The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing

Neuroscience Letters

Volumn 610, Issue , 2016, Pages 36-42

  Sexton, Jane E ^a   Desmonds, Terri ^b   Quick, Kathryn ^a   Taylor, Ruth ^c   Abramowitz, Joel ^d   Forge, Andy ^c   Kros, Corné J ^b,e   Birnbaumer, Lutz ^d   Wood, John N ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF SUSSEX   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^e UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Mechanosensation; Touch; TRP channels

Indexed keywords

TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL 3; TRANSIENT RECEPTOR POTENTIAL CHANNEL 5; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY C, MEMBER 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPC5 PROTEIN, MOUSE; TRPC6 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ARTICLE; AUDITORY MECHANOSENSATION; AUDITORY SYSTEM PARAMETERS; COCHLEA; CONTROLLED STUDY; CUTANEOUS MECHANOSENSATION; HEARING; KNOCKOUT MOUSE; MOUSE; MUTANT; NONHUMAN; OUTER HAIR CELL; PRIORITY JOURNAL; SENSORY SYSTEM PARAMETERS; TOUCH; VESTIBULAR FUNCTION; ANIMAL; C57BL MOUSE; COCHLEAR HAIR CELL; EVOKED BRAIN STEM AUDITORY RESPONSE; GENETICS; PHYSIOLOGY; VESTIBULAR TEST;

ANIMALS; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; HAIR CELLS, AUDITORY; HEARING; MICE, INBRED C57BL; MICE, KNOCKOUT; TOUCH; TRPC CATION CHANNELS; VESTIBULAR FUNCTION TESTS;

EID: 84946429524     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2015.10.052     Document Type: Article

References (34)

