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Volumn 6, Issue 1, 2015, Pages

Sex differences in protein expression in the mouse brain and their perturbations in a model of Down syndrome

Author keywords

Cerebellum; Dp(10)1Yey; Hippocampus; Intellectual disability; Learning; Memory deficits; Mouse chromosome 10; S100B; Trisomy 21; TRPM2

Indexed keywords


EID: 84946429843     PISSN: None     EISSN: 20426410     Source Type: Journal    
DOI: 10.1186/s13293-015-0043-9     Document Type: Article
Times cited : (34)

References (89)
  • 1
    • 72849131622 scopus 로고    scopus 로고
    • Sex differences in molecular neuroscience: From fruit flies to humans
    • Jazin E, Cahill L. Sex differences in molecular neuroscience: from fruit flies to humans. Nat Rev Neurosci. 2010;11:9–17.
    • (2010) Nat Rev Neurosci. , vol.11 , pp. 9-17
    • Jazin, E.1    Cahill, L.2
  • 3
    • 84941879906 scopus 로고    scopus 로고
    • Hippocampal learning, memory, and neurogenesis: Effects of sex and estrogens across the lifespan in adults
    • Duarte-Guterman P, Yagi S, Chow C, Galea LA. Hippocampal learning, memory, and neurogenesis: effects of sex and estrogens across the lifespan in adults. Horm Behav. 2015;74:37–52.
    • (2015) Horm Behav , vol.74 , pp. 37-52
    • Duarte-Guterman, P.1    Yagi, S.2    Chow, C.3    Galea, L.A.4
  • 4
    • 78649749341 scopus 로고    scopus 로고
    • The prefrontal cortex communicates with the amygdala to impair learning after acute stress in females but not in males
    • Maeng LY, Waddell J, Shors TJ. The prefrontal cortex communicates with the amygdala to impair learning after acute stress in females but not in males. J Neurosci. 2010;30:16188–96.
    • (2010) J Neurosci. , vol.30 , pp. 16188-16196
    • Maeng, L.Y.1    Waddell, J.2    Shors, T.J.3
  • 5
    • 77957571306 scopus 로고    scopus 로고
    • Sex differences in the brain, behavior, and neuropsychiatric disorders
    • Bao A-M, Swaab DF. Sex differences in the brain, behavior, and neuropsychiatric disorders. Neuroscientist. 2010;16:550–65.
    • (2010) Neuroscientist , vol.16 , pp. 550-565
    • Bao, A.-M.1    Swaab, D.F.2
  • 6
    • 77956209928 scopus 로고    scopus 로고
    • Why women have more Alzheimer’s disease than men: Gender and mitochondrial toxicity of amyloid-beta peptide
    • Viña J, Lloret A. Why women have more Alzheimer’s disease than men: gender and mitochondrial toxicity of amyloid-beta peptide. J Alzheimers Dis. 2010;20 Suppl 2:S527–33.
    • (2010) J Alzheimers Dis. , vol.20 , pp. S527-S533
    • Viña, J.1    Lloret, A.2
  • 7
    • 84892427565 scopus 로고    scopus 로고
    • Pharmacogenomics, pharmacokinetics and pharmacodynamics: Interaction with biological differences between men and women
    • Franconi F, Campesi I. Pharmacogenomics, pharmacokinetics and pharmacodynamics: interaction with biological differences between men and women. Br J Pharmacol. 2014;171:580–94.
    • (2014) Br J Pharmacol. , vol.171 , pp. 580-594
    • Franconi, F.1    Campesi, I.2
  • 8
    • 84887953610 scopus 로고    scopus 로고
    • Sex differences in the human brain and the impact of sex chromosomes and sex hormones
    • Lentini E, Kasahara M, Arver S, Savic I. Sex differences in the human brain and the impact of sex chromosomes and sex hormones. Cereb Cortex. 2013;23:2322–36.
    • (2013) Cereb Cortex , vol.23 , pp. 2322-2336
    • Lentini, E.1    Kasahara, M.2    Arver, S.3    Savic, I.4
  • 10
    • 15244353967 scopus 로고    scopus 로고
    • X-inactivation profile reveals extensive variability in X-linked gene expression in females
    • Carrel L, Willard HF. X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature. 2005;434:400–4.
    • (2005) Nature , vol.434 , pp. 400-404
    • Carrel, L.1    Willard, H.F.2
  • 11
    • 17444421587 scopus 로고    scopus 로고
    • X-linked genes and mental functioning
    • Skuse DH. X-linked genes and mental functioning. Hum Mol Genet. 2005;15(14 Spec No 1):R27–32.
