Adrenocortical (dys)function in septic shock - A sick euadrenal state

Best Practice and Research: Clinical Endocrinology and Metabolism

Volumn 25, Issue 5, 2011, Pages 719-733

  Venkatesh, Bala ^a   Cohen, Jeremy ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

11 betahydroxysteroid dehydrogenase; adrenal; free cortisol; septic shock; sick euadrenal

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; 11BETA HYDROXYSTEROID DEHYDROGENASE 2; ALDOSTERONE; CYTOKINE; ETOMIDATE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; INTERLEUKIN 1ALPHA; LEUKOCYTE ELASTASE; TETRACOSACTIDE; TRANSCORTIN;

ADAPTATION; ADRENAL DISEASE; ADRENAL FUNCTION; ADRENAL INSUFFICIENCY; ALDOSTERONE BLOOD LEVEL; ARTICLE; CELL STRESS; CIRCADIAN RHYTHM; CORTICOTROPIN TEST; COSYNTROPIN STIMULATION TEST; CRITICALLY ILL PATIENT; CYTOKINE PRODUCTION; ENDOCRINE FUNCTION TEST; ENZYME ACTIVITY; FUNCTIONAL ASSESSMENT; GENE EXPRESSION; GENETIC TRANSCRIPTION; HORMONE ACTION; HUMAN; HYDROCORTISONE BLOOD LEVEL; INFLAMMATION; INJURY SEVERITY; INTESTINE ISCHEMIA; LEUKOCYTE; MONOCYTE; MORTALITY; NONHUMAN; PATHOLOGICAL ANATOMY; PATHOPHYSIOLOGY; PROTEIN BINDING; PROVOCATION TEST; RELIABILITY; SEPSIS; SEPTIC SHOCK; SEX DIFFERENCE; SICK EUADRENAL SYNDROME; STRESS; THERMAL INJURY;

EID: 80052953347     PISSN: 1521690X     EISSN: 15321908     Source Type: Journal    
DOI: 10.1016/j.beem.2011.04.007     Document Type: Review

References (101)

1. M.S. Cooper, and P.M. Stewart Corticosteroid insufficiency in acutely ill patients New England Journal of Medicine 348 2003 727 734 (Pubitemid 36237043)
2. A. Beishuizen, L. Thijs, and I. Vermes Patterns of corticosteroid-binding globulin and the free cortisol index during septic shock and multitrauma Intensive Care Med 27 2001 1584 1591 (Pubitemid 33027954)
3. A.H. Hamrahian, T.S. Oseni, and B.M. Arafah Measurements of serum free cortisol in critically ill patients New England Journal of Medicine 350 16 2004 1629 1638 [see comment] (Pubitemid 38501164)
4. P.E. Marik Critical illness-related corticosteroid insufficiency Chest 135 1 2009 181 193
5. D. Annane Time for a consensus definition of corticosteroid insufficiency in critically ill patients Critical Care Medicine 31 6 2003 1868 1869 (Pubitemid 36714253)
6. J. Cohen, and B. Venkatesh Assessment of tissue cortisol activity Critical Care and Resuscitation 11 4 2009 287 289
7. J. Cohen, R. Deans, and A. Dalley Measurement of tissue cortisol levels in patients with severe burns: a preliminary investigation Critical Care 13 6 2009 R189
8. B. Venkatesh, J. Cohen, and I. Hickman Evidence of altered cortisol metabolism in critically ill patients: a prospective study Intensive Care Medicine 33 10 2007 1746 1753 (Pubitemid 47476642)
9. W. Huang, T.F. Kalhorn, and M. Baillie Determination of free and total cortisol in plasma and urine by liquid chromatography-tandem mass spectrometry Therapeutic Drug Monitoring 29 2 2007 215 224 (Pubitemid 46716189)
10. G.E. Miller, E. Chen, and J. Sze A functional genomic fingerprint of chronic stress in humans: blunted glucocorticoid and increased NF-kappaB signaling Biological Psychiatry 64 4 2008 266 272
11. B. Venkatesh, and J. Cohen Sick adrenal or sick euadrenal? Critical Care and Resuscitation 11 4 2009 301 304
12. H. Selye A syndrome produced by diverse nocuous agents Nature 138 1936 32
13. P.A. Pemberton, P.E. Stein, and M.B. Pepys Hormone binding globulins undergo serpin conformational change in inflammation Nature 336 6196 1988 257 258 (Pubitemid 18264407)
