Renal mineralocorticoid receptor and electrolyte homeostasis

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 309, Issue 9, 2015, Pages R1068-R1070

  Terker, Andrew S ^a   Ellison, David H ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b Veterans Affairs Portland Health Care System   (United States)

Author keywords

Homeostasis; Mineralocorticoid; Na+ Cl cotransporter; Potassium; Sodium

Indexed keywords

ELECTROLYTE; MINERALOCORTICOID RECEPTOR; ALDOSTERONE; POTASSIUM; POTASSIUM CHANNEL;

HOMEOSTASIS; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; BIOLOGICAL MODEL; BLOOD PRESSURE; CHANNEL GATING; ELECTROLYTE BALANCE; HUMAN; KIDNEY; METABOLISM;

ALDOSTERONE; ANIMALS; BLOOD PRESSURE; HUMANS; ION CHANNEL GATING; KIDNEY; MODELS, BIOLOGICAL; POTASSIUM; POTASSIUM CHANNELS; RECEPTORS, MINERALOCORTICOID; WATER-ELECTROLYTE BALANCE;

EID: 84946055486     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00135.2015     Document Type: Review

References (25)

1. Berger S, Bleich M, Schmid W, Cole TJ, Peters J, Watanabe H, Kriz W, Warth R, Greger R, Schutz G. Mineralocorticoid receptor knockout mice: pathophysiology of Na+ metabolism. Proc Natl Acad Sci USA 95: 9424-9429, 1998.
2. Bostanjoglo M, Reeves WB, Reilly RF, Velazquez H, Robertson N, Litwack G, Morsing P, Dorup J, Bachmann S, Ellison DH. 11Betahydroxysteroid dehydrogenase, mineralocorticoid receptor, and thiazidesensitive Na-Cl cotransporter expression by distal tubules. J Am Soc Nephrol 9: 1347-1358, 1998.
3. Bridgham JT, Carroll SM, Thornton JW. Evolution of hormonereceptor complexity by molecular exploitation. Science 312: 97-101, 2006.
4. Chang SS, Grunder S, Hanukoglu A, Rosler A, Mathew PM, Hanukoglu I, Schild L, Lu Y, Shimkets RA, Nelson-Williams C, Rossier BC, Lifton RP. Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type.Nature Genetics 12: 248-253, 1996.
5. Eaton DC, Pooler JP. Vander's Renal Physiology (8th ed). Columbus, OH: McGraw-Hill, 2013.
6. Funder JW, Pearce PT, Smith R, Smith AI. Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated. Science 242: 583-585, 1988.
7. Gennari FJ, Segal AS. Hyperkalemia: An adaptive response in chronic renal insufficiency. Kidney Int 62: 1-9, 2002.
8. Kim GH, Masilamani S, Turner R, Mitchell C, Wade JB, Knepper MA. The thiazide-sensitive Na-Cl cotransporter is an aldosterone-induced protein. Proc Natl Acad Sci USA 95: 14552-14557, 1998.
9. Kyossev Z, Walker PD, Reeves WB. Immunolocalization of NADdependent 11 beta-hydroxysteroid dehydrogenase in human kidney and colon. Kidney Int 49: 271-281, 1996.
10. Magill SB. Pathophysiology, diagnosis, and treatment of mineralocorticoid disorders. Compr Physiol 4: 1083-1119, 2014.
11. Naray-Fejes-Toth A, Fejes-Toth G. Expression cloning of the aldosterone target cell-specific 11 beta-hydroxysteroid dehydrogenase from rabbit collecting duct cells. Endocrinology 136: 2579-2586, 1995.
12. Nguyen Dinh Cat A, Jaisser F. Extrarenal effects of aldosterone. Curr Opin Nephrol Hypertens 21: 147-156, 2012.
13. Palmer LG, Patel A, Frindt G. Regulation and dysregulation of epithelial Na+ channels. Clin Exp Nephrol 16: 35-43, 2012.
14. Ronzaud C, Loffing J, Bleich M, Gretz N, Grone HJ, Schutz G, Berger S. Impairment of sodium balance in mice deficient in renal principal cell mineralocorticoid receptor. J Am Soc Nephrol 18: 1679-1687, 2007.
15. Ronzaud C, Loffing J, Gretz N, Schutz G, Berger S. Inducible renal principal cell-specific mineralocorticoid receptor gene inactivation in mice. Am J Physiol Renal Physiol 300: F756-F760, 2011.
16. Rossier BC, Staub O, Hummler E. Genetic dissection of sodium and potassium transport along the aldosterone-sensitive distal nephron: importance in the control of blood pressure and hypertension. FEBS Lett 587: 1929-1941, 2013.
17. Shimkets RA, Warnock DG, Bositis CM, Nelson-Williams C, Hansson JH, Schambelan M, Gill JR Jr, Ulick S, Milora RV, Findling JW, Canessa CM, Rossier BC, and Lifton RP. Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell 79: 407-414, 1994.
18. Smith RE, Li KX, Andrews RK, Krozowski Z. Immunohistochemical and molecular characterization of the rat 11 beta-hydroxysteroid dehydrogenase type II enzyme. Endocrinology 138: 540-547, 1997.
19. Terker AS, Lazelle RA, Yang CL, Ellison DH. Induced pan-nephron mineralocorticoid receptor knockout causes Na+ wasting and K+ retention. FASEB J 29: 968.962, 2015.
20. Terker AS, Zhang C, McCormick JA, Lazelle RA, Zhang C, Meermeier NP, Siler DA, Park HJ, Fu Y, Cohen DM, Weinstein AM, Wang WH, Yang CL, Ellison DH. Potassium modulates electrolyte balance and blood pressure through effects on distal cell voltage and chloride. Cell Metab 21: 39-50, 2015.
21. Todkar A, Picard N, Loffing-Cueni D, Sorensen MV, Mihailova M, Nesterov V, Makhanova N, Korbmacher C, Wagner CA, Loffing J. Mechanisms of renal control of potassium homeostasis in complete aldosterone deficiency. J Am Soc Nephrol 26: 425-438, 2015.
22. + -Cl- cotransporter. Am J Physiol Renal Physiol 305: F1177-F1188, 2013.
23. Velazquez H, Bartiss A, Bernstein P, Ellison DH. Adrenal steroids stimulate thiazide-sensitive NaCl transport by rat renal distal tubules. Am J Physiol Renal Fluid Electrolyte Physiol 270: F211-F219, 1996.
24. Vitzthum H, Seniuk A, Schulte LH, Muller ML, Hetz H, Ehmke H. Functional coupling of renal K+ and Na+ handling causes high blood pressure in Na+ replete mice. J Physiol 592: 1139-1157, 2014.
25. Zhou MY, Gomez-Sanchez EP, Cox DL, Cosby D, andGomez-Sanchez CE. Cloning, expression, and tissue distribution of the rat nicotinamide adenine dinucleotide-dependent 11 beta-hydroxysteroid dehydrogenase. Endocrinology 136: 3729-3734, 1995.