    • (2005) Hum Mol Genet. , vol.15 , Issue.14 Spec No 1 , pp. R27-R32
    • Skuse, D.H.1
  • 13
    • 77956595381 scopus 로고    scopus 로고
    • Sexual dimorphism in mammalian autosomal gene regulation is determined not only by Sry but by sex chromosome complement as well
    • Wijchers PJ, Yandim C, Panousopoulou E, Ahmad M, Harker N, Saveliev A, et al. Sexual dimorphism in mammalian autosomal gene regulation is determined not only by Sry but by sex chromosome complement as well. Dev Cell. 2010;19:477–84.
    • (2010) Dev Cell , vol.19 , pp. 477-484
    • Wijchers, P.J.1    Yandim, C.2    Panousopoulou, E.3    Ahmad, M.4    Harker, N.5    Saveliev, A.6
  • 14
    • 33845386437 scopus 로고    scopus 로고
    • It is not all hormones: Alternative explanations for sexual differentiation of the brain
    • Davies W, Wilkinson LS. It is not all hormones: alternative explanations for sexual differentiation of the brain. Brain Res. 2006;1126:36–45.
    • (2006) Brain Res. , vol.1126 , pp. 36-45
    • Davies, W.1    Wilkinson, L.S.2
  • 16
    • 0036948248 scopus 로고    scopus 로고
    • The epidemiology of mental retardation: Challenges and opportunities in the new millennium
    • Leonard H, Wen X. The epidemiology of mental retardation: challenges and opportunities in the new millennium. Ment Retard Dev Disabil Res Rev. 2002;8:117–34.
    • (2002) Ment Retard Dev Disabil Res Rev. , vol.8 , pp. 117-134
    • Leonard, H.1    Wen, X.2
  • 17
    • 1642376040 scopus 로고    scopus 로고
    • Molecular and comparative genetics of mental retardation
    • Inlow JK, Restifo LL. Molecular and comparative genetics of mental retardation. Genetics. 2004;166:835–81.
    • (2004) Genetics , vol.166 , pp. 835-881
    • Inlow, J.K.1    Restifo, L.L.2
  • 19
  • 20
    • 54549099195 scopus 로고    scopus 로고
    • Twenty-year trends in prevalence and survival of Down syndrome
    • Irving C, Basu A, Richmond S, Burn J, Wren C. Twenty-year trends in prevalence and survival of Down syndrome. Eur J Hum Genet. 2008;16:1336–40.
    • (2008) Eur J Hum Genet , vol.16 , pp. 1336-1340
    • Irving, C.1    Basu, A.2    Richmond, S.3    Burn, J.4    Wren, C.5
  • 21
    • 32544458799 scopus 로고    scopus 로고
    • Improved national prevalence estimates for 18 major birth defects
    • CDC, Centers for Disease Control and Prevention. Improved national prevalence estimates for 18 major birth defects. MMWR Morb Mortal Wkly Rep. 2006;54:1301–5.
    • (2006) MMWR Morb Mortal Wkly Rep , vol.54 , pp. 1301-1305
  • 22
    • 80051549592 scopus 로고    scopus 로고
    • Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions
    • Sturgeon X, Gardiner K. Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions. Mamm Genome. 2011;22:261–71.
    • (2011) Mamm Genome , vol.22 , pp. 261-271
    • Sturgeon, X.1    Gardiner, K.2
  • 23
    • 85044347178 scopus 로고    scopus 로고
    • The Sanger Center, Hinxton. Accessed 22 July 2015
    • Vertebrate Genome Annotation. The Sanger Center, Hinxton. 2015. http://vega.sanger.ac.uk/index.html. Accessed 22 July 2015.
    • (2015) Vertebrate Genome Annotation
  • 26
    • 0042025827 scopus 로고    scopus 로고
    • Down’s syndrome: A genetic disorder in biobehavioral perspective
    • Nadel L. Down’s syndrome: a genetic disorder in biobehavioral perspective. Genes Brain Behav. 2003;2:156–66.
    • (2003) Genes Brain Behav , vol.2 , pp. 156-166
    • Nadel, L.1
  • 27
    • 84860330689 scopus 로고    scopus 로고
    • Neurological phenotypes for Down syndrome across the life span
    • Lott IT. Neurological phenotypes for Down syndrome across the life span. Prog Brain Res. 2012;197:101–21.
    • (2012) Prog Brain Res. , vol.197 , pp. 101-121
    • Lott, I.T.1
  • 28
    • 84862333723 scopus 로고    scopus 로고
    • Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities
    • Rueda N, Flórez J, Martínez-Cué C. Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities. Neural Plast. 2012;2012:26.