14. O. Fruchter, E. Zoumakis, and S. Alesci Intracrine modulation of gene expression by intracellular generation of active glucocorticoids Steroids 71 11-12 2006 1001 1006 (Pubitemid 44573302)
15. D. Annane Glucocorticoids in the treatment of severe sepsis and septic shock Current Opinion in Critical Care 11 5 2005 449 453 (Pubitemid 41482700)
16. M.S. Cooper, and P.M. Stewart 11Beta-hydroxysteroid dehydrogenase type 1 and its role in the hypothalamus-pituitary-adrenal axis, metabolic syndrome, and inflammation Journal of Clinical Endocrinology & Metabolism 94 12 2009 4645 4654
17. W.J. Scott The influence of the adrenal glands on resistance: I. The susceptibility of adrenalectomized rats to morphine Journal of Experimental Medicine 38 5 1923 543 560
18. H. Shubin, and M.H. Weil Failure of corticosteroid to potentiate sympathomimetic pressor response during shock Journal of the American Medical Association 197 10 1966 808 809
19. C.E. Cooper, and D.H. Nelson ACTH levels in plasma in preoperative and surgically stressed patients Journal of Clinical Investigation 41 8 1962 1599 1605
20. W.R. Beisel, and M.I. Rapoport Inter-relations between adrenocortical functions and infectious illness New England Journal of Medicine 280 11 1969 596 604
21. J.C. Melby, and W.W. Spink Comparative studies on adrenal cortical function and cortisol metabolism in healthy adults and in patients with shock due to infection Journal of Clinical Investigation 37 12 1958 1791 1798
22. B. Chernow, H.R. Alexander, and R.C. Smallridge Hormonal responses to graded surgical stress Archives of Internal Medicine 147 7 1987 1273 1278
23. J. Briegel, W. Kellermann, and H. Forst Low-dose hydrocortisone infusion attenuates the systemic inflammatory response syndrome. The phospholipase A2 study group Journal of Clinical Investigation 72 10 1994 782 787 (Pubitemid 24327776)
24. G. Bouachour, P. Tirot, and J.P. Gouello Adrenocortical function during septic shock Intensive Care Medicine 21 1 1995 57 62
25. E. Barquist, and O. Kirton Adrenal insufficiency in the surgical intensive care unit patient Journal of Trauma 42 1 1997 27 31 (Pubitemid 27045048)
26. P.E. Bollaert, C. Charpentier, and B. Levy Reversal of late septic shock with supraphysiologic doses of hydrocortisone Critical Care Medicine 26 4 1998 645 650 (Pubitemid 28201409)
27. D. Annane, V. Sebille, and C. Charpentier Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock Journal of the American Medical Association 288 7 2002 862 871 [see comment]
28. D. Annane, V. Sebille, and G. Troche A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin Journal of the American Medical Association 283 8 2000 1038 1045 (Pubitemid 30112218)
29. G. Dickstein On the term "relative adrenal insufficiency"-or what do we really measure with adrenal stimulation tests? Journal of Clinical Endocrinology & Metabolism 90 8 2005 4973 4974 (Pubitemid 41159399)
30. D.L. Loriaux, and M. Fleseriu Relative adrenal insufficiency Current Opinion in Endocrinology, Diabetes and Obesity 16 5 2009 392 400
31. R. Udelsman, J. Ramp, and W.T. Gallucci Adaptation during surgical stress. A reevaluation of the role of glucocorticoids Journal of Clinical Investigation 77 4 1986 1377 1381 (Pubitemid 16047162)
32. H. Kehlet, and C. Binder Adrenocortical function and clinical course during and after surgery in unsupplemented glucocorticoid-treated patients British Journal of Anaesthesia 45 10 1973 1043 1048
