Tangeretin from Citrus reticulate Inhibits Respiratory Syncytial Virus Replication and Associated Inflammation in Vivo

Journal of Agricultural and Food Chemistry

Volumn 63, Issue 43, 2015, Pages 9520-9527

  Xu, Jiao Jiao ^a   Liu, Zhong ^a   Tang, Wei ^a   Wang, Guo Cai ^a   Chung, Hau Yin ^b   Liu, Qiu Ying ^a   Zhuang, Ling ^a   Li, Man Mei ^a   Li, Yao Lan ^a  

^a JINAN UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

in vivo antiviral activity; NF B; respiratory syncytial virus replication; RSV induced inflammation; tangeretin

Indexed keywords

BIOLOGICAL ORGANS; PATHOLOGY; POLYMERASE CHAIN REACTION; VIRUSES;

ANTIVIRAL ACTIVITIES; IN VIVO ANTIVIRAL ACTIVITY; IN-VIVO; NUCLEAR FACTOR-ΚB; NUCLEAR FACTORS; RESPIRATORY SYNCYTIAL VIRUS; RESPIRATORY SYNCYTIAL VIRUS REPLICATION; RESPIRATORY SYNCYTIAL VIRUS-INDUCED INFLAMMATION; TANGERETIN; VIRUS REPLICATION;

MAMMALS;

ANTIVIRUS AGENT; FLAVONE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PLANT EXTRACT; TANGERETIN;

ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; CITRUS; DISEASE MODEL; DRUG EFFECTS; HUMAN; HUMAN RESPIRATORY SYNCYTIAL VIRUS; IMMUNOLOGY; LUNG; MALE; MOUSE; PHYSIOLOGY; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; VIROLOGY; VIRUS REPLICATION;

ANIMALS; ANTIVIRAL AGENTS; CITRUS; DISEASE MODELS, ANIMAL; FLAVONES; HUMANS; LUNG; MALE; MICE; MICE, INBRED BALB C; NF-KAPPA B; PLANT EXTRACTS; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUSES; VIRUS REPLICATION;

EID: 84946434399     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/acs.jafc.5b03482     Document Type: Article

References (29)