    • (2012) Neural Plast , vol.2012 , pp. 26
    • Rueda, N.1    Flórez, J.2    Martínez-Cué, C.3
  • 29
    • 77954461956 scopus 로고    scopus 로고
    • A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions
    • Yu T, Li Z, Jia Z, Clapcote SJ, Liu C, Li S, et al. A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions. Hum Mol Genet. 2010;19:2780–91.
    • (2010) Hum Mol Genet , vol.19 , pp. 2780-2791
    • Yu, T.1    Li, Z.2    Jia, Z.3    Clapcote, S.J.4    Liu, C.5    Li, S.6
  • 30
    • 81855226648 scopus 로고    scopus 로고
    • Editing of neurotransmitter receptor and ion channel RNAs in the nervous system
    • Hood J, Emeson R. Editing of neurotransmitter receptor and ion channel RNAs in the nervous system. Curr Top Microbiol Immunol. 2012;353:61–90.
    • (2012) Curr Top Microbiol Immunol , vol.353 , pp. 61-90
    • Hood, J.1    Emeson, R.2
  • 31
    • 57649129042 scopus 로고    scopus 로고
    • RNA editing as a therapeutic target for CNS disorders
    • Morabito MV, Emeson RB. RNA editing as a therapeutic target for CNS disorders. Neuropsychopharmacology. 2009;34:246.
    • (2009) Neuropsychopharmacology , vol.34 , pp. 246
    • Morabito, M.V.1    Emeson, R.B.2
  • 32
    • 77956015613 scopus 로고    scopus 로고
    • The roles of phospholipase C activation and alternative ADAR1 and ADAR2 pre-mRNA splicing in modulating serotonin 2C-receptor editing in vivo
    • Schmauss C, Zimnisky R, Mehta M, Shapiro LP. The roles of phospholipase C activation and alternative ADAR1 and ADAR2 pre-mRNA splicing in modulating serotonin 2C-receptor editing in vivo. RNA. 2010;16:1779–85.
    • (2010) RNA , vol.16 , pp. 1779-1785
    • Schmauss, C.1    Zimnisky, R.2    Mehta, M.3    Shapiro, L.P.4
  • 33
    • 34247372269 scopus 로고    scopus 로고
    • Editing modifies the GABA(A) receptor subunit alpha3
    • Ohlson J, Pedersen JS, Haussler D, Ohman M. Editing modifies the GABA(A) receptor subunit alpha3. RNA. 2007;13:698–703.
    • (2007) RNA , vol.13 , pp. 698-703
    • Ohlson, J.1    Pedersen, J.S.2    Haussler, D.3    Ohman, M.4
  • 35
    • 0034704068 scopus 로고    scopus 로고
    • Coregulation of neurite outgrowth and cell survival by amphoterin and S100 proteins through receptor for advanced glycation end products (RAGE) activation
    • Huttunen HJ, Kuja-Panula J, Sorci G, Agneletti AL, Donato R, Rauvala H. Coregulation of neurite outgrowth and cell survival by amphoterin and S100 proteins through receptor for advanced glycation end products (RAGE) activation. J Biol Chem. 2000;275:40096–105.
    • (2000) J Biol Chem. , vol.275 , pp. 40096-40105
    • Huttunen, H.J.1    Kuja-Panula, J.2    Sorci, G.3    Agneletti, A.L.4    Donato, R.5    Rauvala, H.6
  • 36
    • 75849133906 scopus 로고    scopus 로고
    • Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer’s disease
    • Mori T, Koyama N, Arendash GW, Horikoshi-Sakuraba Y, Tan J, Town T. Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer’s disease. Glia. 2010;58:300–14.
    • (2010) Glia , vol.58 , pp. 300-314
    • Mori, T.1    Koyama, N.2    Arendash, G.W.3    Horikoshi-Sakuraba, Y.4    Tan, J.5    Town, T.6
  • 37
    • 84920984446 scopus 로고    scopus 로고
    • Abnormal microglial activation in the Cstb−/− Mouse, a model for progressive myoclonus epilepsy, EPM1
    • Okuneva O, Körber I, Li Z, Tian L, Joensuu T, Kopra O, et al. Abnormal microglial activation in the Cstb−/− mouse, a model for progressive myoclonus epilepsy, EPM1. Glia. 2015;63:400–11.
    • (2015) Glia , vol.63 , pp. 400-411
    • Okuneva, O.1    Körber, I.2    Li, Z.3    Tian, L.4    Joensuu, T.5    Kopra, O.6
  • 38
    • 0041813308 scopus 로고    scopus 로고
    • Molecular background of progressive myoclonus epilepsy
    • Lehesjoki AE. Molecular background of progressive myoclonus epilepsy. The EMBO Journal. 2003;22:3473–8.
