dammacco F, Sansonno D, Piccoli C, Racanelli V, D'Amore FP, Lauletta G. The lymphoid system in hepatitis C virus infection: autoimmunity, mixed cryoglobulinemia, and Overt B-cell malignancy. Semin Liver Dis 2000; 20:143-57.
30. Ferri C, Zignego AL. Relation between infection and autoimmunity in mixed cryoglobulinemia. Curr Opin Rheumatol 2000; 12:53-60.
31. Dammacco F, Tucci FA, Lauletta G et al. Pegylated interferon-alpha, ribavirin, and rituximab combined therapy of hepatitis C virus-related mixed cryoglobulinemia: a long-term study. Blood 2010; 116:343-53.
32. Sansonno D, Tucci FA, Troiani L et al. Increased serum levels of the chemokine CXCL13 and up-regulation of its gene expression are distinctive features of HCV-related cryoglobulinemia and correlate with active cutaneous vasculitis. Blood 2008; 112:1620-7.
33. Manzo A, Paoletti S, Carulli M et al. Systematic microanatomical analysis of CXCL13 and CCL21 in situ production and progressive lymphoid organization in rheumatoid synovitis. Eur J Immunol 2005; 35:1347-59.
34. Okazaki IM, Hiai H, Kakazu N et al. Constitutive expression of AID leads to tumorigenesis. J Exp Med 2003; 197:1173-81.
35. Epeldegui M, Breen EC, Hung YP, Boscardin WJ, Detels R, Martinez-Maza O. Elevated expression of activation induced cytidine deaminase in peripheral blood mononuclear cells precedes AIDS-NHL diagnosis. Aids 2007; 21:2265-70.
36. Lauletta G, Russi S, Conteduca V, Sansonno L, Dammacco F, Sansonno D. Impact of cryoglobulinemic syndrome on the outcome of chronic hepatitis C virus infection: a 15-year prospective study. Medicine (Balt) 2013; 92:245-56.