1. Alessandri-Haber N., Dina O.A., Chen X., Levine J.D. TRPC1 and TRPC6 channels cooperate with TRPV4 to mediate mechanical hyperalgesia and nociceptor sensitization. J. Neurosci.: Official J. Soc. Neurosci. 2009, 29:6217-6228.
2. Brierley S.M., Castro J., Harrington A.M., Hughes P.A., Page A.J., Rychkov G.Y., Blackshaw L.A. TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity. J. Physiol. 2011, 589:3575-3593.
3. Chun J.N., Lim J.M., Kang Y., Kim E.H., Shin Y.C., Kim H.G., Jang D., Kwon D., Shin S.Y., So I., Jeon J.H. A network perspective on unraveling the role of TRP channels in biology and disease. Pflugers Archiv: Eur. J. Physiol. 2014, 466:173-182.
4. Corns L.F., Johnson S.L., Kros C.J., Marcotti W. Calcium entry into stereocilia drives adaptation of the mechanoelectrical transducer current of mammalian cochlear hair cells. Proc. Natl. Acad. Sci. U. S. A. 2014, 111:14918-14923.
5. Coste B., Mathur J., Schmidt M., Earley T.J., Ranade S., Petrus M.J., Dubin A.E., Patapoutian A. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science 2010, 330:55-60.
6. Dietrich A., Kalwa H., Storch U., Mederos y Schnitzler M., Salanova B., Pinkenburg O., Dubrovska G., Essin K., Gollasch M., Birnbaumer L., Gudermann T. Pressure-induced and store-operated cation influx in vascular smooth muscle cells is independent of TRPC1. Pflugers Archiv: Eur. J. Physiol. 2007, 455:465-477.
7. Dietrich A., Mederos Y.S.M., Gollasch M., Gross V., Storch U., Dubrovska G., Obst M., Yildirim E., Salanova B., Kalwa H., Essin K., Pinkenburg O., Luft F.C., Gudermann T., Birnbaumer L. Increased vascular smooth muscle contractility in TRPC6-/- mice. Mol. Cell. Biol. 2005, 25:6980-6989.
8. Eijkelkamp N., Linley J.E., Torres J.M., Bee L., Dickenson A.H., Gringhuis M., Minett M.S., Hong G.S., Lee E., Oh U., Ishikawa Y., Zwartkuis F.J., Cox J.J., Wood J.N. A role for Piezo2 in EPAC1-dependent mechanical allodynia. Nat. Commun. 2013, 4:1682.
9. Eijkelkamp N., Quick K., Wood J.N. Transient receptor potential channels and mechanosensation. Annu. Rev. Neurosci. 2013, 36:519-546.
10. Elg S., Marmigere F., Mattsson J.P., Ernfors P. Cellular subtype distribution and developmental regulation of TRPC channel members in the mouse dorsal root ganglion. J. Comp. Neurol. 2007, 503:35-46.
11. Garrison S.R., Dietrich A., Stucky C.L. TRPC1 contributes to light-touch sensation and mechanical responses in low-threshold cutaneous sensory neurons. J. Neurophysiol. 2012, 107:913-922.
12. Geleoc G.S., Lennan G.W., Richardson G.P., Kros C.J. A quantitative comparison of mechanoelectrical transduction in vestibular and auditory hair cells of neonatal mice. Proc. Biol. Sci. Royal Soc. 1997, 264:611-621.
13. Gomis A., Soriano S., Belmonte C., Viana F. Hypoosmotic- and pressure-induced membrane stretch activate TRPC5 channels. J. Physiol. 2008, 586:5633-5649.
14. Hardisty-Hughes R.E., Parker A., Brown S.D. A hearing and vestibular phenotyping pipeline to identify mouse mutants with hearing impairment. Nat. Protoc. 2010, 5:177-190.
15. Hartmann J., Dragicevic E., Adelsberger H., Henning H.A., Sumser M., Abramowitz J., Blum R., Dietrich A., Freichel M., Flockerzi V., Birnbaumer L., Konnerth A. TRPC3 channels are required for synaptic transmission and motor coordination. Neuron 2008, 59:392-398.
16. Huber T.B., Schermer B., Muller R.U., Hohne M., Bartram M., Calixto A., Hagmann H., Reinhardt C., Koos F., Kunzelmann K., Shirokova E., Krautwurst D., Harteneck C., Simons M., Pavenstadt H., Kerjaschki D., Thiele C., Walz G., Chalfie M., Benzing T. Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:17079-17086.
17. Kros C.J., Rusch A., Richardson G.P. Mechano-electrical transducer currents in hair cells of the cultured neonatal mouse cochlea. Proc. Biol. Sci. Royal Soc. 1992, 249:185-193.
18. Kwan K.Y., Allchorne A.J., Vollrath M.A., Christensen A.P., Zhang D.S., Woolf C.J., Corey D.P. TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron 2006, 50:277-289.
19. Minasyan A., Keisala T., Zou J., Zhang Y., Toppila E., Syvala H., Lou Y.R., Kalueff A.V., Pyykko I., Tuohimaa P. Vestibular dysfunction in vitamin D receptor mutant mice. J. Steroid Biochem. Mol. Biol. 2009, 114:161-166.
20. Minett M.S., Quick K., Wood J.N. Behavioral measures of pain thresholds. Curr. Protoc. Mouse Biol. 2011, 1:383-412.
21. Petrus M., Peier A.M., Bandell M., Hwang S.W., Huynh T., Olney N., Jegla T., Patapoutian A. A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol. Pain 2007, 3:40.
22. Phelan K.D., Shwe U.T., Abramowitz J., Wu H., Rhee S.W., Howell M.D., Gottschall P.E., Freichel M., Flockerzi V., Birnbaumer L., Zheng F. Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms. Mol. Pharmacol. 2013, 83:429-438.
23. Quick K., Zhao J., Eijkelkamp N., Linley J.E., Rugiero F., Cox J.J., Raouf R., Gringhuis M., Sexton J.E., Abramowitz J., Taylor R., Forge A., Ashmore J., Kirkwood N., Kros C.J., Richardson G.P., Freichel M., Flockerzi V., Birnbaumer L., Wood J.N. TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells. Open Biol. 2012, 2:120068.
24. Ranade S.S., Woo S.H., Dubin A.E., Moshourab R.A., Wetzel C., Petrus M., Mathur J., Begay V., Coste B., Mainquist J., Wilson A.J., Francisco A.G., Reddy K., Qiu Z., Wood J.N., Lewin G.R., Patapoutian A. Piezo2 is the major transducer of mechanical forces for touch sensation in mice. Nature 2014, 516:121-125.
25. Shin Y.C., Shin S.Y., Chun J.N., Cho H.S., Lim J.M., Kim H.G., So I., Kwon D., Jeon J.H. TRIP database 2.0: a manually curated information hub for accessing TRP channel interaction network. PLoS One 2012, 7:e47165.
26. Shin Y.C., Shin S.Y., So I., Kwon D., Jeon J.H. TRIP Database: a manually curated database of protein-protein interactions for mammalian TRP channels. Nucleic Acids Res. 2011, 39:D356-D361.
27. Spassova M.A., Hewavitharana T., Xu W., Soboloff J., Gill D.L. A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:16586-16591.
28. Staaf S., Maxvall I., Lind U., Husmark J., Mattsson J.P., Ernfors P., Pierrou S. Down regulation of TRPC1 by shRNA reduces mechanosensitivity in mouse dorsal root ganglion neurons in vitro. Neurosci. Lett. 2009, 457:3-7.
29. Takumida M., Anniko M. Expression of canonical transient receptor potential channel (TRPC) 1-7 in the mouse inner ear. Acta Oto-Laryngol. 2009, 129:1351-1358.
30. Usoskin D., Furlan A., Islam S., Abdo H., Lonnerberg P., Lou D., Hjerling-Leffler J., Haeggstrom J., Kharchenko O., Kharchenko P.V., Linnarsson S., Ernfors P. Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing. Nat. Neurosci. 2015, 18:145-153.
31. Vandewauw I., Owsianik G., Voets T. Systematic and quantitative mRNA expression analysis of TRP channel genes at the single trigeminal and dorsal root ganglion level in mouse. BMC Neurosci. 2013, 14:21.
32. Vilceanu D., Stucky C.L. TRPA1 mediates mechanical currents in the plasma membrane of mouse sensory neurons. PLoS One 2010, 5:e12177.
33. Woo S.H., Ranade S., Weyer A.D., Dubin A.E., Baba Y., Qiu Z., Petrus M., Miyamoto T., Reddy K., Lumpkin E.A., Stucky C.L., Patapoutian A. Piezo2 is required for Merkel-cell mechanotransduction. Nature 2014, 509:622-626.
34. Zimmermann K., Lennerz J.K., Hein A., Link A.S., Kaczmarek J.S., Delling M., Uysal S., Pfeifer J.D., Riccio A., Clapham D.E. Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:18114-18119.