    • (2003) The EMBO Journal , vol.22 , pp. 3473-3478
    • Lehesjoki, A.E.1
  • 39
    • 84865800824 scopus 로고    scopus 로고
    • Target-derived matricryptins organize cerebellar synapse formation through α3β1 Integrins
    • Su J, Stenbjorn Renee S, Gorse K, Su K, Hauser KF, Ricard-Blum S, et al. Target-derived matricryptins organize cerebellar synapse formation through α3β1 Integrins. Cell Rep. 2012;2:223–30.
    • (2012) Cell Rep. , vol.2 , pp. 223-230
    • Su, J.1    Stenbjorn Renee, S.2    Gorse, K.3    Su, K.4    Hauser, K.F.5    Ricard-Blum, S.6
  • 40
    • 77957970686 scopus 로고    scopus 로고
    • Endostatin binds nerve growth factor and thereby inhibits neurite outgrowth and neuronal migration in-vitro
    • Al Ahmad A, Lee B, Stack J, Parham C, Campbell J, Clarke D, et al. Endostatin binds nerve growth factor and thereby inhibits neurite outgrowth and neuronal migration in-vitro. Brain Res. 2010;1360:28–39.
    • (2010) Brain Res. , vol.1360 , pp. 28-39
    • Al Ahmad, A.1    Lee, B.2    Stack, J.3    Parham, C.4    Campbell, J.5    Clarke, D.6
  • 41
    • 34548452082 scopus 로고    scopus 로고
    • PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor
    • Meyer R, Wolf SS, Obendorf M. PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor. J Steroid Biochem Mol Biol. 2007;107:1–14.
    • (2007) J Steroid Biochem Mol Biol. , vol.107 , pp. 1-14
    • Meyer, R.1    Wolf, S.S.2    Obendorf, M.3
  • 42
    • 0037047399 scopus 로고    scopus 로고
    • Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor α
    • Qi C, Chang J, Zhu Y, Yeldandi AV, Rao SM, Zhu Y-J. Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor α. J Biol Chem. 2002;277:28624–30.
    • (2002) J Biol Chem. , vol.277 , pp. 28624-28630
    • Qi, C.1    Chang, J.2    Zhu, Y.3    Yeldandi, A.V.4    Rao, S.M.5    Zhu, Y.-J.6
  • 43
    • 33645213038 scopus 로고    scopus 로고
    • SUMO-3 enhances androgen receptor transcriptional activity through a sumoylation-independent mechanism in prostate cancer cells
    • Zheng Z, Cai C, Omwancha J, Chen S-Y, Baslan T, Shemshedini L. SUMO-3 enhances androgen receptor transcriptional activity through a sumoylation-independent mechanism in prostate cancer cells. J Biol Chem. 2006;281:4002–12.
    • (2006) J Biol Chem. , vol.281 , pp. 4002-4012
    • Zheng, Z.1    Cai, C.2    Omwancha, J.3    Chen, S.-Y.4    Baslan, T.5    Shemshedini, L.6
  • 44
    • 83755196329 scopus 로고    scopus 로고
    • Dependence of NMDA/GSK-3β mediated metaplasticity on TRPM2 channels at hippocampal CA3-CA1 synapses
    • Xie YF, Belrose JC, Lei G, Tymianski M, Mori Y, Macdonald JF, et al. Dependence of NMDA/GSK-3β mediated metaplasticity on TRPM2 channels at hippocampal CA3-CA1 synapses. Mol Brain. 2011;4:44.
    • (2011) Mol Brain. , vol.4 , pp. 44
    • Xie, Y.F.1    Belrose, J.C.2    Lei, G.3    Tymianski, M.4    Mori, Y.5    Macdonald, J.F.6
  • 45
    • 80455164731 scopus 로고    scopus 로고
    • Sex differences in neuroprotection provided by inhibition of TRPM2 channels following experimental stroke
    • Jia J, Verma S, Nakayama S, Quillinan N, Grafe MR, Hurn PD, et al. Sex differences in neuroprotection provided by inhibition of TRPM2 channels following experimental stroke. J Cereb Blood Flow Metab. 2011;31:2160–8.
    • (2011) J Cereb Blood Flow Metab , vol.31 , pp. 2160-2168
    • Jia, J.1    Verma, S.2    Nakayama, S.3    Quillinan, N.4    Grafe, M.R.5    Hurn, P.D.6
  • 46
    • 79251627273 scopus 로고    scopus 로고
    • Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice
    • Yu T, Liu C, Belichenko P, Clapcote SJ, Li S, Pao A, et al. Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice. Brain Res. 2010;1366:162–71.
