Suppression of Dendritic Cell-Derived IL-12 by Endogenous Glucocorticoids Is Protective in LPS-Induced Sepsis

PLoS Biology

Volumn 13, Issue 10, 2015, Pages 1-16

  Li, Caiyi C ^a   Munitic, Ivana ^a,b   Mittelstadt, Paul R ^a   Castro, Ehydel ^a   Ashwell, Jonathan D ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b University of Rijeka   (Croatia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CD11 ANTIGEN; CD8 ANTIGEN; ENDOTOXIN; GAMMA INTERFERON; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GLYCOPROTEIN P 15095; INTERLEUKIN 12; INTERLEUKIN 12 ANTIBODY; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA; LIPOPOLYSACCHARIDE, E COLI O55-B5; NEUTRALIZING ANTIBODY; NONSTEROID ANTIINFLAMMATORY AGENT; NR3C1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD8+ T LYMPHOCYTE; CELL LOSS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DOWN REGULATION; FEMALE; HORMONE ACTION; HORMONE BLOOD LEVEL; HYPOTHERMIA; IMMUNOREGULATION; MORTALITY; MOUSE; NATURAL KILLER CELL; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SEPSIS; WILD TYPE; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; C57BL MOUSE; CELL CULTURE; CROSS BREEDING; DOSE RESPONSE; DRUG EFFECTS; GENETICS; GERMFREE ANIMAL; IMMUNOLOGY; INNATE IMMUNITY; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOLOGY; SECRETION (PROCESS); SHOCK, SEPTIC; SIGNAL TRANSDUCTION; SPLEEN; TRANSGENIC MOUSE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIBODIES, NEUTRALIZING; ANTIGENS, CD11C; CELLS, CULTURED; CROSSES, GENETIC; DENDRITIC CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLUCOCORTICOIDS; IMMUNITY, INNATE; INTERLEUKIN-12; LIPOPOLYSACCHARIDES; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; RECEPTORS, GLUCOCORTICOID; SHOCK, SEPTIC; SIGNAL TRANSDUCTION; SPECIFIC PATHOGEN-FREE ORGANISMS; SPLEEN;

EID: 84946062798     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1002269     Document Type: Article

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