33. P.M. Rothwell, Z.F. Udwadia, and E.A. Jackson Plasma cortisol levels in patients with septic shock Critical Care Medicine 19 4 1991 589 590
34. J.T. Ho, H. Al-Musalhi, and M.J. Chapman Septic shock and sepsis: a comparison of total and free plasma cortisol levels Journal of Clinical Endocrinology & Metabolism 91 1 2006 105 114 (Pubitemid 43069125)
35. P.E. Bollaert, F. Fieux, and C. Charpentier Baseline cortisol levels, cortisol response to corticotropin, and prognosis in late septic shock Shock 19 1 2003 13 15
36. V. Siraux, D. De Backer, and G. Yalavatti Relative adrenal insufficiency in patients with septic shock: comparison of low-dose and conventional corticotropin tests Critical Care Medicine 33 11 2005 2479 2486
37. O. Yildiz, M. Doganay, and B. Aygen Physiological-dose steroid therapy in sepsis Critical Care 6 3 2002 251 259 [ISRCTN36253388]
38. R.S. Bourne, S.J. Webber, and S.P. Hutchinson Adrenal axis testing and corticosteroid replacement therapy in septic shock patients-local and national perspectives Anaesthesia 58 6 2003 591 596
39. D. Jones, M. Hayes, and S. Webb Relative adrenal insufficiency in etomidate-naive patients with septic shock Anaesthesia and Intensive Care 34 5 2006 599 605 (Pubitemid 44687827)
40. J. Briegel, G. Schelling, and M. Haller A comparison of the adrenocortical response during septic shock and after complete recovery Intensive Care Medicine 22 9 1996 894 899 (Pubitemid 26340636)
41. M. Oppert, A. Reinicke, and K.J. Graf Plasma cortisol levels before and during "low-dose" hydrocortisone therapy and their relationship to hemodynamic improvement in patients with septic shock Intensive Care Medicine 26 12 2000 1747 1755 (Pubitemid 32009993)
42. J.L. Moran, M.J. Chapman, and M.S. O'Fathartaigh Hypocortisolaemia and adrenocortical responsiveness at onset of septic shock Intensive Care Medicine 20 7 1994 489 495 (Pubitemid 24287780)
43. M. Hatherill, S.M. Tibby, and T. Hilliard Adrenal insufficiency in septic shock Archives of Disease in Childhood 80 1 1999 51 55 (Pubitemid 29142525)
44. M. Faber, H. Flachs, and N. Frimodt-Moller Hyponatremia and adrenocortical function in patients with severe bacterial infections Scandinavian Journal of Infectious Diseases 25 1 1993 101 105 (Pubitemid 23099591)
45. S. Manglik, E. Flores, and L. Lubarsky Glucocorticoid insufficiency in patients who present to the hospital with severe sepsis: a prospective clinical trial Critical Care Medicine 31 6 2003 1668 1675 (Pubitemid 36714219)
46. A. Soni, G.M. Pepper, and P.M. Wyrwinski Adrenal insufficiency occurring during septic shock: incidence, outcome, and relationship to peripheral cytokine levels American Journal of Medicine 98 3 1995 266 271
47. P. Marik, and G. Zaloga Adrenal insufficiency during septic shock Critical Care Medicine 31 2003 141 145 (Pubitemid 36151163)
48. B. Aygen, M. Inan, and M. Doganay Adrenal functions in patients with sepsis Experimental and Clinical Endocrinology & Diabetes 105 3 1997 182 186 (Pubitemid 27289434)
49. W. Arlt, and B. Allolio Adrenal insufficiency Lancet 361 9372 2003 1881 1893 (Pubitemid 36645187)
50. W.J. Sibbald, A. Short, and M.P. Cohen Variations in adrenocortical responsiveness during severe bacterial infections. Unrecognized adrenocortical insufficiency in severe bacterial infections Annals of Surgery 186 1 1977 29 33 (Pubitemid 8141580)