    • (2010) Brain Res. , vol.1366 , pp. 162-171
    • Yu, T.1    Liu, C.2    Belichenko, P.3    Clapcote, S.J.4    Li, S.5    Pao, A.6
  • 47
    • 84919599351 scopus 로고    scopus 로고
    • Abnormal protein profiles in hippocampus of mouse models of Down syndrome: Similarities with Alzheimer’s disease
    • Block A, Dhanasekaran AR, Ahmed MM, Gardiner KJ. Abnormal protein profiles in hippocampus of mouse models of Down syndrome: similarities with Alzheimer’s disease. J Alzheimers Dis Parkinsonism. 2014;4:138.
    • (2014) J Alzheimers Dis Parkinsonism , vol.4 , pp. 138
    • Block, A.1    Dhanasekaran, A.R.2    Ahmed, M.M.3    Gardiner, K.J.4
  • 48
    • 84856688136 scopus 로고    scopus 로고
    • Loss of correlations among proteins in brains of the Ts65Dn mouse model of Down syndrome
    • Ahmed MM, Sturgeon X, Ellison M, Davisson MT, Gardiner KJ. Loss of correlations among proteins in brains of the Ts65Dn mouse model of Down syndrome. J Proteome Res. 2012;11:1251–63.
    • (2012) J Proteome Res. , vol.11 , pp. 1251-1263
    • Ahmed, M.M.1    Sturgeon, X.2    Ellison, M.3    Davisson, M.T.4    Gardiner, K.J.5
  • 50
    • 84925678088 scopus 로고    scopus 로고
    • Protein dynamics associated with failed and rescued learning in the Ts65Dn mouse model of Down syndrome
    • Ahmed MM, Dhanasekaran AR, Block A, Tong S, Costa ACS, Stasko M, et al. Protein dynamics associated with failed and rescued learning in the Ts65Dn mouse model of Down syndrome. PLoS ONE. 2015;10:e0119491.
    • (2015) PLoS ONE , vol.10 , pp. e0119491
    • Ahmed, M.M.1    Dhanasekaran, A.R.2    Block, A.3    Tong, S.4    Costa, A.C.S.5    Stasko, M.6
  • 53
    • 84858439862 scopus 로고    scopus 로고
    • Insights into the regulation of protein abundance from proteomic and transcriptomic analyses
    • Vogel C, Marcotte EM. Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. Nat Rev Genet. 2012;13:227–32.
    • (2012) Nat Rev Genet , vol.13 , pp. 227-232
    • Vogel, C.1    Marcotte, E.M.2
  • 54
    • 84856974150 scopus 로고    scopus 로고
    • Fyn knock-down increases Aβ, decreases phospho-tau, and worsens spatial learning in 3×Tg-AD mice
    • e15-24
    • Minami SS, Clifford TG, Hoe HS, Matsuoka Y, Rebeck GW. Fyn knock-down increases Aβ, decreases phospho-tau, and worsens spatial learning in 3×Tg-AD mice. Neurobiol Aging. 2012;33:825. e15-24.
    • (2012) Neurobiol Aging. , vol.33 , pp. 825
    • Minami, S.S.1    Clifford, T.G.2    Hoe, H.S.3    Matsuoka, Y.4    Rebeck, G.W.5
  • 55
    • 80053582151 scopus 로고    scopus 로고
    • Gender specific requirement of GluR1 receptors in contextual conditioning but not spatial learning
    • Dachtler J, Fox KD, Good MA. Gender specific requirement of GluR1 receptors in contextual conditioning but not spatial learning. Neurobiol of Learn and Mem. 2011;96:461–7.
    • (2011) Neurobiol of Learn and Mem , vol.96 , pp. 461-467
    • Dachtler, J.1    Fox, K.D.2    Good, M.A.3
  • 56
    • 36649022067 scopus 로고    scopus 로고
    • Female CREBαδ− Deficient mice show earlier age-related cognitive deficits than males
    • Hebda-Bauer EK, Luo J, Watson SJ, Akil H. Female CREBαδ− deficient mice show earlier age-related cognitive deficits than males. Neuroscience. 2007;150:260–72.
    • (2007) Neuroscience , vol.150 , pp. 260-272
    • Hebda-Bauer, E.K.1    Luo, J.2    Watson, S.J.3    Akil, H.4
  • 57
    • 84911453943 scopus 로고    scopus 로고
    • NMDA receptor-deficient mice display sexual dimorphism in the onset and severity of behavioural abnormalities
    • Milenkovic M, Mielnik CA, Ramsey AJ. NMDA receptor-deficient mice display sexual dimorphism in the onset and severity of behavioural abnormalities. Genes Brain Behav. 2014;13:850–62.
