Resveratrol inhibits inflammation and ameliorates insulin resistant endothelial dysfunction via regulation of AMP-activated protein kinase and sirtuin 1 activities

Journal of Diabetes

Volumn 8, Issue 3, 2016, Pages 324-335

  Liu, Zifeng ^a   Jiang, Cuihua ^b,c   Zhang, Jinghua ^b,c   Liu, Baolin ^b,c   Du, Qun ^a  

^a GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

^c NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

AMP activated protein kinase; Endothelial cells; Inflammation; Insulin resistance; Resveratrol

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; FRUCTOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN RECEPTOR SUBSTRATE 1; INTERLEUKIN 6; METFORMIN; PALMITIC ACID; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN KINASE B; RESVERATROL; SIRTUIN 1; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; NITRIC OXIDE; STILBENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; AORTA; ARTICLE; CELL CYCLE ARREST; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; HUMAN CELL; INFLAMMATION; INSULIN RESISTANCE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RAT; SIGNAL TRANSDUCTION; VASCULAR RING; VASODILATATION; ANIMAL; CHEMICALLY INDUCED; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; SPRAGUE DAWLEY RAT; VASCULAR ENDOTHELIUM; WESTERN BLOTTING;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BLOTTING, WESTERN; CYTOKINES; DIABETES MELLITUS, EXPERIMENTAL; ENDOTHELIUM, VASCULAR; FRUCTOSE; GENE EXPRESSION REGULATION; INFLAMMATION; INSULIN RESISTANCE; MALE; MICROSCOPY, FLUORESCENCE; NITRIC OXIDE; PHOSPHORYLATION; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SIRTUIN 1; STILBENES; VASODILATION;

EID: 84946187178     PISSN: 17530393     EISSN: 17530407     Source Type: Journal    
DOI: 10.1111/1753-0407.12296     Document Type: Article

References (31)