51. P.M. Rothwell, and P.G. Lawler Prediction of outcome in intensive care patients using endocrine parameters Critical Care Medicine 23 1 1995 78 83
52. R.M. Schein, C.L. Sprung, and E. Marcial Plasma cortisol levels in patients with septic shock Critical Care Medicine 18 3 1990 259 263 (Pubitemid 20086851)
53. S. Sam, T.C. Corbridge, and B. Mokhlesi Cortisol levels and mortality in severe sepsis Clinical Endocrinology (Oxford) 60 1 2004 29 35 (Pubitemid 38183494)
54. S. Schroeder, M. Wichers, and D. Klingmuller The hypothalamic-pituitary- adrenal axis of patients with severe sepsis: altered response to corticotropin-releasing hormone Critical Care Medicine 29 2 2001 310 316 (Pubitemid 32171775)
55. M.J. Jarek, E.J. Legare, and M.T. McDermott Endocrine profiles for outcome prediction from the intensive care unit Critical Care Medicine 21 4 1993 543 550 (Pubitemid 23121803)
56. M.F. de Jong, A. Beishuizen, and J.J. Spijkstra Relative adrenal insufficiency as a predictor of disease severity, mortality, and beneficial effects of corticosteroid treatment in septic shock Critical Care Medicine 35 8 2007 1896 1903 (Pubitemid 47220364)
57. I. Dimopoulou, P. Alevizopoulou, and U. Dafni Pituitary-adrenal responses to human corticotropin-releasing hormone in critically ill patients Intensive Care Medicine 33 3 2007 454 459 (Pubitemid 46333833)
58. D. Lipiner-Friedman, C.L. Sprung, and P.F. Laterre Adrenal function in sepsis: the retrospective corticus cohort study Critical Care Medicine 35 4 2007 1012 1018 (Pubitemid 46598949)
59. T.H. Jurney, J.L. Cockrell Jr., and J.S. Lindberg Spectrum of serum cortisol response to ACTH in ICU patients. Correlation with degree of illness and mortality Chest 92 2 1987 292 295 (Pubitemid 17125833)
60. L.F. Span, A.R. Hermus, and A.K. Bartelink Adrenocortical function: an indicator of severity of disease and survival in chronic critically ill patients Intensive Care Medicine 18 2 1992 93 96
61. B. Venkatesh, R.H. Mortimer, and B. Couchman Evaluation of random plasma cortisol and the low dose corticotropin test as indicators of adrenal secretory capacity in critically ill patients: a prospective study Anaesthesia and Intensive Care 33 2 2005 201 209 (Pubitemid 40521020)
62. J.R. Sainsbury, J.C. Stoddart, and M.J. Watson Plasma cortisol levels. A comparison between sick patients and volunteers given intravenous cortisol Anaesthesia 36 1 1981 16 21 (Pubitemid 11007317)
63. E. de Jonge, M.J. Schultz, and L. Spanjaard Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial Lancet 362 9389 2003 1011 1016 (Pubitemid 37186877)
64. A.A. Sandberg, K. Eik-Nes, and C.J. Migeon Metabolism of adrenal steroids in dying patients Journal of Clinical Endocrinology & Metabolism 16 8 1956 1001 1016
65. A.K. Done, R.S. Ely, and V.C. Kelley Studies of 17- hydroxycorticosteroids. XIV. Plasma 17-hydroxycorticosteroid concentrations at death in human subjects A.M.A. Journal of Diseases of Children 96 6 1958 655 665
66. D. Murray Cortisol binding to plasma proteins in man in health, stress and at death Journal of Endocrinology 39 4 1967 571 591
67. I. Carr The human adrenal cortex at the time of death Journal of Pathology & Bacteriology 78 1959 533 541
68. J.I. McKee, and W.E. Finlay Cortisol replacement in severely stressed patients Lancet 1 8322 1983 484 (Pubitemid 13137402)
69. N. Rohleder, N.C. Schommer, and D.H. Hellhammer Sex differences in glucocorticoid sensitivity of proinflammatory cytokine production after psychosocial stress Psychosomatic Medicine 63 6 2001 966 972 (Pubitemid 33101383)