    • (2014) Genes Brain Behav , vol.13 , pp. 850-862
    • Milenkovic, M.1    Mielnik, C.A.2    Ramsey, A.J.3
  • 58
    • 84877006351 scopus 로고    scopus 로고
    • Gender-specific effects of fluoxetine on hippocampal glucocorticoid receptor phosphorylation and behavior in chronically stressed rats
    • Mitic M, Simic I, Djordjevic J, Radojcic MB, Adzic M. Gender-specific effects of fluoxetine on hippocampal glucocorticoid receptor phosphorylation and behavior in chronically stressed rats. Neuropharmacology. 2013;70:100–1159.
    • (2013) Neuropharmacology , vol.70 , pp. 100-1159
    • Mitic, M.1    Simic, I.2    Djordjevic, J.3    Radojcic, M.B.4    Adzic, M.5
  • 59
    • 84939566511 scopus 로고    scopus 로고
    • Fluoxetine signature on hippocampal MAPK signalling in sex-dependent manner
    • Mitic M, Lukic I, Bozovic N, Djordjevic J, Adzic M. Fluoxetine signature on hippocampal MAPK signalling in sex-dependent manner. J Mol Neurosci. 2015;55:335–46.
    • (2015) J Mol Neurosci. , vol.55 , pp. 335-346
    • Mitic, M.1    Lukic, I.2    Bozovic, N.3    Djordjevic, J.4    Adzic, M.5
  • 60
    • 77954412951 scopus 로고    scopus 로고
    • Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome
    • Bianchi P, Ciani E, Guidi S, Trazzi S, Felice D, Grossi G, et al. Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome. J Neurosci. 2010;30:8769–79.
    • (2010) J Neurosci. , vol.30 , pp. 8769-8779
    • Bianchi, P.1    Ciani, E.2    Guidi, S.3    Trazzi, S.4    Felice, D.5    Grossi, G.6
  • 61
    • 84890284361 scopus 로고    scopus 로고
    • Fluoxetine in adulthood normalizes GABA release and rescues hippocampal synaptic plasticity and spatial memory in a mouse model of Down Syndrome
    • Begenisic T, Baroncelli L, Sansevero G, Milanese M, Bonifacino T, Bonanno G, et al. Fluoxetine in adulthood normalizes GABA release and rescues hippocampal synaptic plasticity and spatial memory in a mouse model of Down Syndrome. Neurobiol Dis. 2014;63:12–9.
    • (2014) Neurobiol Dis. , vol.63 , pp. 12-19
    • Begenisic, T.1    Baroncelli, L.2    Sansevero, G.3    Milanese, M.4    Bonifacino, T.5    Bonanno, G.6
  • 62
    • 84916920183 scopus 로고    scopus 로고
    • Long-term effects of neonatal treatment with fluoxetine on cognitive performance in Ts65Dn mice
    • Stagni F, Giacomini A, Guidi S, Ciani E, Ragazzi E, Filonzi M, et al. Long-term effects of neonatal treatment with fluoxetine on cognitive performance in Ts65Dn mice. Neurobiol Dis. 2015;74:204–18.
    • (2015) Neurobiol Dis. , vol.74 , pp. 204-218
    • Stagni, F.1    Giacomini, A.2    Guidi, S.3    Ciani, E.4    Ragazzi, E.5    Filonzi, M.6
  • 63
    • 84919627277 scopus 로고    scopus 로고
    • Pharmacological approaches to improving cognitive function in Down syndrome: Current status and considerations
    • Gardiner KJ. Pharmacological approaches to improving cognitive function in Down syndrome: current status and considerations. Drug Des Devel Ther. 2014;9:103–25.
    • (2014) Drug Des Devel Ther , vol.9 , pp. 103-125
    • Gardiner, K.J.1
  • 64
    • 0025876197 scopus 로고
    • Down syndrome: MR quantification of brain structures and comparison with normal control subjects
    • Weis S, Weber G, Neuhold A, Rett A. Down syndrome: MR quantification of brain structures and comparison with normal control subjects. AJNR Am J Neuroradiol. 1991;12:1207–11.
    • (1991) AJNR Am J Neuroradiol , vol.12 , pp. 1207-1211
    • Weis, S.1    Weber, G.2    Neuhold, A.3    Rett, A.4
  • 65
    • 0033978891 scopus 로고    scopus 로고
    • Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse
    • Baxter LL, Moran TH, Richtsmeier JT, Troncoso J, Reeves RH. Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse. Hum Mol Genet. 2000;9:195–202.
    • (2000) Hum Mol Genet. , vol.9 , pp. 195-202
    • Baxter, L.L.1    Moran, T.H.2    Richtsmeier, J.T.3    Troncoso, J.4    Reeves, R.H.5
  • 67
    • 84887005295 scopus 로고    scopus 로고
    • The cerebellum and cognitive function: 25 years of insight from anatomy and neuroimaging
    • Buckner RL. The cerebellum and cognitive function: 25 years of insight from anatomy and neuroimaging. Neuron. 2013;80:807–15.