1. Muniyappa R, Montagnani M, Koh KK, Quon MJ. Cardiovascular actions of insulin. Endocr Rev. 2007; 28: 463-491.
2. Schenk S, Saberi M, Olefsky JM. Insulin sensitivity: Modulation by nutrients and inflammation. J Clin Invest. 2008; 118: 2992-3002.
3. Chang YC, Chuang LM. The role of oxidative stress in the pathogenesis of type 2 diabetes: From molecular mechanism to clinical implication. Am J Transl Res. 2010; 2: 316-331.
4. Montagnani M, Golovchenko I, Kim I etal. Inhibition of phosphatidylinositol 3-kinase enhances mitogenic actions of insulin in endothelial cells. J Biol Chem. 2002; 277: 1794-1799.
5. Potenza MA, Marasciulo FL, Chieppa DM etal. Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production. Am J Physiol Heart Circ Physiol. 2005; 289: H813-822.
6. Tabit CE, Chung WB, Hamburg NM, Vita JA. Endothelial dysfunction in diabetes mellitus: Molecular mechanisms and clinical implications. Rev Endocr Metab Disord. 2010; 11: 61-74.
7. Kim JA, Montagnani M, Koh KK, Quon MJ. Reciprocal relationships between insulin resistance and endothelial dysfunction: Molecular and pathophysiological mechanisms. Circulation. 2006; 113: 1888-1904.
8. Davis BJ, Xie Z, Viollet B, Zou MH. Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase. Diabetes. 2006; 55: 496-505.
9. Kim JA, Formoso G, Li Y etal. Epigallocatechin gallate, a green tea polyphenol, mediates NO-dependent vasodilation using signaling pathways in vascular endothelium requiring reactive oxygen species and Fyn. J Biol Chem. 2007; 282: 13736-13745.
10. Reiter CE, Kim JA, Quon MJ. Green tea polyphenol epigallocatechin gallate reduces endothelin-1 expression and secretion in vascular endothelial cells: Roles for AMP-activated protein kinase, Akt, and FOXO1. Endocrinology. 2010; 151: 103-114.
11. Schuhmacher S, Foretz M, Knorr M etal. α1AMP-activated protein kinase preserves endothelial function during chronic angiotensin II treatment by limiting Nox2 upregulation. Arterioscler Thromb Vasc Biol. 2011; 31: 560-566.
12. Ruderman NB, Xu XJ, Nelson L etal. AMPK and SIRT1: A long-standing partnership? Am J Physiol Endocrinol Metab. 2010; 298: E751-760.
13. Yang SR, Wright J, Bauter M, Seweryniak K, Kode A, Rahman I. Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-κB in macrophages in vitro and in rat lungs in vivo: Implications for chronic inflammation and aging. Am J Physiol Lung Cell Mol Physiol. 2007; 292: L567-576.
14. Yang Z, Kahn BB, Shi H, Xue BZ. Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1. J Biol Chem. 2010; 285: 19051-19059.
15. Simopoulos AP. The Mediterranean diets: What is so special about the diet of Greece? The scientific evidence. J Nutr. 2001; 131 (Suppl.): S3065-3073.
16. Zhang H, Zhang J, Ungvari Z, Zhang C. Resveratrol improves endothelial function: Role of TNF α and vascular oxidative stress. Arterioscler Thromb Vasc Biol. 2009; 29: 1164-1171.
17. Su HC, Hung LM, Chen JK. Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats. Am J Physiol Endocrinol Metab. 2006; 290: E1339-1346.
18. Kang L, Heng W, Yuan A, Baolin L, Fang H. Resveratrol modulates adipokine expression and improves insulin sensitivity in adipocytes: Relative to inhibition of inflammatory responses. Biochimie. 2010; 92: 789-796.
19. Hardie DG, Ross FA, Hawley SA. AMPK: A nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol. 2012; 13: 251-262.
20. Lagouge M, Argmann C, Gerhart-Hines Z etal. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006; 127: 1109-1122.
21. Gao X, Liu K, Huang F etal. Positive and negative regulation of insulin action by genistein in the endothelium. J Nutr Biochem. 2013; 24: 222-230.
22. Formoso G, Chen H, Kim JA, Montagnani M, Consoli A, Quon MJ. Dehydroepiandrosterone mimics acute actions of insulin to stimulate production of both nitric oxide and endothelin 1 via distinct phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-dependent pathways in vascular endothelium. Mol Endocrinol. 2006; 20: 1153-1163.
23. Steinberg HO, Baron AD. Vascular function, insulin resistance and fatty acids. Diabetologia. 2002; 45: 623-634.
24. Pirola L, Johnston AM, Van Obberghen E. Modulation of insulin action. Diabetologia. 2004; 47: 170-184.
25. Maloney E, Sweet IR, Hockenbery DM etal. Activation of NF-kappaB by palmitate in endothelial cells: A key role for NADPH oxidase-derived superoxide in response to TLR4 activation. Arterioscler Thromb Vasc Biol. 2009; 29: 1370-1375.
26. Kim F, Tysseling KA, Rice J etal. Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta. Arterioscler Thromb Vasc Biol. 2005; 25: 989-994.
27. Yuan M, Konstantopoulos N, Lee J etal. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science. 2001; 293: 1673-1677.
28. Li G, Barrett EJ, Barrett MO, Cao W, Liu Z. Tumor necrosis factor-alpha induces insulin resistance in endothelial cells via a p38 mitogen-activated protein kinase-dependent pathway. Endocrinology. 2007; 148: 3356-3363.
29. Kanety H, Feinstein R, Papa MZ, Hemi R, Karasik A. Tumor necrosis factor alpha-induced phosphorylation of insulin receptor substrate-1 (IRS-1). Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-1. J Biol Chem. 1995; 270: 23780-23784.
30. Gao Z, Hwang D, Bataille F etal. Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. J Biol Chem. 2002; 277: 48115-48121.
31. Cancelas J, Prieto PG, García-Arévalo M etal. Induction and reversibility of insulin resistance in rats exposed to exogenous d-fructose. Horm Metab Res. 2008; 40: 459-466.