Systemic exposure of Paracetamol (acetaminophen) was enhanced by quercetin and chrysin co-administration in Wistar rats and in vitro model: Risk of liver toxicity

Drug Development and Industrial Pharmacy

Volumn 41, Issue 11, 2015, Pages 1793-1800

  Pingili, Ravindra Babu ^a,b   Pawar, A Krishnamanjari ^c   Challa, Siva R ^b  

^a JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

^b KVSR SIDDHARTHA COLLEGE OF PHARMACEUTICAL SCIENCES   (India)

^c ANDHRA UNIVERSITY   (India)

Author keywords

CYP2E1; Flavonoids; Liver toxicity; P glycoprotein; Pharmacokinetics

Indexed keywords

CHRYSIN; KETOCONAZOLE; MULTIDRUG RESISTANCE PROTEIN; PARACETAMOL; QUERCETIN; QUINIDINE; VERAPAMIL; BENZOQUINONE DERIVATIVE; CYTOCHROME P450 2E1; FLAVONOID; IMINE; N-ACETYL-4-BENZOQUINONEIMINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE MOMENT CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFICACY; DRUG EXPOSURE; DRUG METABOLISM; DRUG POTENTIATION; DRUG TRANSPORT; ELIMINATION HALF-LIFE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; INTESTINE; INTESTINE ABSORPTION; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; MULTIPLE DRUG DOSE; NONHUMAN; ORAL CLEARANCE; PLASMA CONCENTRATION-TIME CURVE; RAT; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION; TOXIC HEPATITIS; TOXICOKINETICS; VOLUME OF DISTRIBUTION AT STEADY-STATE; ANIMAL; ANTAGONISTS AND INHIBITORS; AREA UNDER THE CURVE; DOSE RESPONSE; DRUG INTERACTION; DRUG-INDUCED LIVER INJURY; METABOLISM; ORAL DRUG ADMINISTRATION; PROCEDURES; WISTAR RAT;

ACETAMINOPHEN; ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BENZOQUINONES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2E1; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; DRUG-INDUCED LIVER INJURY; FLAVONOIDS; IMINES; INTESTINAL ABSORPTION; MALE; P-GLYCOPROTEIN; QUERCETIN; RATS; RATS, WISTAR;

EID: 84946144799     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2015.1008012     Document Type: Article

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