    • (2013) Neuron , vol.80 , pp. 807-815
    • Buckner, R.L.1
  • 68
    • 77957029374 scopus 로고    scopus 로고
    • Nuclear receptor repression: Regulatory mechanisms and physiological implications
    • Stewart MD, Wong J. Nuclear receptor repression: regulatory mechanisms and physiological implications. Prog Mol Biol Transl Sci. 2009;87:235–59.
    • (2009) Prog Mol Biol Transl Sci. , vol.87 , pp. 235-259
    • Stewart, M.D.1    Wong, J.2
  • 69
    • 79959794425 scopus 로고    scopus 로고
    • TRP channels as mediators of oxidative stress
    • Miller BA, Zhang W. TRP channels as mediators of oxidative stress. Adv Exp Med Biol. 2011;704:531–44.
    • (2011) Adv Exp Med Biol. , vol.704 , pp. 531-544
    • Miller, B.A.1    Zhang, W.2
  • 70
    • 84922101430 scopus 로고    scopus 로고
    • Reduction in traumatic brain injury-induced oxidative stress, apoptosis, and calcium entry in rat hippocampus by melatonin: Possible involvement of TRPM2 channels
    • Yürüker V, Nazıroğlu M, Şenol N. Reduction in traumatic brain injury-induced oxidative stress, apoptosis, and calcium entry in rat hippocampus by melatonin: possible involvement of TRPM2 channels. Metab Brain Dis. 2015;30:223–31.
    • (2015) Metab Brain Dis. , vol.30 , pp. 223-231
    • Yürüker, V.1    Nazıroğlu, M.2    Şenol, N.3
  • 71
    • 84868301057 scopus 로고    scopus 로고
    • TRPM2 channel activation following in vitro ischemia contributes to Male hippocampal cell death
    • Verma S, Quillinan N, Yang YF, Nakayama S, Cheng J, Kelley MH, et al. TRPM2 channel activation following in vitro ischemia contributes to male hippocampal cell death. Neurosci Lett. 2012;530:41–6.
    • (2012) Neurosci Lett. , vol.530 , pp. 41-46
    • Verma, S.1    Quillinan, N.2    Yang, Y.F.3    Nakayama, S.4    Cheng, J.5    Kelley, M.H.6
  • 73
    • 80054875852 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and Down’s syndrome: Is there a role for coenzyme Q(10)?
    • Tiano L, Busciglio J. Mitochondrial dysfunction and Down’s syndrome: is there a role for coenzyme Q(10)? Biofactors. 2011;37:386–92.
    • (2011) Biofactors , vol.37 , pp. 386-392
    • Tiano, L.1    Busciglio, J.2
  • 74
    • 84923301658 scopus 로고    scopus 로고
    • The key role of transient receptor potential melastatin-2 channels in amyloid-β-induced neurovascular dysfunction
    • Park L, Wang G, Moore J, Girouard H, Zhou P, Anrather J, et al. The key role of transient receptor potential melastatin-2 channels in amyloid-β-induced neurovascular dysfunction. Nat Commun. 2014;5.
    • (2014) Nat Commun. , vol.5
    • Park, L.1    Wang, G.2    Moore, J.3    Girouard, H.4    Zhou, P.5    Anrather, J.6
  • 75
    • 77951794067 scopus 로고    scopus 로고
    • Global survey of escape from X inactivation by RNA-sequencing in mouse
    • Yang F, Babak T, Shendure J, Disteche CM. Global survey of escape from X inactivation by RNA-sequencing in mouse. Genome Res. 2010;20:614–22.
    • (2010) Genome Res. , vol.20 , pp. 614-622
    • Yang, F.1    Babak, T.2    Shendure, J.3    Disteche, C.M.4
  • 76
    • 84888367236 scopus 로고    scopus 로고
    • Widespread sex differences in gene expression and splicing in the adult human brain
    • Trabzuni D, Ramasamy A, Imran S, Walker R, Smith C, Weale ME, et al. Widespread sex differences in gene expression and splicing in the adult human brain. Nat Commun. 2013;4:2771.
    • (2013) Nat Commun. , vol.4 , pp. 2771
    • Trabzuni, D.1    Ramasamy, A.2    Imran, S.3    Walker, R.4    Smith, C.5    Weale, M.E.6
  • 77
    • 84901029300 scopus 로고    scopus 로고
    • X chromosome regulation: Diverse patterns in development, tissues and disease
    • Deng X, Berletch JB, Nguyen DK, Disteche CM. X chromosome regulation: diverse patterns in development, tissues and disease. Nat Rev Genet. 2014;15:367–78.