70. J.J. Puder, P.U. Freda, and R.S. Goland Estrogen modulates the hypothalamic-pituitary-adrenal and inflammatory cytokine responses to endotoxin in women Journal of Clinical Endocrinology & Metabolism 86 6 2001 2403 2408 (Pubitemid 32545683)
71. J. Cohen, G. Ward, and J. Prins Variability of cortisol assays can confound the diagnosis of adrenal insufficiency in the critically ill population Intensive Care Medicine 32 11 2006 1901 1905 (Pubitemid 44607383)
72. J. Briegel, C.L. Sprung, and D. Annane Multicenter comparison of cortisol as measured by different methods in samples of patients with septic shock Intensive Care Medicine 35 12 2009 2151 2156
73. I. Watt, and I.M. Ledingham Mortality amongst multiple trauma patients admitted to an intensive therapy unit Anaesthesia 39 10 1984 973 981 (Pubitemid 15076641)
74. T. Tan, L. Chang, and A. Woodward Characterising adrenal function using directly measured plasma free cortisol in stable severe liver disease Journal of Hepatology 53 5 2010 841 848
75. P.F. Speckart, J.T. Nicoloff, and J.E. Bethune Screening for adrenocortical insufficiency with cosyntropin (synthetic ACTH) Archives of Internal Medicine 128 5 1971 761 763
76. I.E. Widmer, J.J. Puder, and C. Konig Cortisol response in relation to the severity of stress and illness Journal of Clinical Endocrinology & Metabolism 90 8 2005 4579 4586 (Pubitemid 41159346)
77. E. Arvat, L. Di Vito, and F. Lanfranco Stimulatory effect of adrenocorticotropin on cortisol, aldosterone, and dehydroepiandrosterone secretion in normal humans: dose-response study Journal of Clinical Endocrinology & Metabolism 85 9 2000 3141 3146
78. A. Beishuizen, L.G. Thijs, and I. Vermes Patterns of corticosteroid- binding globulin and the free cortisol index during septic shock and multitrauma Intensive Care Medicine 27 10 2001 1584 1591 (Pubitemid 33027954)
79. S.K. Cunningham, A. Moore, and T.J. McKenna Normal cortisol response to corticotropin in patients with secondary adrenal failure Archives of Internal Medicine 143 12 1983 2276 2279 (Pubitemid 14209732)
80. G. Dickstein, C. Shechner, and W.E. Nicholson Adrenocorticotropin stimulation test: effects of basal cortisol level, time of day, and suggested new sensitive low dose test Journal of Clinical Endocrinology & Metabolism 72 4 1991 773 778 (Pubitemid 21921764)
81. E.J. Nye, J.E. Grice, and G.I. Hockings Comparison of adrenocorticotropin (ACTH) stimulation tests and insulin hypoglycemia in normal humans: low dose, standard high dose, and 8-hour ACTH-(1-24) infusion tests Journal of Clinical Endocrinology & Metabolism 84 10 1999 3648 3655 (Pubitemid 30645220)
82. D. du Cheyron, A. Lesage, and C. Daubin Hyperreninemic hypoaldosteronism: a possible etiological factor of septic shock-induced acute renal failure Intensive Care Medicine 29 10 2003 1703 1709 (Pubitemid 37373813)
83. A. Beishuizen, and L.G. Thijs The immunoneuroendocrine axis in critical illness: beneficial adaptation or neuroendocrine exhaustion? Current Opinion in Critical Care 10 6 2004 461 467 (Pubitemid 39620195)
84. M. den Brinker, K.F. Joosten, and O. Liem Adrenal insufficiency in meningococcal sepsis: bioavailable cortisol levels and impact of interleukin-6 levels and intubation with etomidate on adrenal function and mortality Journal of Clinical Endocrinology & Metabolism 90 9 2005 5110 5117 (Pubitemid 41262261)
