NLRP3 deficiency improves angiotensin II-induced hypertension but not fetal growth restriction during pregnancy

Endocrinology (United States)

Volumn 156, Issue 11, 2015, Pages 4281-4292

  Shirasuna, Koumei ^a,b   Karasawa, Tadayoshi ^a   Usui, Fumitake ^a   Kobayashi, Motoi ^a   Komada, Tadanori ^a   Kimura, Hiroaki ^a   Kawashima, Akira ^a   Ohkuchi, Akihide ^a   Taniguchi, Shun'Ichiro ^c   Takahashi, Masafumi ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF AGRICULTURE   (Japan)

^c SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II; CRISPR ASSOCIATED PROTEIN; CRYOPYRIN; HYDRALAZINE; INTERLEUKIN 6; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; INFLAMMASOME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; INFLAMMATORY CELL; INTRAUTERINE GROWTH RETARDATION; KIDNEY INJURY; MATERNAL HYPERTENSION; MOUSE; NONHUMAN; PERIODIC ACID SCHIFF STAIN; PREECLAMPSIA; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; BLOOD PRESSURE; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; GENETICS; HYPERTENSION; KIDNEY; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; PLACENTA;

ANGIOTENSIN II; ANIMALS; BLOOD PRESSURE; CARRIER PROTEINS; DISEASE MODELS, ANIMAL; FEMALE; FETAL GROWTH RETARDATION; HYPERTENSION; HYPERTENSION, PREGNANCY-INDUCED; INFLAMMASOMES; INTERLEUKIN-6; KIDNEY; MICE; MICE, KNOCKOUT; PLACENTA; PREGNANCY;

EID: 84946068327     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2015-1408     Document Type: Article

References (37)