1. Miller, A. L.; Sims, G. P.; Brewah, Y. A.; Rebelatto, M. C.; Kearley, J.; Benjamin, E.; Keller, A. E.; Brohawn, P.; Herbst, R.; Coyle, A. J.; Humbles, A. A.; Kolbeck, R. Opposing roles of membrane and soluble forms of the receptor for advanced glycation end products in primary respiratory syncytial virus infection J. Infect. Dis. 2012, 205, 1311-1320 10.1093/infdis/jir826
2. Homaira, N.; Rawlinson, W.; Snelling, T. L.; Jaffe, A. Effectiveness of Palivizumab in Preventing RSV Hospitalization in High Risk Children: A Real-World Perspective Int. J. Pediatr. 2014, 2014, 1-13 10.1155/2014/571609
3. Olszewska, W.; Ispas, G.; Schnoeller, C.; Sawant, D.; Van de Casteele, T.; Nauwelaers, D.; Van Kerckhove, B.; Roymans, D.; De Meulder, M.; Rouan, M. C.; Van Remoortere, P.; Bonfanti, J. F.; Van Velsen, F.; Koul, A.; Vanstockem, M.; Andries, K.; Sowinski, P.; Wang, B.; Openshaw, P.; Verloes, R. Antiviral and lung protective activity of a novel respiratory syncytial virus fusion inhibitor in a mouse model Eur. Respir. J. 2011, 38, 401-408 10.1183/09031936.00005610
4. Antonelli, G.; Turriziani, O. Antiviral therapy: old and current issues Int. J. Antimicrob. Agents 2012, 40, 95-102 10.1016/j.ijantimicag.2012.04.005
5. Openshaw, P. J.; Chiu, C. Protective and dysregulated T cell immunity in RSV infection Curr. Opin. Virol. 2013, 3, 468-474 10.1016/j.coviro.2013.05.005
6. Garg, R.; Shrivastava, P.; van Drunen Littel-van den Hurk, S. The role of dendritic cells in innate and adaptive immunity to respiratory syncytial virus, and implications for vaccine development Expert Rev. Vaccines 2012, 11, 1441-1457 10.1586/erv.12.117
7. Schwarze, J.; Makela, M.; Cieslewicz, G.; Dakhama, A.; Lahn, M.; Ikemura, T.; Joetham, A.; Gelfand, E. W. Transfer of the enhancing effect of respiratory syncytial virus infection on subsequent allergic airway sensitization by T lymphocytes J. Immunol. 1999, 163, 5729-5734
8. Bystrom, J.; Al-Adhoubi, N.; Al-Bogami, M.; Jawad, A. S.; Mageed, R. A. Th17 lymphocytes in respiratory syncytial virus infection Viruses 2013, 5, 777-791 10.3390/v5030777
9. Lu, X.; McCoy, K. S.; Xu, J.; Hu, W.; Chen, H.; Jiang, K.; Han, F.; Chen, P.; Wang, Y. Galectin-9 ameliorates respiratory syncytial virus-induced pulmonary immunopathology through regulating the balance between Th17 and regulatory T cells Virus Res. 2015, 195, 162-171 10.1016/j.virusres.2014.10.011
10. Bueno, S. M.; Gonzalez, P. A.; Pacheco, R.; Leiva, E. D.; Cautivo, K. M.; Tobar, H. E.; Mora, J. E.; Prado, C. E.; Zuniga, J. P.; Jimenez, J.; Riedel, C. A.; Kalergis, A. M. Host immunity during RSV pathogenesis Int. Immunopharmacol. 2008, 8, 1320-1329 10.1016/j.intimp.2008.03.012
11. Marr, N.; Turvey, S. E.; Grandvaux, N. Pathogen recognition receptor crosstalk in respiratory syncytial virus sensing: a host and cell type perspective Trends Microbiol. 2013, 21, 568-574 10.1016/j.tim.2013.08.006
12. Xu, J. J.; Wu, X.; Li, M. M.; Li, G. Q.; Yang, Y. T.; Luo, H. J.; Huang, W. H.; Chung, H. Y.; Ye, W. C.; Wang, G. C.; Li, Y. L. Antiviral activity of polymethoxylated flavones from "Guangchenpi", the edible and medicinal pericarps of citrus reticulata 'Chachi' J. Agric. Food Chem. 2014, 62, 2182-2189 10.1021/jf404310y
13. Huang, D. W.; Wu, C. H.; Shih, C. K.; Liu, C. Y.; Shih, P. H.; Shieh, T. M.; Lin, C. I.; Chiang, W.; Hsia, S. M. Application of the solvent extraction technique to investigation of the anti-inflammatory activity of adlay bran Food Chem. 2014, 145, 445-453 10.1016/j.foodchem.2013.08.071
14. Jang, S. E.; Ryu, K. R.; Park, S. H.; Chung, S.; Teruya, Y.; Han, M. J.; Woo, J. T.; Kim, D. H. Nobiletin and tangeretin ameliorate scratching behavior in mice by inhibiting the action of histamine and the activation of NF-kappa B, AP-1 and p38 Int. Immunopharmacol. 2013, 17, 502-507 10.1016/j.intimp.2013.07.012
