Inactivation of Eed impedes MLL-AF9-mediated leukemogenesis through Cdkn2a-dependent and Cdkn2a-independent mechanisms in a murine model

Experimental Hematology

Volumn 43, Issue 11, 2015, Pages 930-935.e6

  Danis, Etienne ^a,b   Yamauchi, Taylor ^a,b   Echanique, Kristen ^a,b   Haladyna, Jessica ^a,b   Kalkur, Roshni ^a,b   Riedel, Simone ^a,b   Zhu, Nan ^c   Xie, Huafeng ^d,e   Bernt, Kathrin M ^a,b   Orkin, Stuart H ^d,e   Armstrong, Scott A ^c   Neff, Tobias ^a,b  

^a CHILDREN S HOSPITAL COLORADO   (United States)

^b University of Colorado Denver and Children s Hospital Colorado   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; EARLY GROWTH RESPONSE FACTOR 1; EMBRYONIC ECTODERM DEVELOPMENT PROTEIN; HYBRID PROTEIN; POLYCOMB REPRESSIVE COMPLEX 2; RNA; TRANSCRIPTION FACTOR GATA 2; CDKN2A PROTEIN, MOUSE; EED PROTEIN, MOUSE; MLL-AF9 FUSION PROTEIN, MOUSE; ONCOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL GROWTH; CELL TRANSFORMATION; CONTROLLED STUDY; GENE INACTIVATION; IN VITRO STUDY; IN VIVO STUDY; LEUKEMOGENESIS; MOLECULAR MECHANICS; MOUSE; MYELOID LEUKEMIA; MYELOID LEUKEMIA CELL LINE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; RNA SEQUENCE; ANIMAL; EXPERIMENTAL NEOPLASM; GENETICS; LEUKEMIA; METABOLISM; PATHOLOGY; TUMOR CELL CULTURE;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN-DEPENDENT KINASE INHIBITOR P16; LEUKEMIA; MICE; NEOPLASMS, EXPERIMENTAL; ONCOGENE PROTEINS, FUSION; POLYCOMB REPRESSIVE COMPLEX 2; TUMOR CELLS, CULTURED;

EID: 84945965314     PISSN: 0301472X     EISSN: 18732399     Source Type: Journal    
DOI: 10.1016/j.exphem.2015.06.005     Document Type: Article

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