1. Laresgoiti-Servitje E. A leading role for the immune system in the pathophysiology of preeclampsia. J Leukoc Biol. 2013;94:247-257.
2. Maynard SE, Min JY, Merchan J, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest. 2003;111:649-658.
3. Venkatesha S, Toporsian M, Lam C, et al. Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med. 2006;12: 642-649.
4. Redman CW, Sargent IL. Pre-eclampsia, the placenta and the maternal systemic inflammatory response-A review. Placenta 2003; 24(suppl A):S21-S27.
5. Mellembakken JR, Aukrust P, Hestdal K, Ueland T, Abyholm T, Videm V. Chemokines and leukocyte activation in the fetal circulation during preeclampsia. Hypertension. 2001;38:394-398.
6. Mor G, Cardenas I, Abrahams V, Guller S. Inflammation and pregnancy: the role of the immune system at the implantation site. Ann NY Acad Sci. 2011;1221:80-87.
7. Davis BK, Wen H, Ting JP. The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu Rev Immunol. 2011; 29:707-735.
8. Takahashi M. Role of the inflammasome in myocardial infarction. Trends Cardiovasc Med. 2011;21:37-41.
9. Rathinam VA, Vanaja SK, Fitzgerald KA. Regulation of inflammasome signaling. Nat Immunol. 2012;13:333-332.
10. Kawaguchi M, Takahashi M, Hata T, et al. Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia/rep-erfusion injury. Circulation. 2011;123:594-604.
11. Usui F, Shirasuna K, Kimura H, et al. Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II-induced aortic aneurysm. Arterioscler Thromb Vasc Biol. 2015;35:127-136.
12. Chen GY, Nunez G. Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol. 2010;10:826-837.
13. Shirasuna K, Usui F, Karasawa T, et al. Nanosilica-induced placental inflammation and pregnancy complications: different roles of the inflammasome components NLRP3 and ASC. Nanotoxicology. 2015;9:554-567.
14. Inoue Y, Shirasuna K, Kimura H, et al. NLRP3 regulates neutrophil functions and contributes to hepatic ischemia-reperfusion injury independently of inflammasomes. J Immunol. 2014;192:4342-4351.
15. Mizushina Y, Shirasuna K, Usui F, et al. NLRP3 protein deficiency exacerbates hyperoxia-induced lethality through Stat3 protein signaling independent of interleukin-1/3. J Biol Chem. 2015;290:5065-5077.
16. Shigeoka AA, Mueller JL, Kambo A, et al. An inflammasome-inde-pendent role for epithelial-expressed Nlrp3 in renal ischemia-reperfusion injury. J Immunol. 2010;185:6277-6285.
17. Narayan S, Pazar B, Ea HK, et al. Octacalcium phosphate crystals induce inflammation in vivo through interleukin-1 but independent of the NLRP3 inflammasome in mice. Arthritis Rheum. 2011;63: 422-433.
18. Provoost S, Maes T, Pauwels NS, et al. NLRP3/caspase-1-indepen-dent IL-1/3 production mediates diesel exhaust particle-induced pulmonary inflammation. J Immunol. 2011;187:3331-3337.
19. Zhou CC, Ahmad S, Mi T, et al. Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy. Circ Res. 2007;100:88-95.
20. Hering L, Herse F, Geusens N, et al. Effects of circulating and local uteroplacental angiotensin II in rat pregnancy. Hypertension. 2010; 56:311-318.
21. Yamamoto M, Yaginuma K, Tsutsui H, et al. ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-As-sociated signal adaptor molecules. Genes Cells. 2004;9:1055-1067.
22. Komada T, Usui F, Shirasuna K, et al. ASC in renal collecting duct epithelial cells contributes to inflammation and injury after unilateral ureteral obstruction. Am J Pathol. 2014;184:1287-1298.
23. Nishimura S, Manabe I, Nagasaki M, et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med. 2009;15:914-920.
24. Graham CH, Hawley TS, Hawley RG, et al. Establishment and characterization of first trimester human trophoblast cells with extended lifespan. Exp Cell Res. 1993;206:204-211.
25. Zhou CC, Irani RA, Dai Y, et al. Autoantibody-mediated IL-6-de-pendent endothelin-1 elevation underlies pathogenesis in a mouse model of preeclampsia. J Immunol. 2011;186:6024-6034.
26. Brewer J, Liu R, Lu Y, et al. Endothelin-1, oxidative stress, and endogenous angiotensin II: mechanisms of angiotensin II type I receptor autoantibody-enhanced renal and blood pressure response during pregnancy. Hypertension. 2013;62:886-892.
27. Charlton JR, Portilla D, Okusa MD. A basic science view of acute kidney injury biomarkers. Nephrol Dial Transplant. 2014;29: 1301-1311.
28. Furuya M, Ishida J, Aoki I, Fukamizu A. Pathophysiology of pla-centation abnormalities in pregnancy-induced hypertension. Vasc Health Risk Manag. 2008;4:1301-1313.
29. Seki H. The role of the renin-Angiotensin system in the pathogenesis of preeclampsia-new insights into the renin-Angiotensin system in preeclampsia. Med Hypotheses. 2014;82:362-367.
30. Takimoto E, Ishida J, Sugiyama F, Horiguchi H, Murakami K, Fu-kamizuA. Hypertensioninducedinpregnant micebyplacental renin and maternal angiotensinogen. Science. 1996;274:995-998.
31. Zhang W, Wang W, Yu H, et al. Interleukin 6 underlies angiotensin II-induced hypertension and chronic renal damage. Hypertension. 2012;59:136-144.
32. Lee DL, Sturgis LC, Labazi H, et al. Angiotensin II hypertension is attenuated in interleukin-6 knockout mice. Am J Physiol Heart Circ Physiol. 2006;290:H935-H940.
33. Orshal JM, Khalil RA. Reduced endothelial NO-cGMP-mediated vascular relaxation and hypertension in IL-6-infused pregnant rats. Hypertension. 2004;43:434-444.
34. Dudley DJ, Trautman MS, Araneo BA, Edwin SS, Mitchell MD. Decidual cell biosynthesis of interleukin-6: regulation by inflammatory cytokines. J Clin Endocrinol Metab. 1992;74:884-889.
35. Lockwood CJ, Yen CF, Basar M, et al. Preeclampsia-related inflammatory cytokines regulate interleukin-6 expression in human decid-ual cells. Am J Pathol. 2008;172:1571-1579.
36. Cassis LA, Gupte M, Thayer S, et al. ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice. Am J Physiol Heart Circ Physiol. 2009;296:H1660-H1665.
37. Saito T, Ishida J, Takimoto-Ohnishi E, et al. An essential role for angiotensin II type 1a receptor in pregnancy-Associated hypertension with intrauterine growth retardation. FASEB J. 2004;18:388-390.