    • (2014) Nat Rev Genet , vol.15 , pp. 367-378
    • Deng, X.1    Berletch, J.B.2    Nguyen, D.K.3    Disteche, C.M.4
  • 78
    • 84890354567 scopus 로고    scopus 로고
    • Genes that escape X-inactivation in humans have high intraspecific variability in expression, are associated with mental impairment but are not slow evolving
    • Zhang Y, Castillo-Morales A, Jiang M, Zhu Y, Hu L, Urrutia AO, et al. Genes that escape X-inactivation in humans have high intraspecific variability in expression, are associated with mental impairment but are not slow evolving. Mol Biol Evol. 2013;30:2588–601.
    • (2013) Mol Biol Evol. , vol.30 , pp. 2588-2601
    • Zhang, Y.1    Castillo-Morales, A.2    Jiang, M.3    Zhu, Y.4    Hu, L.5    Urrutia, A.O.6
  • 82
    • 1242320013 scopus 로고    scopus 로고
    • Sex differences in performance over 7 years on the Wechsler Intelligence Scale for Children—revised among adults with intellectual disability
    • Kittler P, Krinsky-McHale SJ, Devenny DA. Sex differences in performance over 7 years on the Wechsler Intelligence Scale for Children—revised among adults with intellectual disability. J Intellect Disabil Res. 2004;48:114–22.
    • (2004) J Intellect Disabil Res , vol.48 , pp. 114-122
    • Kittler, P.1    Krinsky-McHale, S.J.2    Devenny, D.A.3
  • 84
    • 79953113713 scopus 로고    scopus 로고
    • Widespread proliferation impairment and hypocellularity in the cerebellum of fetuses with down syndrome
    • Guidi S, Ciani E, Bonasoni P, Santini D, Bartesaghi R. Widespread proliferation impairment and hypocellularity in the cerebellum of fetuses with down syndrome. Brain Pathol. 2011;21:361–73.
    • (2011) Brain Pathol , vol.21 , pp. 361-373
    • Guidi, S.1    Ciani, E.2    Bonasoni, P.3    Santini, D.4    Bartesaghi, R.5
  • 85
    • 84890794994 scopus 로고    scopus 로고
    • Sex differences in the cholinergic basal forebrain in the Ts65Dn mouse model of Down syndrome and Alzheimer’s disease
    • Kelley CM, Powers BE, Velazquez R, Ash JA, Ginsberg SD, Strupp BJ, et al. Sex differences in the cholinergic basal forebrain in the Ts65Dn mouse model of Down syndrome and Alzheimer’s disease. Brain Pathol. 2014;24:33–44.
    • (2014) Brain Pathol , vol.24 , pp. 33-44
    • Kelley, C.M.1    Powers, B.E.2    Velazquez, R.3    Ash, J.A.4    Ginsberg, S.D.5    Strupp, B.J.6
  • 86
    • 33745684724 scopus 로고    scopus 로고
    • Anxiety and panic responses to a predator in Male and female Ts65Dn mice, a model for Down syndrome
    • Martínez-Cué C, Rueda N, García E, Flórez J. Anxiety and panic responses to a predator in male and female Ts65Dn mice, a model for Down syndrome. Genes Brain Behav. 2006;5:413–22.
    • (2006) Genes Brain Behav , vol.5 , pp. 413-422
    • Martínez-Cué, C.1    Rueda, N.2    García, E.3    Flórez, J.4
  • 87
    • 34948884575 scopus 로고    scopus 로고
    • Sex does matter: Comments on the prevalence of Male-only investigations of drug effects on rodent behaviour
    • Hughes RN. Sex does matter: comments on the prevalence of male-only investigations of drug effects on rodent behaviour. Behav Pharmacol. 2007;18:583–9.
    • (2007) Behav Pharmacol , vol.18 , pp. 583-589
    • Hughes, R.N.1
  • 88
    • 84897425769 scopus 로고    scopus 로고
    • Preclinical research: Make mouse studies work
    • Perrin S. Preclinical research: make mouse studies work. Nature. 2014;507:423–5.
    • (2014) Nature , vol.507 , pp. 423-425
    • Perrin, S.1
  • 89
    • 84900526349 scopus 로고    scopus 로고
    • Policy: NIH to balance sex in cell and animal studies
    • Clayton JA, Collins FS. Policy: NIH to balance sex in cell and animal studies. Nature. 2014;509:282–3.
    • (2014) Nature , vol.509 , pp. 282-283
    • Clayton, J.A.1    Collins, F.S.2


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