15. Nagase, H.; Omae, N.; Omori, A.; Nakagawasai, O.; Tadano, T.; Yokosuka, A.; Sashida, Y.; Mimaki, Y.; Yamakuni, T.; Ohizumi, Y. Nobiletin and its related flavonoids with CRE-dependent transcription-stimulating and neuritegentic activities Biochem. Biophys. Res. Commun. 2005, 337, 1330-1336 10.1016/j.bbrc.2005.10.001
16. Lee, S.; Stokes, K. L.; Currier, M. G.; Sakamoto, K.; Lukacs, N. W.; Celis, E.; Moore, M. L. Vaccine-elicited CD8+ T cells protect against respiratory syncytial virus strain A2-line19F-induced pathogenesis in BALB/c mice J. Virol. 2012, 86, 13016-13024 10.1128/JVI.01770-12
17. Huang, Y. S.; Ho, S. C. Polymethoxy flavones are responsible for the anti-inflammatory activity of citrus fruit peel Food Chem. 2010, 119, 868-873 10.1016/j.foodchem.2009.09.092
18. Whitman, E.; Barber, A. NKG2D receptor activation of NF-kappa B enhances inflammatory cytokine production in murine effector CD8(+) T cells Mol. Immunol. 2015, 63, 268-278 10.1016/j.molimm.2014.07.015
19. Haeberle, H. A.; Takizawa, R.; Casola, A.; Brasier, A. R.; Dieterich, H. J.; Van Rooijen, N.; Gatalica, Z.; Garofalo, R. P. Respiratory syncytial virus-induced activation of nuclear factor-kappaB in the lung involves alveolar macrophages and toll-like receptor 4-dependent pathways J. Infect. Dis. 2002, 186, 1199-1206 10.1086/344644
20. Pickles, R. J.; DeVincenzo, J. P. Respiratory syncytial virus (RSV) and its propensity for causing bronchiolitis J. Pathol. 2015, 235, 266-276 10.1002/path.4462
21. Vandini, S.; Bottau, P.; Faldella, G.; Lanari, M. Immunological, Viral, Environmental, and Individual Factors Modulating Lung Immune Response to Respiratory Syncytial Virus BioMed Res. Int. 2015, 2015, 1-7 10.1155/2015/875723
22. Arruvito, L.; Raiden, S.; Geffner, J. Host response to respiratory syncytial virus infection Curr. Opin. Infect. Dis. 2015, 28, 259-266 10.1097/QCO.0000000000000159
23. Oshansky, C. M.; Zhang, W.; Moore, E.; Tripp, R. A. The host response and molecular pathogenesis associated with respiratory syncytial virus infection Future Microbiol. 2009, 4, 279-297 10.2217/fmb.09.1
24. Ugonna, K.; Bingle, C. D.; Plant, K.; Wilson, K.; Everard, M. L. Macrophages are required for dendritic cell uptake of respiratory syncytial virus from an infected epithelium PLoS One 2014, 9, e91855 10.1371/journal.pone.0091855
25. Mercer, J.; Greber, U. F. Virus interactions with endocytic pathways in macrophages and dendritic cells Trends Microbiol. 2013, 21, 380-388 10.1016/j.tim.2013.06.001
26. Lin, H. W.; Chen, Y. C.; Liu, C. W.; Yang, D. J.; Chen, S. Y.; Chang, T. J.; Chang, Y. Y. Regulation of virus-induced inflammatory response by Dunaliella salina alga extract in macrophages Food Chem. Toxicol. 2014, 71, 159-165 10.1016/j.fct.2014.05.026
27. Huang, S. H.; Cao, X. J.; Wei, W. Melatonin decreases TLR3-mediated inflammatory factor expression via inhibition of NF-kappa B activation in respiratory syncytial virus-infected RAW264.7 macrophages J. Pineal Res. 2008, 45, 93-100 10.1111/j.1600-079X.2008.00560.x
28. Abarikwu, S. O. Kolaviron, a natural flavonoid from the seeds of Garcinia kola, reduces LPS-induced inflammation in macrophages by combined inhibition of IL-6 secretion, and inflammatory transcription factors, ERK1/2, NF-kappaB, p38, Akt, p-c-JUN and JNK Biochim. Biophys. Acta, Gen. Subj. 2014, 1840, 2373-2381 10.1016/j.bbagen.2014.03.006
29. Yoo, J. K.; Kim, T. S.; Hufford, M. M.; Braciale, T. J. Viral infection of the lung: host response and sequelae J. Allergy Clin. Immunol. 2013, 132, 1263-1277 10.1016/j.jaci.2013.06.006