85. J.R. Seckl 11 beta-hydroxysteroid dehydrogenase isoforms and their implications for blood pressure regulation European Journal of Clinical Investigation 23 10 1993 589 601 (Pubitemid 23309652)
86. J.W. Tomlinson, E.A. Walker, and I.J. Bujalska 11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response Endocrine Reviews 25 2004 831 866 (Pubitemid 39366049)
87. M.M. Kushnir, R. Neilson, and W.L. Roberts Cortisol and cortisone analysis in serum and plasma by atmospheric pressure photoionization tandem mass spectrometry Clinical Biochemistry 37 5 2004 357 362 (Pubitemid 38490453)
88. M. Vogeser, R. Zachoval, and T.W. Felbinger Increased ratio of serum cortisol to cortisone in acute-phase response Hormone Research. 58 4 2002 172 175
89. M. Vogeser, T.W. Felbinger, and W. Roll Cortisol metabolism in the postoperative period after cardiac surgery Experimental and Clinical Endocrinology & Diabetes 107 8 1999 539 546
90. Z.H. CHuang, H. Gao, and R.B. Xu Study on glucocorticoid receptros during intestinal ischemia and septic shock Circulatory Shock 23 1987 27 36 (Pubitemid 18015055)
91. C.M. Pariante, B.D. Pearce, and T.L. Pisell The proinflammatory cytokine, interleukin-1alpha, reduces glucocorticoid receptor translocation and function Endocrinology 140 9 1999 4359 4366 (Pubitemid 30647135)
92. F. Li, and R.B. Xu Changes in canine leukocyte glucocorticoid receptors during endotoxin shock Circulatory Shock 26 1 1988 99 105
93. D.H. Liu, Y.P. Su, and W. Zhang Changes in glucocorticoid and mineralocorticoid receptors of liver and kidney cytosols after pathologic stress and its regulation in rats Critical Care Medicine 30 3 2002 623 627 (Pubitemid 34214628)
94. G.J. Molijn, J.W. Koper, and C.J. van Uffelen Temperature-induced down-regulation of the glucocorticoid receptor in peripheral blood mononuclear leucocyte in patients with sepsis or septic shock Clinical Endocrinology (Oxford) 43 2 1995 197 203
95. I. Vanhorebeek, R.P. Peeters, and S. Vander Perre Cortisol response to critical illness: effect of intensive insulin therapy Journal of Clinical Endocrinology & Metabolism 91 10 2006 3803 3813 (Pubitemid 44536847)
96. X. Sun, D.R. Fischer, and T.A. Pritts Expression and binding activity of the glucocorticoid receptor are upregulated in septic muscle American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 282 2 2002 R509 R518
97. K. Kamiyama, N. Matsuda, and S. Yamamoto Modulation of glucocorticoid receptor expression, inflammation, and cell apoptosis in septic guinea pig lungs using methylprednisolone American Journal of Physiology - Lung Cell Molecular Physiology 295 6 2008 L998 L1006
98. S.M. Adler, and L. Wartofsky The nonthyroidal illness syndrome Endocrinology Metabolism Clinics of North America 36 3 2007 657 672 (Pubitemid 47135590)
99. M.F. de Jong, A. Beishuizen, and M.J. de Jong The pituitary-adrenal axis is activated more in non-survivors than in survivors of cardiac arrest, irrespective of therapeutic hypothermia Resuscitation 78 3 2008 281 288
100. A. Rydvall, A.K. Brandstrom, and R. Banga Plasma cortisol is often decreased in patients treated in an intensive care unit Intensive Care Medicine 26 5 2000 545 551 (Pubitemid 30325870)
101. Y.S. Kwon, G.Y. Suh, and E.H. Kang Basal serum cortisol levels are not predictive of response to corticotropin but have prognostic significance in patients with septic shock Journal of Korean Medical Science 22 3 2007 470 475